Search filters

List of works by Randall T. Moon

"Omic" risk assessment

scientific article published on 26 May 2009

A PKC wave follows the calcium wave after activation of Xenopus eggs.

scientific article published on February 2004

A Wnt survival guide: from flies to human disease.

scientific article

A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling

scientific article

A new nomenclature for int-1 and related genes: the Wnt gene family

scientific article published in January 1991

A novel functional low-density lipoprotein receptor-related protein 6 gene alternative splice variant is associated with Alzheimer's disease.

scientific article published on 06 December 2012

A plasmid-based system for expressing small interfering RNA libraries in mammalian cells

scientific article

A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression.

scientific article

A role for xGCNF in midbrain-hindbrain patterning in Xenopus laevis.

scientific article

A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development

scientific article published on 11 September 2012

A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development.

scientific article

AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.

scientific article

APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development

scientific article published on 20 May 2008

Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP.

scientific article

Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function

scientific journal article

Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development

scientific article

Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities

scientific article

Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1.

scientific article published on 13 August 2008

Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine.

scientific article

An assessment of the masked message hypothesis: sea urchin egg messenger ribonucleoprotein complexes are efficient templates for in vitro protein synthesis.

scientific article published on October 1982

Analysis of the Signaling Activities of Localization Mutants of β-Catenin during Axis Specification in Xenopus ⬇️

scientific article published on October 6, 1997

Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+ signaling.

scientific article published on August 2001

Antisense RNA inhibits expression of membrane skeleton protein 4.1 during embryonic development of Xenopus.

scientific article published on May 1988

Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct

scientific article

BMP-2/-4 and Wnt-8 cooperatively pattern the Xenopus mesoderm ⬇️

scientific article published on February 1, 1998

Beta-catenin signaling increases in proliferating NG2+ progenitors and astrocytes during post-traumatic gliogenesis in the adult brain.

scientific article

Beta-catenin-independent Wnt pathways: signals, core proteins, and effectors.

scientific article published on January 2008

Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6

scientific article (publication date: 2009)

Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells

scholarly article

Botulinum toxin induces muscle paralysis and inhibits bone regeneration in zebrafish

scientific article

Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus

scientific journal article

Canonical Wnt3a modulates intracellular calcium and enhances excitatory neurotransmission in hippocampal neurons

scientific journal article

Chemical-genetic screen identifies riluzole as an enhancer of Wnt/β-catenin signaling in melanoma ⬇️

scientific article published on November 24, 2010

Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling

scientific article

Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway

scientific article

Competence modifiers synergize with growth factors during mesoderm induction and patterning in Xenopus

scientific article published on November 27, 1992

Control of neural crest cell fate by the Wnt signalling pathway.

scientific article

Crystal Structure of a Full-Length β-Catenin

scientific article

Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment

scientific article

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

scientific article

Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation

scientific article

Developmental biology: signalling polarity

scientific article published in May 2002

Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation

scientific article published on 19 June 2011

Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus.

scientific article published on September 1999

Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos.

scientific article

Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling

scientific article

Disruptive CHD8 mutations define a subtype of autism early in development

scientific article

Distinct Wnt signaling pathways have opposing roles in appendage regeneration

scientific article published on 21 December 2006

Distinct effects of ectopic expression of Wnt-1, activin B, and bFGF on gap junctional permeability in 32-cell Xenopus embryos

scientific article published on May 1, 1992

Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis.

scientific article published in September 1989

Ectopic induction of dorsal mesoderm by overexpression of Xwnt-8 elevates the neural competence of Xenopus ectoderm.

scientific article published on July 1992

Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells

scientific article published on 13 April 2015

Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of dishevelled that is dependent on cortical rotation

scientific article

Expression, crystallization and preliminary X-ray studies of the PDZ domain of Dishevelled protein.

scientific article published on February 2000

FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells.

scientific article published on 31 May 2013

From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus ⬇️

scientific article published on July 1, 1998

Functional genomic analysis of the Wnt-wingless signaling pathway

scientific article published on 07 April 2005

G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway.

scientific article published on June 2001

Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration

scientific article (publication date: 20 March 2009)

Hematopoietic stem cell biology: too much of a Wnt thing

scientific article published on 01 October 2006

High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration

scientific article published on 24 May 2007

Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency.

scientific article

Inhibition of Tcf3 binding by I-mfa domain proteins

scientific article

Injected Wnt RNA induces a complete body axis in Xenopus embryos ⬇️

scientific article published on November 15, 1991

Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling ⬇️

scientific article published on November 27, 1997

Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver.

scientific article published on 31 January 2012

Involvement of Wnt1 and Pax2 in the formation of the midbrain‐hindbrain boundary in the zebrafish gastrula ⬇️

scientific article published on January 1, 1995

LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1.

scientific article published on 9 January 2013

Lentiviral-mediated transgene expression can potentiate intestinal mesenchymal-epithelial signaling.

scientific article

Lymphoid Enhancer Factor-1 Links Two Hereditary Leukemia Syndromes through Core-binding Factor α Regulation of ELA2 ⬇️

scientific article published on October 31, 2003

Macrophages modulate adult zebrafish tail fin regeneration

scientific article

Membrane skeleton protein 4.1 in developing Xenopus: expression in postmitotic cells of the retina.

scientific article published on June 1990

Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling

scientific article published on 8 January 2013

Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells

scientific article

Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of β-catenin signaling

scientific article

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling

scientific article

Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1.

scientific article

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

scientific article

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

scientific article

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

scientific article

New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening

scientific article

Patterning activities of vertebrate hedgehog proteins in the developing eye and brain.

scientific article published on August 1995

Porous implants modulate healing and induce shifts in local macrophage polarization in the foreign body reaction.

scientific article

Positive and Negative Regulation of Muscle Cell Identity by Members of the hedgehog and TGF-β Gene Families ⬇️

scientific article published on October 6, 1997

Prolonged in vivo gene silencing by electroporation-mediated plasmid delivery of small interfering RNA.

scientific article published on September 2007

Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner

scientific journal article

Protein kinase C isozymes have distinct roles in neural induction and competence in Xenopus

scientific article published on March 20, 1992

Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells

scientific article published on 10 October 2013

Proximal events in Wnt signal transduction

scientific article (publication date: July 2009)

Regulating the response to targeted MEK inhibition in melanoma: enhancing apoptosis in NRAS- and BRAF-mutant melanoma cells with Wnt/β-catenin activation.

scientific article published on 16 August 2012

Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP

scientific article

Simvastatin promotes adult hippocampal neurogenesis by enhancing Wnt/β-catenin signaling

scientific article published on 26 December 2013

Small-molecule synergist of the Wnt/beta-catenin signaling pathway

scientific article

Specification of the Anteroposterior Neural Axis through Synergistic Interaction of the Wnt Signaling Cascade withnogginandfollistatin ⬇️

scientific article published on November 1, 1995

Structurally related receptors and antagonists compete for secreted Wnt ligands.

scientific article published on March 1997

Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase

scientific article

Synthesis and assembly of spectrin during avian erythropoiesis: stoichiometric assembly but unequal synthesis of alpha and beta spectrin.

scientific article published on April 1983

TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby

scientific article

TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer

scientific article (publication date: June 2006)

Targeted BRAF inhibition impacts survival in melanoma patients with high levels of Wnt/β-catenin signaling

scientific article

Targeting Wnt pathways in disease ⬇️

scientific article published on November 1, 2012

The APC tumor suppressor protein in development and cancer.

scientific article published on July 1997

The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation

scientific article

The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning.

scientific article published on March 2005

The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling

scientific article

The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape

scientific journal article

The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.

scientific article

The armadillo homologs beta-catenin and plakoglobin are differentially expressed during early development of Xenopus laevis

scientific article published on October 1, 1992

The bHLH class protein pMesogenin1 can specify paraxial mesoderm phenotypes.

scientific article

The cytoskeletal framework of sea urchin eggs and embryos: developmental changes in the association of messenger RNA.

scientific article published on February 1983

The interaction of the Wnt and Notch pathways modulates natural killer versus T cell differentiation.

scientific article published on 19 July 2007

The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos.

scientific article published on January 2002

The promise and perils of Wnt signaling through beta-catenin.

scientific article

The tuberin-hamartin complex negatively regulates beta-catenin signaling activity

scientific article (publication date: 21 February 2003)

Transcription-based reporters of Wnt/beta-catenin signaling

scientific article published on June 2009

Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation.

scientific article published on October 2006

Translational control in sea urchin eggs and embryos: initiation is rate limiting in blastula stage embryos.

scientific article

Two tcf3 genes cooperate to pattern the zebrafish brain.

scientific article published on May 2003

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

scientific article

WNT signalling pathways as therapeutic targets in cancer

scientific article (publication date: 2013)

WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors.

scientific article

WNTS and WNT receptors as therapeutic tools and targets in human disease processes.

scientific article

When Wnts antagonize Wnts.

scientific article published on September 2003

Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein ⬇️

scientific article published on January 3, 2012

Wnt and FGF pathways cooperatively pattern anteroposterior neural ectoderm in Xenopus.

scientific article published on December 1997

Wnt and related signaling pathways in melanomagenesis.

scientific article published on 26 May 2010

Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3

scientific article published on 27 October 2011

Wnt signaling induces epithelial differentiation during cutaneous wound healing

scientific article

Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells

scientific article

Wnt signaling: why is everything so negative?

scientific article published on April 1998

Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo.

scholarly article

Wnt-beta-catenin signaling initiates taste papilla development

scientific journal article

Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis.

scientific article published on May 2009

Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish.

scientific article published on 16 March 2005

Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.

scientific article published on 10 January 2012

Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4

scientific article published on 5 March 2012

Wnt/β-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cells.

scientific article published on 02 July 2013

Wnt3a activates dormant c-Kit(-) bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity.

scientific article published on August 2010

Wnt4 affects morphogenesis when misexpressed in the zebrafish embryo.

scientific article published on August 1995

Wnt5a and Wnt11 are essential for second heart field progenitor development.

scientific article

Zebrafish mdk2, a novel secreted midkine, participates in posterior neurogenesis.

scientific article

Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.

scientific article published on April 2003

Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning.

scientific article published on July 2001

beta-Spectrin limits alpha-spectrin assembly on membranes following synthesis in a chicken erythroid cell lysate.

scientific article published on September 1983

Paulina is supported by:

About Paulina

Help