List of works - Edith M Hessel

A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma

scientific article published on 14 September 2018

A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice.

scientific article

A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure

scientific article published in February 2002

Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition

scientific article published on 11 April 2016

Airway epithelial Fas ligand expression: potential role in modulating bronchial inflammation

scientific article published on 01 March 1998

Allergen-specific T cell responses to immunotherapy monitored by CD154 and intracellular cytokine expression

scientific article published on 13 April 2010

Altered fatty acid metabolism and reduced stearoyl-coenzyme a desaturase activity in asthma

scientific article published on 11 April 2017

Ampicillin resistance in Haemophilus influenzae from COPD patients in the UK.

scientific article

An investigation of the anti-inflammatory effects and a potential biomarker of PI3Kδ inhibition in COPD T cells.

scientific article published on 15 May 2017

Biomarkers measuring the activity of Toll-like receptor ligands in clinical development programs.

scientific article published in January 2009

Bronchoconstriction and airway hyperresponsiveness after ovalbumin inhalation in sensitized mice.

scientific article

Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-alpha/beta-inducible gene expression, without significant toxicity.

scientific article published on 9 September 2004

Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage

scientific article published on 13 December 2019

CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans

scientific article published on 10 August 2009

Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model.

scientific article published on 11 July 2016

Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration

scientific article published on 01 March 1997

Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse

scientific article published in December 1996

Eosinophilic rhinitis accompanies the development of lower airway inflammation and hyper-reactivity in sensitized mice exposed to aerosolized allergen

scientific article published on 01 May 2001

First-in-Human Study With the Inhaled TLR9 Oligonucleotide Agonist AZD1419 Results in Interferon Responses in the Lung, and Is Safe and Well-Tolerated.

scientific article published on 14 November 2017

Functions of T cells in asthma: more than just T(H)2 cells.

scientific article

Genome-wide transcription profiling in neutrophils in acute respiratory distress syndrome

scientific article published in February 2015

Histamine-secreting microbes are increased in the gut of adult asthma patients.

scientific article

IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment.

scientific article published on 11 August 2016

Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction

scientific article

Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses

scientific article

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

scientific article published on 13 January 2020

Intranasal Bifidobacterium longum protects against viral-induced lung inflammation and injury in a murine model of lethal influenza infection

scientific article published on 11 September 2020

Involvement of IL-16 in the induction of airway hyper-responsiveness and up-regulation of IgE in a murine model of allergic asthma

scientific article published on 01 March 1998

Lung inflammation and epithelial changes in a murine model of atopic asthma

scientific article published on 01 May 1996

Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages.

scientific article

Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation.

scientific article published in October 2001

Minimal immunological changes in structurally malformed rats after prenatal exposure to cyclophosphamide

scientific article

Nonhuman primate models of asthma

scientific article published on June 2005

Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells

scientific article

Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients

scientific article published on 13 December 2019

PI3K inhibitors in inflammation, autoimmunity and cancer.

scientific article published on 18 June 2015

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

scientific article published in Nature Communications

Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib

scientific article published on 18 March 2019

Repeated measurement of respiratory function and bronchoconstriction in unanesthetized mice

scientific article published on 01 November 1995

Safety, Tolerability, and Pharmacokinetics of Single and Repeat Doses of Nemiralisib Administered via the Ellipta Dry Powder Inhaler to Healthy Subjects

scientific article published on 25 July 2018

Safety, pharmacokinetics and dose-response characteristics of GSK2269557, an inhaled PI3Kδ inhibitor under development for the treatment of COPD.

scientific article

Superior activity of the type C class of ISS in vitro and in vivo across multiple species.

scientific article

Targeting phosphoinositide 3-kinase δ for the treatment of respiratory diseases.

scientific article published on March 2013

The effect of phosphatidylinositol-3 kinase inhibition on matrix metalloproteinase-9 and reactive oxygen species release from chronic obstructive pulmonary disease neutrophils.

scientific article published on 3 April 2016

The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages

scientific article published on 2 March 2018

Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

scientific article published on May 2007

Use of autologous 99mTechnetium-labelled neutrophils to quantify lung neutrophil clearance in COPD

scientific article published on 23 January 2019

List of works by Edith M Hessel

A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma

A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice.

A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure

Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition

Airway epithelial Fas ligand expression: potential role in modulating bronchial inflammation

Allergen-specific T cell responses to immunotherapy monitored by CD154 and intracellular cytokine expression

Altered fatty acid metabolism and reduced stearoyl-coenzyme a desaturase activity in asthma

Ampicillin resistance in Haemophilus influenzae from COPD patients in the UK.

An investigation of the anti-inflammatory effects and a potential biomarker of PI3Kδ inhibition in COPD T cells.

Biomarkers measuring the activity of Toll-like receptor ligands in clinical development programs.

Bronchoconstriction and airway hyperresponsiveness after ovalbumin inhalation in sensitized mice.

Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-alpha/beta-inducible gene expression, without significant toxicity.

Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage

CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans

Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model.

Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration

Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse

Eosinophilic rhinitis accompanies the development of lower airway inflammation and hyper-reactivity in sensitized mice exposed to aerosolized allergen

First-in-Human Study With the Inhaled TLR9 Oligonucleotide Agonist AZD1419 Results in Interferon Responses in the Lung, and Is Safe and Well-Tolerated.

Functions of T cells in asthma: more than just T(H)2 cells.

Genome-wide transcription profiling in neutrophils in acute respiratory distress syndrome

Histamine-secreting microbes are increased in the gut of adult asthma patients.

IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment.

Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction

Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

Intranasal Bifidobacterium longum protects against viral-induced lung inflammation and injury in a murine model of lethal influenza infection

Involvement of IL-16 in the induction of airway hyper-responsiveness and up-regulation of IgE in a murine model of allergic asthma

Lung inflammation and epithelial changes in a murine model of atopic asthma

Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages.

Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation.

Minimal immunological changes in structurally malformed rats after prenatal exposure to cyclophosphamide

Nonhuman primate models of asthma

Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells

Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients

PI3K inhibitors in inflammation, autoimmunity and cancer.

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib

Repeated measurement of respiratory function and bronchoconstriction in unanesthetized mice

Safety, Tolerability, and Pharmacokinetics of Single and Repeat Doses of Nemiralisib Administered via the Ellipta Dry Powder Inhaler to Healthy Subjects

Safety, pharmacokinetics and dose-response characteristics of GSK2269557, an inhaled PI3Kδ inhibitor under development for the treatment of COPD.

Superior activity of the type C class of ISS in vitro and in vivo across multiple species.

Targeting phosphoinositide 3-kinase δ for the treatment of respiratory diseases.

The effect of phosphatidylinositol-3 kinase inhibition on matrix metalloproteinase-9 and reactive oxygen species release from chronic obstructive pulmonary disease neutrophils.

The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages

Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

Use of autologous 99mTechnetium-labelled neutrophils to quantify lung neutrophil clearance in COPD