Search filters

List of works by Carmen Abate

1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity

scientific article published on January 2011

2-Aminopyridine derivatives as potential σ(2) receptor antagonists

scientific article published on 13 August 2012

4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity

scientific article published on April 2004

Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers

scientific article published on 13 January 2011

Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines

scientific article

Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers

scientific article published on 30 May 2011

Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration

scientific article published on 23 October 2020

Classes of sigma2 (σ2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity

scientific article published on January 2012

Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents

scientific article published on 4 November 2014

Design and evaluation of naphthol- and carbazole-containing fluorescent sigma ligands as potential probes for receptor binding studies

scientific article published on 22 August 2007

Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ₂ receptors

scientific article published on 20 September 2013

Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors

scientific article published on 13 December 2015

Editorial [Hot Topic: Sigma Receptor Research: Progress Towards Diagnostic and Therapeutic Uses of Sigma Ligands (Executive Guest Editor: Carmen Abate )]

scientific article published on 01 January 2012

Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor

scientific article published on 3 April 2015

Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).

scientific article

Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells

scientific article

From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: Small structural changes address the mechanism of interaction at the efflux pump

scientific article published on 30 October 2014

Interaction of chiral MS-245 analogs at h5-HT6 receptors

scientific article

Interaction of the sigma(2) receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer

scientific article

Investigation of σ receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines

scientific article published on 29 January 2013

Is the sigma2 receptor a histone binding protein?

scientific article

Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries

scientific article published on 7 February 2015

Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer

scientific article

Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma(1) receptor

scientific article published in December 2005

Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity

scientific article

Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2Receptors in Living Cells

scientific article published on 10 March 2015

Novel derivatives of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with improved fluorescent and σ receptors binding properties

scientific article published on 14 April 2014

Novel metal chelators thiosemicarbazones with activity at the σ2 receptors and P-glycoprotein: an innovative strategy for resistant tumor treatment

scholarly article in RSC Advances, vol. 5 no. 125, 2015

PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma

scientific article published on 2 February 2008

Proceedings from the Fourth International Symposium on sigma-2 Receptors: Role in Health and Disease

scientific article published on 07 October 2020

Quantum Dot Based Luminescent Nanoprobes for Sigma-2 Receptor Imaging

scientific article published on 11 December 2017

Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracers

scholarly article in RSC Advances, vol. 6 no. 91, 2016

Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: hints for collateral sensitivity

scientific article published on 19 September 2013

Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1.

scientific article published on 19 December 2016

Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ1 receptor ligands

scientific article published on 17 October 2011

Synthesis and pharmacological evaluation of ¹¹C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging.

scientific article

The effects of new sigma (σ) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity.

scientific article

The sigma-1 receptor antagonist PB212 reduces the Ca²⁺-release through the inositol (1, 4, 5)-trisphosphate receptor in SK-N-SH cells

scientific article

Tritium radiolabelling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization

scientific article published on 25 December 2007

Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells

scientific article published on 02 July 2019

Paulina is supported by:

About Paulina

Help