List of works - David R Withers

A Stromal Cell Niche for Human and Mouse Type 3 Innate Lymphoid Cells.

scientific article

Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.

scientific article

Absence of thymus crosstalk in the fetus does not preclude hematopoietic induction of a functional thymus in the adult

scientific article published in September 2009

Anti-microbial Functions of Group 3 Innate Lymphoid Cells in Gut-Associated Lymphoid Tissues Are Regulated by G-Protein-Coupled Receptor 183 ⬇️

scientific article published on 01 June 2018

Antigen localisation influences the magnitude and kinetics of the endogenous adaptive immune response to recombinant Salmonella vaccines.

scientific article published on 11 September 2017

Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria

article

Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1.

scientific article published on 29 December 2015

CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.

scientific article

CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin

scientific article published on 20 December 2017

CD117⁺ CD3⁻ CD56⁻ OX40Lhigh cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues.

scientific article published on 25 May 2011

CD30 is required for CCL21 expression and CD4 T cell recruitment in the absence of lymphotoxin signals

scientific article published in April 2009

CLEC-2 is required for development and maintenance of lymph nodes.

scientific article published on 14 February 2014

CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver

scientific article published on 14 July 2012

Characterisation of innate lymphoid cell populations at different sites in mice with defective T cell immunity

scientific article published on 14 December 2017

Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity.

scientific article published on 23 June 2017

Corrigendum: CCR7-dependent trafficking of RORγ(+) ILCs creates a unique microenvironment within mucosal draining lymph nodes

scientific article published on 29 March 2016

Cutting edge: lymphoid tissue inducer cells maintain memory CD4 T cells within secondary lymphoid tissue

scientific article published on August 2012

Developmentally programmed expression of AID in chicken B cells

scientific article

Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver

scientific article published on 17 February 2010

Diversified bursal medullary B cells survive and expand independently after depletion following neonatal infectious bursal disease virus infection

scientific article

Dynamic changes in intrathymic ILC populations during murine neonatal development

article

Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

scientific article published on 19 January 2021

Evolving strategies for cancer and autoimmunity: back to the future

scientific article (publication date: 2014)

Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation

scientific article

Expression of Plet1 controls interstitial migration of murine small intestinal dendritic cells

scientific article published on 14 December 2018

Group 3 Innate Lymphoid Cells: Communications Hubs of the Intestinal Immune System

scientific article published on 16 October 2017

Heterogeneity of lymphoid tissue inducer cell populations present in embryonic and adult mouse lymphoid tissues.

scientific article

ICOS is required for the generation of both central and effector CD4(+) memory T-cell populations following acute bacterial infection

scientific article published on 7 April 2015

IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors

scientific article published on 15 September 2020

IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs

scientific article

Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells

scientific article published on 23 April 2015

Immunology. Innate lymphoid cell relations

scientific article published on 01 October 2010

Infectious bursal disease virus-induced immunosuppression in the chick is associated with the presence of undifferentiated follicles in the recovering bursa

scientific article published in January 2005

Infectious bursal disease virus: strains that differ in virulence differentially modulate the innate immune response to infection in the chicken bursa.

scientific article published in January 2006

Inflammation-induced formation of fat-associated lymphoid clusters

scientific article published on 29 June 2015

Innate lymphoid cell regulation of adaptive immunity

scientific article

Innate lymphoid cells: the new kids on the block

scientific article published on August 2015

Lymphoid tissue inducer cells ⬇️

scientific article published on May 24, 2011

Lymphoid tissue inducer cells and the evolution of CD4 dependent high-affinity antibody responses.

scientific article published on January 2010

Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses.

scientific article published on 14 April 2008

Lymphoid tissue inducer cells: innate cells critical for CD4+ T cell memory responses? ⬇️

scientific article published on January 19, 2012

Lymphoid tissue inducer cells: pivotal cells in the evolution of CD4 immunity and tolerance?

scientific article published on 29 February 2012

MHC-II: a mutual support system for ILCs and T cells?

scientific article published on 01 August 2014

MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production

scientific article published on 19 August 2013

Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis

scientific article published on 11 December 2018

NK cells protect secondary lymphoid tissue from cytomegalovirus via a CD30-dependent mechanism

scientific article published on 01 October 2009

OX40 and CD30 signals in CD4+ T‐cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4+ T‐cell memory but not effector function ⬇️

scientific article published on November 1, 2011

OX40 controls effector CD4+ T-cell expansion, not follicular T helper cell generation in acute Listeria infection

scientific article published on 21 May 2014

Peripheral lymph nodes contain migratory and resident innate lymphoid cell populations

scientific article published on 01 May 2019

RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers

scientific article published on 12 January 2017

Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium

scientific article

Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity

scientific article published on 23 September 2021

Retention of Ag-specific memory CD4+ T cells in the draining lymph node indicates lymphoid tissue resident memory populations

scientific article

Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input

scientific article published in April 2008

Splenic stromal cells mediate IL-7 independent adult lymphoid tissue inducer cell survival.

scientific article published in February 2010

Stable Epigenetic Programming of Effector and Central Memory CD4 T Cells Occurs Within 7 Days of Antigen Exposure <i>In Vivo</i>

scientific article published on 24 May 2021

Synergistic OX40 and CD30 signals sustain CD8+ T cells during antigenic challenge.

scientific article published in August 2009

T Cell Receptor and Cytokine Signaling Can Function at Different Stages to Establish and Maintain Transcriptional Memory and Enable T Helper Cell Differentiation.

scientific article published on 3 March 2017

T cell-dependent survival of CD20+ and CD20- plasma cells in human secondary lymphoid tissue.

scientific article published on 13 February 2007

T-bet and RORα control lymph node formation by regulating embryonic innate lymphoid cell differentiation

scientific article published in 2021

T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion

scientific article published on 7 September 2012

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology.

scientific article published on 11 May 2016

Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues

scientific article published on 09 July 2020

Th17 effector cells support B cell responses outside of germinal centres

scientific article (publication date: 2012)

The role of lymphoid tissue inducer cells in splenic white pulp development

scientific article published on 01 November 2007

The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals

scientific article published on 28 September 2009

Transcriptional profiling reveals a possible role for the timing of the inflammatory response in determining susceptibility to a viral infection

scientific article published in September 2006

Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

scientific article

Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization.

scientific article published on January 2009

List of works by David R Withers

A Stromal Cell Niche for Human and Mouse Type 3 Innate Lymphoid Cells.

Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.

Absence of thymus crosstalk in the fetus does not preclude hematopoietic induction of a functional thymus in the adult

Anti-microbial Functions of Group 3 Innate Lymphoid Cells in Gut-Associated Lymphoid Tissues Are Regulated by G-Protein-Coupled Receptor 183 ⬇️

Antigen localisation influences the magnitude and kinetics of the endogenous adaptive immune response to recombinant Salmonella vaccines.

Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria

Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1.

CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.

CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin

CD117⁺ CD3⁻ CD56⁻ OX40Lhigh cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues.

CD30 is required for CCL21 expression and CD4 T cell recruitment in the absence of lymphotoxin signals

CLEC-2 is required for development and maintenance of lymph nodes.

CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver

Characterisation of innate lymphoid cell populations at different sites in mice with defective T cell immunity

Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity.

Corrigendum: CCR7-dependent trafficking of RORγ(+) ILCs creates a unique microenvironment within mucosal draining lymph nodes

Cutting edge: lymphoid tissue inducer cells maintain memory CD4 T cells within secondary lymphoid tissue

Developmentally programmed expression of AID in chicken B cells

Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver

Diversified bursal medullary B cells survive and expand independently after depletion following neonatal infectious bursal disease virus infection

Dynamic changes in intrathymic ILC populations during murine neonatal development

Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

Evolving strategies for cancer and autoimmunity: back to the future

Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation

Expression of Plet1 controls interstitial migration of murine small intestinal dendritic cells

Group 3 Innate Lymphoid Cells: Communications Hubs of the Intestinal Immune System

Heterogeneity of lymphoid tissue inducer cell populations present in embryonic and adult mouse lymphoid tissues.

ICOS is required for the generation of both central and effector CD4(+) memory T-cell populations following acute bacterial infection

IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors

IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs

Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells

Immunology. Innate lymphoid cell relations

Infectious bursal disease virus-induced immunosuppression in the chick is associated with the presence of undifferentiated follicles in the recovering bursa

Infectious bursal disease virus: strains that differ in virulence differentially modulate the innate immune response to infection in the chicken bursa.

Inflammation-induced formation of fat-associated lymphoid clusters

Innate lymphoid cell regulation of adaptive immunity

Innate lymphoid cells: the new kids on the block

Lymphoid tissue inducer cells ⬇️

Lymphoid tissue inducer cells and the evolution of CD4 dependent high-affinity antibody responses.

Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses.

Lymphoid tissue inducer cells: innate cells critical for CD4+ T cell memory responses? ⬇️

Lymphoid tissue inducer cells: pivotal cells in the evolution of CD4 immunity and tolerance?

MHC-II: a mutual support system for ILCs and T cells?

MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production

Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis

NK cells protect secondary lymphoid tissue from cytomegalovirus via a CD30-dependent mechanism

OX40 and CD30 signals in CD4+ T‐cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4+ T‐cell memory but not effector function ⬇️

OX40 controls effector CD4+ T-cell expansion, not follicular T helper cell generation in acute Listeria infection

Peripheral lymph nodes contain migratory and resident innate lymphoid cell populations

RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers

Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium

Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity

Retention of Ag-specific memory CD4+ T cells in the draining lymph node indicates lymphoid tissue resident memory populations

Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input

Splenic stromal cells mediate IL-7 independent adult lymphoid tissue inducer cell survival.

Stable Epigenetic Programming of Effector and Central Memory CD4 T Cells Occurs Within 7 Days of Antigen Exposure <i>In Vivo</i>

Synergistic OX40 and CD30 signals sustain CD8+ T cells during antigenic challenge.

T Cell Receptor and Cytokine Signaling Can Function at Different Stages to Establish and Maintain Transcriptional Memory and Enable T Helper Cell Differentiation.

T cell-dependent survival of CD20+ and CD20- plasma cells in human secondary lymphoid tissue.

T-bet and RORα control lymph node formation by regulating embryonic innate lymphoid cell differentiation

T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology.

Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues

Th17 effector cells support B cell responses outside of germinal centres

The role of lymphoid tissue inducer cells in splenic white pulp development

The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals

Transcriptional profiling reveals a possible role for the timing of the inflammatory response in determining susceptibility to a viral infection

Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization.