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List of works by Paola Perego

7-Azaindole-1-carboxamides as a new class of PARP-1 inhibitors

scientific article published on 22 December 2013

A proteomic approach for evaluating the cell response to a novel histone deacetylase inhibitor in colon cancer cells

scientific article

A proteomic approach to cisplatin resistance in the cervix squamous cell carcinoma cell line A431.

scientific article published on October 2004

A role for c-myc in DNA damage-induced apoptosis in a human TP53-mutant small-cell lung cancer cell line

scientific article

Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks.

scientific article

Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt.

scientific article

Antisecretive and Antitumor Activity of Abiraterone Acetate in Human Adrenocortical Cancer: A Preclinical Study

scientific article published on 14 September 2016

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

scientific article published on 27 November 2013

Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response.

scientific article

Ascites Regression and Survival Increase in Mice Bearing Advanced-stage Human Ovarian Carcinomas and Repeatedly Treated Intraperitoneally With CpG-ODN

scientific article published on 01 January 2010

Association of promoter polymorphism -765G>C in the PTGS2 gene with malignant melanoma in Italian patients and its correlation to gene expression in dermal fibroblasts.

scientific article published in October 2014

Axl molecular targeting counteracts aggressiveness but not platinum-resistance of ovarian carcinoma cells

scientific article

Bcl-2 phosphorylation in a human breast carcinoma xenograft: a common event in response to effective DNA-damaging drugs

scientific article published in July 2000

Biological properties of IDN5174, a new synthetic camptothecin with the open lactone ring

scientific article published on November 2006

Camptothecin Resistance in Cancer: Insights into the Molecular Mechanisms of a DNA-Damaging Drug ⬇️

scientific article published on January 1, 2013

Cellular bases of the antitumor activity of a 7-substituted camptothecin in hormone-refractory human prostate carcinoma models

scientific article published in April 2003

Cellular pharmacology of cisplatin in relation to the expression of human copper transporter CTR1 in different pairs of cisplatin-sensitive and -resistant cells

scientific article published on July 2004

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

scientific article published on 28 December 2017

Cellular sensitivity to beta-diketonato complexes of ruthenium(III), chromium(III) and rhodium(III).

scientific article published on May 2006

Characterization of an established human, malignant, glioblastoma cell line (GBM) and its response to conventional drugs.

scientific article published on January 1994

Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma

scientific article published on 19 August 2013

Cooperation between p53 and p73 in cisplatin-induced apoptosis in ovarian carcinoma cells

scientific article published in May 2008

Decreased drug accumulation and increased tolerance to DNA damage in tumor cells with a low level of cisplatin resistance

scientific article published on April 1998

Defining targets of modulation of human tumor cell response to cisplatin.

scientific article published on 8 January 2008

Design, synthesis and biological evaluation of novel dimeric and tetrameric cRGD-paclitaxel conjugates for integrin-assisted drug delivery

scientific article published on July 2015

Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.

scientific article

Development of resistance to a trinuclear platinum complex in ovarian carcinoma cells.

scientific article published on July 2003

Different accumulation of cisplatin, oxaliplatin and JM216 in sensitive and cisplatin-resistant human cervical tumour cells

scientific article published on 17 July 2006

Differential outcome of MEK1/2 inhibitor-platinum combinations in platinum-sensitive and -resistant ovarian carcinoma cells

scientific article published on 24 February 2014

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

scientific article

Drug Combinations with Proteasome Inhibitors in Antitumor Therapy ⬇️

scientific article published on January 1, 2013

Editorial (The Ubiquitin Proteasome System as a Source of Drug Targets for Cancer Therapy) ⬇️

scientific article published on January 1, 2013

Editorial: Targeting Drug-resistant and Metastatic Tumors by Interference with Tumor and Microenvironment-related Alterations

scientific article published in January 2017

Effect of modulation of protein kinase C activity on cisplatin cytotoxicity in cisplatin-resistant and cisplatin-sensitive human osteosarcoma cells

scientific article published on August 1993

Efficacy of a Selective Binder of αVβ3 Integrin Linked to the Tyrosine Kinase Inhibitor Sunitinib in Ovarian Carcinoma Preclinical Models

scientific article published on 13 April 2019

Electron microscopy analysis of early localization of cisplatin in ovarian carcinoma cells.

scientific article published on September 2002

Enhanced antitumour efficacy of gimatecan in combination with Bcl-2 antisense oligonucleotide in human melanoma xenografts.

scientific article

Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer

scientific article published in August 2002

Extra-cellular thiol metabolism in clones of human metastatic melanoma with different gamma-glutamyl transpeptidase expression: implications for cell response to platinum-based drugs

scientific article published in February 2002

Fas/CD95-mediated apoptosis in human glioblastoma cells: a target for sensitisation to topoisomerase I inhibitors

scientific article published on March 2002

Fast Cyclization of a Proline-Derived Self-Immolative Spacer Improves the Efficacy of Carbamate Prodrugs

scientific article published on 22 January 2020

FoxO-1 contributes to the efficacy of the combination of the XPO1 inhibitor selinexor and cisplatin in ovarian carcinoma preclinical models.

scientific article published on 16 November 2017

Gene expression profiles in the cellular response to a multinuclear platinum complex

scientific article published on April 2004

Global gene expression of fission yeast in response to cisplatin.

scientific article published in September 2004

Growth inhibition and sensitization to cisplatin by zoledronic acid in osteosarcoma cells

scientific article published on 20 November 2006

Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment

scientific article

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

scientific article published in 2012

Identification of MET and SRC activation in melanoma cell lines showing primary resistance to PLX4032.

scientific article published on December 2011

Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment.

scientific article published on 17 December 2013

In vitro and in vivo interaction between cisplatin and topotecan in ovarian carcinoma systems

scientific article

Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin.

scientific article published on 31 December 2009

Increased sensitivity to cisplatin in non-small cell lung cancer cell lines after FHIT gene transfer

scientific article

Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles.

scientific article

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

scientific article

Integrin-Targeted Peptide- and Peptidomimetic-Drug Conjugates for the Treatment of Tumors

scientific article published on 3 February 2017

KiSS1 in regulation of metastasis and response to antitumor drugs

scientific article published on 01 January 2019

Mechanisms controlling sensitivity to platinum complexes: role of p53 and DNA mismatch repair.

scientific article

Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine

scientific article published on 18 June 2010

Microenvironment-Modulated Metastatic CD133+/CXCR4+/EpCAM- Lung Cancer-Initiating Cells Sustain Tumor Dissemination and Correlate with Poor Prognosis

scientific article

Modulation of cell growth and cisplatin sensitivity by membrane gamma-glutamyltransferase in melanoma cells.

scientific article published on 22 August 2006

Modulation of cell sensitivity to antitumor agents by targeting survival pathways.

scientific article published on 3 August 2010

Modulation of epidermal growth factor receptor tyrosine phosphorylation by tumor necrosis factor

scientific article published on May 1991

Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors.

scientific article published on September 2004

Modulation of survival pathways in ovarian carcinoma cell lines resistant to platinum compounds

scientific article

Molecular alterations of cells resistant to platinum drugs: role of PKCalpha

scientific article published on 6 January 2006

Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7.

scientific article published on 10 October 2017

Molecular mechanisms controlling sensitivity to toxic metal ions in yeast

scientific article published on December 1997

New mechanisms for old drugs: Insights into DNA-unrelated effects of platinum compounds and drug resistance determinants

scientific article published on 07 May 2015

Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity

scientific article

Novel 7-substituted camptothecins with potent antitumor activity

scientific article

Novel Insights into Targeting ATP-Binding Cassette Transporters for Antitumor Therapy ⬇️

scientific article published on January 1, 2011

Novel bis-platinum complexes endowed with an improved pharmacological profile

scientific article

Novel cytotoxic 7-iminomethyl and 7-aminomethyl derivatives of camptothecin.

scientific article

Nucleolar targeting by platinum: p53-independent apoptosis follows rRNA inhibition, cell-cycle arrest, and DNA compaction.

scientific article

Orchestration of DSB repair: a novel BRCA2 connection

scientific article published on 01 June 2015

Ovarian cancer cisplatin-resistant cell lines: multiple changes including collateral sensitivity to Taxol.

scientific article published on April 1998

Oxaliplatin in the era of personalized medicine: from mechanistic studies to clinical efficacy

scientific article

PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells

scientific article published on 20 August 2016

PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues

scientific article published in January 2015

Preface: Histone Deacetylases as Therapeutic Targets

scientific article published in 2015

Protein kinase C activation by anthracyclines in Swiss 3T3 cells

scientific article published on January 1991

Proteomic analysis of cellular response to novel proapoptotic agents related to atypical retinoids in human IGROV-1 ovarian carcinoma cells

scientific article published on 18 January 2011

RECQL4 Modulates MDR1 Expression and Chemoresistance-Letter

scientific article published on 6 December 2016

Relationship between folate-binding protein expression and cisplatin sensitivity in ovarian carcinoma cell lines ⬇️

scientific article published on January 1, 1997

Role of Bcl-2 and its post-transcriptional modification in response to antitumor therapy.

scientific article

Role of FoxO Proteins in Cellular Response to Antitumor Agents

scientific article published on 14 January 2019

Role of apoptotic response in cellular resistance to cytotoxic agents

scientific article published on October 1997

Role of the Receptor Tyrosine Kinase Axl and its Targeting in Cancer Cells

scientific article published on 5 April 2016

Role of the sugar moiety in the pharmacological activity of anthracyclines: development of a novel series of disaccharide analogs.

scientific article

Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition.

scientific article published on 29 September 2011

Sensitivity to Cisplatin and Platinum-Containing Compounds ofSchizosaccharomyces pombe Rad Mutants ⬇️

scientific article published on July 1, 1998

Sensitization of tumor cells by targeting histone deacetylases

scientific article

Sensitization to gimatecan-induced apoptosis by tumor necrosis factor-related apoptosis inducing ligand in prostate carcinoma cells

scientific article published on 24 January 2006

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity

scientific article

Synergistic cooperation between sunitinib and cisplatin promotes apoptotic cell death in human medullary thyroid cancer

scientific article published on 25 November 2013

Synergistic interaction between the novel histone deacetylase inhibitor ST2782 and the proteasome inhibitor bortezomib in platinum-sensitive and resistant ovarian carcinoma cells

scientific article

Synthetic sulfoglycolipids targeting the serine-threonine protein kinase Akt.

scientific article published on 18 May 2016

Targeting DNA topoisomerase I with non-camptothecin poisons.

scientific article published on January 2012

Targeting peptidyl-prolyl isomerase pin1 to inhibit tumor cell aggressiveness.

scientific article

Targeting the Akt Kinase to Modulate Survival, Invasiveness and Drug Resistance of Cancer Cells ⬇️

scientific article published on January 1, 2013

Targeting the invasive phenotype of cisplatin-resistant non-small cell lung cancer cells by a novel histone deacetylase inhibitor.

scientific article

Targeting topoisomerase I: molecular mechanisms and cellular determinants of response to topoisomerase I inhibitors

scientific article published on 9 September 2008

Tau Mutations Serve as a Novel Risk Factor for Cancer

scientific article published on 24 May 2018

Tau Mutations as a Novel Risk Factor for Cancer-Response

scientific article published on 29 October 2018

The ABC of glycosylation

scientific article published on 10 June 2010

The cellular basis of the efficacy of the trinuclear platinum complex BBR 3464 against cisplatin-resistant cells

scientific article published on 01 October 1999

The human homolog of fission yeast Rad17 is implicated in tumor growth

scientific article

The rediscovery of platinum-based cancer therapy

scientific article published on 30 October 2020

Tyrosyl-DNA phosphodiesterase 1 targeting for modulation of camptothecin-based treatment.

scientific article published on January 2010

Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.

scientific article

[Pharmacologic basis of the effectiveness of topotecan in the treatment of ovarian carcinoma]

scientific article published on 01 May 1999

gamma-Glutamyl transpeptidase catalyses the extracellular detoxification of cisplatin in a human cell line derived from the proximal convoluted tubule of the kidney

scientific article published on May 2003

p53-dependent activation of microRNA-34a in response to etoposide-induced DNA damage in osteosarcoma cell lines not impaired by dominant negative p53 expression

scientific article published on 9 December 2014

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