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List of works by Bruno Ségui

Anti-TNF, a magic bullet in cancer immunotherapy?

scientific article published on 14 November 2019

Apolipoprotein E-deficient mice develop an anti-Chlamydophila pneumoniae T helper 2 response and resist vascular infection.

scientific article published on September 2010

Blocking Tumor Necrosis Factor α Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma

scientific article published on 14 May 2015

CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway.

scientific article

CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation

scientific article published on 7 November 2011

Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis.

scientific article

Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk

scientific article

Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs

scientific article published in March 2006

Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death

scientific article published on 25 September 2009

Ceramide in apoptosis: a revisited role.

scientific article

Chemotherapy with ceramide in TNBC.

scientific article published on 21 August 2015

Chlamydia pneumoniae alters mildly oxidized low-density lipoprotein-induced cell death in human endothelial cells, leading to necrosis rather than apoptosis.

scientific article

Chronic vascular rejection: histologic comparison between two murine experimental models

scientific article published on 01 July 2005

Cleavage and cytoplasmic relocalization of histone deacetylase 3 are important for apoptosis progression

scientific article published on 13 November 2006

Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility

scientific article published on 17 March 2014

Downregulation of sphingosine kinase-1 induces protective tumor immunity by promoting M1 macrophage response in melanoma

scientific article published on 30 September 2016

Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells

scientific article

Engraftment of human T, B and NK cells in CB.17 SCID/beige mice by transfer of human spleen cells

scientific article published on 08 August 2005

Evidence for the lack of involvement of sphingomyelin hydrolysis in the tumor necrosis factor-induced secretion of nerve growth factor in primary astrocyte cultures.

scientific article published in August 1998

Expression of membrane-bound and soluble FasL in Fas- and FADD-dependent T lymphocyte apoptosis induced by mildly oxidized LDL

scientific article published on 20 November 2003

FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling

scientific article published on 9 June 2010

FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response.

scientific article published on 28 September 2009

Genetic disorders of simple sphingolipid metabolism.

scientific article published on January 2013

Glucosylceramidases and malignancies in mammals.

scientific article

Human genetic disorders of sphingolipid biosynthesis

scientific article

Human immune reconstitution with spleen cells in SCID/Beige mice

scientific article published on 01 July 2005

IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis

scientific article

IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells

scientific article published on 04 January 2019

Interleukin-6 deficiency fails to prevent chronic rejection after aortic allografts in apolipoprotein E-deficient mice

scientific article published on 27 September 2008

Involvement of FAN in TNF-induced apoptosis

scientific article

Is active acid sphingomyelinase required for the antiproliferative response to rituximab?

scientific article published on 01 March 2011

Liquid Chromatography-High Resolution Mass Spectrometry Method to Study Sphingolipid Metabolism Changes in Response to CD95L

scientific article published on 01 January 2017

Lysosomal sphingomyelinase is not solicited for apoptosis signaling

scientific article

Method to Measure Sphingomyelin Synthase Activity Changes in Response to CD95L.

scientific article published in January 2017

Monogenic neurological disorders of sphingolipid metabolism

scientific article published on 07 February 2015

Morniga G: a plant lectin as an endocytic ligand for photosensitizer molecule targeting toward tumor-associated T/Tn antigens

scientific article published on 8 December 2010

Morniga-G, a T/Tn-Specific Lectin, Induces Leukemic Cell Death via Caspase and DR5 Receptor-Dependent Pathways ⬇️

scientific article published on 08 January 2019

Multiple human mesenteric arterial grafts from the same donor to study human chronic vascular rejection in humanized SCID/beige mice

scientific article published on 02 May 2006

OPA1 cleavage depends on decreased mitochondrial ATP level and bivalent metals

scientific article published on 19 August 2007

Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis

scientific article published on 28 January 2012

Phosphatidylinositol transfer protein beta displays minimal sphingomyelin transfer activity and is not required for biosynthesis and trafficking of sphingomyelin

scientific article published on August 2002

Phosphorylation of a distinct structural form of phosphatidylinositol transfer protein alpha at Ser166 by protein kinase C disrupts receptor-mediated phospholipase C signaling by inhibiting delivery of phosphatidylinositol to membranes

scientific article

Phosphorylation of serine palmitoyltransferase long chain-1 (SPTLC1) on tyrosine 164 inhibits its activity and promotes cell survival.

scientific article published on 29 April 2013

Regulation of death and growth signals at the plasma membrane by sphingomyelin synthesis: implications for hematological malignancies

scientific article published on September 2011

Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1

scientific article published on 23 January 2020

Retrovirus-mediated correction of the metabolic defect in cultured Farber disease cells.

scientific article published on May 1999

Role of FAN in tumor necrosis factor-alpha and lipopolysaccharide-induced interleukin-6 secretion and lethality in D-galactosamine-sensitized mice

scientific article published on 25 February 2004

S1P: the elixir of life for naive T cells

scientific article published on 30 October 2017

Sphingolipid signalling: molecular basis and role in TNF-alpha-induced cell death.

scientific article published on 20 December 2002

Sphingolipid-mediated apoptotic signaling pathways

scientific article

Sphingolipids modulate the epithelial-mesenchymal transition in cancer.

scientific article published on 12 October 2015

Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid Reprogramming and a Worse Prognosis in Melanoma

scientific article published on 30 April 2019

Stress-induced apoptosis is not mediated by endolysosomal ceramide

scientific article

TNF-R1, an immune checkpoint in melanoma?

scientific article published on September 2015

TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma.

scientific article published on 22 December 2017

Targeting TNF alpha as a novel strategy to enhance CD8(+) T cell-dependent immune response in melanoma?

scientific article published on 12 August 2015

Targeting of T/Tn antigens with a plant lectin to kill human leukemia cells by photochemotherapy

scientific article

Targeting the Sphingosine 1-Phosphate Axis Exerts Potent Antitumor Activity in BRAFi-Resistant Melanomas

scientific article published on 27 November 2018

The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan.

scientific article published in May 2001

The TNF Paradox in Cancer Progression and Immunotherapy

scientific article published on 31 July 2019

The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells

scientific article

The pro-inflammatory action of tumour necrosis factor-α in non-alcoholic steatohepatitis is independent of the NSMAF gene product

scientific article

The tricyclodecan-9-yl-xanthogenate D609 triggers ceramide increase and enhances FasL-induced caspase-dependent and -independent cell death in T lymphocytes

scientific article published on 16 July 2012

Two structurally identical mannose-specific jacalin-related lectins display different effects on human T lymphocyte activation and cell death.

scientific article published on 28 April 2009

Use of human mesenteric arteries to study chronic vascular rejection in SCID/beige mice reconstituted with human spleen cells

scientific article published on 01 January 2005

[Anti-TNFα antibodies in melanoma immunotherapy]

scientific article published on 01 October 2018

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