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List of works by Paul W Denny

A BONCAT-iTRAQ method enables temporally resolved quantitative profiling of newly synthesised proteins in Leishmania mexicana parasites during starvation

scientific article published on 19 December 2019

A complex interplay between sphingolipid and sterol metabolism revealed by perturbations to the Leishmania metabolome caused by miltefosine.

scientific article published on 20 February 2018

A plastid of probable green algal origin in Apicomplexan parasites.

scientific article

A plate-based assay system for analyses and screening of the Leishmania major inositol phosphorylceramide synthase

scientific article published on 16 June 2010

Acylation-dependent Protein Export in Leishmania

scientific article published in Journal of Biological Chemistry

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity.

scientific article

An evolutionarily conserved coiled-coil protein implicated in polycystic kidney disease is involved in basal body duplication and flagellar biogenesis in Trypanosoma brucei

scientific article

Antimicrobial peptides for leishmaniasis.

scientific article published on August 2010

Aqueous synthesis of N,S-dialkylthiophosphoramidates: design, optimisation and application to library construction and antileishmanial testing.

scientific article

Chalcones identify cTXNPx as a potential antileishmanial drug target

scientific article published on 15 November 2021

Crystal Structure of a Hidden Protein, YcaC, a Putative Cysteine Hydrolase from Pseudomonas aeruginosa, with and without an Acrylamide Adduct

scientific article

Direct transport across the plasma membrane of mammalian cells of Leishmania HASPB as revealed by a CHO export mutant.

scientific article

Endocytosis and Sphingolipid Scavenging in Leishmania mexicana Amastigotes

scientific article published on 21 September 2011

Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major.

scientific article published on 27 August 2003

Evaluation of the <i>Leishmania</i> Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach

scientific article published in 2024

Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesis

scientific article published on 22 June 2017

Evidence for a Single Origin of the 35 kb Plastid DNA in Apicomplexans

scientific article published in February 1998

Exploring Leishmania major inositol phosphorylceramide synthase (LmjIPCS): insights into the ceramide binding domain

scientific article published on 26 January 2011

Expression levels of inositol phosphorylceramide synthase modulate plant responses to biotic and abiotic stress in Arabidopsis thaliana

scientific article published on 23 May 2019

Expression of the AM gene locus in infective stages of Leishmania

scientific article published on June 2000

Functional Analyses of a Putative, Membrane-Bound, Peroxisomal Protein Import Mechanism from the Apicomplexan Protozoan

article

Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthase

scientific article published on 23 March 2010

Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites

scientific article published on 2 June 2017

Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform

scientific article published on 2 March 2018

Investigating the anti-leishmanial effects of linear peptoids.

scientific article published on 15 December 2014

Leishmania RAB7: characterisation of terminal endocytic stages in an intracellular parasite.

scientific article published in August 2002

Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite

scientific article published on 15 December 2004

Lipid metabolism as a therapeutic target.

scientific article published on 12 April 2012

Lytic reactions of drugs with lipid membranes

scientific article published on 03 December 2018

Meeting report: Molecular Parasitology XI, Woods Hole, USA, September 17-21, 2000

scientific article published on 01 May 2001

Microbial protein targets: towards understanding and intervention

scientific article published on 16 November 2017

Mining for natural product antileishmanials in a fungal extract library

scientific article published on 11 June 2019

Phenotypic changes associated with deletion and overexpression of a stage-regulated gene family in Leishmania

scientific article published on 01 August 2001

Rafts and sphingolipid biosynthesis in the kinetoplastid parasitic protozoa.

scientific article published in August 2004

Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art

scientific article

Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets ⬇️

scientific article published on February 9, 2012

Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii

scientific article published on 16 December 2012

Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity.

scientific article published in April 2004

Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa.

scientific article

Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania

scholarly article published by John G M Mina in 2018

The Histidine Ammonia Lyase of Trypanosoma cruzi Is Involved in Acidocalcisome Alkalinization and Is Essential for Survival under Starvation Conditions

scientific article published on 02 November 2021

The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target.

scientific article published on 21 June 2009

The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis

scientific article published on 10 May 2017

The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis - Corrigendum.

scientific article

The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system.

scientific article

The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity.

scientific article published on 30 May 2019

The in vivo conformation of the plastid DNA of Toxoplasma gondii: implications for replication

scientific article published in February 2001

The protozoan inositol phosphorylceramide synthase: a novel drug target that defines a new class of sphingolipid synthase

scientific article published on 22 July 2006

The role of phosphoglycans in the susceptibility of Leishmania mexicana to the temporin family of anti-microbial peptides.

scientific article published on 6 February 2015

The utility of yeast as a tool for cell-based, target-directed high-throughput screening.

scientific article published on 24 April 2013

Thiostrepton binds to malarial plastid rRNA.

scientific article published in April 1997

Yeast as a potential vehicle for neglected tropical disease drug discovery

scientific article

Yeast: bridging the gap between phenotypic and biochemical assays for high-throughput screening

scientific article published on 16 October 2018

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