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List of works by Paula I. Moreira

A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss

scientific article published on 01 July 2019

A second look into the oxidant mechanisms in Alzheimer's disease

scientific article

A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease

scientific article

Altered redox balance in disease: Can we change the new equilibria?

Alzheimer Disease: Oxidative Stress and Compensatory Responses

article

Alzheimer disease and the role of free radicals in the pathogenesis of the disease

scientific article published on February 2008

Alzheimer disease as a vascular disorder: where do mitochondria fit?

scientific article published on 21 July 2012

Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine

scientific article published on 21 June 2016

Alzheimer's disease and diabetes: an integrative view of the role of mitochondria, oxidative stress, and insulin

scientific article published on January 2012

Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers

scientific article published on 7 May 2015

Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies.

scientific article

Alzheimer's disease-related misfolded proteins and dysfunctional organelles on autophagy menu.

scientific article published on 09 February 2015

Alzheimer's disease: a lesson from mitochondrial dysfunction.

scientific article published on October 2007

Alzheimer's disease: an intracellular movement disorder?

scientific article published in September 2005

Alzheimer's disease: diverse aspects of mitochondrial malfunctioning

scientific article

Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations

scientific article

Alzheimers Disease and Oxidative Stress: The Old Problem Remains Unsolved

scholarly article published 1 March 2005

Amyloid beta-peptide promotes permeability transition pore in brain mitochondria

scientific article published in December 2001

Amyloid-beta disrupts calcium and redox homeostasis in brain endothelial cells

scientific article published on 16 May 2014

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

scholarly article

An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease

scientific article published on January 2009

An overview of glutaminyl cyclase inhibitors for Alzheimer's disease

scientific article published on 01 December 2019

Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile ⬇️

scientific article published on August 16, 2012

Antioxidant therapy in Alzheimer's disease: theory and practice

scientific article

Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort

scientific article published on 20 August 2020

Autophagocytosis of mitochondria is prominent in Alzheimer disease

scientific article

Autophagy in Alzheimer's disease

scientific article published on July 2010

Beneficial effects of white wine polyphenols-enriched diet on Alzheimer’s disease-like pathology

scientific article published on 10 February 2018

Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats

scientific article published on 2 June 2017

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

scientific article published on 24 July 2020

Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease.

scientific article published on 19 February 2018

Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes.

scientific article published on 20 February 2007

Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen.

scientific article

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.

scientific article published on 28 March 2008

Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration?

scientific article published on December 2014

Cardiolipin profile changes are associated to the early synaptic mitochondrial dysfunction in Alzheimer's disease

scientific article

Cerebrovascular and mitochondrial abnormalities in Alzheimer's disease: a brief overview

scientific article

Chronological primacy of oxidative stress in Alzheimer disease

scientific article published in May 2005

CoQ10 therapy attenuates amyloid beta-peptide toxicity in brain mitochondria isolated from aged diabetic rats.

scientific article published on 29 August 2005

Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors

scientific article published on 01 April 2020

Compensatory responses induced by oxidative stress in Alzheimer disease

scientific article

Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes

scientific article published on 22 September 2013

Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia.

scientific article published on 8 July 2010

Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration.

scientific article published on 11 January 2013

Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: role of mitochondrial reactive oxygen species and HIF-1α

scientific journal article

Daily consumption of white tea (Camellia sinensis (L.)) improves the cerebral cortex metabolic and oxidative profile in prediabetic Wistar rats

scientific article

Decline in mitochondrial bioenergetics underlies central insulin resistance in streptozocin-induced model of sporadic Alzheimer's disease

scholarly article by Sónia Correia et al published July 2011 in Alzheimer's and Dementia

Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease

scientific article published in January 2010

Diabesity and Brain Energy Metabolism: The Case of Alzheimer's Disease

scientific article published on January 2017

Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies

scientific article published on 06 November 2018

Doxorubicin increases the susceptibility of brain mitochondria to Ca(2+)-induced permeability transition and oxidative damage

scientific article

Doxorubicin: the good, the bad and the ugly effect

scientific article published on September 2009

Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington's Disease.

scientific article published on 12 June 2018

Effect of amyloid beta-peptide on permeability transition pore: a comparative study.

scientific article

Effect of streptozotocin-induced diabetes on rat brain mitochondria

scientific article published in January 2004

Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status.

scientific article published on 17 May 2014

Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease

scientific article published on 03 May 2011

Enhanced amyloidogenic processing of amyloid precursor protein and cell death under prolonged endoplasmic reticulum stress in brain endothelial cells.

scientific article published on 17 August 2014

Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats.

scientific article

Exposure to 2,4-dichlorophenoxyacetic acid alters glucose metabolism in immature rat Sertoli cells

scientific article published on 26 March 2013

Food deprivation promotes oxidative imbalance in rat brain

scientific article published in January 2009

Glycogen synthase kinase 3: a point of integration in Alzheimer's disease and a therapeutic target?

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

scientific article

High-sugar diets, type 2 diabetes and Alzheimerʼs disease ⬇️

scientific article published on July 1, 2013

Hormonal control of Sertoli cell metabolism regulates spermatogenesis ⬇️

scientific article published on July 20, 2012

Human predisposition to cognitive impairment and its relation with environmental exposure to potentially toxic elements

scientific article

Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover

scientific article published on 12 November 2011

Hydroxytamoxifen protects against oxidative stress in brain mitochondria.

scientific article

Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins.

scientific article published on May 2013

Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration?

scientific article published on 20 October 2009

Impact of Diabetes in Blood-Testis and Blood-Brain Barriers: Resemblances and Differences

Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters

scientific article published on 20 October 2010

Increased susceptibility to amyloid-β toxicity in rat brain microvascular endothelial cells under hyperglycemic conditions

scientific article

Increased vulnerability of brain mitochondria in diabetic (Goto-Kakizaki) rats with aging and amyloid-beta exposure.

scientific article published in June 2003

Indices of metabolic dysfunction and oxidative stress

scientific article published on 7 March 2007

Insights into the human brain proteome: Disclosing the biological meaning of protein networks in cerebrospinal fluid.

scientific article published on 10 April 2017

Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets

scientific article published on 23 December 2009

Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease - How Anti-Diabetics Could be a Solution for Dementia

scientific article

Insulin attenuates diabetes-related mitochondrial alterations: a comparative study.

scientific article published in May 2006

Insulin in Central Nervous System: More than Just a Peripheral Hormone ⬇️

scientific article published on February 21, 2012

Insulin is a two-edged knife on the brain

scientific article published on January 2009

Insulin protects against amyloid beta-peptide toxicity in brain mitochondria of diabetic rats.

scientific article published on April 2005

Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation

scientific article published on 12 January 2012

Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats.

scientific article

Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance

scientific article

Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease?

scientific article

Involvement of oxidative stress in Alzheimer disease

scientific article

Iron: the Redox-active center of oxidative stress in Alzheimer disease

scientific article published on 17 May 2007

Is Alzheimer's disease an inflammasomopathy?

scientific article published on 29 September 2019

Is exercise-in-a-bottle likely to proffer new insights into Alzheimer's disease?

scientific article published on October 2013

Kaurane diterpenes as mitochondrial alterations preventive agents under experimental oxidative stress conditions

scientific article published on October 2015

Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area

scientific article published on 18 November 2019

Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts.

scientific article published on September 2007

Lipoic acid and N-acetyl cysteine protect against mitochondrial-related oxidative stress in fibroblasts from Alzheimer disease patients

Liraglutide Protects Against Brain Amyloid-β1-42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation

scientific article published on 04 March 2020

Mechanism of inhibition of mitochondrial ATP synthase by 17β−Estradiol

scientific article published on 29 December 2012

Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview

scientific article

Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities

scientific article published on 16 March 2012

Metabolic fingerprints in testicular biopsies from type 1 diabetic patients.

scientific article

Metal ions and oxidative protein modification in neurological disease.

scientific article

Metformin and male reproduction: effects on Sertoli cell metabolism

scientific article published on February 2014

Metformin in the diabetic brain: friend or foe?

scientific article

Metformin promotes isolated rat liver mitochondria impairment.

scientific article published on 2 October 2007

Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes.

scientific article published in July 2008

Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology.

scientific article published on 11 October 2016

Mini-Symposium: Energy Demand and Energy Supply in Alzheimer's Disease - Introduction

scientific article published on 21 June 2016

Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease

scientific article published on July 2016

Mitochondria as a therapeutic target in Alzheimer's disease and diabetes

scientific article published on December 2009

Mitochondria as potential targets in antidiabetic therapy

scientific article published on January 2011

Mitochondria from distinct tissues are differently affected by 17β-estradiol and tamoxifen

scientific article published on 13 October 2010

Mitochondria in Alzheimer's Disease and Diabetes-Associated Neurodegeneration: License to Heal!

scientific article

Mitochondria: a therapeutic target in neurodegeneration

scientific article published on 21 October 2009

Mitochondria: the missing link between preconditioning and neuroprotection

scientific article

Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease

scientific article published on 7 December 2012

Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease.

scientific article published on July 2006

Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease

scientific article published in May 2013

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

scientific article published on 21 October 2009

Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases

scientific article published on January 2012

Mitochondrial preconditioning: a potential neuroprotective strategy

scientific article published on 26 August 2010

Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes.

scientific article published on 16 May 2014

Mitochondrial traffic jams in Alzheimer's disease - pinpointing the roadblocks

scientific article

Mitochondrial-targeted protective properties of isolated diterpenoids from sideritis spp. in response to the deleterious changes induced by H2O2.

scientific article published on 15 May 2013

Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease

scientific article published in February 2005

Mitophagy in neurodegeneration: an opportunity for therapy?

scientific article published on June 2011

Molecular mechanisms beyond glucose transport in diabetes-related male infertility.

scientific article published on 21 January 2013

Natural Oxidant Balance in Parkinson Disease

scholarly article by George Perry et al published 1 December 2009 in Archives of Neurology

Neurodegenerative pathways in Parkinson's disease: therapeutic strategies

scientific article

Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer’s Disease

article

Neurofilament proteins in neurodegenerative diseases

scientific article

Neurofilamentopathy in neurodegenerative diseases

scientific article published on 26 August 2011

Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links ⬇️

scientific article published on May 10, 2013

Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases

scientific article published on December 2007

Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?

scientific article published on May 2007

Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream

scientific article published on 3 May 2006

New insights into the mechanisms of mitochondrial preconditioning-triggered neuroprotection

scientific article published on January 2011

Nuclear and mitochondrial DNA oxidation in Alzheimer's disease

scientific article published on 23 January 2012

Nucleic acid oxidation in Alzheimer disease

scientific article published on 18 January 2008

O-GlcNAcylation and neuronal energy status: Implications for Alzheimer’s disease

scientific article published on 19 May 2018

Oxidative RNA damage and neurodegeneration

scientific article published on January 2007

Oxidative Stress Signaling in Alzheimers Disease

scientific article

Oxidative Stress and Balance in Neurodegenerative Diseases

Oxidative Stress in Alzheimer’s Disease: A Critical Appraisal of the Causes and the Consequences

Oxidative Stress in Parkinson`s Disease

scholarly article by Avi L. Friedlich et al published 20 May 2009 in The open pathology journal

Oxidative damage and Alzheimer's disease: are antioxidant therapies useful?

scientific article

Oxidative damage to RNA in aging and neurodegenerative disorders

scientific article published on 06 June 2012

Oxidative stress and neurodegeneration

scientific article

Oxidative stress: the old enemy in Alzheimer's disease pathophysiology

scientific article

P3-375

Pathology's new role: defining disease process and protective responses.

scientific article published in January 2008

Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection

scientific article published on 14 September 2014

Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells

scientific journal article

Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: implications for Alzheimer's disease

scientific article published on 10 July 2013

Physical exercise as a possible strategy for brain protection: evidence from mitochondrial-mediated mechanisms.

scientific article published on 23 August 2012

Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers

scientific article published on 24 June 2015

Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling

scientific journal article

Post-translational modifications in brain health and disease

scientific article published on 15 May 2019

Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress

scientific article published on 20 December 2013

Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice".

scientific article published on 19 January 2006

Prevention and treatment of Alzheimer disease and aging: antioxidants

scientific article published on February 2007

RNA oxidation in Alzheimer disease and related neurodegenerative disorders

scientific article published on 07 March 2009

Redox Active Iron at the Center of Oxidative Stress in Alzheimer Disease

article published in 2005

Redox metals and oxidative abnormalities in human prion diseases

scientific article published on 11 August 2005

Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer's disease: a longitudinal multimodal in vivo study

scientific article published on 13 November 2019

Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron

scientific article

Role of Oxidative Insult and Neuronal Survival in Alzheimer’s and Parkinson’s Diseases

scholarly article

Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia

scientific article published on October 2009

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

scientific article

Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology.

scientific article published on 11 October 2016

Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets.

scientific article published on 26 August 2007

Staying connected: synapses in Alzheimer disease

scientific article

Sublethal RNA oxidation as a mechanism for neurodegenerative disease

scientific article published on 20 May 2008

Susceptibility to beta-amyloid-induced toxicity is decreased in goto-kakizaki diabetic rats: involvement of oxidative stress.

scientific article published on January 2000

Sweet Mitochondria: A Shortcut to Alzheimer's Disease.

scientific article

Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure.

scientific article published on 12 January 2006

Tau phosphorylation in Alzheimer's disease: pathogen or protector?

scientific article (publication date: April 2005)

Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy?

scientific article

Testosterone deficiency induced by progressive stages of diabetes mellitus impairs glucose metabolism and favors glycogenesis in mature rat Sertoli cells

scientific article

The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease

scientific article

The Key Role of Oxidative Stress in Alzheimer's Disease

scholarly article published 2007

The Potential Application of Antioxidant Agents in Alzheimer Disease Therapeutics

The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer's Disease: Critical Aspects to Unravel

scientific article published on 05 January 2019

The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy.

scientific article

The impairment of insulin signaling in Alzheimer's disease ⬇️

scientific article published on November 6, 2012

The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice

scientific article published on 18 November 2019

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: implications for Alzheimer's disease.

scientific article published on 14 May 2014

The role of iron as a mediator of oxidative stress in Alzheimer disease

scientific article published on 23 March 2012

The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases

scientific article published on 19 June 2015

Therapeutic opportunities in Alzheimer disease: one for all or all for one?

scientific article

Therapeutic options in Alzheimer's disease

scientific article published on June 2006

Therapeutic potential of oxidant mechanisms in Alzheimer's disease

scientific article

Thinking Outside the Box in Alzheimer Disease Treatment

Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer's Disease

scientific article published on 01 January 2019

Type 2 diabetes aggravates Alzheimer's disease-associated vascular alterations of the aorta in mice

scientific article

Type 2 diabetic and Alzheimer's disease mice present similar behavioral, cognitive, and vascular anomalies

scientific article

UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats.

scientific article published on 17 March 2013

Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects

scientific article

Vascular oxidative stress in Alzheimer disease

scientific article

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