List of works - Alessandro Datti

A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin.

scientific article published on 17 September 2007

A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis

scientific article (publication date: September 2007)

A coupled assay for UDP-GlcNAc:Gal beta 1-3GalNAc-R beta 1,6-N-acetylglucosaminyltransferase (GlcNAc to GalNAc).

scientific article

A fluorescent assay for the determination of UDP-GlcNAc: Gal beta 1,3GalNAc-R (GlcNAc to GalNAc) beta 1,6-N-acetylglucosaminyltransferase activity

scientific article published on March 1995

A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization

scientific article

A homogeneous cell-based assay to identify N-linked carbohydrate processing inhibitors

scientific article published on 01 April 2000

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

scientific article published on 08 October 2013

A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90.

scientific article

A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside

scientific article

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.

scientific article published on 6 December 2010

A solid-phase glycosyltransferase assay for high-throughput screening in drug discovery research

scientific article

A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.

scientific article

Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease

scientific article published in September 2011

Activity levels of a β1,6 N-acetylglucosaminyltransferase in lymphomonocytes from multiple sclerosis patients

scientific article published on 01 October 1997

An endogenous PI3K interactome promoting astrocyte mediated neuroprotection identifies a novel association with RNA binding protein ZC3H14

scientific article published on 24 November 2020

Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy

scientific article published on 21 May 2015

Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway

scientific article

COX inhibitors and bone: A safer impact on osteoblasts by NO-releasing NSAIDs

scientific article published on 07 July 2018

Cell-based high-throughput screen for small molecule inhibitors of Bax translocation

scientific article published on 13 December 2018

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

scientific article published on 9 July 2009

Clinical validation of a link between TNF-alpha and the glycosylation enzyme core 2 GlcNAc-T and the relationship of this link to diabetic retinopathy.

scientific article

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

scientific article

Complex N-glycan and metabolic control in tumor cells.

scientific article

Coordinated involvement of cathepsins S, D and cystatin C in the commitment of hematopoietic stem cells to dendritic cells.

scientific article published on 17 February 2011

Cyproheptadine displays preclinical activity in myeloma and leukemia

scientific article published on 23 May 2008

Digitoxin-induced cytotoxicity in cancer cells is mediated through distinct kinase and interferon signaling networks

scientific article

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma

scientific article published on 22 March 2016

Drug-mediated inhibition of Fli-1 for the treatment of leukemia

scientific article

Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells

scientific article published on 31 May 2009

Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells

scientific article published on September 2016

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

scientific article

Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells

scientific article published on 09 September 2016

Expression of cathepsins S and D signals a distinctive biochemical trait in CD34+ hematopoietic stem cells of relapsing-remitting multiple sclerosis patients

scientific article published on 25 February 2013

Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming

scientific article

High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer.

scientific article

High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitor

scientific article

High-throughput screening identifies cardiac glycosides as potent inhibitors of human tissue kallikrein expression: implications for cancer therapies

scientific article

High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines.

scientific article

Highly conserved cysteines of mouse core 2 beta1,6-N-acetylglucosaminyltransferase I form a network of disulfide bonds and include a thiol that affects enzyme activity

scientific article published on 3 September 2003

Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes

scientific article published on 13 January 2022

Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism

scientific article published on 27 November 2015

Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer

scientific article published on 01 April 2018

Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair.

scientific article published on 23 December 2015

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain

scientific article

Inhibition of intracellular dipeptidyl peptidases 8 and 9 enhances parthenolide's anti-leukemic activity.

scientific article published on 15 January 2013

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia

scientific article published on November 2011

Inhibition of osteoclast bone resorption by disrupting vacuolar H+-ATPase a3-B2 subunit interaction.

scientific article

Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation

scientific article

Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function

scientific article

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis

scientific article published on January 2010

Lestaurtinib is a potent inhibitor of anaplastic thyroid cancer cell line models

scientific article published in PLoS ONE

Luteolin inhibition of V-ATPase a3-d2 interaction decreases osteoclast resorptive activity.

scientific article

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

scientific article

Lysosomal β-galactosidase and β-hexosaminidase activities correlate with clinical stages of dementia associated with Alzheimer's disease and type 2 diabetes mellitus.

scientific article published in January 2011

MicroRNA implications across neurodevelopment and neuropathology

scientific article published on 13 October 2009

Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors

scientific article published in February 2017

Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming

scientific article

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.

scientific article

PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae

scientific article published on 18 October 2011

RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation

scientific article published on 29 August 2016

RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs

scientific article

ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

scientific article published on 03 January 2020

Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer

scientific article published on 20 April 2017

Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells

scientific article published on July 2015

Selenium maintains cytosolic Ca2+ homeostasis and preserves germination rates of maize pollen under H2O2-induced oxidative stress

scientific article published on 18 September 2019

Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells

scientific article

Sorafenib as an Inhibitor of RUVBL2

scientific article published on 14 April 2020

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

scientific article published on 27 March 2011

Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer

scientific article

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

scientific article published in June 2015

The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination

scientific article

The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin

scientific article

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

scientific article published on 19 July 2010

Tumor necrosis factor-alpha in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial cells: significance of core 2 GlcNAc-T in diabetic retinopathy

scientific article

Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer

scientific article published on January 2011

beta1,6 N-acetylglucosaminyltransferase (core 2 GlcNAc-T) expression in normal rat tissues and different cell lines: evidence for complex mechanisms of regulation

scientific journal article

β-N-Acetylhexosaminadases in human cerebrospinal fluid and serum of patients with multiple sclerosis

scientific article published on 01 August 1991

List of works by Alessandro Datti

A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin.

A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis

A coupled assay for UDP-GlcNAc:Gal beta 1-3GalNAc-R beta 1,6-N-acetylglucosaminyltransferase (GlcNAc to GalNAc).

A fluorescent assay for the determination of UDP-GlcNAc: Gal beta 1,3GalNAc-R (GlcNAc to GalNAc) beta 1,6-N-acetylglucosaminyltransferase activity

A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization

A homogeneous cell-based assay to identify N-linked carbohydrate processing inhibitors

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90.

A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.

A solid-phase glycosyltransferase assay for high-throughput screening in drug discovery research

A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.

Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease

Activity levels of a β1,6 N-acetylglucosaminyltransferase in lymphomonocytes from multiple sclerosis patients

An endogenous PI3K interactome promoting astrocyte mediated neuroprotection identifies a novel association with RNA binding protein ZC3H14

Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy

Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway

COX inhibitors and bone: A safer impact on osteoblasts by NO-releasing NSAIDs

Cell-based high-throughput screen for small molecule inhibitors of Bax translocation

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

Clinical validation of a link between TNF-alpha and the glycosylation enzyme core 2 GlcNAc-T and the relationship of this link to diabetic retinopathy.

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

Complex N-glycan and metabolic control in tumor cells.

Coordinated involvement of cathepsins S, D and cystatin C in the commitment of hematopoietic stem cells to dendritic cells.

Cyproheptadine displays preclinical activity in myeloma and leukemia

Digitoxin-induced cytotoxicity in cancer cells is mediated through distinct kinase and interferon signaling networks

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma

Drug-mediated inhibition of Fli-1 for the treatment of leukemia

Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells

Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells

Expression of cathepsins S and D signals a distinctive biochemical trait in CD34+ hematopoietic stem cells of relapsing-remitting multiple sclerosis patients

Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming

High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer.

High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitor

High-throughput screening identifies cardiac glycosides as potent inhibitors of human tissue kallikrein expression: implications for cancer therapies

High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines.

Highly conserved cysteines of mouse core 2 beta1,6-N-acetylglucosaminyltransferase I form a network of disulfide bonds and include a thiol that affects enzyme activity

Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes

Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism

Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer

Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair.

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain

Inhibition of intracellular dipeptidyl peptidases 8 and 9 enhances parthenolide's anti-leukemic activity.

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia

Inhibition of osteoclast bone resorption by disrupting vacuolar H+-ATPase a3-B2 subunit interaction.

Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation

Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis

Lestaurtinib is a potent inhibitor of anaplastic thyroid cancer cell line models

Luteolin inhibition of V-ATPase a3-d2 interaction decreases osteoclast resorptive activity.

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

Lysosomal β-galactosidase and β-hexosaminidase activities correlate with clinical stages of dementia associated with Alzheimer's disease and type 2 diabetes mellitus.

MicroRNA implications across neurodevelopment and neuropathology

Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors

Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.

PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae

RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation

RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs

ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer

Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells

Selenium maintains cytosolic Ca2+ homeostasis and preserves germination rates of maize pollen under H2O2-induced oxidative stress

Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells

Sorafenib as an Inhibitor of RUVBL2

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination

The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

Tumor necrosis factor-alpha in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial cells: significance of core 2 GlcNAc-T in diabetic retinopathy

Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer

beta1,6 N-acetylglucosaminyltransferase (core 2 GlcNAc-T) expression in normal rat tissues and different cell lines: evidence for complex mechanisms of regulation

β-N-Acetylhexosaminadases in human cerebrospinal fluid and serum of patients with multiple sclerosis