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List of works by Cinzia Lanzi

Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases

scientific article published on 25 June 2016

Antitumor efficacy of the heparanase inhibitor SST0001 alone and in combination with antiangiogenic agents in the treatment of human pediatric sarcoma models.

scientific article published on March 2013

Antitumour and antiangiogenic effects of IDN 5390, a novel C-seco taxane, in a paclitaxel-resistant human ovarian tumour xenograft

scientific article published on April 2004

Apoptotic cell death induction and angiogenesis inhibition in large established medullary thyroid carcinoma xenografts by Ret inhibitor RPI-1.

scientific article published on 6 June 2006

Axl molecular targeting counteracts aggressiveness but not platinum-resistance of ovarian carcinoma cells

scientific article

Cell cycle checkpoint efficiency and cellular response to paclitaxel in prostate cancer cells

scientific article

Clavilactones, a novel class of tyrosine kinase inhibitors of fungal origin

scientific article

Concomitant downregulation of proliferation/survival pathways dependent on FGF-R3, JAK2 and BCMA in human multiple myeloma cells by multi-kinase targeting.

scientific article

DUSP6/MKP3 is overexpressed in papillary and poorly differentiated thyroid carcinoma and contributes to neoplastic properties of thyroid cancer cells.

scientific article published on 21 January 2013

Decreased drug accumulation and increased tolerance to DNA damage in tumor cells with a low level of cisplatin resistance

scientific article published on April 1998

Development of resistance to the atypical retinoid, ST1926, in the lung carcinoma cell line H460 is associated with reduced formation of DNA strand breaks and a defective DNA damage response

scientific article published on July 2005

Differential outcome of MEK1/2 inhibitor-platinum combinations in platinum-sensitive and -resistant ovarian carcinoma cells

scientific article published on 24 February 2014

Diversity of effects of two antitumor anthracycline analogs on the pathway of activation of PKC in intact human platelets

scientific article published on 01 September 1988

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Heparan Sulfate Mimetics in Cancer Therapy: The Challenge to Define Structural Determinants and the Relevance of Targets for Optimal Activity

scientific article published on 8 November 2018

IDN 5390: an oral taxane candidate for protracted treatment schedules

scientific article published on March 2003

Identification of MET and SRC activation in melanoma cell lines showing primary resistance to PLX4032.

scientific article published on December 2011

Inactivation of Ret/Ptc1 oncoprotein and inhibition of papillary thyroid carcinoma cell proliferation by indolinone RPI-1.

scientific article published in July 2003

Induction of apoptosis and stress response in ovarian carcinoma cell lines treated with ST1926, an atypical retinoid

scientific article published on March 2004

Inhibition of c-Met and prevention of spontaneous metastatic spreading by the 2-indolinone RPI-1.

scientific article published on September 2006

Interplay between Ret and Fap-1 regulates CD95-mediated apoptosis in medullary thyroid cancer cells

scientific article published on 2 July 2011

Lipid peroxidation, phosphoinositide turnover and protein kinase C activation in human platelets treated with anthracyclines and their complexes with Fe(III)

scientific article published on 01 April 1992

Microenvironment modulation and enhancement of antilymphoma therapy by the heparanase inhibitor roneparstat

scientific article published on 21 July 2017

Modulation of survival pathways in ovarian carcinoma cell lines resistant to platinum compounds

scientific article

Modulation of survival signaling pathways and persistence of the genotoxic stress as a basis for the synergistic interaction between the atypical retinoid ST1926 and the epidermal growth factor receptor inhibitor ZD1839.

scientific article

New mechanisms for old drugs: Insights into DNA-unrelated effects of platinum compounds and drug resistance determinants

scientific article published on 07 May 2015

Overactive IGF1/Insulin Receptors and NRASQ61R Mutation Drive Mechanisms of Resistance to Pazopanib and Define Rational Combination Strategies to Treat Synovial Sarcoma

scientific article published on 22 March 2019

Pre-clinical and clinical significance of heparanase in Ewing's sarcoma.

scientific article

Protein kinase C activation by anthracyclines in Swiss 3T3 cells

scientific article published on January 1991

Proteomics study of medullary thyroid carcinomas expressing RET germ-line mutations: identification of new signaling elements.

scientific article published on March 2009

RET/PTC1-driven neoplastic transformation and proinvasive phenotype of human thyrocytes involve Met induction and beta-catenin nuclear translocation

scientific article

Role of c-myc protein in hormone refractory prostate carcinoma: cellular response to paclitaxel

scientific article

Role of daunosamine and hydroxyacetyl side chain in reaction with iron and lipid peroxidation by anthracyclines.

scientific article published in September 1988

Selection of monoclonal antibodies which induce internalization and phosphorylation of p185HER2 and growth inhibition of cells with HER2/NEU gene amplification.

scientific article published on April 1991

Stratification of clear cell renal cell carcinoma by signaling pathway analysis

scientific article

Structure elucidation of clavilactone D: an inhibitor of protein tyrosine kinases

scientific article

Supersulfated low-molecular weight heparin synergizes with IGF1R/IR inhibitor to suppress synovial sarcoma growth and metastases

scientific article published on 7 December 2017

Synergistic cooperation between sunitinib and cisplatin promotes apoptotic cell death in human medullary thyroid cancer

scientific article published on 25 November 2013

Synthesis and RET protein kinase inhibitory activity of 3-arylureidobenzylidene-indolin-2-ones

scientific article published on 30 April 2007

Synthesis, modeling, and RET protein kinase inhibitory activity of 3- and 4-substituted beta-carbolin-1-ones

scientific article published on December 2008

Synthetic sulfoglycolipids targeting the serine-threonine protein kinase Akt.

scientific article published on 18 May 2016

Targeting RET for thyroid cancer therapy

scientific article

Targeting heparan sulfate proteoglycans and their modifying enzymes to enhance anticancer chemotherapy efficacy and overcome drug resistance.

scientific article published on 16 February 2017

Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer.

scientific article published on 16 June 2016

Targeting the Akt kinase to modulate survival, invasiveness and drug resistance of cancer cells

scientific article published on January 2013

Targeting the invasive phenotype of cisplatin-resistant non-small cell lung cancer cells by a novel histone deacetylase inhibitor.

scientific article

The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects.

scientific article

The heparanase/heparan sulfate proteoglycan axis: A potential new therapeutic target in sarcomas.

scientific article published on 22 September 2016

Upregulation of ERK-EGR1-heparanase axis by HDAC inhibitors provides targets for rational therapeutic intervention in synovial sarcoma

scientific article published on 02 December 2021

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