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List of works by Michael S. Kinch

2014 in review: FDA approval of new drugs

scientific article published on 19 June 2015

2015 in review: FDA approval of new drugs

scientific article published on 19 April 2016

2016 in review: FDA approvals of new molecular entities

scientific article

2017 in review: FDA approvals of new molecular entities

article

A history of drug development in four acts

scientific article published on 20 April 2015

A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo

scientific article

A mechanism for trabecular meshwork cell retraction: ethacrynic acid initiates the dephosphorylation of focal adhesion proteins

scientific article published in October 1997

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

scientific article

Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade

scientific article (publication date: 31 October 2002)

An analysis of FDA-approved drugs for cardiovascular diseases

scientific article published on 15 September 2014

An analysis of FDA-approved drugs for infectious disease: HIV/AIDS drugs

scientific article published on 28 May 2014

An analysis of FDA-approved drugs for infectious disease: antibacterial agents

scientific article published on 17 July 2014

An analysis of FDA-approved drugs for inflammation and autoimmune diseases

scientific article published on 17 February 2015

An analysis of FDA-approved drugs for metabolic diseases

scientific article published on 11 February 2015

An analysis of FDA-approved drugs for neurological disorders

scientific article published on 11 February 2015

An analysis of FDA-approved drugs for oncology

scientific article published on 27 August 2014

An analysis of FDA-approved drugs for pain and anesthesia

scientific article

An analysis of FDA-approved drugs for psychiatric disorders

scientific article published on 6 September 2014

An analysis of FDA-approved drugs: natural products and their derivatives

scientific article

An analysis of original research contributions toward FDA-approved drugs

article

An overview of FDA-approved biologics medicines

scientific article published on 16 September 2014

An overview of FDA-approved new molecular entities: 1827-2013.

scientific article

An overview of FDA-approved vaccines & their innovators

scientific article published on 21 September 2017

Analysis of EphA2 expression and mutant p53 in ovarian carcinoma

scientific article published on 31 October 2006

Analysis of FDA-approved imaging agents

scientific article published on 21 March 2017

Antibody targeting of the EphA2 tyrosine kinase inhibits malignant cell behavior

scientific article

Antibody-dependent cell-mediated cytotoxicity effector-enhanced EphA2 agonist monoclonal antibody demonstrates potent activity against human tumors

scientific article published on June 2009

Antiviral activity of a small-molecule inhibitor of filovirus infection

scientific article

Assessing the public landscape of clinical-stage pharmaceuticals through freely available online databases

scientific article published on 25 January 2019

Decreased tumorigenic potential of EphA2-overexpressing breast cancer cells following treatment with adenoviral vectors that express EphrinA1.

scientific article published on November 2004

Development of a broad-spectrum antiviral with activity against Ebola virus

scientific article

Differential EphA2 epitope display on normal versus malignant cells

scientific article published in November 2003

Differential regulation of EphA2 in normal and malignant cells

scientific article

Direct targeting of alphavbeta3 integrin on tumor cells with a monoclonal antibody, Abegrin

scientific article published on December 2006

Disease stage variation in CD4+ and CD8+ T-cell reactivity to the receptor tyrosine kinase EphA2 in patients with renal cell carcinoma.

scientific article published in August 2003

Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer

scientific article published on 3 July 2010

Dynamic interaction of PTPmu with multiple cadherins in vivo

scientific article

E-cadherin binding modulates EGF receptor activation

scientific article published on March 2003

E-cadherin engagement stimulates tyrosine phosphorylation

scientific article published on March 1997

Efficacy and antivascular effects of EphA2 reduction with an agonistic antibody in ovarian cancer

scientific article published on November 2006

Enhancement in specific CD8+ T cell recognition of EphA2+ tumors in vitro and in vivo after treatment with ligand agonists

scientific article

EphA2 as a glioma-associated antigen: a novel target for glioma vaccines

scientific article published on August 2005

EphA2 as a target for ovarian cancer therapy

scientific article

EphA2 expression is associated with aggressive features in ovarian carcinoma

scientific article published on August 2004

EphA2 induction of fibronectin creates a permissive microenvironment for malignant cells.

scientific article

EphA2 overexpression is associated with angiogenesis in ovarian cancer

scientific article published on January 2007

EphA2 overexpression promotes ovarian cancer growth

scientific article published on 19 April 2008

Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase

scientific article

Expression and purification of the intact cytoplasmic domain of the human ephrin receptor A2 tyrosine kinase in Escherichia coli

scientific article published on 20 December 2005

Expression of EphA2 and Ephrin A-1 in carcinoma of the urinary bladder

scientific article published in January 2006

Expression of EphA2 is prognostic of disease-free interval and overall survival in surgically treated patients with renal cell carcinoma

scientific article published on January 2005

Food and microbiota in the FDA regulatory framework

scientific article published in July 2017

Function-first approaches to improve target identification in cancer

scientific article published on June 2009

High-level expression of EphA2 receptor tyrosine kinase in prostatic intraepithelial neoplasia

scientific article

Identification of PTCH1 requirement for influenza virus using random homozygous gene perturbation

scientific article

Identification of a Small-molecule Antiviral with Broad-spectrum Application to Multiple, Lethal Virus Types

scientific article published in 2009

Identification of novel host-oriented targets for Human Immunodeficiency Virus type 1 using Random Homozygous Gene Perturbation

scientific article published on 29 September 2009

Identification of tyrosine phosphorylated adhesion proteins in human cancer cells

scientific article published in June 1998

Innovator Organizations in New Drug Development: Assessing the Sustainability of the Biopharmaceutical Industry

scientific article published on June 2016

Ligand binding up-regulates EphA2 messenger RNA through the mitogen-activated protein/extracellular signal-regulated kinase pathway.

scientific article

Loss of 14-3-3sigma in prostate cancer and its precursors

scientific article

Lost medicines: a longer view of the pharmaceutical industry with the potential to reinvigorate discovery

scholarly article by Michael S. Kinch et al published 14 September 2018 in Drug Discovery Today

NIH Support for FDA-Approved Medicines

scientific article published in November 2017

New drug discovery: extraordinary opportunities in an uncertain time

scientific article published on 17 December 2014

Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer

scientific article (publication date: 2003)

Overexpression of the EphA2 tyrosine kinase in prostate cancer

scientific article published in December 1999

PC cell-derived growth factor expression in prostatic intraepithelial neoplasia and prostatic adenocarcinoma

scientific article published in February 2004

Post-approval fate of pharmaceutical companies

scientific article published on 4 November 2014

Predicting the sites of metastases from lung cancer using molecular biologic markers

scientific article

Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival.

scientific article

Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation

scientific article (publication date: 18 October 2002)

Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells ⬇️

scientific article published on November 1, 1997

Selective targeting and potent control of tumor growth using an EphA2/CD3-Bispecific single-chain antibody construct

scientific article published on April 2007

Sources of innovation for new medicines: questions of sustainability

scientific article published on 01 November 2020

Sources of innovation: an assessment of intellectual property

article

TEL, a putative tumor suppressor, induces apoptosis and represses transcription of Bcl-XL.

scientific article published on 5 September 2003

TSG101 exposure on the surface of HIV-1 infected cells: implications for monoclonal antibody therapy for HIV/AIDS ⬇️

scientific article published on July 20, 2010

Target selection for FDA-approved medicines

scientific article

The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation.

scientific article

The engagement of β1 integrins on promonocytic cells promotes phosphorylation of Syk and formation of a protein complex containing Lyn and β1 integrin

scientific article published on 01 May 1999

The rise (and decline?) of biotechnology

scholarly article by Michael S. Kinch published November 2014 in Drug Discovery Today

The use of Random Homozygous Gene Perturbation to identify novel host-oriented targets for influenza

scientific article

Trends in pharmaceutical targeting of clinical indications: 1930-2013.

scientific article published on 29 May 2014

Tumor-selective response to antibody-mediated targeting of alphavbeta3 integrin in ovarian cancer

scientific article

Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia

scientific article

VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway: implications for vasculogenic mimicry

scientific article published on 14 February 2006

Workgroup 2: Human xenograft models of prostate cancer

scientific article published on 01 June 1998

c-Cbl-dependent EphA2 protein degradation is induced by ligand binding.

scientific article

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