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List of works by Marc Ouellette

A combined proteomic and transcriptomic approach to the study of stage differentiation in Leishmania infantum

scientific article

A genomic approach to understand interactions between Streptococcus pneumoniae and its bacteriophages

scientific article published on 18 November 2015

A new type of high affinity folic acid transporter in the protozoan parasite Leishmania and deletion of its gene in methotrexate-resistant cells

scientific article published on 22 May 2002

A protein of the leucine-rich repeats (LRRs) superfamily is implicated in antimony resistance in Leishmania infantum amastigotes.

scientific article published on 22 November 2007

A proteomic analysis of penicillin resistance in Streptococcus pneumoniae reveals a novel role for PstS, a subunit of the phosphate ABC transporter

scientific article published on 01 December 2005

A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death.

scientific article published on 17 October 2006

A recombinant non-pathogenic Leishmania vaccine expressing human immunodeficiency virus 1 (HIV-1) Gag elicits cell-mediated immunity in mice and decreases HIV-1 replication in human tonsillar tissue following exposure to HIV-1 infection

scientific article published in January 2007

ABC transporters involved in drug resistance in human parasites.

scientific article published on September 2011

ATP-binding cassette transporters: from multidrug resistance to genetic disease, Gosau, Austria, 20-27 February 1999

scientific article published on 01 April 1999

Adaptation of Leishmania cells to in vitro culture results in a more efficient reduction and transport of biopterin

scientific article published in March 2001

Analysis of membrane-enriched and high molecular weight proteins in Leishmania infantum promastigotes and axenic amastigotes

scientific article published on 10 July 2012

Analysis of stage-specific expression of basic proteins in Leishmania infantum

scientific article published on 01 August 2010

Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis.

scientific article published on 19 July 2007

Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism

scientific article

Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae.

scientific article published on June 1997

Comparative proteomics analyses reveal a potential biomarker for the detection of vancomycin-intermediate Staphylococcus aureus strains

scientific article published on 13 November 2007

Coordinated gene expression by post-transcriptional regulons in African trypanosomes

scientific article

Coordinating funding in public health emergencies

scientific article

Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania.

scientific article published on 09 May 2016

DNA repair pathways in trypanosomatids: from DNA repair to drug resistance.

scientific article published on March 2014

DNA transformation of Leishmania infantum axenic amastigotes and their use in drug screening

scientific article

Deep-sequencing revealing mutation dynamics in the miltefosine transporter gene in Leishmania infantum selected for miltefosine resistance.

scientific article published on 26 July 2016

Differences in antibiotic-induced oxidative stress responses between laboratory and clinical isolates of Streptococcus pneumoniae

scientific article

Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms

scientific article

Differential protein expression analysis of Leishmania major reveals novel roles for methionine adenosyltransferase and S-adenosylmethionine in methotrexate resistance.

scientific article published on 9 June 2004

Discovery of factors linked to antimony resistance in Leishmania panamensis through differential proteome analysis

scientific article published on 17 March 2012

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

scientific article published on May 1997

Divergence among genes encoding the elongation factor Tu of Yersinia Species.

scientific article published on 12 September 2008

Down regulation of KMP-11 in Leishmania infantum axenic antimony resistant amastigotes as revealed by a proteomic screen.

scientific article published on 3 June 2009

Drug resistance analysis by next generation sequencing in Leishmania

scientific article

Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin.

scientific article

Efflux systems and increased trypanothione levels in arsenite-resistant Leishmania

scientific article published on 01 November 1997

Exoproteome dynamics in Leishmania infantum

scientific article

Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease

scientific article (publication date: December 2014)

Functional analysis and complex gene rearrangements of the folate/biopterin transporter (FBT) gene family in the protozoan parasite Leishmania

scientific article

Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance

scientific article published on 27 September 2003

Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum

scientific article

Gene amplification in amphotericin B-resistant Leishmania tarentolae

scientific article published in November 2001

Gene disruption of the P-glycoprotein related gene pgpa of Leishmania tarentolae

scientific article published on July 1996

Gene expression modulation and the molecular mechanisms involved in Nelfinavir resistance in Leishmania donovani axenic amastigotes

scientific article

Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum.

scientific article

Gene expression profiling and molecular characterization of antimony resistance in Leishmania amazonensis

scientific article

Generation of Leishmania hybrids by whole genomic DNA transformation

scientific article

Generation of an aquaglyceroporin AQP1 null mutant in Leishmania major

scientific article published on 26 July 2015

Genetic polymorphisms and drug susceptibility in four isolates of Leishmania tropica obtained from Canadian soldiers returning from Afghanistan

scientific article

Genome annotation and intraviral interactome for the Streptococcus pneumoniae virulent phage Dp-1

scientific article

Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance

scientific article

Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species

scientific article published on 13 October 2011

Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species

scientific article

Genome-wide stochastic adaptive DNA amplification at direct and inverted DNA repeats in the parasite Leishmania

scientific article published on 20 May 2014

Genomic analyses of DNA transformation and penicillin resistance in Streptococcus pneumoniae clinical isolates.

scientific article

Genomic analysis and reconstruction of cefotaxime resistance in Streptococcus pneumoniae.

scientific article published on 21 April 2013

Genomic characterization of ciprofloxacin resistance in a laboratory-derived mutant and a clinical isolate of Streptococcus pneumoniae.

scientific article published on 22 July 2013

Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs

scientific article published on 05 July 2007

Growth phase regulation of the main folate transporter of Leishmania infantum and its role in methotrexate resistance

scientific article published on 4 October 2004

HIV-1 replication is stimulated by sodium stibogluconate, the therapeutic mainstay in the treatment of leishmaniasis

scientific article published on 13 December 2006

High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family

scientific article published on 20 April 2010

Identification of developmentally-regulated proteins in Leishmania panamensis by proteome profiling of promastigotes and axenic amastigotes

scientific article published on 9 February 2006

In primary human monocyte-derived macrophages exposed to Human immunodeficiency virus type 1, does the increased intracellular growth of Leishmania infantum rely on its enhanced uptake?

scientific article published in May 2006

Inactivation of the Leishmania tarentolae pterin transporter (BT1) and reductase (PTR1) genes leads to viable parasites with changes in folate metabolism and hypersensitivity to the antifolate methotrexate

scientific article published on 23 February 2004

Inactivation of the cytosolic and mitochondrial serine hydroxymethyl transferase genes in Leishmania major

scientific article published on 8 February 2016

Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae

scientific article published on May 1999

Induced tigecycline resistance in Streptococcus pneumoniae mutants reveals mutations in ribosomal proteins and rRNA.

scientific article

Inhibition of MRSA and of Clostridium difficile by durancin 61A: synergy with bacteriocins and antibiotics

scientific article published on 20 February 2017

Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum

scientific article

Intracellular localization of the ABCC proteins of Leishmania and their role in resistance to antimonials

scientific article published on 23 March 2009

Intracellular survival of Leishmania species that cause visceral leishmaniasis is significantly reduced by HIV-1 protease inhibitors

scientific article published on November 2008

Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis

scientific article (publication date: February 2015)

Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in Leishmania

scientific article published on 21 June 2011

Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug pentostam.

scientific article

Leishmaniasis: drugs in the clinic, resistance and new developments.

scientific article

Live nonpathogenic parasitic vector as a candidate vaccine against visceral leishmaniasis

scientific article

Microfluidic device for rapid (<15 min) automated microarray hybridization.

scientific article published on 17 August 2005

Mitochondrial Proteomics of Antimony and Miltefosine Resistant Leishmania infantum.

scientific article

Modulation in aquaglyceroporin AQP1 gene transcript levels in drug-resistant Leishmania.

scientific article published in September 2005

Modulation of Leishmania ABC protein gene expression through life stages and among drug-resistant parasites.

scientific article

Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy.

scientific article published on 18 July 2008

Modulation of gene expression in human macrophages treated with the anti-leishmania pentavalent antimonial drug sodium stibogluconate.

scientific article published on 10 December 2007

Multiple mutations and increased RNA expression in tetracycline-resistant Streptococcus pneumoniae as determined by genome-wide DNA and mRNA sequencing

scientific article published on 09 April 2015

Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing

scientific article

New mechanisms of drug resistance in parasitic protozoa

scientific article published on January 1995

Next Generation Vaccine Biomarkers workshop October 30-31, 2014--Ottawa, Canada

scientific article published on 18 September 2015

Nisin is an effective inhibitor of Clostridium difficile vegetative cells and spore germination

scientific article

On Lactococcus lactis UL719 competitivity and nisin (Nisaplin(®)) capacity to inhibit Clostridium difficile in a model of human colon

scientific article

Parasite susceptibility to amphotericin B in failures of treatment for visceral leishmaniasis in patients coinfected with HIV type 1 and Leishmania infantum.

scientific article

Phylogeny of the Enterobacteriaceae based on genes encoding elongation factor Tu and F-ATPase beta-subunit

scientific article published on September 2005

Prefractionation by digitonin extraction increases representation of the cytosolic and intracellular proteome of Leishmania infantum

scientific article published in July 2006

Proteome mapping of the protozoan parasite Leishmania and application to the study of drug targets and resistance mechanisms

scientific article published on 15 March 2003

Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant

scientific article (publication date: 2013)

Proteomic and transcriptomic analysis of linezolid resistance in Streptococcus pneumoniae

scientific article published on 13 September 2011

Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1.

scientific article

Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum

scientific article published on 16 May 2014

Rapid detection of group B streptococci in pregnant women at delivery

scientific article published on 01 July 2000

Resistance of Leishmania donovani to sodium stibogluconate is related to the expression of host and parasite gamma-glutamylcysteine synthetase

scientific article published in January 2006

Resistance to antimony and treatment failure in human Leishmania (Viannia) infection

scientific article published on 07 April 2006

Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani.

scientific article published on 9 January 2007

Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes.

scientific article

Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes.

scientific article published on 23 April 2007

Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum.

scientific article

Selective killing of Leishmania amastigotes expressing a thymidine kinase suicide gene

scientific article published on January 1997

Separation of basic proteins from Leishmania using a combination of Free flow electrophoresis (FFE) and 2D electrophoresis (2-DE) under basic conditions

scientific article published on 01 January 2015

Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania

scientific article published on 13 July 2006

Structure-function analysis of the highly conserved charged residues of the membrane protein FT1, the main folic acid transporter of the protozoan parasite Leishmania

scientific article published on 4 August 2009

Studies on the parasite Leishmania in the post-genomic era

scientific article

Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brucei.

scientific article

Telomeric gene deletion and intrachromosomal amplification in antimony‐resistant Leishmania ⬇️

scholarly article by Angana Mukherjee et al published April 2013 in Molecular Microbiology

The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase.

scientific article published on 16 April 2001

The gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants

scientific article published on 8 October 2009

The impact of distinct culture media in Leishmania infantum biology and infectivity

scientific article published on 6 September 2013

The initial state of the human gut microbiome determines its reshaping by antibiotics.

scientific article published on 11 September 2015

The role of reduced pterins in resistance to reactive oxygen and nitrogen intermediates in the protozoan parasite Leishmania

scientific article

Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania

scientific article published on September 2011

Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites

scientific article

Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism

scientific article published on 05 December 2013

Use of phylogenetical analysis to predict susceptibility of pathogenic Candida spp. to antifungal drugs

scientific article

Use of tuf sequences for genus-specific PCR detection and phylogenetic analysis of 28 streptococcal species.

scientific article published on August 2004

Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations.

scientific article

Whole genome sequencing of penicillin-resistant Streptococcus pneumoniae reveals mutations in penicillin-binding proteins and in a putative iron permease.

scientific article published on 22 November 2011

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