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List of works by Olivier Elemento

A Computational Approach for Identifying Synergistic Drug Combinations

scientific article

A Computational Drug Repositioning Approach for Targeting Oncogenic Transcription Factors

scientific article published on 31 May 2016

A Data-Driven Approach to Predicting Successes and Failures of Clinical Trials

scientific article

A Novel Approach for Characterizing Microsatellite Instability in Cancer Cells ⬇️

scientific article published on May 6, 2013

A machine learning and network framework to discover new indications for small molecules

scientific article published on 07 August 2020

A molecular single-cell lung atlas of lethal COVID-19

scientific article

A primer on precision medicine informatics

scientific article published on 05 June 2015

A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis ⬇️

scientific article published on June 30, 2013

A universal framework for regulatory element discovery across all genomes and data types

scientific article

Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity

scientific article

Abstract LB-081: A nuclear cAMP microdomain functions as a tumor suppressor in melanoma

scholarly article

Akt suppression of TGFβ signaling contributes to the maintenance of vascular identity in embryonic stem cell-derived endothelial cells

scientific article published on January 2014

An Epigenomic Approach to Improving Response to Neoadjuvant Cisplatin Chemotherapy in Bladder Cancer

scientific article published on 02 September 2016

An integrated ChIP-seq analysis platform with customizable workflows ⬇️

scientific article published on July 7, 2011

Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma

scientific article

Clinical and Genetic Characteristics of Covid-19 Patients from UK Biobank

scientific article published on 05 May 2020

Clinical interpretation of whole-genome and whole-transcriptome sequencing for precision oncology

scientific article published on 10 July 2021

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

scientific article published on 24 November 2015

Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons

scientific article

Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors

scientific article

Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease ⬇️

scientific article published on January 1, 2012

Coupling of zygotic transcription to mitotic control at the Drosophila mid-blastula transition

scientific article

DISPARE: DIScriminative PAttern REfinement for Position Weight Matrices

scientific article

DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID

scientific article

DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma

scientific article

DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation

scientific article

Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy

scientific article published on September 2016

Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia

scientific article published on 25 June 2015

Discovery and clinical introduction of first-in-class imipridone ONC201.

scientific article published on September 2016

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.

scientific article

ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages

scientific article

ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis

scientific article

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

scientific journal article

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

scientific article published on May 2013

EZH2 mutations are frequent and represent an early event in follicular lymphoma

scientific article published on 19 September 2013

Efficient Direct Reprogramming of Mature Amniotic Cells into Endothelial Cells by ETS Factors and TGFβ Suppression ⬇️

scientific article published on October 18, 2012

Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis

scientific article published on 21 December 2016

Epigenetic analysis identifies factors driving racial disparity in prostate cancer

scientific article published on 13 December 2018

Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells

scientific article published on 27 April 2016

Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression

scientific article published on 11 December 2012

Epigenomic alterations in localized and advanced prostate cancer

scientific article published on April 2013

Epigenomic evolution in diffuse large B-cell lymphomas

scientific article published on 20 April 2015

Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach

scientific article

Faster sequencers, larger datasets, new challenges ⬇️

scientific article published on January 1, 2012

Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis

scientific article

Genome-Wide Detection of Genes Targeted by Non-Ig Somatic Hypermutation in Lymphoma ⬇️

scientific article published on July 12, 2012

Global miRNA expression analysis identifies novel key regulators of plasma cell differentiation and malignant plasma cell

scientific article

Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation

scientific article

Histone variant H3.3 is an essential maternal factor for oocyte reprogramming

scientific article

Identification and Genome-Wide Prediction of DNA Binding Specificities for the ApiAP2 Family of Regulators from the Malaria Parasite ⬇️

scientific article (publication date: 28 October 2010)

Identification of Reprogrammed Myeloid Cell Transcriptomes in NSCLC

scientific article published on 5 June 2015

Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk

scientific article published on 10 April 2012

Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib

scientific article

Inferring chromatin-bound protein complexes from genome-wide binding assays

scientific article published on 03 April 2013

Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

scientific article published on 06 July 2016

Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET-rearranged thyroid cancer

scientific article published on 05 May 2022

Integrative clinical genomics of advanced prostate cancer

scientific article

Large-Scale Discovery and Characterization of Protein Regulatory Motifs in Eukaryotes ⬇️

scientific article published on December 29, 2010

Longitudinal immune profiling of mild and severe COVID-19 reveals innate and adaptive immune dysfunction and provides an early prediction tool for clinical progression

scientific article published on 09 September 2020

Melanoma genome evolution across species

scientific article

Metabolic Alterations in Lung Cancer–Associated Fibroblasts Correlated with Increased Glycolytic Metabolism of the Tumor ⬇️

scientific article published on 08 March 2013

Molecular diagnosis of autosomal dominant polycystic kidney disease using next-generation sequencing

scientific article

Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration

scientific article

Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa

scientific article published on 12 November 2010

NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche

scientific article published on 6 February 2013

Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis

scientific article published on 11 February 2016

Oncogene-mediated alterations in chromatin conformation

scientific article

Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression

scientific article

Oncogenic transcription factors as master regulators of chromatin topology: a new role for ERG in prostate cancer

scientific article

Prediction of Genetic Interactions Using Machine Learning and Network Properties

scientific article

Punctuated evolution of prostate cancer genomes

scientific article published on April 2013

R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

scientific article

Revealing posttranscriptional regulatory elements through network-level conservation

scientific article

Reversible methylation of m6Am in the 5' cap controls mRNA stability

scientific article

Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

scientific article

Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19

scientific article published in 2022

Silencing of UCHL1 by CpG promoter hyper-methylation is associated with metastatic gastroenteropancreatic well-differentiated neuroendocrine (carcinoid) tumors

scientific article

Single-cell TCRseq: paired recovery of entire T-cell alpha and beta chain transcripts in T-cell receptors from single-cell RNAseq

scientific article published on 27 July 2016

Sox17 drives functional engraftment of endothelium converted from non-vascular cells

scientific article published on 16 January 2017

Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps

scientific article published on 9 March 2021

Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies

scientific article published on 21 December 2016

Tbx5 is required for avian and Mammalian epicardial formation and coronary vasculogenesis

scientific article published on 22 September 2014

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.

scientific article published on 23 March 2009

The NF-κB Transcriptional Footprint Is Essential for SARS-CoV-2 Replication

scientific article published on 15 September 2021

The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretations

scientific article

The chromatin Remodeler CHD8 is required for activation of progesterone receptor-dependent enhancers

scientific article published on 20 April 2015

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry

scientific article

The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

scientific article

Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes

scientific article published on 25 October 2016

Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo

scientific article

Use of RNA sequencing to evaluate rheumatic disease patients

scientific article

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

scientific article published on 28 December 2015

Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells

scientific article

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.

scientific article

let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts

scientific article

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