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List of works by Matthew S Macauley

A highly concise preparation of O-deacetylated arylthioglycosides of N-acetyl-D-glucosamine from 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-glucopyranosyl chloride and aryl thiols or disulfides

scientific article published on 10 February 2006

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

scientific article

A quantitative, high-throughput method identifies protein-glycan interactions via mass spectrometry

scientific article published on 22 July 2019

A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells.

scientific article

A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands

scientific article published on 09 October 2020

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

scientific article

Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis.

scientific article published on 3 June 2013

Assessing Retinal Microglial Phagocytic Function In Vivo Using a Flow Cytometry-based Assay

Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence

scientific article published on 29 November 2005

CRISPR-Click Enables Dual-Gene Editing with Modular Synthetic sgRNAs

scientific article published in 2022

CUPRA-ZYME: An Assay for Measuring Carbohydrate-Active Enzyme Activities, Pathways, and Substrate Specificities

scientific article published on 07 February 2020

Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.

scientific article published on 08 July 2013

Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas

scientific article

Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).

scientific article published on 28 July 2009

Elevation of Global O-GlcNAc in Rodents Using a Selective O-GlcNAcase Inhibitor Does Not Cause Insulin Resistance or Perturb Glucohomeostasis

scientific article published in October 2010

Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis

scientific article published on September 2010

Encapsulating an Immunosuppressant Enhances Tolerance Induction by Siglec-Engaging Tolerogenic Liposomes

scientific article published on 23 February 2017

Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase

scientific article published on 20 April 2009

Erratum: Author Correction: Repression of phagocytosis by human CD33 is not conserved with mouse CD33

scientific article published on 16 January 2020

Exploiting CD22 To Selectively Tolerize Autoantibody Producing B-Cells in Rheumatoid Arthritis

scientific article published on 20 March 2019

Exploiting CD22 on antigen-specific B cells to prevent allergy to the major peanut allergen Ara h 2.

scientific article published on 20 August 2016

Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase

scientific article

Glycoengineering of NK Cells with Glycan Ligands of CD22 and Selectins for B-Cell Lymphoma Therapy

scientific article published on 14 December 2020

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

scientific article published on 17 August 2016

Hypersialylation in Cancer: Modulation of Inflammation and Therapeutic Opportunities.

scientific article published on 18 June 2018

Immunology: glyco-engineering 'super-self'.

scientific article published on January 2014

Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase.

scientific article published on 04 August 2009

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

scientific article published on 26 February 2012

Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes

scientific article

Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes

scholarly article by Matthew S Macauley published in October 2010

Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: INTRACELLULAR  -O-LINKED N-GLYCOLYLGLUCOSAMINE (GlcNGc), UDP-GlcNGc, AND THE BIOCHEMICAL AND STRUCTURAL RATIONALE FOR THE SUBSTRATE TOLERANCE OF  -O-LINKED  -N-ACETYLGLUCOSAMINIDASE

scientific article

Murine Red Blood Cells Lack Ligands for B Cell Siglecs, Allowing Strong Activation by Erythrocyte Surface Antigens.

scientific article published on 29 December 2017

Neuraminidase inhibitors rewire neutrophil function in murine sepsis and COVID-19 patient cells

scientific article published on 12 November 2020

O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis

scientific article

O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

scientific article published on 28 March 2005

Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships

scientific article published in September 2009

Repression of phagocytosis by human CD33 is not conserved with mouse CD33

scientific article published on 03 December 2019

Reproducing SIVΔnef vaccine correlates of protection: trimeric gp41 antibody concentrated at mucosal front lines

scientific article

Siglec-F is a novel intestinal M cell marker.

scientific article published on 11 August 2016

Siglec-mediated regulation of immune cell function in disease.

scientific article

Siglecs as sensors of self in innate and adaptive immune responses ⬇️

scientific article published on January 30, 2012

Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells

scientific article published on 24 September 2014

Structural advances of Siglecs: insight into synthetic glycan ligands for immunomodulation

scientific article published on 01 August 2020

Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1

scientific article

Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation

scientific article

Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases

scientific article

Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation

scientific article

Targeted self-destruction

scientific article published on 17 August 2020

Targeting Selectins and Their Ligands in Cancer

scientific article

The CD33 short isoform is a gain-of-function variant that enhances Aβ<sub>1-42</sub> phagocytosis in microglia

scientific article published on 25 March 2021

Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.

scientific article published on October 2015

Tools for Studying Glycans: Recent Advances in Chemoenzymatic Glycan Labeling

scientific article

Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing

scientific article (publication date: October 2014)

Transfection of microRNA Mimics Should Be Used with Caution.

scientific article

Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man.

scientific article

Visualizing the reaction coordinate of an O-GlcNAc hydrolase

scientific article

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