List of works by Davide Melisi

A circulating TH2 cytokines profile predicts survival in patients with resectable pancreatic adenocarcinoma.

scientific article

A phase II study of liposomal irinotecan with 5-fluorouracil, leucovorin and oxaliplatin in patients with resectable pancreatic cancer: the nITRO trial

scientific article published on 04 September 2020

A phase II trial of the FGFR inhibitor pemigatinib in patients with metastatic esophageal-gastric junction/gastric cancer trastuzumab resistant: the FiGhTeR trial

scientific article published on 07 July 2020

Adipocytes sustain pancreatic cancer progression through a non-canonical WNT paracrine network inducing ROR2 nuclear shuttling.

scientific article published on 20 November 2017

Adjuvant chemotherapy is associated with improved postoperative survival in specific subtypes of invasive intraductal papillary mucinous neoplasms (IPMN) of the pancreas: it is time for randomized controlled data

scientific article published on 23 October 2018

An FGFR3 Autocrine Loop Sustains Acquired Resistance to Trastuzumab in Gastric Cancer Patients.

scientific article published on 7 June 2016

Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer.

scientific article published in February 2018

Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype.

scientific article

Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy.

scientific article published on January 2004

CT Texture Analysis of Ductal Adenocarcinoma Downstaged After Chemotherapy

scientific article published on 01 August 2018

Clinicogenomic analysis of FGFR2-rearranged cholangiocarcinoma identifies correlates of response and mechanisms of resistance to pemigatinib

scientific article published on 20 November 2020

Combined inhibition of IL1, CXCR1/2, and TGFβ signaling pathways modulates in-vivo resistance to anti-VEGF treatment

scientific article published on 15 October 2015

Cooperative antitumor effect of multitargeted kinase inhibitor ZD6474 and ionizing radiation in glioblastoma

scientific article

Current Strategies to Overcome Resistance to ALK-Inhibitor Agents

scientific article published on 12 August 2015

Data demonstrating the role of peroxiredoxin 2 as important anti-oxidant system in lung homeostasis.

scientific article published on 30 September 2017

EMT and Treatment Resistance in Pancreatic Cancer.

scientific article published on 12 September 2017

HER2 loss in HER2-positive gastric or gastroesophageal cancer after trastuzumab therapy: Implication for further clinical research.

scientific article published on 31 August 2016

HOX Genes Family and Cancer: A Novel Role for Homeobox B9 in the Resistance to Anti-Angiogenic Therapies

scientific article published on 08 November 2020

Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients.

scientific article published on 15 March 2017

IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF-κB Activation.

scientific article published on 23 October 2015

Induction of immunosuppressive functions and NF-κB by FLIP in monocytes

scientific article published in Nature Communications

Key cancer cell signal transduction pathways as therapeutic targets.

scientific article

MEKK3 Sustains EMT and Stemness in Pancreatic Cancer by Regulating YAP and TAZ Transcriptional Activity.

scientific article published in April 2018

Mechanisms of resistance to chemotherapeutic and anti-angiogenic drugs as novel targets for pancreatic cancer therapy.

scientific article published on 30 April 2013

Metastatic pancreatic cancer: Is there a light at the end of the tunnel?

scientific article

Modulating TAK1 Expression Inhibits YAP and TAZ Oncogenic Functions in Pancreatic Cancer

scientific article published on 27 September 2019

Modulation of pancreatic cancer chemoresistance by inhibition of TAK1

scientific article

NF-κB as a target for pancreatic cancer therapy.

scientific article published on 23 March 2012

Novel Biomarkers for Prediction of Response to Preoperative Systemic Therapies in Gastric Cancer

scientific article published on 13 November 2019

Oral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity

scientific article

Outcomes of Advanced Gastric Cancer Patients Treated with at Least Three Lines of Systemic Chemotherapy

scientific article published in February 2018

Outcomes of Advanced Gastric Cancer Patients Treated with at Least Three Lines of Systemic Chemotherapy.

scientific article published on 31 August 2017

Outcomes of Primary Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Ductal Adenocarcinoma

scientific article published on 24 July 2019

Pancreatic Cancer and Obesity: Molecular Mechanisms of Cell Transformation and Chemoresistance

scientific article published on 25 October 2018

Pancreatic cancer: between bench and bedside

scientific article published on 01 June 2012

Pancreatic ductal adenocarcinoma cell lines display a plastic ability to bi‑directionally convert into cancer stem cells.

scientific article published on 12 December 2014

Pemigatinib, a potent inhibitor of FGFRs for the treatment of cholangiocarcinoma

scientific article published on 09 October 2020

Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension

scientific article published on 08 August 2017

Plasma Interleukin-8 is a biomarker for TAK1 activation and predicts resistance to nanoliposomal irinotecan in patients with gemcitabine-refractory pancreatic cancer

scientific article published on 12 June 2020

Population pharmacokinetics and exposure-overall survival analysis of the transforming growth factor-β inhibitor galunisertib in patients with pancreatic cancer

scientific article published on 03 September 2019

Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS-Dependent Pancreatic Ductal Adenocarcinoma

scientific article published on 05 September 2019

Predictive biomarkers for the treatment of resectable esophageal and esophago-gastric junction adenocarcinoma: from hypothesis generation to clinical validation.

scientific article published on 16 March 2018

Prognostic factors in 868 advanced gastric cancer patients treated with second-line chemotherapy in the real world.

scientific article published on 27 December 2016

Prognostic impact of early nutritional support in patients affected by locally advanced and metastatic pancreatic ductal adenocarcinoma undergoing chemotherapy.

scientific article published on 26 March 2018

Quality of life in metastatic pancreatic cancer patients receiving liposomal irinotecan plus 5-fluorouracil and leucovorin

scientific article published on 17 November 2018

Quality-adjusted survival with combination nal-IRI+5-FU/LV vs 5-FU/LV alone in metastatic pancreatic cancer patients previously treated with gemcitabine-based therapy: a Q-TWiST analysis

scientific article published on 28 March 2017

Screening/surveillance programs for pancreatic cancer in familial high-risk individuals: A systematic review and proportion meta-analysis of screening results

scientific article published on 10 April 2018

Second-line chemotherapy for advanced pancreatic cancer: Which is the best option?

scientific article published on 20 April 2017

Second-line treatment efficacy and toxicity in older vs. non-older patients with advanced gastric cancer: A multicentre real-world study

scientific article published on 11 December 2018

Selecting patients for gastrectomy in metastatic esophago-gastric cancer: clinics and pathology are not enough.

scientific article published on 4 October 2017

TAK-ing aim at chemoresistance: The emerging role of MAP3K7 as a target for cancer therapy.

scientific article published on 3 November 2017

TAK1-regulated expression of BIRC3 predicts resistance to preoperative chemoradiotherapy in oesophageal adenocarcinoma patients

scientific article

TGFβ receptor inhibitor galunisertib is linked to inflammation- and remodeling-related proteins in patients with pancreatic cancer

scientific article published on 18 March 2019

Targeting the epidermal growth factor receptor in solid tumors: focus on safety.

scientific article published on April 2014

The curious case of Gαs gain-of-function in neoplasia.

scientific article

The development of PARP as a successful target for cancer therapy

scientific article published on 20 December 2017

Therapeutic integration of signal transduction targeting agents and conventional anti-cancer treatments.

scientific article published on March 2004

Toll-Like Receptor 9 Agonists for Cancer Therapy

scientific article published on 4 August 2014

Toll-like receptor 9 agonist IMO cooperates with cetuximab in K-ras mutant colorectal and pancreatic cancers

scientific article

Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells.

scientific article

Zoledronic acid cooperates with a cyclooxygenase-2 inhibitor and gefitinib in inhibiting breast and prostate cancer.

scientific article published on December 2005

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