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List of works by Alma Martelli

(+/-)-Naringenin as large conductance Ca(2+)-activated K+ (BKCa) channel opener in vascular smooth muscle cells

scientific article published on 6 November 2006

1,2,3-Triazol-carboxanilides and 1,2,3-triazol-(N-benzyl)-carboxamides as BK-potassium channel activators. XII.

scientific article published on 7 March 2008

1,4- and 2,4-substituted-1,2,3-triazoles as potential potassium channel activators. VII.

scientific article

1,4-Benzothiazine ATP-sensitive potassium channel openers: modifications at the C-2 and C-6 positions

scientific article published on 28 May 2013

1,5-Diarylsubstituted 1,2,3-triazoles as potassium channel activators. VI.

scientific article

A Series of COX-2 Inhibitors Endowed with NO-Releasing Properties: Synthesis, Biological Evaluation, and Docking Analysis

scientific article published on 27 May 2016

Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle

scientific article published on 03 May 2019

Anti-ischaemic activity of an antioxidant aldose reductase inhibitor on diabetic and non-diabetic rat hearts

scientific article published on January 2010

Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel

scientific article

Anticancer properties of erucin, an H2 S-releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC-1)

scientific article published on 10 January 2019

Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo

scientific article

Benzoyl and/or benzyl substituted 1,2,3-triazoles as potassium channel activators. VIII.

scientific article published on 3 March 2005

Cardioprotective effects of different flavonoids against myocardial ischaemia/reperfusion injury in Langendorff-perfused rat hearts

scientific article published on 26 February 2013

Correction to Novel Analgesic/Anti-Inflammatory Agents: 1,5-Diarylpyrrole Nitrooxyalkyl Ethers and Related Compounds as Cyclooxygenase-2 Inhibiting Nitric Oxide Donors

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

scientific article published on 22 October 2015

Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease?

scientific article published on 27 September 2019

Different patterns of H2S/NO activity and cross-talk in the control of the coronary vascular bed under normotensive or hypertensive conditions

scientific article

Differential effects of fondaparinux and bemiparin on angiogenic and vasculogenesis-like processes

scientific article published on 11 April 2012

Effect of glucoraphanin and sulforaphane against chemotherapy-induced neuropathic pain: Kv7 potassium channels modulation by H S release in vivo

scientific article published on 02 August 2018

Effects of natural and synthetic isothiocyanate-based H2S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels

scientific article published on 18 April 2017

Efficacy of isothiocyanate-based compounds on different forms of persistent pain

Enantioresolution, stereochemical characterization and biological activity of a chiral large-conductance calcium-activated potassium channel opener

Enantioselectivity in Cardioprotection induced by (S)- (−)-2,2-Dimethyl-N-(4′-acetamido-benzyl)-4-spiromorpholone-chromane

scientific article published on 01 March 2009

Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors

scientific article published on 18 December 2013

Eruca sativa Meal against Diabetic Neuropathic Pain: An H2S-Mediated Effect of Glucoerucin

scientific article published on 19 August 2019

Eruca sativa Mill. seed extract promotes anti-obesity and hypoglycemic effects in mice fed with a high-fat diet

scientific article published on 03 November 2020

Erucin exhibits vasorelaxing effects and antihypertensive activity by H2 S-releasing properties

scientific article published on 15 April 2019

Evaluation of the NO-releasing properties of NO-donor linkers

scientific article published in February 2008

Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection.

scientific article published on 29 December 2015

First Examples of H2S-Releasing Glycoconjugates: Stereoselective Synthesis and Anticancer Activities

scientific article published on 16 January 2019

Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels

scientific article published on 04 January 2007

Heterocyclic analogs of benzanilide derivatives as potassium channel activators. IX.

scientific article published on 19 April 2006

Hydrogen Sulphide: Biopharmacological Roles in the Cardiovascular System and Pharmaceutical Perspectives ⬇️

scientific article published on January 1, 2012

Hydrogen sulfide inhalation ameliorates allergen induced airway hypereactivity by modulating mast cell activation

scientific article published on August 2015

Hydrogen sulfide releasing capacity of natural isothiocyanates: is it a reliable explanation for the multiple biological effects of Brassicaceae?

scientific article published on 25 June 2014

Hydrogen sulphide: novel opportunity for drug discovery

scientific article published on 07 December 2010

Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects.

scientific article

Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme

scientific article published on 18 October 2012

Inhibitors of the renal outer medullary potassium channel: a patent review

scientific article published on 25 May 2015

Large conductance Ca(2+)-activated K(+) channel (BKCa) activating properties of a series of novel N-arylbenzamides: Channel subunit dependent effects.

scientific article published on 14 May 2013

Mitochondrial potassium channels as pharmacological target for cardioprotective drugs.

scientific article

Mitochondriotropic and Cardioprotective Effects of Triphenylphosphonium-Conjugated Derivatives of the Diterpenoid Isosteviol.

scientific article published on 26 September 2017

N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors

scientific article published on 24 October 2007

NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs.

scientific article published on 27 June 2009

NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs

scientific article published in November 2004

NSAID-induced enteropathy: are the currently available selective COX-2 inhibitors all the same?

scientific article

New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties

scientific article published on 01 December 2006

New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design, Synthesis, and Biopharmacological Properties

scientific article published on 01 April 2006

New amido derivatives as potential BKCa potassium channel activators. XI

scientific article published on 05 July 2007

Novel 1,4-benzothiazine derivatives as large conductance Ca2+-activated potassium channel openers

scientific article

Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors

scientific article published on 11 April 2013

Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties

scientific article published on 31 October 2011

Pathophysiological role of mitochondrial potassium channels and their modulation by drugs.

scientific article published on 12 October 2017

Pharmacodynamic hybrids coupling established cardiovascular mechanisms of action with additional nitric oxide releasing properties

scientific article published on January 2009

Pharmacological characterization of the vascular effects of aryl isothiocyanates: is hydrogen sulfide the real player?

scientific article published on 25 November 2013

Phosphorylation of AKT and ERK1/2 and mutations of PIK3CA and PTEN are predictive of breast cancer cell sensitivity to everolimus in vitro

scientific article published on 23 February 2018

Potassium Channels: A Big Family, Many Different Targets, Great Pharmacological Opportunities

scientific article published on 01 January 2018

Protective effect of high-dose montelukast on salbutamol-induced homologous desensitisation in airway smooth muscle

scientific article published on 27 June 2013

QSAR studies on BK channel activators

scientific article published on 5 November 2008

Recent efforts in drug discovery on vascular inflammation and consequent atherosclerosis

scientific article published on 30 November 2020

Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel

scientific article

Structural modifications of benzanilide derivatives, effective potassium channel openers. X

Synthesis and biological activity of novel substituted benzanilides as potassium channel activators. V.

scientific article

Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia

scientific article published on 13 January 2011

Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications

scientific article published on 26 December 2014

Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties

scientific article published on 2 August 2010

The Citrus Flavanone Naringenin Produces Cardioprotective Effects in Hearts from 1 Year Old Rat, through Activation of mitoBK Channels.

scientific article

The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage.

scientific article published on 12 March 2017

The Renal Outer Medullary Potassium channel (ROMK): an intriguing pharmacological target for an innovative class of diuretic drugs

scientific article published on 12 October 2017

The activation of mitochondrial BK potassium channels contributes to the protective effects of naringenin against myocardial ischemia/reperfusion injury.

scientific article

The novel H2 S donor 4-carboxy-phenyl isothiocyanate inhibits mast cell degranulation and renin release by decreasing intracellular calcium.

scientific article published on 22 August 2016

The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress

scientific article published on 8 September 2016

The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and end

scientific article

The role of hydrogen sulfide and H2S-donors in myocardial protection against ischemia/reperfusion injury

scientific article published on 12 February 2018

Tumor Suppressor Role of hsa-miR-193a-3p and -5p in Cutaneous Melanoma

scientific article published on 27 August 2020

Using hydrogen sulfide to design and develop drugs

scientific article

Vascular Effects of H2S-Donors: Fluorimetric Detection of H2S Generation and Ion Channel Activation in Human Aortic Smooth Muscle Cells

scientific article published on 01 January 2019

Vasorelaxation by hydrogen sulphide involves activation of Kv7 potassium channels.

scientific article

Voltage-operated potassium (Kv) channels contribute to endothelium-dependent vasorelaxation of carvacrol on rat aorta

scientific article published on 23 June 2016

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