List of works - Mario Sechi

A versatile salicyl hydrazonic ligand and its metal complexes as antiviral agents

scientific article published on 27 May 2015

An integrated biological approach to guide the development of metal-chelating inhibitors of influenza virus PA endonuclease

scientific article published on 4 December 2014

Antiretroviral activity of metal-chelating HIV-1 integrase inhibitors

scientific article

Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry

scientific article published on 7 June 2014

Design and Synthesis of Novel Reactive Oxygen Species Inducers for the Treatment of Pancreatic Ductal Adenocarcinoma.

scientific article published on 12 January 2018

Design and discovery of novel quinazolinedione-based redox modulators as therapies for pancreatic cancer

scientific article

Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors.

scientific article published in October 2008

Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors

scientific article

Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors

scientific article published in October 2004

Design, synthesis, molecular modeling, and anti-HIV-1 integrase activity of a series of photoactivatable diketo acid-containing inhibitors as affinity probes.

scientific article

Development of polymeric microbubbles targeted to prostate-specific membrane antigen as prototype of novel ultrasound contrast agents

scientific article published on 13 May 2011

Dietary flavonoid fisetin binds to β-tubulin and disrupts microtubule dynamics in prostate cancer cells

scientific article

Effect of chitosan concentration on PLGA microcapsules for controlled release and stability of resveratrol.

scientific article published on 16 September 2014

Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: findings from 3-D melanoma skin equivalents and computational modeling

scientific article published on 24 March 2014

From ligand to complexes. Part 2. Remarks on human immunodeficiency virus type 1 integrase inhibition by beta-diketo acid metal complexes

scientific article published in November 2008

From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes.

scientific article published in July 2006

Graphene-containing thermoresponsive nanocomposite hydrogels of poly(N-isopropylacrylamide) prepared by frontal polymerization

HIV-1 IN strand transfer chelating inhibitors: a focus on metal binding

scientific article published on 8 March 2011

Hyperbranched molecular structures with potential antiviral activity: derivatives of 5,6-dihydroxyindole-2-carboxylic Acid.

scientific article published on 18 December 2006

Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors

scientific article published on 2 August 2012

Inhibitory Effect of 2,3,5,6-Tetrafluoro-4-[4-(aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide Derivatives on HIV Reverse Transcriptase Associated RNase H Activities.

scientific article published on 20 August 2016

Investigating the role of metal chelation in HIV-1 integrase strand transfer inhibitors.

scientific article

Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease

scientific article published on September 2015

Mechanisms underlying the cytotoxicity of a novel quinazolinedione-based redox modulator, QD232, in pancreatic cancer cells

scientific article

Metal-chelating 2-hydroxyphenyl amide pharmacophore for inhibition of influenza virus endonuclease

scientific article published on 25 November 2013

N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes

scientific article published on 11 August 2016

Nanoencapsulation of dietary flavonoid fisetin: Formulation and in vitro antioxidant and α-glucosidase inhibition activities.

scientific article published on 14 June 2016

Nanoencapsulation of natural triterpenoid celastrol for prostate cancer treatment

scientific article published on 30 October 2015

Nanoparticle therapeutics for prostate cancer treatment.

scientific article published on 26 May 2012

Novel docetaxel-loaded nanoparticles based on poly(lactide-co-caprolactone) and poly(lactide-co-glycolide-co-caprolactone) for prostate cancer treatment: formulation, characterization, and cytotoxicity studies

scientific article

Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors

scientific article published on 08 September 2014

Polymeric Nanoparticles Encapsulating White Tea Extract for Nutraceutical Application

scientific article published on 10 February 2015

Resveratrol nanoformulation for cancer prevention and therapy

scientific article published on 24 June 2015

Resveratrol-loaded nanoparticles based on poly(epsilon-caprolactone) and poly(D,L-lactic-co-glycolic acid)-poly(ethylene glycol) blend for prostate cancer treatment

scientific article published on 4 September 2013

Ruthenium arene complexes as HIV-1 integrase strand transfer inhibitors

scientific article

Search for the pharmacophore in prazosin for Transport-P.

scientific article

Single amino acid substitution in HIV-1 integrase catalytic core causes a dramatic shift in inhibitor selectivity

scientific article published on 20 February 2007

Single-step green synthesis and characterization of gold-conjugated polyphenol nanoparticles with antioxidant and biological activities

scientific article

Synthesis and D2-like binding affinity of 4,5-dihydro-1H-benzo[g]indole-3-carboxamide derivatives as conformationally restricted 5-phenyl-pyrrole-3-carboxamide analogs

scientific article published on 01 October 1998

Synthesis and dopamine D2-like receptor binding affinity of substituted 5-phenyl-pyrrole-3-carboxamides

scientific article

Synthesis and evaluation of different fatty acid esters formulated into Precirol ATO-Based lipid nanoparticles as vehicles for topical delivery.

scientific article published in July 2009

Synthesis and in vitro anticancer activity evaluation of biscarbamic esters of 2,3-bis(hydroxymethyl)-1-methyl-7- and 7,8-substituted-benzo[g]indoles

scientific article published on 01 February 1998

Targeted Nanoparticles for the Delivery of Novel Bioactive Molecules to Pancreatic Cancer Cells

scientific article published on 3 May 2016

Targeted biocompatible nanoparticles for the delivery of (-)-epigallocatechin 3-gallate to prostate cancer cells

scientific article published on 9 February 2011

Targeted therapy using nanotechnology: focus on cancer

scientific article

Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors.

scientific article

Virtual screening-driven identification of human carbonic anhydrase inhibitors incorporating an original, new pharmacophore

scientific article published in 2011

List of works by Mario Sechi

A versatile salicyl hydrazonic ligand and its metal complexes as antiviral agents

An integrated biological approach to guide the development of metal-chelating inhibitors of influenza virus PA endonuclease

Antiretroviral activity of metal-chelating HIV-1 integrase inhibitors

Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry

Design and Synthesis of Novel Reactive Oxygen Species Inducers for the Treatment of Pancreatic Ductal Adenocarcinoma.

Design and discovery of novel quinazolinedione-based redox modulators as therapies for pancreatic cancer

Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors.

Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors

Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors

Design, synthesis, molecular modeling, and anti-HIV-1 integrase activity of a series of photoactivatable diketo acid-containing inhibitors as affinity probes.

Development of polymeric microbubbles targeted to prostate-specific membrane antigen as prototype of novel ultrasound contrast agents

Dietary flavonoid fisetin binds to β-tubulin and disrupts microtubule dynamics in prostate cancer cells

Effect of chitosan concentration on PLGA microcapsules for controlled release and stability of resveratrol.

Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: findings from 3-D melanoma skin equivalents and computational modeling

From ligand to complexes. Part 2. Remarks on human immunodeficiency virus type 1 integrase inhibition by beta-diketo acid metal complexes

From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes.

Graphene-containing thermoresponsive nanocomposite hydrogels of poly(N-isopropylacrylamide) prepared by frontal polymerization

HIV-1 IN strand transfer chelating inhibitors: a focus on metal binding

Hyperbranched molecular structures with potential antiviral activity: derivatives of 5,6-dihydroxyindole-2-carboxylic Acid.

Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors

Inhibitory Effect of 2,3,5,6-Tetrafluoro-4-[4-(aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide Derivatives on HIV Reverse Transcriptase Associated RNase H Activities.

Investigating the role of metal chelation in HIV-1 integrase strand transfer inhibitors.

Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease

Mechanisms underlying the cytotoxicity of a novel quinazolinedione-based redox modulator, QD232, in pancreatic cancer cells

Metal-chelating 2-hydroxyphenyl amide pharmacophore for inhibition of influenza virus endonuclease

N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes

Nanoencapsulation of dietary flavonoid fisetin: Formulation and in vitro antioxidant and α-glucosidase inhibition activities.

Nanoencapsulation of natural triterpenoid celastrol for prostate cancer treatment

Nanoparticle therapeutics for prostate cancer treatment.

Novel docetaxel-loaded nanoparticles based on poly(lactide-co-caprolactone) and poly(lactide-co-glycolide-co-caprolactone) for prostate cancer treatment: formulation, characterization, and cytotoxicity studies

Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors

Polymeric Nanoparticles Encapsulating White Tea Extract for Nutraceutical Application

Resveratrol nanoformulation for cancer prevention and therapy

Resveratrol-loaded nanoparticles based on poly(epsilon-caprolactone) and poly(D,L-lactic-co-glycolic acid)-poly(ethylene glycol) blend for prostate cancer treatment

Ruthenium arene complexes as HIV-1 integrase strand transfer inhibitors

Search for the pharmacophore in prazosin for Transport-P.

Single amino acid substitution in HIV-1 integrase catalytic core causes a dramatic shift in inhibitor selectivity

Single-step green synthesis and characterization of gold-conjugated polyphenol nanoparticles with antioxidant and biological activities

Synthesis and D2-like binding affinity of 4,5-dihydro-1H-benzo[g]indole-3-carboxamide derivatives as conformationally restricted 5-phenyl-pyrrole-3-carboxamide analogs

Synthesis and dopamine D2-like receptor binding affinity of substituted 5-phenyl-pyrrole-3-carboxamides

Synthesis and evaluation of different fatty acid esters formulated into Precirol ATO-Based lipid nanoparticles as vehicles for topical delivery.

Synthesis and in vitro anticancer activity evaluation of biscarbamic esters of 2,3-bis(hydroxymethyl)-1-methyl-7- and 7,8-substituted-benzo[g]indoles

Targeted Nanoparticles for the Delivery of Novel Bioactive Molecules to Pancreatic Cancer Cells

Targeted biocompatible nanoparticles for the delivery of (-)-epigallocatechin 3-gallate to prostate cancer cells

Targeted therapy using nanotechnology: focus on cancer

Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors.

Virtual screening-driven identification of human carbonic anhydrase inhibitors incorporating an original, new pharmacophore