List of works - Klaus Okkenhaug

A point mutation in CD28 distinguishes proliferative signals from survival signals

scientific article

A protocol for construction of gene targeting vectors and generation of homologous recombinant embryonic stem cells.

scientific article published in January 2013

Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.

scientific article

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers

scientific article published on 09 May 2016

Blockade of phosphatidylinositol 3-kinase PI3Kδ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis

scientific article

CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway

scientific article

CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.

scientific article published on 15 November 2007

CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway

scientific article published in January 2005

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

scientific article

Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

scientific article published on 08 July 2020

Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages

scientific article published on 16 July 2003

Class IA PI3Ks regulate subcellular and functional dynamics of IDO1

scientific article published on 07 November 2020

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study ⬇️

scientific article published on 16 July 2016

Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy

scientific article published on 07 June 2018

Cowden's syndrome with immunodeficiency

scientific article published on 5 August 2015

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

scientific journal article

Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex

scientific article published on 19 January 2010

Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing

scientific article

Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells.

scientific article

Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells

scientific article published on 01 November 2006

Does the PI3K pathway promote or antagonize regulatory T cell development and function?

scientific article published on 14 August 2012

Editorial: Lipid Signaling in T Cell Development and Function

scientific article published on 10 August 2015

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

scientific article

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

scientific article

Firefly luciferin-activated rose bengal: in vitro photodynamic therapy by intracellular chemiluminescence in transgenic NIH 3T3 cells.

scientific article

Gene targeting in mice: a review

scientific article

Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases

scientific article

Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production

scientific article published in October 2008

Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts

scientific article

Grb2 Forms an Inducible Protein Complex with CD28 through a Src Homology 3 Domain-Proline Interaction ⬇️

scientific article published on August 14, 1998

Haematological cancer: idelalisib-targeting PI3Kδ in patients with B-cell malignancies

scientific article published on 18 March 2014

IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells

scientific article published on 27 January 2014

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance

scientific article

Immunomodulation of Selective Naive T Cell Functions by p110δ Inactivation Improves the Outcome of Mismatched Cell Transplantation

scientific article

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

scientific article (publication date: 9 August 2002)

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

scientific article (publication date: 19 June 2014)

Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.

scientific article published on 12 July 2007

Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production

scientific article published on 19 January 2016

Integrity in Scientific Research: Creating an Environment that Promotes Responsible Conduct

scientific article published in October 2003

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

scientific article published on 14 September 2016

Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells

scientific article published on 22 September 2005

Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation

scientific article published on 15 May 2020

MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells

scientific article published on 16 November 2009

Multi-tissue DNA methylation age predictor in mouse

scientific article

New responsibilities for the PI3K regulatory subunit p85 alpha.

scientific article

Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals.

scientific article published on 30 January 2017

Oncogenic PI3Kα promotes multipotency in breast epithelial cells

scientific article

P-Rex1 regulates neutrophil function

scientific article

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

scientific article published on 26 November 2012

PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

scientific article published on 17 June 2020

PI3K Signaling in B Cell and T Cell Biology.

scientific article published on 3 November 2014

PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)

scientific article

PI3K in lymphocyte development, differentiation and activation

scientific article (publication date: April 2003)

PI3K induces B-cell development and regulates B cell identity

scientific article

PI3K inhibitors in inflammation, autoimmunity and cancer.

scientific article published on 18 June 2015

PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans

scientific article published on 15 January 2010

PI3K p110δ is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTβR mRNA levels

scientific journal article

PI3K-signalling in B- and T-cells: insights from gene-targeted mice

scientific article

PI3Ks in lymphocyte signaling and development

scientific article published in January 2010

PI3Kβ plays a critical role in neutrophil activation by immune complexes.

scientific article

PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes

scientific article published on 26 August 2015

PI3Kδ and primary immunodeficiencies.

scientific article published on 12 September 2016

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

scientific article published in Nature Communications

PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1.

scientific article

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

scientific article

Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction

scientific article

Phosphoinositide 3-kinase in T cell activation and survival.

scientific article published on April 2004

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

scientific article

Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors.

scientific article

Phosphoinositide 3-kinase δ is a regulatory T-cell target in cancer immunotherapy

scientific article published on 01 July 2019

Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28

scientific article

Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells

scientific article published on 01 September 2008

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

scientific article

Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma.

scientific article published on 18 May 2012

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

scientific article published in November 2017

Requirement for phosphoinositide 3-kinase p110delta signaling in B cell antigen receptor-mediated antigen presentation

scientific article published on 01 February 2007

Requirement of bic/microRNA-155 for normal immune function

scientific article

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

scientific article (publication date: 2 October 2009)

Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets

scientific article published on May 2005

Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation

scientific article published on 01 February 2007

Rules of engagement: distinct functions for the four class I PI3K catalytic isoforms in immunity ⬇️

scientific article published on March 1, 2013

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

scientific article

Signaling by the phosphoinositide 3-kinase family in immune cells

scientific article

Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation

scientific article

T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice

scientific article

Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapy

scientific article (publication date: 21 September 2016)

The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.

scientific article

The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function

scientific article published on 28 January 2019

The PI3K p110δ regulates expression of CD38 on regulatory T cells

scientific article (publication date: March 2011)

The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28

scientific article published on 01 October 1997

The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases

scientific article

The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

scholarly article

The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells.

scientific article

The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells

scientific article published on 01 October 2006

The transcription factor BACH2 promotes tumor immunosuppression.

scientific article published on 5 January 2016

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

scientific article published on 17 July 2020

Two birds with one stone: dual p110δ and p110γ inhibition

scientific article published in November 2013

p110δ is required for innate immunity to transplantable lymphomas

scientific article published on 01 April 2007

List of works by Klaus Okkenhaug

A point mutation in CD28 distinguishes proliferative signals from survival signals

A protocol for construction of gene targeting vectors and generation of homologous recombinant embryonic stem cells.

Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers

Blockade of phosphatidylinositol 3-kinase PI3Kδ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis

CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway

CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.

CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages

Class IA PI3Ks regulate subcellular and functional dynamics of IDO1

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study ⬇️

Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy

Cowden's syndrome with immunodeficiency

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex

Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing

Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells.

Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells

Does the PI3K pathway promote or antagonize regulatory T cell development and function?

Editorial: Lipid Signaling in T Cell Development and Function

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

Firefly luciferin-activated rose bengal: in vitro photodynamic therapy by intracellular chemiluminescence in transgenic NIH 3T3 cells.

Gene targeting in mice: a review

Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases

Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production

Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts

Grb2 Forms an Inducible Protein Complex with CD28 through a Src Homology 3 Domain-Proline Interaction ⬇️

Haematological cancer: idelalisib-targeting PI3Kδ in patients with B-cell malignancies

IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance

Immunomodulation of Selective Naive T Cell Functions by p110δ Inactivation Improves the Outcome of Mismatched Cell Transplantation

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.

Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production

Integrity in Scientific Research: Creating an Environment that Promotes Responsible Conduct

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells

Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation

MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells

Multi-tissue DNA methylation age predictor in mouse

New responsibilities for the PI3K regulatory subunit p85 alpha.

Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals.

Oncogenic PI3Kα promotes multipotency in breast epithelial cells

P-Rex1 regulates neutrophil function

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

PI3K Signaling in B Cell and T Cell Biology.

PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)

PI3K in lymphocyte development, differentiation and activation

PI3K induces B-cell development and regulates B cell identity

PI3K inhibitors in inflammation, autoimmunity and cancer.

PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans

PI3K p110δ is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTβR mRNA levels

PI3K-signalling in B- and T-cells: insights from gene-targeted mice

PI3Ks in lymphocyte signaling and development

PI3Kβ plays a critical role in neutrophil activation by immune complexes.

PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes

PI3Kδ and primary immunodeficiencies.

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1.

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction

Phosphoinositide 3-kinase in T cell activation and survival.

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors.

Phosphoinositide 3-kinase δ is a regulatory T-cell target in cancer immunotherapy

Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28

Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma.

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

Requirement for phosphoinositide 3-kinase p110delta signaling in B cell antigen receptor-mediated antigen presentation

Requirement of bic/microRNA-155 for normal immune function

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets