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List of works by Nadia Zaffaroni

1,4-Substituted Triazoles as Nonsteroidal Anti-Androgens for Prostate Cancer Treatment

scientific article published on 8 March 2017

A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers.

scientific article published on 12 January 2018

A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT.

scientific article

A new avenue toward androgen receptor pan-antagonists: C2 sterically hindered substitution of hydroxy-propanamides

scientific article published on 28 August 2014

A new indole-3-carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines.

scientific article

Absolute and relative activities of 4' -iodo-4'-deoxydoxorubicin against human colo-rectal tumors, as evaluated by a short-term in vitro assay.

scientific article published in January 1990

Absolute and relative activities of platinum-complexes on human tumors as evaluated by an antimetabolic in vitro assay

scientific article published in January 1987

Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands.

scientific article published on 18 August 2015

Activity of a chartreusin analog, elsamicin A, on breast cancer cells

scientific article published on December 1, 1992

Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: cytotoxicity and induction and gene-specific repair of DNA lesions

scientific article published on May 2001

Activity of axitinib in progressive advanced solitary fibrous tumour: Results from an exploratory, investigator-driven phase 2 clinical study

scientific article published on 05 December 2018

Advances in clinical research and management of diffuse peritoneal mesothelioma

scientific article published on 01 January 2007

Analysis of plasma cytokines and angiogenic factors in patients with pretreated urothelial cancer receiving Pazopanib: the role of circulating interleukin-8 to enhance the prognostic accuracy

scientific article

Anaplastic lymphoma kinase aberrations correlate with metastatic features in pediatric rhabdomyosarcoma.

scientific article published on July 2016

Androgen Receptor-Directed Molecular Conjugates for Targeting Prostate Cancer

scientific article published on 28 May 2019

Anti-tumor activity of CpG-ODN aerosol in mouse lung metastases

scientific article published on 12 February 2013

Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin.

scientific article published on May 2015

Antisecretive and Antitumor Activity of Abiraterone Acetate in Human Adrenocortical Cancer: A Preclinical Study

scientific article published on 14 September 2016

Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells.

scientific article

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

scientific article published on 27 November 2013

Antitumor activity of hyperthermia alone or in combination with cisplatin and melphalan in primary cultures of human malignant melanoma

article

Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

scientific article published on 18 January 2017

Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases

scientific article published on 25 June 2016

Antitumor efficacy of the heparanase inhibitor SST0001 alone and in combination with antiangiogenic agents in the treatment of human pediatric sarcoma models.

scientific article published on March 2013

Apollon gene silencing induces apoptosis in breast cancer cells through p53 stabilisation and caspase-3 activation

scientific article published on 17 February 2009

Application of an in vitro antimetabolic assay to human germ cell testicular tumors for the preclinical evaluation of drug sensitivity.

scientific article

Assessment of gene promoter G‑quadruplex binding and modulation by a naphthalene diimide derivative in tumor cells

scientific article

Attenuation of telomerase activity does not increase sensitivity of human melanoma cells to anticancer agents

scientific article

Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage

scientific article published on 25 May 2012

Axl molecular targeting counteracts aggressiveness but not platinum-resistance of ovarian carcinoma cells

scientific article

Biomolecular markers of outcome prediction in prostate cancer.

scientific article published on July 2009

Bone osteoblastic and mesenchymal stromal cells lack primarily tumoral features in multiple myeloma patients

scientific article published on 20 May 2010

Breast cancer stem cells: an overview.

scientific article

Breast cancer-initiating cells: insights into novel treatment strategies.

scientific article published on 16 March 2011

Camptothecin Resistance in Cancer: Insights into the Molecular Mechanisms of a DNA-Damaging Drug ⬇️

scientific article published on January 1, 2013

Cell growth inhibition, G2M cell cycle arrest and apoptosis induced by the imidazoacridinone C1311 in human tumour cell lines

scientific article

Characterization of novel antisense HIF-1α transcripts in human cancers

scientific article published on 15 September 2011

Characterization of stress response in human retinal epithelial cells

scientific article published on 4 December 2012

Coexpression of survivin and TERT in soft-tissue sarcoma.

scientific article

Combined effects of lonidamine and hyperthermia on malignant melanoma and lung carcinoma surgical specimens

scientific article published on 01 January 1992

Combined effects of lonidamine and tamoxifen in human breast-cancer cell-lines.

scientific article published on May 1995

Comparative evaluation of C1311 cytotoxic activity and interference with cell cycle progression in a panel of human solid tumour and leukaemia cell lines.

scientific article published on October 2007

Comparative in vitro sensitivity of human cholangiocarcinoma and colon adenocarcinoma cells to anticancer agents.

scientific article published on March 1997

Comparison between an antimetabolic assay and a cytocidal assay for in vitro chemosensitivity testing of human tumors

scientific article published on 01 October 1987

Comparison of an antimetabolic assay and an antiproliferative assay, both using 3H-thymidine incorporation, to test drug sensitivity of human tumors

scientific article published on 01 November 1988

Core Biopsies from Prostate Cancer Patients in Active Surveillance Protocols Harbor PTEN and MYC Alterations

scientific article published on 10 September 2018

CpG-oligodeoxynucleotides exert remarkable antitumor activity against diffuse malignant peritoneal mesothelioma orthotopic xenografts.

scientific article published on 25 January 2016

Dacarbazine in solitary fibrous tumor: a case series analysis and preclinical evidence vis-a-vis temozolomide and antiangiogenics

scientific article published on 25 July 2013

Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads.

scientific article published on 16 February 2017

Design, modeling, synthesis and biological activity evaluation of camptothecin-linked platinum anticancer agents

scientific article published on March 2013

Design, synthesis and biological evaluation of novel dimeric and tetrameric cRGD-paclitaxel conjugates for integrin-assisted drug delivery

scientific article published on July 2015

Detection of DNA polymerase-beta gene expression by competitive polymerase chain reaction in human ovarian carcinoma cells.

scientific article published on January 1993

Development of a nucleotide precursor incorporation assay for testing drug sensitivity of human tumors

scientific article published on 01 January 1984

Differential effect of 9 beta-chloro-16, 16-dimethyl prostaglandin E2 (nocloprost) on the radiation response of human normal fibroblasts and colon adenocarcinoma cells

scientific article published on 01 July 1993

Differential expression of telomerase activity in neuroendocrine lung tumours: correlation with gene product immunophenotyping.

scientific article published in September 2003

Differential outcome of MEK1/2 inhibitor-platinum combinations in platinum-sensitive and -resistant ovarian carcinoma cells

scientific article published on 24 February 2014

Dimerizable redox-sensitive triazine-based cationic lipids for in vitro gene delivery

scientific article published on March 2007

Dissecting the role of microRNAs in prostate cancer metastasis: implications for the design of novel therapeutic approaches

scientific article published on 12 March 2016

Distinct biological responses of metastatic castration resistant prostate cancer cells upon exposure to G-quadruplex interacting naphthalenediimide derivatives

scientific article published on 24 May 2019

Down-Regulation of the Androgen Receptor by G-Quadruplex Ligands Sensitizes Castration-Resistant Prostate Cancer Cells to Enzalutamide

scientific article published on 20 September 2018

Drug Combinations with Proteasome Inhibitors in Antitumor Therapy ⬇️

scientific article published on January 1, 2013

Drug sensitivity of different tumor lesions from the same patient evaluated by a short-term assay

scientific article published on 01 April 1988

Effect of hyperthermia on the formation and removal of DNA interstrand cross-links induced by melphalan in primary cultures of human malignant melanoma

article

Effect of melphalan and hyperthermia on cell cycle progression and cyclin B1 expression in human melanoma cells

scientific article published on 01 November 1995

Effect of melphalan and hyperthermia on p34cdc2 kinase activity in human melanoma cells

scientific article

Effects of a novel trinuclear platinum complex in cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines: interference with cell cycle progression and induction of apoptosis.

scientific article published on March 2001

Effects of liposome-entrapped annamycin in human breast cancer cells: interference with cell cycle progression and induction of apoptosis.

scientific article

Eleven-year management of prostate cancer patients on active surveillance: what have we learned?

scientific article published on 14 June 2017

Emerging Role of G-quadruplex DNA as Target in Anticancer Therapy

scientific article published on 01 January 2016

Emerging role of microRNAs in prostate cancer: implications for personalized medicine.

scientific article published on March 2010

Enhancement of cisplatin activity by lonidamine in human ovarian cancer cells

scientific article published on November 1992

Epithelioid peritoneal mesothelioma: a hybrid phenotype within a mesenchymal-epithelial/epithelial-mesenchymal transition framework

scientific article published on 26 September 2016

Evaluation of Mediators Associated with the Inflammatory Response in Prostate Cancer Patients Undergoing Radiotherapy.

scientific article published on 25 February 2018

Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies.

scientific article

Experience with peritoneal mesothelioma at the Milan National Cancer Institute.

scientific article

Expression of P-glycoprotein and in vitro or in vivo resistance to doxorubicin and cisplatin in breast and ovarian cancers

scientific article

Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer

scientific article published in August 2002

Feasibility and safety of adoptive immunotherapy with ex vivo-generated autologous, cytotoxic T lymphocytes in patients with solid tumor

scientific article published on 23 September 2011

Fludarabine as a modulator of cisplatin activity in human tumour primary cultures and established cell lines

article

Flunarizine as a modulator of doxorubicin resistance in human colon-adenocarcinoma cells

scientific article published on October 1993

FoxO-1 contributes to the efficacy of the combination of the XPO1 inhibitor selinexor and cisplatin in ovarian carcinoma preclinical models.

scientific article published on 16 November 2017

G-quadruplex structures in the human genome as novel therapeutic targets.

scientific article published on 08 October 2013

Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors.

scientific article published on 22 September 2009

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HSPH1 inhibition downregulates Bcl-6 and c-Myc and hampers the growth of human aggressive B-cell non-Hodgkin lymphoma.

scientific article

Heterogeneous radiation and heat sensitivity in vitro of human melanoma xenograft lines established from different lesions in the same patient. Comparisons with the radiation and heat sensitivity of cells isolated from the donor patient's surgical s

scientific article published on June 1990

High efficacy of CpG-ODN, Cetuximab and Cisplatin combination for very advanced ovarian xenograft tumors ⬇️

scientific article published on January 29, 2013

High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma

scientific article published on 15 April 2008

Histone deacetylase inhibitor-temozolomide co-treatment inhibits melanoma growth through suppression of Chemokine (C-C motif) ligand 2-driven signals

scientific article

Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms

scientific article published in October 2007

Hybrid ligand-alkylating agents targeting telomeric G-quadruplex structures.

scientific article

Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment.

scientific article published on 17 December 2013

In vitro activity of 4? -iodo-4? -deoxydoxorubicin on human colo-rectal cancer as measured by a short-term antimetabolic assay

scientific article published on 01 May 1990

In vitro effect of lonidamine on the cytotoxicity of mitomycin C and BCNU in human colon adenocarcinoma cells

scientific article published on 01 January 1994

Inactivation of Ret/Ptc1 oncoprotein and inhibition of papillary thyroid carcinoma cell proliferation by indolinone RPI-1.

scientific article published in July 2003

Induction of apoptosis by taxol and cisplatin and effect on cell cycle-related proteins in cisplatin-sensitive and -resistant human ovarian cells ⬇️

scientific article published on May 1, 1998

Inhibition of DNA synthesis in selection of anticancer therapy

scientific article published on 01 January 1988

Inhibition of Telomerase Activity by a Hammerhead Ribozyme Targeting the RNA Component of Telomerase in Human Melanoma Cells

scientific article published on 01 February 2000

Inhibition of telomerase activity by a cell-penetrating peptide nucleic acid construct in human melanoma cells

scientific article published on 01 May 2000

Inhibition of telomerase activity by a distamycin derivative: effects on cell proliferation and induction of apoptosis in human cancer cells

scientific article published on September 2002

Inhibition of telomerase activity by geldanamycin and 17-allylamino, 17-demethoxygeldanamycin in human melanoma cells

scientific article published on May 2003

Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation

scientific article published on 8 September 2015

Interplay between Ret and Fap-1 regulates CD95-mediated apoptosis in medullary thyroid cancer cells

scientific article published on 2 July 2011

Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

scientific article (publication date: July 2005)

LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation

scientific article published in Nature Communications

Lack of a correlation between micronucleus formation and radiosensitivity in established and primary cultures of human tumours.

scientific article

Lack of a correlation between p53 protein expression and radiation response in human tumor primary cultures

article

Lack of p21waf1 and p27kip1 protein induction by interferon-alpha2a in human melanoma cell lines

scientific article published on 01 October 1999

Lack of telomerase activity in lung carcinoids is dependent on human telomerase reverse transcriptase transcription and alternative splicing and is associated with long telomeres.

scientific article

Ligands Tethering to Biocompatible Ultrasound Active Polymeric Microbubbles Surface

Lonidamine as a modulator of taxol activity in human ovarian cancer cells: effects on cell cycle and induction of apoptosis.

scientific article published on October 1998

MicroRNA-Mediated Control of Prostate Cancer Metastasis: Implications for the Identification of Novel Biomarkers and Therapeutic Targets ⬇️

scientific article published on January 1, 2013

MicroRNA-dependent regulation of telomere maintenance mechanisms: a field as much unexplored as potentially promising.

scientific article published on January 2014

MicroRNAs as new therapeutic targets and tools in cancer.

scientific article published on 05 January 2011

Microenvironment modulation and enhancement of antilymphoma therapy by the heparanase inhibitor roneparstat

scientific article published on 21 July 2017

Mitochondria are primary targets in apoptosis induced by the mixed phosphine gold species chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I) in melanoma cell lines

scientific article published on 28 November 2006

Modulation by lonidamine on the combined activity of cisplatin and epidoxorubicin in human breast cancer cells

scientific article published on 01 January 1997

Modulation of cytotoxic drug activity by mitotane and lonidamine in human adrenocortical carcinoma cells.

scientific article published on January 1999

Modulation of melphalan and cisplatin cytotoxicity in human ovarian cancer cells resistant to alkylating drugs

scientific article published on 01 June 1997

Modulation of melphalan cytotoxic activity in human melanoma cell lines.

scientific article

Modulation of sensitivity to antitumor agents by targeting the MAPK survival pathway.

scientific article published on January 2013

Multiple Mechanisms of Telomere Maintenance Exist and Differentially Affect Clinical Outcome in Diffuse Malignant Peritoneal Mesothelioma

scientific article published on 01 July 2008

Multiple effects of the Na(+)/H (+) antiporter inhibitor HMA on cancer cells

scientific article published on December 2013

Naphthalene diimides as red fluorescent pH sensors for functional cell imaging

scientific article

Natural variation in the appendicular skeleton of Triturus carnifex (Amphibia: Salamandridae)

scientific article published on 01 November 1996

Neoadjuvant sorafenib, gemcitabine, and cisplatin administration preceding cystectomy in patients with muscle-invasive urothelial bladder carcinoma: An open-label, single-arm, single-center, phase 2 study.

scientific article published on 11 September 2017

New Directions for Biologic Targets in Urothelial Carcinoma - Letter

article

New mechanisms for old drugs: Insights into DNA-unrelated effects of platinum compounds and drug resistance determinants

scientific article published on 07 May 2015

Nimodipine as a modulator of resistance to doxorubicin in human colon-adenocarcinoma cells.

scientific article published on July 1996

Novel 1H-pyrrolo[2,3-b]pyridine derivative nortopsentin analogues: synthesis and antitumor activity in peritoneal mesothelioma experimental models.

scientific article published on 23 August 2013

Novel 20(S)-sulfonylamidine derivatives of camptothecin and the use thereof as a potent antitumor agent: a patent evaluation of WO2015048365 (A1).

scientific article published on 27 January 2016

Novel Insights into Targeting ATP-Binding Cassette Transporters for Antitumor Therapy ⬇️

scientific article published on January 1, 2011

Novel PVA-based hydrogel microparticles for doxorubicin delivery

scientific article

Oligomer-mediated modulation of hTERT alternative splicing induces telomerase inhibition and cell growth decline in human prostate cancer cells.

scientific article

Overactive IGF1/Insulin Receptors and NRASQ61R Mutation Drive Mechanisms of Resistance to Pazopanib and Define Rational Combination Strategies to Treat Synovial Sarcoma

scientific article published on 22 March 2019

PF-03446962, a fully-human monoclonal antibody against transforming growth-factor β (TGFβ) receptor ALK1, in pre-treated patients with urothelial cancer: an open label, single-group, phase 2 trial.

scientific article

PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells

scientific article published on 20 August 2016

PLK1 is a critical determinant of tumor cell sensitivity to CPT11 and its inhibition enhances the drug antitumor efficacy in squamous cell carcinoma models sensitive and resistant to camptothecins.

scientific article published in April 2015

Patient-derived solitary fibrous tumour xenografts predict high sensitivity to doxorubicin/dacarbazine combination confirmed in the clinic and highlight the potential effectiveness of trabectedin or eribulin against this tumour.

scientific article published on 8 March 2017

Pazopanib in advanced and platinum-resistant urothelial cancer: an open-label, single group, phase 2 trial.

scientific article published on 20 July 2012

Pazopanib in advanced germ cell tumors after chemotherapy failure: results of the open-label, single-arm, phase 2 Pazotest trial.

scientific article published on 5 April 2017

Photochemical internalization of a peptide nucleic acid targeting the catalytic subunit of human telomerase.

scientific article

Photochemical internalization: a new tool for drug delivery.

scientific article published on December 2007

Photochemically enhanced delivery of a cell-penetrating peptide nucleic acid conjugate targeting human telomerase reverse transcriptase: effects on telomere status and proliferative potential of human prostate cancer cells.

scientific article published on December 2007

Platinum-Based Drugs and DNA Interactions Studied by Single-Molecule and Bulk Measurements

scientific article published on May 2016

Pleiotropic antitumor effects of the pan-HDAC inhibitor ITF2357 against c-Myc-overexpressing human B-cell non-Hodgkin lymphomas.

scientific article published on 26 March 2014

Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment

scientific article

Possible Regulation of Telomerase Activity by Transcription and Alternative Splicing of Telomerase Reverse Transcriptase in Human Melanoma

scientific article published on 01 June 2001

Potentiation of cisplatin cytotoxicity by lonidamine in primary cultures of human ovarian cancer

scientific article published on 01 May 1994

Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.

scientific article published in September 2005

Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma.

scientific article published on 18 July 2016

Preclinical and clinical evaluation of four gemcitabine plus carboplatin schedules as front-line treatment for stage IV non-small-cell lung cancer

scientific article

Preclinical and clinical evidence of activity of pazopanib in solitary fibrous tumour

scientific article published on 27 September 2014

Predictive relevance for clinical outcome of in vitro sensitivity evaluated through antimetabolic assay

scientific article published on 01 January 1984

Preface: Special Issue on MicroRNAs as Novel Cancer Biomarkers and Therapeutic Targets

scientific article published on 01 January 2013

Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis.

scientific article

RNA interference-mediated validation of genes involved in telomere maintenance and evasion of apoptosis as cancer therapeutic targets.

scientific article published on January 2009

RNA interference-mediated validation of survivin and Apollon/BRUCE as new therapeutic targets for cancer therapy.

scientific article published on January 2012

Radiosensitization of human melanoma cells by ribozyme-mediated inhibition of survivin expression

scientific article published on April 2003

Rational design of allosteric modulators of the aromatase enzyme: An unprecedented therapeutic strategy to fight breast cancer

scientific article published on 13 February 2019

Rational design of shepherdin, a novel anticancer agent.

scientific article

Receptor tyrosine kinase and downstream signalling analysis in diffuse malignant peritoneal mesothelioma.

scientific article published on 6 August 2010

Redox-Sensitive PEG-Polypeptide Nanoporous Particles for Survivin Silencing in Prostate Cancer Cells

scientific article

Redox-active polymer microcapsules for the delivery of a survivin-specific siRNA in prostate cancer cells.

scientific article published on 12 January 2011

Relevance of cell kinetic and ploidy characteristics for the thermal response of malignant-melanoma primary cultures

scientific article published on 01 April 1993

Reliability of a primary culture system to test cytotoxic drug activity in human-malignant melanoma

scientific article published on 01 November 1992

Remarkable interference with telomeric function by a G-quadruplex selective bisantrene regioisomer.

scientific article

Reprogramming the lung microenvironment by inhaled immunotherapy fosters immune destruction of tumor

scientific article published on 20 September 2016

Ribozyme-mediated down-regulation of survivin expression sensitizes human melanoma cells to topotecan in vitro and in vivo

scientific article published on 4 February 2004

Ribozyme-mediated inhibition of PKCalpha sensitizes androgen-independent human prostate cancer cells to cisplatin-induced apoptosis

scientific article

Ribozyme-mediated inhibition of survivin expression increases spontaneous and drug-induced apoptosis and decreases the tumorigenic potential of human prostate cancer cells

scientific article published on January 2004

Role of Apollon in human melanoma resistance to antitumor agents that activate the intrinsic or the extrinsic apoptosis pathways

scientific article

Role of FoxO Proteins in Cellular Response to Antitumor Agents

scientific article published on 14 January 2019

Role of proliferation in HER2 status predicted response to doxorubicin.

scientific article published in July 2003

Role of the Receptor Tyrosine Kinase Axl and its Targeting in Cancer Cells

scientific article published on 5 April 2016

Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition.

scientific article published on 29 September 2011

SPOP Deregulation Improves the Radiation Response of Prostate Cancer Models by Impairing DNA Damage Repair

scientific article published on 04 June 2020

Schedule-dependent modulation of idarubicin cytotoxicity by lonidamine in human lymphoma cell lines

scientific article published on 01 October 1997

Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival [...]

scientific article

Selinexor Sensitizes TRAIL-R2-Positive TNBC Cells to the Activity of TRAIL-R2xCD3 Bispecific Antibody

scientific article published on 02 October 2020

Senescent stroma promotes prostate cancer progression: the role of miR-210.

scientific article

Silencing of survivin gene by small interfering RNAs produces supra-additive growth suppression in combination with 17-allylamino-17-demethoxygeldanamycin in human prostate cancer cells

scientific article published on January 2006

Small-Molecule Targeting of Heat Shock Protein 90 Chaperone Function: Rational Identification of a New Anticancer Lead

scientific article published on 01 December 2006

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma

scientific article published on 20 December 2018

Strategies to translate preclinical information to breast cancer patient benefit.

scientific article

Structural Requirements of Benzofuran Derivatives Dehydro-δ- and Dehydro-ε-Viniferin for Antimicrobial Activity Against the Foodborne Pathogen Listeria monocytogenes

scientific article published on 21 March 2020

Supersulfated low-molecular weight heparin synergizes with IGF1R/IR inhibitor to suppress synovial sarcoma growth and metastases

scientific article published on 7 December 2017

Survivin expression and resistance to anticancer treatments: perspectives for new therapeutic interventions.

scientific article

Survivin is highly expressed and promotes cell survival in malignant peritoneal mesothelioma.

scientific article

Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number

scientific article published on 10 December 2013

Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo

scientific article (publication date: 2011)

Synergistic cooperation between sunitinib and cisplatin promotes apoptotic cell death in human medullary thyroid cancer

scientific article published on 25 November 2013

Synergistic interaction between the novel histone deacetylase inhibitor ST2782 and the proteasome inhibitor bortezomib in platinum-sensitive and resistant ovarian carcinoma cells

scientific article

Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline

scientific article

Synthesis and antiproliferative activity of substituted 3[2-(1H-indol-3-yl)- 1,3-thiazol-4-yl]-1H-pyrrolo[3,2-b]pyridines, marine alkaloid nortopsentin analogues.

scientific article published on January 2014

Synthesis and antitumor activity of 3-(2-phenyl-1,3-thiazol-4-yl)-1H-indoles and 3-(2-phenyl-1,3-thiazol-4-yl)-1H-7-azaindoles.

scientific article published on 26 April 2011

Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D.

scientific article

Synthesis, spectroscopy (IR, multinuclear NMR, ESI-MS), diffraction, density functional study and in vitro antiproliferative activity of pyrazole-beta-diketone dihalotin(IV) compounds on 5 melanoma cell lines.

scientific article published on 28 November 2005

Synthetic sulfoglycolipids targeting the serine-threonine protein kinase Akt.

scientific article published on 18 May 2016

TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression

scientific article

TLR9 agonists oppositely modulate DNA repair genes in tumor versus immune cells and enhance chemotherapy effects.

scientific article

Targeted doxorubicin delivery by chitosan-galactosylated modified polymer microbubbles to hepatocarcinoma cells

scientific article published on 13 May 2013

Targeting DNA topoisomerase I with non-camptothecin poisons.

scientific article published on January 2012

Targeting heparan sulfate proteoglycans and their modifying enzymes to enhance anticancer chemotherapy efficacy and overcome drug resistance.

scientific article published on 16 February 2017

Targeting loop adenines in G-quadruplex by a selective oxirane.

scientific article published on 04 December 2012

Targeting microRNAs to withstand cancer metastasis

scientific article

Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer.

scientific article published on 16 June 2016

Targeting survivin in cancer therapy

scientific article

Targeting survivin in cancer therapy: fulfilled promises and open questions

scientific article

Targeting telomerase by antisense-based approaches: perspectives for new anti-cancer therapies.

scientific article

Targeting the Akt Kinase to Modulate Survival, Invasiveness and Drug Resistance of Cancer Cells ⬇️

scientific article published on January 1, 2013

Targeting the invasive phenotype of cisplatin-resistant non-small cell lung cancer cells by a novel histone deacetylase inhibitor.

scientific article

Taxol induces apoptosis in various cancer cell lines: comparison among different methodological approaches

scientific article published on 01 January 1997

Telomerase activity and telomere length in human ovarian cancer and melanoma cell lines: correlation with sensitivity to DNA damaging agents

scientific article published on 01 May 2000

Telomerase activity in benign and malignant breast lesions: a pilot prospective study on fine-needle aspirates

scientific article published on 01 April 1998

Telomere Maintenance Mechanisms in Liposarcomas: Association with Histologic Subtypes and Disease Progression

scientific article published on 01 September 2006

Telomere as a Therapeutic Target in Dedifferentiated Liposarcoma

scientific article published on 25 May 2022

Telomere maintenance in Wilms tumors: first evidence for the presence of alternative lengthening of telomeres mechanism.

scientific article

Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance

scientific article

Telomeres as targets for anticancer therapies.

scientific article published on 03 February 2011

Tethering functional ligands onto shell of ultrasound active polymeric microbubbles

scientific article published in February 2006

The 6-year attendance of a multidisciplinary prostate cancer clinic in Italy: incidence of management changes

scientific article published on 8 March 2012

The Role of Alternative Lengthening of Telomeres Mechanism in Cancer: Translational and Therapeutic Implications

scientific article published on 11 April 2020

The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects.

scientific article

The heparanase/heparan sulfate proteoglycan axis: A potential new therapeutic target in sarcomas.

scientific article published on 22 September 2016

To bleed or not to bleed. A prediction based on individual gene profiling combined with dose-volume histogram shapes in prostate cancer patients undergoing three-dimensional conformal radiation therapy.

scientific article

Towards the definition of prostate cancer-related microRNAs: where are we now?

scientific article published on 27 August 2009

Transcription and alternative splicing of telomerase reverse transcriptase in benign and malignant breast tumours and in adjacent mammary glandular tissues: implications for telomerase activity

scientific article published on 01 September 2002

Unravelling "off-target" effects of redox-active polymers and polymer multilayered capsules in prostate cancer cells

scientific article

Use of ribozymes in validation of targets involved in tumor progression.

scientific article published on October 2004

Validation of telomerase and survivin as anticancer therapeutic targets using ribozymes and small-interfering RNAs.

scientific article published on January 2007

Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action.

scientific article

XPO1/CRM1-selective inhibitors of nuclear export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa).

scientific article published on 5 October 2014

YM155 sensitizes triple-negative breast cancer to membrane-bound TRAIL through p38 MAPK- and CHOP-mediated DR5 upregulation.

scientific article published on 5 June 2014

[1,2]Oxazolo[5,4-e]isoindoles as promising tubulin polymerization inhibitors.

scientific article published on 05 September 2016

[18F]FDG and [18F]FLT PET for the evaluation of response to neo-adjuvant chemotherapy in a model of triple negative breast cancer.

scientific article published on 23 May 2018

[Peritoneal mesothelioma: results of a complicated and aggressive procedure incorporating peritonectomy and intraperitoneal hyperthermic chemotherapy, and prospects derived from bench-to-bedside research].

scientific article

miR-1272 Exerts Tumor-Suppressive Functions in Prostate Cancer via HIP1 Suppression

scientific article published on 13 February 2020

miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon.

scientific article

miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKCε and ZEB1 inhibition

scientific article published on 04 February 2019

miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts

scientific article published on 17 September 2013

miR-205 impairs the autophagic flux and enhances cisplatin cytotoxicity in castration-resistant prostate cancer cells

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