List of works - Gabriele Möller

17beta-hydroxysteroid dehydrogenase type 7--an ancient 3-ketosteroid reductase of cholesterogenesis.

scientific article

17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.

scientific article

A common atopy-associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding

scientific article published on 25 March 2014

A novel 17beta-hydroxysteroid dehydrogenase in the fungus Cochliobolus lunatus: new insights into the evolution of steroid-hormone signalling

scientific article

Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates

scientific article

Assay Tools for Metabolomics

Characterization of 17beta-hydroxysteroid dehydrogenase type 7 in reproductive tissues of the marmoset monkey

scientific article published on 22 January 2003

Coenzyme specificity in fungal 17beta-hydroxysteroid dehydrogenase

scientific article published in September 2005

Control of glycoprotein synthesis. Characterization of (1-->4)-N-acetyl-beta-D-glucosaminyltransferases acting on the alpha-D-(1-->3)- and alpha-D-(1-->6)-linked arms of N-linked oligosaccharides

scientific article published on 01 December 1992

Control of glycoprotein synthesis: substrate specificity of rat liver UDP-GlcNAc:Man alpha 3R beta 2-N-acetylglucosaminyltransferase I using synthetic substrate analogues

scientific article published on August 1992

Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D.

scientific article published in July 2002

Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1)

scientific journal article

Differences between human plasma and serum metabolite profiles

scientific article

Discovery of a novel enzyme mediating glucocorticoid catabolism in fish: 20beta-hydroxysteroid dehydrogenase type 2.

scientific article published on 28 October 2011

Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis

scientific article published in August 2012

Expression and regulation of 17beta-hydroxysteroid dehydrogenase 7 in the rabbit

scientific article published in January 2001

HSD17B4 overexpression, an independent biomarker of poor patient outcome in prostate cancer

scientific article published on 28 November 2008

Identification of biomarkers for apoptosis in cancer cell lines using metabolomics: tools for individualized medicine

scientific article published on November 2013

Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening

scientific article published on 12 February 2011

Inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: comparison with other steroid metabolizing enzymes.

scientific article

Inhibitory effects of fluorine-substituted estrogens on the activity of 17beta-hydroxysteroid dehydrogenases

scientific article published on 06 January 2006

Innovations in phenotyping of mouse models in the German Mouse Clinic

scientific article

Introduction of an electron withdrawing group on the hydroxyphenylnaphthol scaffold improves the potency of 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors

scientific article published on 19 October 2011

Ligand-based NMR spectra demonstrate an additional phytoestrogen binding site for 17beta-hydroxysteroid dehydrogenase type 1.

scientific article

Metabolic Signatures in Apoptotic Human Cancer Cell Lines ⬇️

scientific article published on February 19, 2011

Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis.

scientific article published on 23 September 2015

Molecular basis of d-bifunctional protein deficiency

scientific article (publication date: 2001)

Mouse Genetics and Metabolic Mouse Phenotyping

article

Mouse phenotyping

scientific article

Perspectives in understanding the role of human 17beta-hydroxysteroid dehydrogenases in health and disease.

scientific article

Phytoestrogens inhibit human 17beta-hydroxysteroid dehydrogenase type 5.

scientific article

Posterior subcapsular cataracts are a late effect after acute exposure to 0.5 Gy ionizing radiation in mice

scientific article published on 19 January 2021

Recent advances in 17beta-hydroxysteroid dehydrogenases

scientific article

Species used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1

scientific article

Steroids in teleost fishes: A functional point of view

scientific article published on 20 June 2015

Stiff-man syndrome: identification of 17 beta-hydroxysteroid dehydrogenase type 4 as a novel 80-kDa antineuronal antigen

scientific journal article

Structural optimization of 2,5-thiophene amides as highly potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis

scientific article

Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone

scientific article published on 3 October 2009

Synthetic substrate analogues for UDP-GlcNAc: Man alpha 1-6R beta(1-2)-N-acetylglucosaminyltransferase II. Substrate specificity and inhibitors for the enzyme

scientific article published on 01 June 1994

Targeted Metabolomics of Dried Blood Spot Extracts

The pathologic effect of a novel neomorphic Fgf9(Y162C) allele is restricted to decreased vision and retarded lens growth

scientific journal article

The role of 17 beta-hydroxysteroid dehydrogenases.

scientific article

Zebrafish 20β-Hydroxysteroid Dehydrogenase Type 2 Is Important for Glucocorticoid Catabolism in Stress Response ⬇️

scientific article published on January 22, 2013

Zebrafish and steroids: what do we know and what do we need to know?

scientific article published on 30 January 2013

List of works by Gabriele Möller

17beta-hydroxysteroid dehydrogenase type 7--an ancient 3-ketosteroid reductase of cholesterogenesis.

17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.

A common atopy-associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding

A novel 17beta-hydroxysteroid dehydrogenase in the fungus Cochliobolus lunatus: new insights into the evolution of steroid-hormone signalling

Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates

Assay Tools for Metabolomics

Characterization of 17beta-hydroxysteroid dehydrogenase type 7 in reproductive tissues of the marmoset monkey

Coenzyme specificity in fungal 17beta-hydroxysteroid dehydrogenase

Control of glycoprotein synthesis. Characterization of (1-->4)-N-acetyl-beta-D-glucosaminyltransferases acting on the alpha-D-(1-->3)- and alpha-D-(1-->6)-linked arms of N-linked oligosaccharides

Control of glycoprotein synthesis: substrate specificity of rat liver UDP-GlcNAc:Man alpha 3R beta 2-N-acetylglucosaminyltransferase I using synthetic substrate analogues

Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D.

Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1)

Differences between human plasma and serum metabolite profiles

Discovery of a novel enzyme mediating glucocorticoid catabolism in fish: 20beta-hydroxysteroid dehydrogenase type 2.

Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis

Expression and regulation of 17beta-hydroxysteroid dehydrogenase 7 in the rabbit

HSD17B4 overexpression, an independent biomarker of poor patient outcome in prostate cancer

Identification of biomarkers for apoptosis in cancer cell lines using metabolomics: tools for individualized medicine

Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening

Inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: comparison with other steroid metabolizing enzymes.

Inhibitory effects of fluorine-substituted estrogens on the activity of 17beta-hydroxysteroid dehydrogenases

Innovations in phenotyping of mouse models in the German Mouse Clinic

Introduction of an electron withdrawing group on the hydroxyphenylnaphthol scaffold improves the potency of 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors

Ligand-based NMR spectra demonstrate an additional phytoestrogen binding site for 17beta-hydroxysteroid dehydrogenase type 1.

Metabolic Signatures in Apoptotic Human Cancer Cell Lines ⬇️

Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis.

Molecular basis of d-bifunctional protein deficiency

Mouse Genetics and Metabolic Mouse Phenotyping

Mouse phenotyping

Perspectives in understanding the role of human 17beta-hydroxysteroid dehydrogenases in health and disease.

Phytoestrogens inhibit human 17beta-hydroxysteroid dehydrogenase type 5.

Posterior subcapsular cataracts are a late effect after acute exposure to 0.5 Gy ionizing radiation in mice

Recent advances in 17beta-hydroxysteroid dehydrogenases

Species used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1

Steroids in teleost fishes: A functional point of view

Stiff-man syndrome: identification of 17 beta-hydroxysteroid dehydrogenase type 4 as a novel 80-kDa antineuronal antigen

Structural optimization of 2,5-thiophene amides as highly potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis

Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone

Synthetic substrate analogues for UDP-GlcNAc: Man alpha 1-6R beta(1-2)-N-acetylglucosaminyltransferase II. Substrate specificity and inhibitors for the enzyme

Targeted Metabolomics of Dried Blood Spot Extracts

The pathologic effect of a novel neomorphic Fgf9(Y162C) allele is restricted to decreased vision and retarded lens growth

The role of 17 beta-hydroxysteroid dehydrogenases.

Zebrafish 20β-Hydroxysteroid Dehydrogenase Type 2 Is Important for Glucocorticoid Catabolism in Stress Response ⬇️

Zebrafish and steroids: what do we know and what do we need to know?