List of works - Jorge L Ruas

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

scientific article

A Transcriptomic Analysis of the Development of Skeletal Muscle Atrophy in Cancer-Cachexia in Tumor-Bearing Mice

article

Allele frequency of CYP2C19 in a Portuguese population

scientific article published on 01 August 1997

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

scientific article

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

scientific article published on 26 September 2015

Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization

scientific article

Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors

article

Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300.

scientific article

Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status

scientific article published on 18 November 2019

Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice

scientific article published on 15 February 2021

Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans

scientific article

Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

scientific article published on 12 October 2021

Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN

scientific article published on 11 May 2020

Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein

scientific article published on 19 July 2002

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

scientific article

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

scientific article published in Nature

Heart specific PGC-1α deletion identifies metabolome of cardiac restricted metabolic heart failure

scientific article published on 01 January 2019

High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles

scientific article published on 19 March 2021

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

scientific article published on January 2017

Hypoxia inducible factor regulates the cardiac expression and secretion of apelin

scientific article published in June 2007

Hypoxia requires notch signaling to maintain the undifferentiated cell state

scientific article published on November 2005

Hypoxia-dependent activation of HIF into a transcriptional regulator

scientific article

Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product

scientific article published on 4 December 2002

Inflammation, immunology, stress and depression: a role for kynurenine metabolism in physical exercise and skeletal muscle

scientific article published on 2 February 2016

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

scientific article

Intercellular: local and systemic actions of skeletal muscle PGC-1s

scientific article published on 28 April 2015

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation

scientific article published in February 2018

Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health

scientific article

LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force

scientific article published on 31 October 2019

Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation

scientific article

Mechano-signalling pathways in an experimental intensive critical illness myopathy model

scientific article

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

scientific journal article

Modeling the transport of nuclear proteins along single skeletal muscle cells

scientific article published on 27 January 2020

Modulation of vascular gene expression by hypoxia

scientific article published on October 2007

Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling

scientific article published on 24 March 2021

Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk.

scientific article published on 05 August 2016

Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation

scientific article published on 7 November 2017

PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis

scientific article

PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types

scientific journal article

PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments

scientific article published on 11 January 2020

Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes

scientific article published on 26 May 2016

Peroxisome proliferator-activated receptor-γ coactivator 1 α1 induces a cardiac excitation-contraction coupling phenotype without metabolic remodelling

scientific article published on 26 September 2016

Regulation of CDKN2B expression by interaction of Arnt with Miz-1--a basis for functional integration between the HIF and Myc gene regulatory pathways

scientific article published on 11 March 2014

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

scientific journal article

Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons

scientific article

Role of CBP in regulating HIF-1-mediated activation of transcription.

scientific article

Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise.

scientific article

Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase

scientific article

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression

scientific article

Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

scientific article published on 24 June 2019

Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration

scientific article published on 3 February 2018

Targeting mitochondrial mRNA translation to tackle obesity-induced insulin resistance: thumbs up for exercise.

scientific article

The Kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain

scientific article published on 25 March 2020

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction

scientific article published in August 2016

The hitchhiker's guide to PGC-1α isoform structure and biological functions

scientific article published on 25 June 2015

The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells.

scientific article published on December 2016

The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle

scientific article published on 04 December 2009

The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex

scientific article

The weight of nutrients: kynurenine metabolites in obesity and exercise

scientific article published on 25 September 2018

List of works by Jorge L Ruas

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

A Transcriptomic Analysis of the Development of Skeletal Muscle Atrophy in Cancer-Cachexia in Tumor-Bearing Mice

Allele frequency of CYP2C19 in a Portuguese population

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization

Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors

Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300.

Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status

Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice

Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans

Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN

Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

Heart specific PGC-1α deletion identifies metabolome of cardiac restricted metabolic heart failure

High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

Hypoxia inducible factor regulates the cardiac expression and secretion of apelin

Hypoxia requires notch signaling to maintain the undifferentiated cell state

Hypoxia-dependent activation of HIF into a transcriptional regulator

Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product

Inflammation, immunology, stress and depression: a role for kynurenine metabolism in physical exercise and skeletal muscle

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

Intercellular: local and systemic actions of skeletal muscle PGC-1s

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation

Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health

LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force

Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation

Mechano-signalling pathways in an experimental intensive critical illness myopathy model

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

Modeling the transport of nuclear proteins along single skeletal muscle cells

Modulation of vascular gene expression by hypoxia

Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling

Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk.

Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation

PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis

PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types

PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments

Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes

Peroxisome proliferator-activated receptor-γ coactivator 1 α1 induces a cardiac excitation-contraction coupling phenotype without metabolic remodelling

Regulation of CDKN2B expression by interaction of Arnt with Miz-1--a basis for functional integration between the HIF and Myc gene regulatory pathways

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons

Role of CBP in regulating HIF-1-mediated activation of transcription.

Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise.

Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression

Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration

Targeting mitochondrial mRNA translation to tackle obesity-induced insulin resistance: thumbs up for exercise.

The Kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction

The hitchhiker's guide to PGC-1α isoform structure and biological functions

The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells.

The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle

The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex

The weight of nutrients: kynurenine metabolites in obesity and exercise