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List of works by Michael Pusch

A chloride channel widely expressed in epithelial and non-epithelial cells

scientific journal article

A kick-start for CLC antiporters' pharmacology

scientific article published on 01 November 2012

A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.

scientific article published on September 2010

A single point mutation reveals gating of the human ClC-5 Cl-/H+ antiporter

scientific article published on 07 October 2013

Activation and inactivation of homomeric KvLQT1 potassium channels.

scientific article

Activation and inhibition of kidney CLC-K chloride channels by fenamates

scientific article published on 21 October 2005

Alkaline pH block of CLC-K kidney chloride channels mediated by a pore lysine residue.

scientific article

An optical assay of the transport activity of ClC-7.

scientific article

Biophysical properties of acid-sensing ion channels (ASICs).

scientific article

Buffered diffusion around a spherical proton pumping cell: a theoretical analysis

scientific article

CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease

scientific article published on 01 July 2018

CLC chloride channels in Caenorhabditis elegans

scientific article

Ca(2+)-activated chloride channels go molecular.

scientific article published on April 2004

Channel or transporter? The CLC saga continues.

scientific article

Chloride dependence of hyperpolarization-activated chloride channel gates

scientific article published in March 1999

Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5.

scientific article

Cisplatin activates volume sensitive LRRC8 channel mediated currents in Xenopus oocytes

scientific article published on 25 January 2017

ClC-5: Physiological role and biophysical mechanisms.

scientific article

Conformational changes in the pore of CLC-0.

scientific article published on 11 August 2003

Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1.

scientific article published in April 2003

Conversion of the 2 Cl(-)/1 H+ antiporter ClC-5 in a NO3(-)/H+ antiporter by a single point mutation

scientific article published on 8 January 2009

Determinants of anion-proton coupling in mammalian endosomal CLC proteins

scientific article published on 6 December 2007

Dissecting a regulatory calcium-binding site of CLC-K kidney chloride channels

scientific article published on 12 November 2012

Expanding the spectrum of megalencephalic leukoencephalopathy with subcortical cysts in two patients with GLIALCAM mutations

scientific article published on 8 November 2013

Expression of LRRC8/VRAC Currents in Xenopus Oocytes: Advantages and Caveats.

scientific article published on 2 March 2018

Extracellular determinants of anion discrimination of the Cl-/H+ antiporter protein CLC-5.

scientific article published on 15 September 2011

Fast and slow gating relaxations in the muscle chloride channel CLC-1.

scientific article

Functional analyses of mutations in HEPACAM causing megalencephalic leukoencephalopathy

scientific article published on 18 August 2014

Functional and structural conservation of CBS domains from CLC chloride channels.

scientific article

Gain of function of sporadic/familial hemiplegic migraine-causing SCN1A mutations: Use of an optimized cDNA

scientific article published on 09 July 2018

Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channels

scientific article published on January 2000

Gating competence of constitutively open CLC-0 mutants revealed by the interaction with a small organic Inhibitor

scientific article published on 11 August 2003

Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion

scientific article

GlialCAM, a CLC-2 Cl(-) channel subunit, activates the slow gate of CLC chloride channels.

scientific article

GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit

scientific article published in March 2012

Heteromultimeric CLC chloride channels with novel properties

scientific article published on November 1996

I-J loop involvement in the pharmacological profile of CLC-K channels expressed in Xenopus oocytes

scientific article published on 26 July 2014

Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels.

scientific article published on August 2010

Identification of the Ca2+ blocking site of acid-sensing ion channel (ASIC) 1: implications for channel gating

scientific article

Increase of the single-channel conductance of KvLQT1 potassium channels induced by the association with minK.

scientific article published in December 1998

Independent gating of single pores in CLC-0 chloride channels

scientific article published on August 1997

Interaction of hydrophobic anions with the rat skeletal muscle chloride channel ClC-1: effects on permeation and gating

scientific article

Intracellular proton regulation of ClC-0

scientific article published on July 2008

Intracellular regulation of human ClC-5 by adenine nucleotides

scientific article published on 28 August 2009

Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers

scientific article published in January 2004

Inward rectification in ClC-0 chloride channels caused by mutations in several protein regions

scientific article published on August 1997

It's the proton also in ClC-2.

scientific article

Localization and functional analyses of the MLC1 protein involved in megalencephalic leukoencephalopathy with subcortical cysts

scientific article

Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II.

scientific article published in November 1991

Mechanism of Interaction of Niflumic Acid with Heterologously Expressed Kidney CLC-K Chloride Channels

scientific article published on 01 April 2007

Mechanism of block of single protopores of the Torpedo chloride channel ClC-0 by 2-(p-chlorophenoxy)butyric acid (CPB).

scientific article published on July 2001

Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin.

scientific article published on 9 January 2012

Mechanisms of block of muscle type CLC chloride channels (Review).

scientific article

Molecular Pharmacology of Kidney and Inner Ear CLC-K Chloride Channels ⬇️

scientific article published on October 25, 2010

Molecular and clinical heterogeneity in CLCN7-dependent osteopetrosis: report of 20 novel mutations.

scientific article published in January 2010

Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.

scientific article published in May 2005

Molecular determinants of differential pore blocking of kidney CLC-K chloride channels

scientific article

Molecular modeling of p-chlorophenoxyacetic acid binding to the CLC-0 channel

scientific article published in May 2003

Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid

scientific article

Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine

scientific article

Mutations in dominant human myotonia congenita drastically alter the voltage dependence of the CIC-1 chloride channel

scientific article

Myotonia caused by mutations in the muscle chloride channel gene CLCN1.

scientific article

Myotonia-related mutations in the distal C-terminus of ClC-1 and ClC-0 chloride channels affect the structure of a poly-proline helix

scientific article published on April 2007

Niflumic acid inhibits chloride conductance of rat skeletal muscle by directly inhibiting the CLC-1 channel and by increasing intracellular calcium.

scientific article

On the mechanism of gating charge movement of ClC-5, a human Cl(-)/H(+) antiporter

scientific article published in May 2012

Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions

scientific article published on May 1998

Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels

scientific article published on 23 October 2003

Pharmacology of CLC Chloride Channels and Transporters

scholarly article by Michael Pusch et al published 2006 in Advances in Molecular and Cell Biology

Rates of diffusional exchange between small cells and a measuring patch pipette.

scientific article

Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume

scientific article published on December 1992

Regulatory-auxiliary subunits of CLC chloride channel-transport proteins

scientific article

Relaxing messages from the sarcolemma

scientific article published on 15 November 2010

Single point mutations of the sodium channel drastically reduce the pore permeability without preventing its gating

scientific article published on January 1991

Single-channel analysis of a ClC-2-like chloride conductance in cultured rat cortical astrocytes

scientific article published on 01 August 2000

Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium

scientific article published on 20 March 2006

Structural basis of PI(4,5)P2-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A)

scientific article

Structural basis of slow activation gating in the cardiac I Ks channel complex

scientific article (publication date: 2011)

Structural determinants of interaction, trafficking and function in the ClC-2/MLC1 subunit GlialCAM involved in leukodystrophy.

scientific article published on June 2015

Structural insights into chloride and proton-mediated gating of CLC chloride channels.

scientific article published on February 2004

Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1.

scientific article published on August 2003

Structure of the human ClC-1 chloride channel

scientific article published on 25 April 2019

Subunit-dependent oxidative stress sensitivity of LRRC8 volume-regulated anion channels

scientific article

Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy

scientific article (publication date: 5 May 2000)

Systematic analysis of three FHM genes in 39 sporadic patients with hemiplegic migraine

scientific article published on 01 December 2007

Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes

scientific article

Taurine and skeletal muscle disorders

scientific article published on January 2004

Temperature dependence of fast and slow gating relaxations of ClC-0 chloride channels

scientific article

The Arabidopsis central vacuole as an expression system for intracellular transporters: functional characterization of the Cl-/H+ exchanger CLC-7.

scientific article published on 28 May 2012

The ClC family of voltage-gated chloride channels: structure and function

scientific article published on December 1993

The biophysics of piezo1 and piezo2 mechanosensitive channels

scientific article published on 11 July 2015

The muscle chloride channel ClC-1 has a double-barreled appearance that is differentially affected in dominant and recessive myotonia

scientific article published on March 1999

The novel p.L1649Q mutation in the SCN1A epilepsy gene is associated with familial hemiplegic migraine: genetic and functional studies. Mutation in brief #957. Online

scientific article published in May 2007

The role of protons in fast and slow gating of the Torpedo chloride channel ClC-0.

scientific article published on 9 January 2009

Thermal sensitivity of CLC and TMEM16 chloride channels and transporters

scientific article

Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels

scientific article published in October 2003

Two open states and rate-limiting gating steps revealed by intracellular Na+ block of human KCNQ1 and KCNQ1/KCNE1 K+ channels

scientific article

Two physically distinct pores in the dimeric ClC-0 chloride channel.

scientific article

Unique structure and function of chloride transporting CLC proteins

scientific article

Washout phenomena in dialyzed mast cells allow discrimination of different steps in stimulus-secretion coupling

scientific article published in April 1987

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