List of works - Jussara Amato

A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids

scientific article published on 26 October 2016

A facile synthesis of 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR): a novel non-phosphorylable AICAR analogue.

scientific article published on 2 November 2012

A solid-phase approach to the synthesis of N-1-alkyl analogues of cyclic inosine-diphosphate-ribose (cIDPR)

Aminosilane functionalizations of mesoporous oxidized silicon for oligonucleotide synthesis and detection ⬇️

scientific article published on March 27, 2013

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex

scientific article

Characterization of monovarietal extra virgin olive oils from the province of Béjaïa (Algeria)

scholarly article by Firdousse Laincer et al published November 2016 in Food Research International

Common G-Quadruplex Binding Agents Found to Interact With i-Motif-Forming DNA: Unexpected Multi-Target-Directed Compounds.

scientific article published on 24 July 2018

Controlled Pore Glass-based oligonucleotide affinity support: towards High Throughput Screening methods for the identification of conformation-selective G-quadruplex ligands

scientific article published on 03 May 2018

DNA-based nanostructures: The effect of the base sequence on octamer formation from d(XGGYGGT) tetramolecular G-quadruplexes

scientific article published on 4 December 2013

Design, synthesis and biochemical investigation, by in vitro luciferase reporter system, of peptide nucleic acids as new inhibitors of miR-509-3p involved in the regulation of cystic fibrosis disease-gene expression

article

Direct Synthesis of Oligonucleotides on Nanostructured Silica Multilayers

Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

scientific article

Enantiomeric Selection Properties of β-homoDNA: Enhanced Pairing for Heterochiral Complexes

scientific article published on 13 May 2013

Enantioselective nitrile anion cyclization to substituted pyrrolidines. A highly efficient synthesis of (3S,4R)-N-tert-butyl-4-arylpyrrolidine-3-carboxylic acid.

scientific article published in April 2005

Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones

scientific article published on 5 August 2015

Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence

scientific article published on 27 November 2013

Facile Solid-Phase Synthesis of AICAR 5′-Monophosphate (ZMP) and Its 4-N-Alkyl Derivatives

G-Quadruplex on Oligo Affinity Support (G4-OAS): An Easy Affinity Chromatography-Based Assay for the Screening of G-Quadruplex Ligands

scientific article published on 14 April 2014

G-Quadruplexes from Human Telomeric DNA: How Many Conformations in PEG Containing Solutions?

scientific article published on 08 February 2012

G-triplex structure and formation propensity

scientific article

HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?

scientific article published on 01 August 2018

How are thermodynamically stable G-quadruplex–duplex hybrids?

Hybridization of short complementary PNAs to G-quadruplex forming oligonucleotides: An electrospray mass spectrometry study

scientific article

Identification of an acetal derivative of the piperonyl methyl ketone in tablets seized for suspected drug trafficking

Identification of novel interactors of human telomeric G-quadruplex DNA

Impact of phytosterols on liver and distal colon metabolome in experimental murine colitis model: an explorative study

scientific article published on 01 December 2019

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

scientific article published on 27 October 2015

Investigating the role of T7 and T12 residues on the biological properties of thrombin-binding aptamer: enhancement of anticoagulant activity by a single nucleobase modification.

scientific article

Label-Free Probing of G-Quadruplex Formation by Surface-Enhanced Raman Scattering

scientific article published on 09 August 2011

Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment.

scientific article

Ligand binding to G-quadruplex DNA: new insights from ultraviolet resonance Raman spectroscopy

scientific article published on 04 April 2020

Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations

scientific article published on 23 February 2017

Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug-like molecules

scientific article

Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells

scientific article published on 18 March 2020

New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity

scientific article

Noncanonical DNA secondary structures as drug targets: the prospect of the i-motif

scientific article published on 24 June 2014

Optical tweezers as a probe for oligodeoxyribonucleotide structuration

PNA as a potential modulator of COL7A1 gene expression in dominant dystrophic epidermolysis bullosa: a physico-chemical study

scientific article

Probing the interaction of distamycin A with S100β: the “unexpected” ability of S100β to bind to DNA-binding ligands

scholarly article by Linda Cerofolini published in February 2015

Probing the reactivity of nebularine N1-oxide. A novel approach to C-6 C-substituted purine nucleosides

Solid phase synthesis of nucleobase and ribose modified inosine nucleoside analogues

scientific article

Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose

scientific article published on 21 September 2011

Solid-phase synthesis and pharmacological evaluation of novel nucleoside-tethered dinuclear platinum(II) complexes

scientific article

Structure of a Stable G-Hairpin.

scientific article published on 20 February 2017

Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system

scientific article published on 09 August 2012

Synthesis and characterization of DNA quadruplexes containing T-tetrads formed by bunch-oligonucleotides

scientific article published on 01 February 2006

Synthesis and characterization of monomolecular DNA G-quadruplexes formed by tetra-end-linked oligonucleotides

scientific article published in July 2006

Synthesis and characterization of tetra-end linked oligonucleotides capable of forming monomolecular G-quadruplexes

scientific article published in January 2007

Synthesis of 3′−3′-Linked Pyrimidine Oligonucleotides Containing an Acridine Moiety for Alternate Strand Triple Helix Formation

Synthesis of 4-N-alkyl and ribose-modified AICAR analogues on solid support

article published in 2008

Synthesis of N-1 and ribose modified inosine analogues on solid support

Synthesis of a Dibromoperylene Phosphoramidite Building Block and Its Incorporation at the 5′ End of a G-Quadruplex Forming Oligonucleotide: Spectroscopic Properties and Structural Studies of the Resulting Dibromoperylene Conjugate

scientific article published on 30 June 2011

Synthesis of a new N-9 ribityl analogue of cyclic inosine diphosphate ribose (cIDPR) as a mimic of cyclic ADP ribose (cADPR).

scientific article

Synthesis of a new ribose modified analogue of cyclic inosine diphosphate ribose

scientific article published in January 2007

Synthesis of new acadesine (AICA-riboside) analogues having acyclic D-ribityl or 4-hydroxybutyl chains in place of the ribose.

scientific article published on 6 August 2013

Synthesis of quadruplex-forming tetra-end-linked oligonucleotides: effects of the linker size on quadruplex topology and stability

scientific article published in June 2009

Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.

scientific article

Targeting G-quadruplex structure in the human c-Kit promoter with short PNA sequences

scientific article

Targeting the BCL2 Gene Promoter G-Quadruplex with a New Class of Furopyridazinone-Based Molecules

scientific article published on 18 January 2018

Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity

article

Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives

scientific article published on 21 October 2020

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives

article

Unusual monomolecular DNA quadruplex structures using bunch-oligonucleotides

scientific article published in January 2005

Visible-Light Photocatalytic Functionalization of Isocyanides for the Synthesis of Secondary Amides and Ketene Aminals

scientific article published on 19 October 2020

d(CGGTGGT) forms an octameric parallel G-quadruplex via stacking of unusual G(:C):G(:C):G(:C):G(:C) octads ⬇️

scientific article published on June 28, 2011

List of works by Jussara Amato

A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids

A facile synthesis of 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR): a novel non-phosphorylable AICAR analogue.

A solid-phase approach to the synthesis of N-1-alkyl analogues of cyclic inosine-diphosphate-ribose (cIDPR)

Aminosilane functionalizations of mesoporous oxidized silicon for oligonucleotide synthesis and detection ⬇️

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex

Characterization of monovarietal extra virgin olive oils from the province of Béjaïa (Algeria)

Common G-Quadruplex Binding Agents Found to Interact With i-Motif-Forming DNA: Unexpected Multi-Target-Directed Compounds.

Controlled Pore Glass-based oligonucleotide affinity support: towards High Throughput Screening methods for the identification of conformation-selective G-quadruplex ligands

DNA-based nanostructures: The effect of the base sequence on octamer formation from d(XGGYGGT) tetramolecular G-quadruplexes

Design, synthesis and biochemical investigation, by in vitro luciferase reporter system, of peptide nucleic acids as new inhibitors of miR-509-3p involved in the regulation of cystic fibrosis disease-gene expression

Direct Synthesis of Oligonucleotides on Nanostructured Silica Multilayers

Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

Enantiomeric Selection Properties of β-homoDNA: Enhanced Pairing for Heterochiral Complexes

Enantioselective nitrile anion cyclization to substituted pyrrolidines. A highly efficient synthesis of (3S,4R)-N-tert-butyl-4-arylpyrrolidine-3-carboxylic acid.

Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones

Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence

Facile Solid-Phase Synthesis of AICAR 5′-Monophosphate (ZMP) and Its 4-N-Alkyl Derivatives

G-Quadruplex on Oligo Affinity Support (G4-OAS): An Easy Affinity Chromatography-Based Assay for the Screening of G-Quadruplex Ligands

G-Quadruplexes from Human Telomeric DNA: How Many Conformations in PEG Containing Solutions?

G-triplex structure and formation propensity

HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?

How are thermodynamically stable G-quadruplex–duplex hybrids?

Hybridization of short complementary PNAs to G-quadruplex forming oligonucleotides: An electrospray mass spectrometry study

Identification of an acetal derivative of the piperonyl methyl ketone in tablets seized for suspected drug trafficking

Identification of novel interactors of human telomeric G-quadruplex DNA

Impact of phytosterols on liver and distal colon metabolome in experimental murine colitis model: an explorative study

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

Investigating the role of T7 and T12 residues on the biological properties of thrombin-binding aptamer: enhancement of anticoagulant activity by a single nucleobase modification.

Label-Free Probing of G-Quadruplex Formation by Surface-Enhanced Raman Scattering

Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment.

Ligand binding to G-quadruplex DNA: new insights from ultraviolet resonance Raman spectroscopy

Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations

Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug-like molecules

Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells

New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity

Noncanonical DNA secondary structures as drug targets: the prospect of the i-motif

Optical tweezers as a probe for oligodeoxyribonucleotide structuration

PNA as a potential modulator of COL7A1 gene expression in dominant dystrophic epidermolysis bullosa: a physico-chemical study

Probing the interaction of distamycin A with S100β: the “unexpected” ability of S100β to bind to DNA-binding ligands

Probing the reactivity of nebularine N1-oxide. A novel approach to C-6 C-substituted purine nucleosides

Solid phase synthesis of nucleobase and ribose modified inosine nucleoside analogues

Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose

Solid-phase synthesis and pharmacological evaluation of novel nucleoside-tethered dinuclear platinum(II) complexes

Structure of a Stable G-Hairpin.

Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system

Synthesis and characterization of DNA quadruplexes containing T-tetrads formed by bunch-oligonucleotides

Synthesis and characterization of monomolecular DNA G-quadruplexes formed by tetra-end-linked oligonucleotides

Synthesis and characterization of tetra-end linked oligonucleotides capable of forming monomolecular G-quadruplexes

Synthesis of 3′−3′-Linked Pyrimidine Oligonucleotides Containing an Acridine Moiety for Alternate Strand Triple Helix Formation

Synthesis of 4-N-alkyl and ribose-modified AICAR analogues on solid support

Synthesis of N-1 and ribose modified inosine analogues on solid support

Synthesis of a Dibromoperylene Phosphoramidite Building Block and Its Incorporation at the 5′ End of a G-Quadruplex Forming Oligonucleotide: Spectroscopic Properties and Structural Studies of the Resulting Dibromoperylene Conjugate

Synthesis of a new N-9 ribityl analogue of cyclic inosine diphosphate ribose (cIDPR) as a mimic of cyclic ADP ribose (cADPR).

Synthesis of a new ribose modified analogue of cyclic inosine diphosphate ribose

Synthesis of new acadesine (AICA-riboside) analogues having acyclic D-ribityl or 4-hydroxybutyl chains in place of the ribose.

Synthesis of quadruplex-forming tetra-end-linked oligonucleotides: effects of the linker size on quadruplex topology and stability

Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.

Targeting G-quadruplex structure in the human c-Kit promoter with short PNA sequences

Targeting the BCL2 Gene Promoter G-Quadruplex with a New Class of Furopyridazinone-Based Molecules

Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity

Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives

Unusual monomolecular DNA quadruplex structures using bunch-oligonucleotides

Visible-Light Photocatalytic Functionalization of Isocyanides for the Synthesis of Secondary Amides and Ketene Aminals

d(CGGTGGT) forms an octameric parallel G-quadruplex via stacking of unusual G(:C):G(:C):G(:C):G(:C) octads ⬇️