Search filters

List of works by Giulio G. Muccioli

(S)-1-(Pent-4'-enoyl)-4-(hydroxymethyl)-azetidin-2-one derivatives as inhibitors of human fatty acid amide hydrolase (hFAAH): synthesis, biological evaluation and molecular modelling

scientific article published on 09 October 2013

1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists

scientific article published in November 2005

3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors

scientific article published on 24 May 2008

3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.

scientific article

4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands: structural insights into the design of a novel inverse agonist series

scientific article published on 27 October 2010

4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis

scientific article published on 12 October 2012

A comparative study of curcumin-loaded lipid-based nanocarriers in the treatment of inflammatory bowel disease

scientific article published on 16 March 2016

Aberrant Membrane Composition and Biophysical Properties Impair Erythrocyte Morphology and Functionality in Elliptocytosis

scientific article published on 29 July 2020

Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota.

scientific article

Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue.

scientific article

An optimized GC-MS method detects nanomolar amounts of anandamide in mouse brain

scientific article published on 29 September 2007

Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds

scientific article

Binding mode of new (thio)hydantoin inhibitors of fatty acid amide hydrolase: comparison with two original compounds, OL-92 and JP104

scientific article published on 17 July 2006

Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors

scientific article published in November 2009

Blocking the cannabinoid receptors: drug candidates and therapeutic promises

scientific article published on August 2007

Budesonide-loaded nanostructured lipid carriers reduce inflammation in murine DSS-induced colitis.

scientific article published on 18 May 2013

Butyricimonas faecalis sp. nov., isolated from human faeces and emended description of the genus Butyricimonas

scientific article published on 01 February 2019

COX-2-derived endocannabinoid metabolites as novel inflammatory mediators.

scientific article published on 29 March 2014

Characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid CB1 and CB2 receptors

scientific article

Chemical Compositional Changes in Over-Oxidized Fish Oils

scientific article published on 20 October 2020

Chemistry around imidazopyrazine and ibuprofen: discovery of novel fatty acid amide hydrolase (FAAH) inhibitors

scientific article published on 11 May 2010

Chronic endocannabinoid system stimulation induces muscle macrophage and lipid accumulation in type 2 diabetic mice independently of metabolic endotoxaemia

scientific article

Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis.

scientific article published on 4 December 2014

Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy

scientific article published on 23 July 2013

Current knowledge on the antagonists and inverse agonists of cannabinoid receptors.

scientific article

Cyclosporine A-loaded lipid nanoparticles in inflammatory bowel disease

scientific article published on 10 March 2016

Dereplication and Quantification of Major Compounds of Convolvulus arvensis L. Extracts and Assessment of Their Effect on LPS-Activated J774 Macrophages

scientific article published in 2022

Development and validation of an HPLC-MS method for the simultaneous quantification of key oxysterols, endocannabinoids, and ceramides: variations in metabolic syndrome

scientific article published on 12 November 2015

Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo

scientific article published on 13 February 2012

Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling

scientific article published on 01 July 2007

Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth

scientific article

Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.

scientific article

EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes

scientific article published on 29 March 2022

Eco-friendly synthesis and antiproliferative evaluation of some oxygen substituted diaryl ketones.

scientific article published on 16 August 2013

Effect of drug-targeting nebulization on lung delivery

scientific article

Endocannabinoid biosynthesis and inactivation, from simple to complex

scientific article published on 19 March 2010

Endocannabinoids and related N-acylethanolamines in the control of appetite and energy metabolism: emergence of new molecular players

scientific article

Endocannabinoids and the Digestive Tract and Bladder in Health and Disease

scientific article published on January 2015

From correlation to causality: the case of <i>Subdoligranulum</i>

scientific article published on 01 November 2020

Functionally selective cannabinoid receptor signalling: therapeutic implications and opportunities

scientific article published on 03 March 2010

GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity

scientific article published on 31 January 2022

Genetic manipulation of palmitoylethanolamide production and inactivation in Saccharomyces cerevisiae

scientific article

Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ecto-phospholipase C acting as an endocannabinoid signaling switch

scientific article published on 11 September 2020

Gut microbiota-derived propionate reduces cancer cell proliferation in the liver

scientific article

Harnessing the anti-inflammatory potential of palmitoylethanolamide.

scientific article

Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets

scientific article

High Dose Versus Low Dose Syngeneic Hepatocyte Transplantation in <i>Pex1</i>-G844D NMRI Mouse Model is Safe but Does Not Achieve Long Term Engraftment

scientific article published on 30 December 2020

ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan

scientific article published on 19 May 2016

Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells

scientific article published on March 2007

Identification of new enterosynes using prebiotics: roles of bioactive lipids and mu-opioid receptor signalling in humans and mice

scientific article published on 05 October 2020

Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6.

scientific article published on 07 October 2013

Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism

scientific article

Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation

scientific article published on 06 May 2011

Inflammation-induced cholestasis in cancer cachexia

scientific article published on 22 December 2020

Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling

scientific article published on 11 September 2015

Inhibitors of the endocannabinoid-degrading enzymes, or how to increase endocannabinoid's activity by preventing their hydrolysis

scientific article published on April 2012

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

scientific article

Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis

scientific article published in Nature Communications

Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice

scientific article published on 05 November 2010

Jejunum Inflammation in Obese and Diabetic Mice Impairs Enteric Glucose Detection and Modifies Nitric Oxide Release in the Hypothalamus

scientific article published on 29 September 2010

Lipid transport function is the main target of oral oleoylethanolamide to reduce adiposity in high-fat-fed mice

scientific article

Metabolite profiling reveals the interaction of chitin-glucan with the gut microbiota

scientific article published on 01 November 2020

Microglia produce and hydrolyze palmitoylethanolamide

scientific article

Modulation of the activity of moxifloxacin and solithromycin in an in vitro pharmacodynamic model of Streptococcus pneumoniae naive and induced biofilms

scientific article published on 23 February 2015

Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase

scientific journal article

N-Acylethanolamine-hydrolyzing acid amidase inhibition increases colon N-palmitoylethanolamine levels and counteracts murine colitis

scientific article

N-acylethanolamine-hydrolyzing acid amidase and fatty acid amide hydrolase inhibition differentially affect N-acylethanolamine levels and macrophage activation

scientific article published on 5 January 2017

NIR-mbc94, a fluorescent ligand that binds to endogenous CB(2) receptors and is amenable to high-throughput screening

scientific article

New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis

scientific article published on 06 May 2011

Non Digestible Oligosaccharides Modulate the Gut Microbiota to Control the Development of Leukemia and Associated Cachexia in Mice.

scientific article published on 22 June 2015

Non-invasive in vivo imaging of early metabolic tumor response to therapies targeting choline metabolism

scientific article

Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling.

scientific article published in January 2006

Novel insights into the genetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin

scientific article published on 28 June 2021

Obesity is associated with changes in oxysterol metabolism and levels in mice liver, hypothalamus, adipose tissue and plasma

scientific article

Obesity-Induced Neuroinflammation: Beyond the Hypothalamus

scientific article published on 16 March 2017

Oral Palmitoylethanolamide Treatment Is Associated with Reduced Cutaneous Adverse Effects of Interferon-β1a and Circulating Proinflammatory Cytokines in Relapsing-Remitting Multiple Sclerosis

scientific article published on 8 February 2016

Oxysterols: From cholesterol metabolites to key mediators.

scientific article

PET imaging of fatty acid amide hydrolase in the brain: synthesis and biological evaluation of an 11C-labelled URB597 analogue

scientific article published on 6 May 2010

Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequences in receptor affinity and functionality

scientific article published on 4 October 2007

Post-operative pain in mice is prolonged by diet-induced obesity and rescued by dietary intervention

scientific article published on 30 July 2018

Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors

scientific article

Resistant starch can improve insulin sensitivity independently of the gut microbiota

scientific article published on 07 February 2017

Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice

scientific article

SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process

scientific article published on 20 September 2011

Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells

scientific article published on 9 September 2016

Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates

scientific article published in January 2006

Substituted 5,5'-diphenyl-2-thioxoimidazolidin-4-one as CB1 cannabinoid receptor ligands: synthesis and pharmacological evaluation

scientific article published in April 2005

Synthesis and Cytotoxic Activity on Human Cancer Cells of Novel Isoquinolinequinone-Amino Acid Derivatives.

scientific article published on 08 September 2016

Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptor inverse agonists/antagonists

scientific article published in February 2006

Synthesis and biological evaluation of carbon-11- and fluorine-18-labeled 2-oxoquinoline derivatives for type 2 cannabinoid receptor positron emission tomography imaging.

scientific article published on 26 March 2009

Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.

scientific article published in December 2009

Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors

scientific article

Synthesis, half-wave potentials and antiproliferative activity of 1-aryl-substituted aminoisoquinolinequinones.

scientific article published in January 2013

Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging

scientific article published on 16 June 2011

Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain

scientific article published in August 2009

The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB₁- and FAAH-independent mechanisms

scientific article published on June 2013

The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action

scientific article

The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity

scientific article published on 21 August 2012

The endocannabinoid system links gut microbiota to adipogenesis

scientific article

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

scientific article

Versatile access to benzhydryl-phenylureas through an unexpected rearrangement during microwave-enhanced synthesis of hydantoins

scientific article published on 01 October 2003

beta-Lactams derived from a carbapenem chiron are selective inhibitors of human fatty acid amide hydrolase versus human monoacylglycerol lipase

scientific article

miRNA profile is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions

scientific article published on 17 September 2020

Paulina is supported by:

About Paulina

Help