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List of works by Gerald T Nepom

3.2-01 A genetically controlled pairing anomaly between HLA-DQα and HLA-DQβ molecules

4.3-14 Further DNA sequence microheterogeneity of the HLA-DR4/DW13 haplotype group: Importance of amino acid position 86 of the DR beta 1 chain for T cell recognition

6.2-12 Mutagenesis and expression studies of the Dw14 (DR4) epitope

A Contra Capture Protein Array Platform for Studying Post-translationally Modified (PTM) Auto-antigenomes

scientific article published on 02 May 2016

A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.

scientific article published on 30 December 2015

A Structural Model for TCR Recognition of the HLA Class II Shared Epitope Sequence Implicated in Susceptibility to Rheumatoid Arthritis

article

A composite immune signature parallels disease progression across T1D subjects

scientific article published on 05 December 2019

A deletion mutant defines DQβ variants within DR4 positive DQw3 positive haplotypes

scientific article published in October 1986

A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis.

scientific article

A functional framework for interpretation of genetic associations in T1D

scientific article

A genetically controlled pairing anomaly between HLA-DQ alpha and HLA-DQ beta chains.

scientific article

A nexus of science and clinical immunology: the Federation of Clinical Immunology Societies and the FOCIS Centers of Excellence

scientific article published on May 2008

A real-time PCR approach for rapid high resolution subtyping of HLA-DRB1*04.

scientific article published on 2 October 2006

A real-time polymerase chain reaction assay for the rapid identification of the autoimmune disease-associated allele HLA-DQB1*0602.

scientific article

A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis

scientific article

A specific nucleotide sequence defines a functional T-cell recognition epitope shared by diverse HLA-DR specificities

scientific article published on April 1988

A unified hypothesis for the complex genetics of HLA associations with IDDM

article

A unified hypothesis for the complex genetics of HLA associations with IDDM.

scientific article published on October 1990

ASHI Workshop Summary Report of the Science and Education Subcommittee: structural and functional relationships of human class II MHC molecules

scientific article published on 01 January 1986

Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance

scientific article published on 25 January 2019

Academic, Foundation, and Industry Collaboration in Finding New Therapies

scientific article published on May 2017

Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset

scientific article

Adult-onset type 1 diabetes patients display decreased IGRP-specific Tr1 cells in blood

scientific article published on 2 September 2015

Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice.

scientific article published on 18 September 2006

Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients.

scientific article

Allele-specific DNA-protein interactions associated with the X-box regulatory region of the DQB1*0302 gene

scientific article

Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase.

scientific article

Allele-specific transcriptional regulation of HLA-DQB1 genes

article

Allelic polymorphism in transcriptional regulatory regions of HLA-DQB genes

scientific article

Allelic variants of MHC class II Molecules can ACT as partial agonists of antigen-specific T cell responses

article

Allelic variation in key peptide-binding pockets discriminates between closely related diabetes-protective and diabetes-susceptible HLA-DQB1*06 alleles

scientific article published on February 2006

Allelic variation in transcription modulates MHC class II expression and function.

scientific article

Alloreactive T-cell clones identify multiple HLA-DQw3 variants

scientific article published on January 1991

Allorecognition of HLA-DQw8 molecules: Influence of single amino acid substitutions

article

Allospecific epitopes of the DQw3.2 (DQw8) molecule

Alteration of Cellular and Humoral Immunity by Mutant p53 Protein and Processed Mutant Peptide in Head and Neck Cancer

scientific article published on 01 December 2007

Amino acids in the peptide-binding groove influence an antibody-defined, disease-associated HLA-DR epitope

scientific article published on June 1994

An HLA-D region restriction fragment length polymorphism associated with celiac disease

scientific article

An extended HLA-D region haplotype associated with celiac disease.

scientific article

Analysis of HLA-DQA1 and -DQB1 genes in Mexican Americans with insulin-dependent diabetes mellitus

scientific article published on 01 August 1993

Analysis of HLA-DQA1 and -DQB1 genes in Mexican Americans with insulin-dependent diabetes mellitus

article

Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes

article

Analysis of differential HLA-DQB expression in autologous B cell lines.

scientific article published on June 1993

Analysis of overlapping T- and B-cell antigenic sites on rubella virus E1 envelope protein. Influence of HLA-DR4 polymorphism on T-cell clonal recognition.

scientific article published on March 1994

Ancestral major histocompatibility complex DRB genes beget conserved patterns of localized polymorphisms

scientific article published on May 1996

Animal models of human type 1 diabetes.

scientific article published on February 2009

Anti-cytokine therapies in T1D: Concepts and strategies

scientific article published on 14 February 2013

Anti-idiotypic antibodies and the induction of specific tumor immunity.

scientific article published on January 1987

Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide

scientific article

Antibody responses to trinitrophenyl (TNP)-l-glutamic acid60-l-alanine30-l-tyrosine10 (GAT) in microcultures: Anti-hapten and anti-carrier responses appear to be under separable control

article

Antigen recognition

scientific article published on 01 February 2000

Antigen-Specific CD4+ T Cells Recognize Epitopes of Protective Antigen following Vaccination with an Anthrax Vaccine.

scientific article published in September 2007

Antigen-Specific T Cell Analysis Reveals That Active Immune Responses to β Cell Antigens Are Focused on a Unique Set of Epitopes.

scientific article published on 26 May 2017

Antigen-specific CD4+ T cells recognize epitopes of protective antigen following vaccination with an anthrax vaccine.

scientific article published on 5 February 2007

Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope

scientific article published on 3 October 2013

Approaching the Heisenberg principle of immunology

scientific article published on 21 July 2008

Association of HLA–Dw16 with rheumatoid arthritis in Yakima Indians. Further evidence for the “shared epitope” hypothesis ⬇️

scientific article published on January 1, 1991

Association of tumor necrosis factor alpha polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort

scientific article published in April 2006

Autoantigen T Cell Immune Responses Observed in the DR0401/DR0404 MHC-generated T Cell Repertoire that are Absent in the Homozygous DR0401 or DR0404 Restricted T Cell Repertoire

article

Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

scientific article published on 01 January 2020

Autoreactive T cells from a type I diabetic recognize multiple class II products

scientific article published on 01 April 1993

Autoreactive T cells in a partially humanized murine model of T1D.

scientific article published on 21 March 2007

Autoreactive human T-cell receptor initiates insulitis and impaired glucose tolerance in HLA DR4 transgenic mice

scientific article published on 18 October 2007

Avidity-dependent programming of autoreactive T cells in T1D

scientific article

Beta 57-Asp plays an essential role in the unique SDS stability of HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC allele associated with protection from insulin-dependent diabetes mellitus

scientific article published on September 2000

Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes

scientific article published on 30 March 2020

Binding of outer surface protein A and human lymphocyte function-associated antigen 1 peptides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme arthritis

scientific article published on 01 February 2003

Biochemical definition of distinct HLA haplotypes associated with juvenile rheumatoid arthritis

Biomarkers for antigen immunotherapy in allergy and type 1 diabetes

scientific article published on 26 June 2015

CD11b+CD28-CD4+ human T cells: activation requirements and association with HLA-DR alleles

scientific article published on 01 December 1996

CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta

scientific article published on 27 July 2009

Challenges in the pursuit of immune tolerance.

scientific article

Changes in autoreactive T cell avidity during type 1 diabetes development.

scientific article published on 23 May 2009

Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles

scientific article

Characterization of a Novel Reverse-orientation Model for a Peptide/MHC Complex Putatively Associated with Type I Diabetes Mellitus

article

Characterization of effector functions of human peptide-specific CD4+ T-cell clones for an intracellular pathogen

scientific article published on 25 June 2008

Characterization of specific HLA-DQ alpha allospecificities by genomic, biochemical, and serologic analysis

scientific article published on 01 June 1987

Characterization of the HLA-restrictive elements of a rubella virus-specific cytotoxic T cell clone: influence of HLA-DR4 beta chain residue 74 polymorphism on antigenic peptide-T cell interaction

scientific article published on October 1996

Characterizing T-Cell Autoimmunity

Class II antigens and disease susceptibility

scientific article

Class II peptide multimers: promise for type 1A diabetes?

scientific article published on 01 April 2002

Clinical trial data access: Opening doors with TrialShare

scientific article published on 12 July 2016

Common variants in P2RY11 are associated with narcolepsy

scientific article

Complexity of human immune response profiles for CD4+ T cell epitopes from the diabetes autoantigen GAD65.

scientific article

Conservation of the HLA-DQB2 locus in nonhuman primates

scientific article published in February 1992

Conservation of the HLA-DQB2 locus in nonhuman primates ⬇️

scientific article published on 01 October 1992

Conserved sequence motifs create a pattern of MHC genetic diversification within primate DRB lineages

Conversations with GAD.

scientific article

Coordinate defects in human histocompatibility leukocyte antigen class II expression and antigen presentation in bare lymphocyte syndrome.

scientific article

Correlation Among Hypoglycemia, Glycemic Variability, and C-Peptide Preservation After Alefacept Therapy in Patients with Type 1 Diabetes Mellitus: Analysis of Data from the Immune Tolerance Network T1DAL Trial.

scientific article

Critical contribution of beta chain residue 57 in peptide binding ability of both HLA-DR and -DQ molecules

scientific article published on July 1996

Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells

scientific article published in July 2007

DNA restriction fragment length polymorphism of HLA-DR2: Correlation with HLA-DR2-associated functions

scientific article published on 01 September 1986

DQw3 variants defined by cloned alloreactive T cells

scientific article published on 01 January 1988

DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype

scholarly article

DX and DQ Promoter Regions Contain Homologous Sequences That Differ in Extent of Methylation

De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells

scientific article

Decline in the Frequencies of Borrelia burgdorferi OspA161-175-Specific T Cells after Antibiotic Therapy in HLA-DRB1*0401-Positive Patients with Antibiotic-Responsive or Antibiotic-Refractory Lyme Arthritis

scientific article published on 01 November 2007

Defective CD4+ T-lymphocyte reconstitution in major histocompatibility complex class II-deficient transplant models

scientific article published on 01 June 1995

Deficient antigen-presenting cell function in multiple genetic complementation groups of type II bare lymphocyte syndrome

scientific article published on July 1995

Defining antigen-specific responses with human MHC class II tetramers.

scientific article

Detection of CD4+ autoreactive T cells in T1D using HLA class II tetramers

scientific article

Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects

scientific article

Determinants of genetic susceptibility in HLA-associated autoimmune disease

scientific article published in November 1989

Differential antigen sensitivity and costimulatory requirements in human Th1 and Th2 antigen-specific CD4+ cells with similar TCR avidity

scientific article

Differential expression of HLA-DQB1 alleles in a heterozygous cell line ⬇️

scientific article published on January 1, 1995

Differential expression of related HLA class II DQ beta genes caused by nucleotide variation in transcriptional regulatory elements ⬇️

scientific article published on February 15, 1992

Differential immunogenetic determinants of polyclonal insulin autoimmune syndrome (Hirata's disease) and monoclonal insulin autoimmune syndrome

scientific article published in October 1995

Differential immunogenetic determinants of polyclonal insulin autoimmune syndrome (Hirata's disease) and monoclonal insulin autoimmune syndrome

Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1*0401-positive individuals

scientific article published on August 1999

Differential presentation of group A streptococcal superantigens by HLA class II DQ and DR alleles

scientific article published in September 2002

Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells

scientific article

Differential transcription elements direct expression of HLA-DQ genes

scientific article published on February 1995

Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes

scientific article published on 21 August 2019

Disease markers and new therapeutics. Dual objectives of genetics in rheumatology

scientific article published on November 1992

Distinct T cell interactions with HLA class II tetramers characterize a spectrum of TCR affinities in the human antigen-specific T cell response

scientific article

ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors.

scientific article

Electrophoretic analysis of human HLA-DR antigens from HLA-DR4 homozygous cell lines: correlation between beta-chain diversity and HLA-D.

scientific article

Electrophoretic variation between class II molecules expressed on HLA-DRw8 homozygous typing cells reveals multiple distinct haplotypes

scientific article

Enhanced detection of immunoglobulin binding by a modified ELISA

scientific article published on 01 May 1983

Erosive rheumatoid factor negative and positive rheumatoid arthritis are immunogenetically similar.

scientific article published in February 1994

Erratum: Common variants in P2RY11 are associated with narcolepsy

scholarly article published in Nature Genetics

Erratum: Narcolepsy is strongly associated with the T-cell receptor alpha locus

scholarly article published in Nature Genetics

Evidence for an Increase in the Functional Avidity of the GAD-reactive CD4+ T Cell Population Prior to Diabetes Onset

article

Evidence for molecular mimicry between human T cell epitopes in rotavirus and pancreatic islet autoantigens

scientific article published on 18 January 2010

Evolution of DQw2-Related Haplotypes

Exceptional stability of the HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus.

scientific article published on December 1998

Exhausted-like CD8 T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects ⬇️

scientific article published on 22 December 2020

Exon-specific oligonucleotide probes localize HLA-DQ ? allelic polymorphisms

scientific article published on 01 January 1986

Extensive replicative capacity of human central memory T cells

scientific article published in June 2004

F.69. Selection of Antigen Specific Autoreactive T Cells is Influenced by INS-VNTR Genotype

Functional avidity directs T-cell fate in autoreactive CD4+ T cells

scientific article published on 19 July 2005

Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1.

scientific article published on September 1995

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

scientific article published on May 2015

Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects

scientific article published on February 2009

Functional polymorphisms among HLA-DR4+ DR beta chains associated with limited peptide diversity

scientific article published in May 1987

Further DNA sequence microheterogeneity of the HLA-DR4/Dw13 haplotype group: importance of amino acid position 86 of the DR beta 1 chain for T-cell recognition

scientific article published on April 1990

GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects

article

GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes

scientific article

GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65.

scientific article published in October 2000

Gene therapy in the treatment of autoimmune diseases

scientific article

Genetic and immunological markers of insulin dependent diabetes in Black Americans

scientific article published in January 1995

Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease.

scientific article published on 28 April 2016

Genetics and disease association of the major histocompatibility complex

scientific article published on September 1988

Genetics of Rheumatoid Arthritis

scholarly article by Gerald T Nepom published 15 November 1999 in Arthritis Research

Genetics of rheumatoid arthritis: is there a scientific explanation for the human leukocyte antigen association?

scientific article

Genetics of type 1A diabetes

scientific article

Glutamic acid decarboxylase and other autoantigens in IDDM

scientific article

H5N1 strain-specific hemagglutinin CD4+ T cell epitopes restricted by HLA DR4.

scientific article published on 3 May 2009

HLA Class II Variants: Structural Studies and Disease Associations

scientific article published on 01 January 1986

HLA DQ beta 3.2 identifies subtypes of DR4+ haplotypes permissive for IDDM.

scientific article

HLA and Rheumatoid Arthritis

scholarly article published 2000

HLA and Type I Diabetes

HLA and type I diabetes

scientific article published on September 1990

HLA class I and class II profiles of patients presenting with Sydenham's chorea

scientific article published on February 2000

HLA class I and class II profiles of patients presenting with Sydenham’s chorea

HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T cells

scientific article

HLA class II typing using oligonucleotide probes

scientific article

HLA genes associated with rheumatoid arthritis. Identification of susceptibility alleles using specific oligonucleotide probes

scientific article

HLA heterozygosity in insulin-dependent diabetes is most frequent at the DQ locus

scientific article published on April 1990

HLA tetramer-based artificial antigen-presenting cells for stimulation of CD4+ T cells

article

HLA-DP and HLA-DO genes in presumptive HLA-identical siblings: structural and functional identification of allelic variation

scientific article published on 01 March 1987

HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation.

scientific article published on March 1993

HLA-DQ and Diabetes Mellitus: A Genetic and Structural Paradigm for Models of Disease Susceptibility

HLA-DQ beta sequence polymorphism and genetic susceptibility to IDDM

HLA-DQ beta sequence polymorphism and genetic susceptibility to IDDM.

scientific article published in January 1990

HLA-DQ heterogeneity among HLA-DRw11(5) haplotypes

scientific article published on 01 November 1986

HLA-DQ molecules form alpha-beta heterodimers of mixed allotype.

scientific article published in November 1988

HLA-DQ polymorphisms are highly selective for peptide binding interactions ⬇️

scientific article published on September 1, 1995

HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells

scientific article published in April 2000

HLA-DQB1 codon 57 is critical for peptide binding and recognition.

scientific article

HLA-DR antigens on lymphoid cells differ from those on myeloid cells ⬇️

scientific article published on October 6, 1983

HLA-DR4-Associated Disease: Oligonucleotide Probes Identify Specific Class II Susceptibility Genes in Type I Diabetes and Rheumatoid Arthritis

article

HLA-DR4-associated haplotypes are genotypically diverse within HLA

scientific article published on 01 July 1985

HLA-DRB1 typing in rheumatoid arthritis: predicting response to specific treatments ⬇️

scientific article published on April 1, 1998

HLA‐DR Class II Associations with Rubella Vaccine‐Induced Joint Manifestations

scientific article published on 01 January 1998

High Molecular Weight Hyaluronan Promotes the Suppressive Effects of CD4+CD25+ T-reg

article by Paul Bollyky et al published 2007 in Clinical Immunology

High affinity presentation of an autoantigenic peptide in type I diabetes by an HLA class II protein encoded in a haplotype protecting from disease.

scientific article published on August 1997

High genetic risk for IDDM in the Pacific Northwest. First report from the Washington State Diabetes Prediction Study

scientific article published in January 1994

High genetic risk for IDDM in the Pacific Northwest. First report from the Washington State Diabetes Prediction Study

Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells

scientific article published on August 1998

How important is GAD in the etiology of spontaneous disease in human and murine type 1 diabetes?

scientific article published on 01 May 2003

Human Immune Response Genes

article

Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis

scientific article

Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration

scientific article

IDENTIFICATION OF HLA-Dw14 GENES IN DR4+ RHEUMATOID ARTHRITIS

scientific article published in The Lancet

IL-10 induction from implants delivering pancreatic islets and hyaluronan

scientific article published on 22 July 2013

Identification and functional characterization of T cells reactive to citrullinated vimentin in HLA-DRB1*0401-positive humanized mice and rheumatoid arthritis patients

scientific article published on October 2011

Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65).

scientific article

Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives

scientific article

Identification of a hemagglutinin-specific idiotype associated with reovirus recognition shared by lymphoid and neural cells ⬇️

scientific article published on January 1, 1982

Identification of a polymorphic variant associated with HLA-DQw3 and characterized by specific restriction sites within the DQ beta-chain gene.

scientific article published on December 1985

Identification of a specific HLA DR2 Ia molecule as a restriction element for measles virus-specific HLA class II-restricted cytotoxic T cell clones

scientific article

Identification of idiotypic receptors on reovirus-specific cytolytic T cells.

scientific article

Idiotypic interactions in immune responses to tumor-associated antigens

scientific article

Immune-directed therapy for type 1 diabetes at the clinical level: the Immune Tolerance Network (ITN) experience

scientific article

Immunity to T cell receptor peptides in multiple sclerosis. III. Preferential immunogenicity of complementarity determi4ning region 2 peptides from disease-associated TCR BV

Immunity to T cell receptor peptides in multiple sclerosis. III. Preferential immunogenicity of complementarity-determining region 2 peptides from disease-associated T cell receptor BV genes ⬇️

scientific article published on July 15, 1998

Immunization to a syngeneic sarcoma by a monoclonal auto-anti-idiotypic antibody

scientific article published in Nature

Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire

scientific article published on July 1997

Immunogenetic analysis suggests different pathogenesis for obese and lean African-Americans with diabetic ketoacidosis

article

Immunogenetics of Disease Susceptibility: New Perspectives in HLA

scientific article published on 01 January 1986

Immunogenetics of HLA-associated diseases

scientific article published on January 1988

Immunological biomarkers: catalysts for translational advances in autoimmune diabetes

scientific article (publication date: May 2013)

Impaired binding of a DQ2 and DQ8-binding HSV VP16 peptide to a DQA1*0501/DQB1*0302 trans class II heterodimer

scientific article published on January 1999

Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis

scientific article

Increased frequency of HLA class II alleles DRB1*0301 and DQB1*0201 in Lambert-Eaton myasthenic syndrome without associated cancer

scientific article

Increased lymphocyte-mediated destruction of tumor cells in microcytotoxicity assays seen after addition of inhibitors of protein synthesis

article

Induction of Donor-Specific Tolerance to Islet Allografts in Nonhuman Primates

Induction of donor-specific tolerance to islet allografts in nonhuman primates

scientific article published in April 2002

Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice

scientific article

Induction of islet allotolerance in nonhuman primates

scientific article published in April 2002

Inherited diseases in North American Mennonites: focus on Old Colony (Chortitza) Mennonites.

scientific article

Inhibition of altered peptide ligand-mediated antagonism of human GAD65-responsive CD4+ T cells by non-antagonizable T cells

scientific article

Insulin Gene VNTR Genotype Associates with Frequency and Phenotype of the Autoimmune Response to Proinsulin

article

Insulin gene VNTR genotype associates with frequency and phenotype of the autoimmune response to proinsulin

scientific article published on 7 January 2010

Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity

scientific article

Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells.

scientific article published on 28 April 2009

Intact hyaluronan promotes maintenance of immune tolerance

Interaction between RANKL and HLA-DRB1 genotypes may contribute to younger age at onset of seropositive rheumatoid arthritis in an inception cohort.

scientific article published in October 2004

Interactions of peptide side chains with structurally complementary pockets in DQ molecules are critical for allele-specific peptide binding and T cell reactivity

article

Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing

scientific article published on July 1997

Investigating the HLA component in rheumatoid arthritis: an additive (dominant) mode of inheritance is rejected, a recessive mode is preferred

scientific article published on January 1991

Investigating the role of T-cell avidity and killing efficacy in relation to type 1 diabetes prediction

scientific article

Is DQB2 Functional Among Nonhuman Primates?

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

scientific article

Locus- and allele-specific DNA-protein interactions in the HLA-DQB1 X box.

scientific article published on January 1993

Looking behind the data curtain

scientific article published on 22 July 2017

Lost in translation: barriers to implementing clinical immunotherapeutics for autoimmunity

scientific article published on November 2005

Low HERV-K(C4) copy number is associated with type 1 diabetes

scientific article published on 15 January 2014

Low-avidity recognition by CD4+ T cells directed to self-antigens

scientific article

Low-dose streptozotocin induces sustained hyperglycemia in Macaca nemestrina.

scientific article

MHC Class II Tetramers ⬇️

scientific article published on March 15, 2012

MHC Class II tetramers and the pursuit of antigen-specific T cells: define, deviate, delete

scientific article published on March 2004

MHC and autoimmune diseases.

scientific article

MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen

scientific article published on December 1999

MHC class-II molecules and autoimmunity

scientific article published on January 1991

MHC genes in HLA-associated disease

scientific article published on April 1989

MHC multimers: expanding the clinical toolkit.

scientific article

MHC-DRB allelic sequences incorporate distinct intragenic trans-specific segments

scientific article published in April 1997

MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition

scientific article published on July 1999

Major Histocompatibility Complex and Autoimmunity

Major Histocompatibility Complex-Directed Susceptibility to Rheumatoid Arthritis

scientific article published on January 1, 1998

Mhc Class-Ii Molecules And Autoimmunity

scholarly article by G. Nepom published 1 January 1991 in Annual Review of Immunology

Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions.

scientific article published in December 1996

Modulation of T cell response to hGAD65 peptide epitopes

scientific article

Modulation of peptide-dependent allospecific epitopes on HLA-DR4 molecules by HLA-DM.

scientific article

Molecular Genetic Analysis of HLA Class II Polymorphism

Molecular Genetics of Autoimmunity

article

Molecular analysis of DQ beta 3.1 genes

scientific article published in March 1988

Molecular aspects of HLA class II alphabeta heterodimers associated with IDDM susceptibility and protection.

scientific article

Molecular autoimmunity

Molecular basis for HLA-DQ associations with IDDM

Molecular basis for HLA-DQ associations with IDDM.

scientific article published in August 1998

Molecular biology of immune diseases and immune response

scientific article published on 01 May 1990

Monoclonal antibodies to cell surface antigens shared by chemically induced mouse bladder carcinomas

scientific article published on 01 May 1985

Mucosal matters

scientific article published on 01 June 2008

Multiple Ia-like molecules characterize HLA-DR2-associated haplotypes which differ in HLA-D

scientific article published on 01 July 1984

Mutagenesis and Expression of Putative Class II Susceptibility Genes: a “Reverse Immunogenetics” Approach to Analysis of HLA and Disease ⬇️

scientific article published on January 1, 1990

Mutational analysis of critical residues determining antigen presentation and activation of HLA-DQ0602 restricted T-cell clones

scientific article

Mutational analysis of the HLA-DQ3.2 insulin-dependent diabetes mellitus susceptibility gene

scientific article

Narcolepsy is strongly associated with the T-cell receptor alpha locus

scientific article

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.

scientific article

Nonprogression of subclinical beta-cell dysfunction among first-degree relatives of IDDM patients. 5-yr follow-up of the Seattle Family Study

scientific article

Nonprogression of subclinical beta-cell dysfunction among first-degree relatives of IDDM patients. 5-yr follow-up of the Seattle Family Study

OR.31. CD44 Cross-linking Potently Induces FoxP3 and Promotes CD4+CD25+ Regulatory T Cell Mediated Suppression

OR.45. Induction of Autoantigen-Specific Cd4+Cd25+ Regulatory T‐Cells In Vitro

OR.9. A Shift in Autoreactive CD4 T Cell Avidity Preceding Diagnosis with Type 1 Diabetes is Correlated with the Outgrowth of Distinct T Cell Clonotypes

Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes

scientific article published on 03 March 2016

Omics-oriented research illustrated with the LEAP study and the OASIS bioinformatics tool

scientific article published in 2023

On-chip activation and subsequent detection of individual antigen-specific T cells

scientific article

Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes

scientific article published on 18 November 2016

Peptide binding affinity and pH variation establish functional thresholds for activation of HLA-DQ-restricted T cell recognition

scientific article published on July 1999

Polyglot and polymorphism. An HLA update

scientific article published on December 1995

Polymorphic DQ alpha and DQ beta interactions dictate HLA class II determinants of allo-recognition

scientific article

Polymorphism of the HLA-D region in American blacks. A DR3 haplotype generated by recombination

scientific article

Prediction and pathogenesis in type 1 diabetes.

scientific article

Prediction of susceptibility to rheumatoid arthritis by human leukocyte antigen genotyping

scientific article published on November 1992

Presentation of an autoantigenic (GAD65) peptide in IDDM by an HLA allele protecting from disease

article published in 1996

Prognostic implications of HLA genotyping in the early assessment of patients with rheumatoid arthritis

scientific article published on March 1996

Proliferative T lymphocyte clones identify multiple recognition sites on DQw3 molecules

Promiscuous T-cell recognition of a rubella capsid protein epitope restricted by DRB1*0403 and DRB1*0901 molecules sharing an HLA DR supertype.

scientific article

Protective Versus Aggressive T Cell Responses to the Major Proinsulin73–90 Epitope in Beta-Islet Cell Autoimmunity

article

Radiographic hand joint space width assessed by computer is a sensitive measure of change in early rheumatoid arthritis.

scientific article published in June 2004

Radioimmunoassay for glutamic acid decarboxylase-65.

scientific article

Rapid epitope identification from complex class-II-restricted T-cell antigens.

scientific article published in November 2001

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity

scientific article

Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes

scientific article published in November 2006

Recognition of altered self major histocompatibility complex molecules modulated by specific peptide interactions

scientific article published in April 1996

Recognition of contiguous allele-specific peptide elements in the rubella virus E1 envelope protein.

scientific article published on April 1997

Recurrence of autoimmunity in pancreas transplant patients: research update ⬇️

scientific article published on March 1, 2011

Recurrence of autoreactive antigen-specific CD4+ T cells in autoimmune diabetes after pancreas transplantation.

scientific article published on 2 May 2008

Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells.

scientific article

Reduced CD11b Integrin Expression with Short-term Administration of an IL-1R Antagonist in Type 1 Diabetes Patients

Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes

scientific article published on 18 August 2017

Remodeling rodent models to mimic human type 1 diabetes

article

Restoring the balance: immunotherapeutic combinations for autoimmune disease

scientific article

Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms

scientific article

Reversal of Diabetes in Mice with a Bioengineered Islet Implant Incorporating a Type I Collagen Hydrogel and Sustained Release of Vascular Endothelial Growth Factor

Reversal of diabetes in mice with a bioengineered islet implant incorporating a type I collagen hydrogel and sustained release of vascular endothelial growth factor

scientific article

Reverse Immunogenetics: Investigations of HLA-Associated Disease Based on the Structural and Genetic Identification of Candidate Susceptibility Genes

article

Role of HLA Susceptibility in Predisposing to Insulin-Dependent Diabetes mellitus

S.48. Longitudinal Dynamics of CD4+T Cell Responses to an Insulin Peptide in Healthy, Autoantibody-positive and Type 1 Diabetic Subjects

article

Searching for borrelial T cell epitopes associated with antibiotic-refractory Lyme arthritis

scientific article published on 11 January 2008

Selective T-cell-receptor gene usage in allorecognition and graft-versus-host disease ⬇️

scientific article published on May 1, 1993

Self-reactive human CD4 T cell clones form unusual immunological synapses

scientific article published on 6 February 2012

Sequence analysis of HLA class II domains: characterization of the DQw3 family of DQB genes

scientific article published in January 1989

Short-term IL-1β blockade reduces monocyte CD11b integrin expression in an IL-8 dependent fashion in patients with type 1 diabetes

scientific article published on 18 May 2010

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.

scientific article published on 31 May 2017

Six variants of HLA-1327 identified by isoelectric focusing

scientific article published on 01 January 1986

Specific HLA-DR4-associated histocompatibility molecules characterize patients with seropositive juvenile rheumatoid arthritis

scientific article

Specific allelic variation among linked HLA class II genes

scientific article published in December 1987

Specific blocking factors--are they important?

scientific article published on December 1977

Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis

scientific article

Structural and functional constraints on HLA class II dimers implicated in susceptibility to insulin dependent diabetes mellitus

scientific article published on September 1991

Structural and genetic features of human leukocytic antigen class II elements associated with rheumatoid arthritis

scientific article published on December 1988

Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR.

scientific article published on October 1998

Structural requirements for recognition of the HLA-Dw14 class II epitope: a key HLA determinant associated with rheumatoid arthritis

scientific article

Structural variation among major histocompatibility complex class-II genes which predispose to autoimmunity

scientific article

Su.20. Analysis of the Cd4 Effector T-Cell Response to Regulation in Diabetes Mellitus

Su.36. Gad-Reactive, Effector Memory Cd4+ T-Cells Cultured from Type 1 Diabetic Patients Express Increased Levels of the Voltage-Gated Potassium Channel Kv1.3: a Potential Therapeutic Target

Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies: an 8-year follow-up of the Washington State Diabetes Prediction Study

scientific article published in March 2002

Suppressor factors in tumor immunity

scientific article published on 01 April 1984

Suppressor mechanisms in tumor immunity

scientific article

Synchronous Immune Alterations Mirror Clinical Response During Allergen Immunotherapy.

scientific article published on 8 November 2017

Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines

scientific article

T cell autoreactivity in the transplant milieu.

scientific article published on 29 May 2012

T cell receptor heterogeneity in the clonal recognition of HLA Dw14

T cell selection and differential activation on structurally related HLA-DR4 ligands

scientific article

T-cell clones identify three distinct epitopes associated with HLA-Dw14

scientific article published on 01 November 1991

T-cell receptor V beta selectivity in T-cell clones alloreactive to HLA-Dw14.

scientific article

T.128. Short-term Administration of Anakinra does not Appear to Affect Stimulated C-peptide Responses Acutely in Patients with Type 1 Diabetes

article

Targeting T lymphocytes for immune monitoring and intervention in autoimmune diabetes

scientific article

Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial

scientific article published on 23 September 2013

Tetramer analysis of human autoreactive CD4-positive T cells

scientific article

Tetramer-guided epitope mapping: rapid identification and characterization of immunodominant CD4+ T cell epitopes from complex antigens

scientific article published on June 2001

Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse

scientific article published on 15 March 2010

The Effects of Variations in Human Immune-Response Genes

article

The HLA genetic contribution to rheumatoid arthritis

scholarly article published September 1990

The HLA-DR4 family of haplotypes consists of series of distinct DR and DS molecules

scientific article published on February 1984

The Immune Tolerance Network at 10 years: tolerance research at the bedside

scientific article

The MALT1 locus and peanut avoidance in the risk for peanut allergy

scientific article published on 27 February 2019

The Major Histocompatibility Complex

The Prevention of IDDM: Injecting Insulin Into the Cytokine Network

scientific article published on 01 July 1995

The insulin A-chain epitope recognized by human T cells is posttranslationally modified

scientific article

The molecular basis for HLA class II associations with rheumatoid arthritis

article

The role of MHC antigens in autoimmunity

The role of the DR4 shared epitope in selection and commitment of autoreactive T cells in rheumatoid arthritis.

scientific article published in May 2001

The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury

scientific article

Therapy of autoimmune diseases: clinical trials and new biologics

scientific article

Tissue Environment Modulates FoxP3+Regulatory T Cells (Treg) Through Interactions with Extracellular Matrix

Transcomplementation of HLA genes in IDDM. HLA-DQ alpha- and beta-chains produce hybrid molecules in DR3/4 heterozygotes

article

Transcomplementation of HLA genes in IDDM. HLA-DQ alpha- and beta-chains produce hybrid molecules in DR3/4 heterozygotes

scientific article published on 01 January 1987

Transcript array analysis in rheumatology

scientific article

Transfer and Expression of an IDDM Susceptibility Gene into Lymphoblastoid Cell Lines by Retroviral Vectors

article

Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice

scientific article

Tryptic peptide mapping identifies structural heterogeneity among six variants of HLA-B27

scientific article published on 01 January 1986

Ultra-sensitive detection of rare T cell clones.

scientific article published on 10 September 2011

Ultrastructural allelic variation in HLA-DQB1 promoter elements

scientific article published in August 1995

Use of T cell receptor/HLA-DRB1*04 molecular modeling to predict site-specific interactions for the DR shared epitope associated with rheumatoid arthritis

scientific article published on July 1997

Use of T cell receptor/HLA-DRB1*04 molecular modeling to predict site-specific interactions for the DR shared epitope associated with rheumatoid arthritis

scholarly article by Julie E. Penzotti et al published July 1997 in Arthritis and Rheumatism

Use of a polymorphic dinucleotide repeat DNA marker in a T-cell receptor V beta gene to identify a distinct subset of pauciarticular-onset juvenile rheumatoid arthritis patients

scientific article published in July 1995

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