List of works - Rob Hooft van Huijsduijnen

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

scientific article

A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study

scientific article published on 13 September 2016

A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria

article

An NF kappa B-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription

scientific article

Anticancer properties of distinct antimalarial drug classes

scientific article (publication date: 2013)

Applying the SPOT peptide synthesis procedure to the study of protein tyrosine phosphatase substrate specificity: probing for the heavenly match in vitro

scientific article

Both Intrinsic Substrate Preference and Network Context Contribute to Substrate Selection of Classical Tyrosine Phosphatases

scientific article published on 3 February 2017

Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation

scientific article

Characterization of three highly purified influenza virus strains by electron microscopy

scientific article published in April 1984

Chemical inducers and transcriptional markers of oligodendrocyte differentiation

scientific article published on September 2010

Commonly used cat reporter vectors contain a cAMP-inducible, cryptic enhancer that co-operates with NF-kappa B-sites.

scientific article published in December 1994

Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits

scientific journal article

DNA-methylation of the E-selectin promoter represses NF-kappa B transactivation

scientific article published on 01 July 1993

Decompartmentalizing target validation-thinking outside the pipeline boxes

scientific article published on 5 August 2006

Designing the next generation of medicines for malaria control and eradication

scientific article

Distamycin prolongs E-selectin expression by interacting with a specific NF-kappaB-HMG-I(Y) binding site in the promoter

scientific article published on January 1997

Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers

scientific article published on 05 June 2016

Erratum to: New developments in anti-malarial target candidate and product profiles

scientific article published on 18 April 2017

Evolutionary variation of the CCAAT-binding transcription factor NF-Y

scientific article

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression

scientific article

Ferroquine: welcome to the next generation of antimalarials

scientific article published on 2 September 2015

Growth hormone signalling: sprouting links between pathways, human genetics and therapeutic options

scientific article published on 28 November 2006

Highly controlled gene expression using combinations of a tissue-specific promoter, recombinant adenovirus and a tetracycline-regulatable transcription factor

scientific article published in September 1998

Hit and lead criteria in drug discovery for infectious diseases of the developing world

scientific article published on 05 October 2015

Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach

scientific article (publication date: 2012)

Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor

scientific article

Improvement of peripheral endothelial dysfunction by protein tyrosine phosphatase inhibitors in heart failure.

scientific article

Inducible inhibition of eukaryotic gene expression.

scientific article

Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats

scientific article

Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria

article

Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPρ/PTPRT)

scientific article

Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration

scientific article

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

scientific article

Malaria

scholarly article by Margaret A. Phillips et al published 3 August 2017 in Nature Reviews Disease Primers

Malaria medicines: a glass half full?

scientific article published on 22 May 2015

Mapping and identification of protein-protein interactions by two-dimensional far-Western immunoblotting

scientific article published on 01 October 2000

Mapping of synergistic components of weakly interacting protein-protein motifs using arrays of paired peptides

scientific article

Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines.

scientific article

New developments in anti-malarial target candidate and product profiles

scientific article

One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes ⬇️

scientific article published on November 1, 1991

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

scientific article (publication date: July 2016)

Open data in drug discovery and development: lessons from malaria

scientific article

PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit

scientific article

Probing protein-tyrosine phosphatase substrate specificity using a phosphotyrosine-containing phage library

scientific article published on 24 October 2003

Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine

scientific article

Properties of a CCAAT box-binding protein

scientific article

Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs

scientific article published in August 2004

Protein tyrosine phosphatases as drug targets: PTP1B and beyond

scientific article

Protein tyrosine phosphatases in glioma biology

scientific article published on 21 November 2009

Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease

scientific article published on March 2008

Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth

scientific article published on 4 October 2007

Reassessing therapeutic antibodies for neglected and tropical diseases

scientific article published on 30 January 2020

Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B.

scientific article

Sap-1/PTPRH activity is regulated by reversible dimerization

scientific article published in June 2005

Selecting protein tyrosine phosphatases as drug targets

scientific article

Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB

scientific article

The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities

scientific article

The antimalarial pipeline

The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions

scientific journal article

Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases

scientific article

Two distinct NF-kappa B complexes differing in their larger subunit bind the E-selectin promoter kappa B element ⬇️

scientific article published on August 1993

List of works by Rob Hooft van Huijsduijnen

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study

A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria

An NF kappa B-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription

Anticancer properties of distinct antimalarial drug classes

Applying the SPOT peptide synthesis procedure to the study of protein tyrosine phosphatase substrate specificity: probing for the heavenly match in vitro

Both Intrinsic Substrate Preference and Network Context Contribute to Substrate Selection of Classical Tyrosine Phosphatases

Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation

Characterization of three highly purified influenza virus strains by electron microscopy

Chemical inducers and transcriptional markers of oligodendrocyte differentiation

Commonly used cat reporter vectors contain a cAMP-inducible, cryptic enhancer that co-operates with NF-kappa B-sites.

Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits

DNA-methylation of the E-selectin promoter represses NF-kappa B transactivation

Decompartmentalizing target validation-thinking outside the pipeline boxes

Designing the next generation of medicines for malaria control and eradication

Distamycin prolongs E-selectin expression by interacting with a specific NF-kappaB-HMG-I(Y) binding site in the promoter

Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers

Erratum to: New developments in anti-malarial target candidate and product profiles

Evolutionary variation of the CCAAT-binding transcription factor NF-Y

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression

Ferroquine: welcome to the next generation of antimalarials

Growth hormone signalling: sprouting links between pathways, human genetics and therapeutic options

Highly controlled gene expression using combinations of a tissue-specific promoter, recombinant adenovirus and a tetracycline-regulatable transcription factor

Hit and lead criteria in drug discovery for infectious diseases of the developing world

Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach

Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor

Improvement of peripheral endothelial dysfunction by protein tyrosine phosphatase inhibitors in heart failure.

Inducible inhibition of eukaryotic gene expression.

Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats

Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria

Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPρ/PTPRT)

Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

Malaria

Malaria medicines: a glass half full?

Mapping and identification of protein-protein interactions by two-dimensional far-Western immunoblotting

Mapping of synergistic components of weakly interacting protein-protein motifs using arrays of paired peptides

Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines.

New developments in anti-malarial target candidate and product profiles

One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes ⬇️

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Open data in drug discovery and development: lessons from malaria

PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit

Probing protein-tyrosine phosphatase substrate specificity using a phosphotyrosine-containing phage library

Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine

Properties of a CCAAT box-binding protein

Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs

Protein tyrosine phosphatases as drug targets: PTP1B and beyond

Protein tyrosine phosphatases in glioma biology

Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease

Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth

Reassessing therapeutic antibodies for neglected and tropical diseases

Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B.

Sap-1/PTPRH activity is regulated by reversible dimerization

Selecting protein tyrosine phosphatases as drug targets

Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB

The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities

The antimalarial pipeline

The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions

Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases

Two distinct NF-kappa B complexes differing in their larger subunit bind the E-selectin promoter kappa B element ⬇️