List of works by Rüdiger Köhling

A mutation in the NADH-dehydrogenase subunit 2 suppresses fibroblast aging

scientific article published in April 2015

A new neurophysiological/neuropathological ex vivo model localizes the origin of glioma-associated epileptogenesis in the invasion area

scientific article published on 6 September 2003

A portable chamber for long-distance transport of surviving human brain slice preparations

scientific article published in August 1996

Acute protective effect of nimodipine and dimethyl sulfoxide against hypoxic and ischemic damage in brain slices.

scientific article published in December 2000

Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitro

scientific article

Age-related decrease of adenosine-mediated relaxation in rat detrusor is a result of A2B receptor downregulation.

scientific article published on 28 February 2015

Altered physiology and pharmacology in the corticostriatal system in a model of temporal lobe epilepsy

scientific article published on 10 November 2010

Alternative splicing of the NMDAR1 glutamate receptor subunit in human temporal lobe epilepsy

scientific article published on 01 March 2000

Animal models of tumour-associated epilepsy

scientific article published on 16 June 2015

Anoxia blocks the presynaptic control of GABA release at inhibitory terminals in the rat hippocampus

scientific article published in December 1996

Anoxic terminal negative DC-shift in human neocortical slices in vitro

scientific article published in November 1996

Anti-GAD65 Containing Cerebrospinal Fluid Does not Alter GABAergic Transmission

scientific article published on 18 May 2016

Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro

scientific article published on 19 August 2009

Basement membrane protein nidogen-1 shapes hippocampal synaptic plasticity and excitability

scientific article published in May 2010

Bioelectrical behaviour of hypoxic human neocortical tissue under the influence of nimodipine and dimethyl sulfoxide

scientific article

Changes of extracellular calcium concentration induced by application of excitatory amino acids in the human neocortex in vitro

scientific article published on 01 February 1995

Characterization of a fast transient outward current in neocortical neurons from epilepsy patients

scientific article published in March 2004

Contribution of L-type calcium channels to epileptiform activity in hippocampal and neocortical slices of guinea-pigs

scientific article published on 01 January 2000

Contribution of calcium ions to the generation of epileptic activity and antiepileptic calcium antagonism

scientific article

Current-source-density profiles associated with sharp waves in human epileptic neocortical tissue

scientific article published on 01 January 1999

Cutting of living hippocampal slices by a highly pressurised water jet (macromingotome)

scientific article published on 01 October 2000

Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse

scientific article

Deep brain stimulation by optimized stimulators in a phenotypic model of dystonia: Effects of different frequencies

scientific article published on 06 November 2020

Detection of electrophysiological indicators of neurotoxicity in human and rat brain slices by a three-dimensional microelectrode array.

scientific article published in December 2005

Differential Involvement of L-Type Calcium Channels in Epileptogenesis of Rat Hippocampal Slices during Ontogenesis

scientific article published on 01 August 2000

Differential sensitivity to induction of spreading depression by partial disinhibition in chronically epileptic human and rat as compared to native rat neocortical tissue

scientific article published in June 2003

Dimethyl sulfoxide increases latency of anoxic terminal negativity in hippocampal slices of guinea pig in vitro

scientific article

Distinct Effects of Stereotactically Injected Human Cerebrospinal Fluid Containing Glutamic Acid Decarboxylase Antibodies into the Hippocampus of Rats on the Development of Spontaneous Epileptic Activity

scientific article published on 22 February 2020

Does interictal synchronization influence ictogenesis?

scientific article published on 06 July 2012

Dopamine induces contraction in the proximal, but relaxation in the distal rat isolated small intestine

scientific article published on 3 September 2009

Effect of levetiracetam on epileptiform discharges in human neocortical slices

scientific article published in December 2002

Effects of glutamate application on the rhythm of low magnesium-induced epileptiform activity in hippocampal slices of guinea-pigs

scientific article published in October 1996

Effects of methohexital on bioelectrical reactions in guinea pig hippocampal slices during hypoxia

scientific article published in August 2002

Effects of nifedipine on rhythmic synchronous activity of human neocortical slices

scientific article published on 01 January 2000

Effects of oxygen insufflation during pilocarpine-induced status epilepticus on mortality, tissue damage and seizures

scientific article published on 12 November 2013

Effects of retigabine on rhythmic synchronous activity of human neocortical slices

scientific article published in May 2001

Electrophysiology in ischemic neocortical brain slices: species differences vs. influences of anaesthesia and preparation

scientific article

Enhanced NMDA receptor-dependent LTP in the epileptic CA1 area via upregulation of NR2B.

scientific article

Epileptiform activity preferentially arises outside tumor invasion zone in glioma xenotransplants

scientific article published on 22 November 2005

Extracellular potassium elevations in the hippocampus of rats with long-term pilocarpine seizures

scientific article published on 01 December 1995

Flat and steep terminal negativity in the DC-potential after deprivation of oxygen and glucose in human neocortical slices

scientific article published in May 1998

Flunarizine shows increased antiepileptic efficacy with elevated K+ levels in low magnesium induced epileptic activity (neocortical slices, guinea pig).

scientific article published in May 1994

Functional Metaplasticity of Hippocampal Schaffer Collateral-CA1 Synapses Is Reversed in Chronically Epileptic Rats.

scientific article published on 2 October 2017

Functional, metabolic, and synaptic changes after seizures as potential targets for antiepileptic therapy.

scientific article published on 12 August 2010

GABA(A) receptor inhibition does not affect mGluR-dependent LTD at hippocampal Schaffer collateral-CA1 synapses

scientific article published in October 2009

GABAA receptor-dependent synchronization leads to ictogenesis in the human dysplastic cortex

scientific article

Gabapentin potentiation of the antiepileptic efficacy of vigabatrin in an in vitro model of epilepsy

scientific article published in May 1998

HCN1 channels constrain DHPG-induced LTD at hippocampal Schaffer collateral-CA1 synapses

scientific article published on 25 November 2009

High K+-induced contraction requires depolarization-induced Ca2+ release from internal stores in rat gut smooth muscle

scientific article published on 6 July 2009

High-frequency magnetic stimulation induces long-term potentiation in rat hippocampal slices.

scientific article

How thoughts give rise to action - conscious motor intention increases the excitability of target-specific motor circuits

scientific article

Human Osteoblast Migration in DC Electrical Fields Depends on Store Operated Ca2+-Release and Is Correlated to Upregulation of Stretch-Activated TRPM7 Channels

scientific article published on 12 December 2019

Hypersynchronous ictal onset in the perirhinal cortex results from dynamic weakening in inhibition

scientific article published on 14 December 2015

Ictal epileptiform activity is facilitated by hippocampal GABAA receptor-mediated oscillations.

scientific article published in September 2000

In vivo treatment with the casein kinase 2 inhibitor 4,5,6,7- tetrabromotriazole augments the slow afterhyperpolarizing potential and prevents acute epileptiform activity

scientific article published in January 2014

Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching

scientific article

Increased excitability and compromised long-term potentiation in the neocortex of NPC1(-/-) mice

scientific article published on 17 January 2012

Increased excitability in cortico-striatal synaptic pathway in a model of paroxysmal dystonia

scientific article

Increasing extracellular potassium results in subthalamic neuron activity resembling that seen in a 6-hydroxydopamine lesion.

scientific article published on 2 April 2008

Interplay between interictal spikes and behavioral seizures in young, but not aged pilocarpine-treated epileptic rats

scientific article published on 26 February 2016

Intrinsic excitability, synaptic potentials, and short-term plasticity in human epileptic neocortex

scientific article published in June 2005

Inverse relationship of Rho kinase and myosin-light chain kinase expression in the aging human detrusor smooth muscle

scientific article published on 15 October 2015

Ionotropic glutamate and GABA receptors in human epileptic neocortical tissue: quantitative in vitro receptor autoradiography

scientific article published on 01 January 1999

Limbic networks and epileptiform synchronization: the view from the experimental side.

scientific article published on January 2014

Low magnesium induced epileptiform discharges in neocortical slices (guinea pig): increased antiepileptic efficacy of organic calcium antagonist verapamil with elevation of extracellular K+ concentration.

scientific article published in September 1992

Lowering of the potassium concentration induces epileptiform activity in guinea-pig hippocampal slices

scientific article published in July 2001

Lowering the extracellular potassium concentration elicits epileptic activity in neocortical tissue of epileptic patients

scientific article published in February 2001

Maternally Inherited Differences within Mitochondrial Complex I Control Murine Healthspan

scientific article published on 13 July 2019

Melatonin reduces low-Mg2+ epileptiform activity in human temporal slices

scientific article published on 01 January 1995

Microcutting of living brain slices by a pulsed ultrafine water jet which allows simultaneous electrophysiological recordings (micromingotome).

scientific article

Mortality is associated with inflammation, anemia, specific diseases and treatments, and molecular markers

scientific article

Muscarinic acetylcholine receptor stimulation induces expression of the activity-regulated cytoskeleton-associated gene (ARC).

scientific article published on February 2004

Mycophenolate mofetil prevents the delayed T cell response after pilocarpine-induced status epilepticus in mice

scientific article

NMDA receptor-dependent metaplasticity by high-frequency magnetic stimulation

scientific article published on 28 October 2014

Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro.

scientific article

Network excitability in a model of chronic temporal lobe epilepsy critically depends on SK channel-mediated AHP currents

scientific article published on 25 August 2011

Neuroprotection of mild hypothermia: differential effects

scientific article published in March 1998

Neuroscience. GABA becomes exciting

scientific article published in November 2002

NiCl2 and amiloride induce spreading depression in guinea pig hippocampal slices

scientific article published in October 2000

OSS-DBS: Open-source simulation platform for deep brain stimulation with a comprehensive automated modeling

scientific article published on 06 July 2020

Optical imaging of epileptiform activity in experimentally induced cortical malformations

scientific article

Optical monitoring of PO2 changes and simultaneous recording of bioelectric activity in human and animal brain slices

scientific article published in December 1998

Optical monitoring of neuronal activity during spontaneous sharp waves in chronically epileptic human neocortical tissue

scientific article published on 01 October 2000

P2Y receptor-mediated transient relaxation of rat longitudinal ileum preparations involves phospholipase C activation, intracellular Ca(2+) release and SK channel activation.

scientific article published on 28 March 2016

Perampanel attenuates epileptiform phenotype in C6 glioma

scientific article published on 14 November 2019

Persistent changes of corticostriatal plasticity in dt(sz) mutant hamsters after age-dependent remission of dystonia

scientific article published on 2 July 2013

Phase-locking characteristics of limbic P3 responses in hippocampal sclerosis

scientific article published on 31 December 2004

Picrotoxin-induced epileptic activity in hippocampal and neocortical slices (guinea pig): suppression by organic calcium channel blockers

scientific article published in September 1994

Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus

scientific article published in September 2011

Potassium Channels in Epilepsy.

scientific article published on 2 May 2016

Pre- rather than co-application of vigabatrin increases the efficacy of tiagabine in hippocampal slices

scientific article published in December 2002

Prolonged epileptiform bursting induced by 0-Mg(2+) in rat hippocampal slices depends on gap junctional coupling

scientific article published in January 2001

Prolonged seizures: what are the mechanisms that predispose or cease to be protective? A review of animal data.

scientific article

Quinine suppresses extracellular potassium transients and ictal epileptiform activity without decreasing neuronal excitability in vitro

scientific article published in January 2002

RNA editing (R/G site) and flip-flop splicing of the AMPA receptor subunit GluR2 in nervous tissue of epilepsy patients

scientific article published in March 2004

Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants

scientific article

Reduction of human neocortical and guinea pig CA1-neuron A-type currents by organic calcium channel blockers

scientific article published in September 2004

Repetitive hypoxic exposure of brain slices and electrophysiological responses as an experimental model for investigation of cerebroprotective measurements

scientific article published in August 1996

Role of striatal NMDA receptor subunits in a model of paroxysmal dystonia

scientific article

Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm

scientific article published on 29 July 2011

Sodium currents in striatal neurons from dystonic dt(sz) hamsters: altered response to lamotrigine

scientific article

Spatio-temporal distribution of epileptiform activity in slices from human neocortex: recordings with voltage-sensitive dyes

scientific article

Specific imbalance of excitatory/inhibitory signaling establishes seizure onset pattern in temporal lobe epilepsy

scientific article published on 13 April 2016

Spontaneous and stimulus-triggered epileptic discharges: delayed antiepileptic effect with triggering

scientific article published in January 1994

Spontaneous sharp waves in human neocortical slices excised from epileptic patients

scientific article published in June 1998

Spreading depression in human neocortical slices

scientific article

Status Epilepticus Enhances Depotentiation after Fully Established LTP in an NMDAR-Dependent but GluN2B-Independent Manner

scientific article published on 3 January 2016

Stereotactic injection of cerebrospinal fluid from anti-NMDA receptor encephalitis into rat dentate gyrus impairs NMDA receptor function

scientific article

Stimulus-induced patterns of bioelectric activity in human neocortical tissue recorded by a voltage sensitive dye.

scientific article

Strychnine-induced epileptiform activity in hippocampal and neocortical slice preparations: suppression by the organic calcium antagonists verapamil and flunarizine

scientific article published in October 1997

Superfusion of verapamil on the cerebral cortex does not suppress epileptic discharges due to restricted diffusion (rats, in vivo)

scientific article published on 01 October 1993

Synchronization of rat hippocampal neurons in the absence of excitatory amino acid-mediated transmission

scientific article published in October 1996

Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro

scientific article published on 01 June 1996

Synchronous potentials and elevations in [K+]o in the adult rat entorhinal cortex maintained in vitro

scientific article published on 01 February 1995

Systems biology approaches in aging research.

scientific article

Targeting of neural stem cells in the hippocampus of adult rats by custom-made Ad vectors.

scientific article

The 27-kDa heat shock protein (HSP27) is a reliable hippocampal marker of full development of pilocarpine-induced status epilepticus

scientific article published on 14 September 2011

The afterhyperpolarizing potential following a train of action potentials is suppressed in an acute epilepsy model in the rat Cornu Ammonis 1 area

scientific article published on 10 November 2011

The effects of verapamil and flunarizine on epileptiform activity induced by bicuculline and low Mg2+ in neocortical tissue of epileptic and primary non-epileptic patients

scientific article published in September 1996

The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus.

scientific article published in May 2006

The problems facing epilepsy therapy

scientific article published on 19 February 2013

Translational perspectives: Interneurones start seizures

scientific article published on 30 October 2019

Uncoupling protein 2 protects mice from aging

scientific article published on 27 June 2016

Upregulation of presynaptic mGluR2, but not mGluR3 in the epileptic medial perforant path

scientific article published on 17 December 2011

Vigabatrin reduces epileptiform activity in brain slices from pharmacoresistant epilepsy patients

scientific article published on 01 August 2000

Voltage-gated calcium channels in the etiopathogenesis and treatment of absence epilepsy.

scientific article published on 22 December 2009

Voltage-gated sodium channels in epilepsy.

scientific article

What is the source of the EEG?

scientific article published on July 2009

ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses

scientific article

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