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List of works by Flávio Reis

A fast and reliable method for GHB quantitation in whole blood by GC-MS/MS (TQD) for forensic purposes

scientific article published on 28 November 2015

Aging is Associated with Impaired Renal Function, INF-gamma Induced Inflammation and with Alterations in Iron Regulatory Proteins Gene Expression

scientific article

Anti-inflammatory, anti-proliferative and antioxidant profiles of selective cyclooxygenase-2 inhibition as chemoprevention for rat bladder carcinogenesis

scientific article published on 7 September 2009

Apoptosis of Peripheral CD4+T-Lymphocytes in End-Stage Renal Disease Patients Under Hemodialysis and rhEPO Therapies

scientific article published on 01 January 2011

Are threshold levels of signal transduction required for the protective effect of cilostazol against cardiac ischaemia-reperfusion injury? ⬇️

scientific article published on 01 October 2011

Beneficial Effects of Dietary Polyphenols on Gut Microbiota and Strategies to Improve Delivery Efficiency

scientific article published on 13 September 2019

Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicits Transcriptomics Reprogramming in Healthy Wistar Rats

scientific article published on 14 November 2020

Body mass index and resistance to recombinant human erythropoietin therapy in maintenance hemodialysis patients.

scientific article published on 2 September 2013

C-reactive protein and leucocyte activation in psoriasis vulgaris according to severity and therapy

scientific article published on 11 December 2009

CKD ANAEMIA

scholarly article

Cardiac antiapoptotic and proproliferative effect of recombinant human erythropoietin in a moderate stage of chronic renal failure in the rat.

scientific article published on January 2012

Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model.

scientific article

Characterization of a rat model of moderate chronic renal failure--focus on hematological, biochemical, and cardio-renal profiles

scientific article published in January 2009

Characterization of solid lipid nanoparticles produced with carnauba wax for rosmarinic acid oral delivery

scholarly article in RSC Advances, vol. 5 no. 29, 2015

Chemopreventive efficacy of Atorvastatin against nitrosamine-induced rat bladder cancer: antioxidant, anti-proliferative and anti-inflammatory properties.

scientific article

Circadian and seasonal variation of endogenous ubiquinone plasma level.

scientific article published in May 2002

Circulating adipokine levels in Portuguese patients with psoriasis vulgaris according to body mass index, severity and therapy

article

Circulating cell-free DNA levels in hemodialysis patients and its association with inflammation, iron metabolism, and rhEPO doses.

scientific article

Circulating levels of adiponectin, oxidized LDL and C-reactive protein in Portuguese patients with psoriasis vulgaris, according to body mass index, severity and duration of the disease

article

Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem interval

scientific article published on 4 February 2016

Conversion to sirolimus ameliorates cyclosporine-induced nephropathy in the rat: focus on serum, urine, gene, and protein renal expression biomarkers

scientific article

Crescent-Like Lesions as an Early Signature of Nephropathy in a Rat Model of Prediabetes Induced by a Hypercaloric Diet

scientific article published on 25 March 2020

Curative isosorbide-5-mononitrate treatment, in opposition to the beneficial preventive one, aggravates the prothrombotic and proconstrictor state in cyclosporine-induced hypertensive rats

scientific article published in August 2005

Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment

scientific article published on 21 June 2014

Cyclosporine A-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat.

scientific article published on April 2015

DIALYSIS. PATHOPHYSIOLOGY AND CLINICAL STUDIES

DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties.

scientific article

DMT1 (NRAMP2/DCT1) Genetic Variability and Resistance to Recombinant Human Erythropoietin Therapy in Chronic Kidney Disease Patients under Haemodialysis

scientific article published on 01 August 2008

Development of a Healthy Lifestyle Assessment Toolkit for the General Public

scientific article published on 27 June 2019

Dexmedetomidine: Current Role in Anesthesia and Intensive Care ⬇️

scientific article published on January 1, 2012

Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women

scientific article published on 9 April 2013

Diabetic gut microbiota dysbiosis as an inflammaging and immunosenescence condition that fosters progression of retinopathy and nephropathy

scientific article published on 01 October 2018

Diabetic nephropathy amelioration by a low-dose sitagliptin in an animal model of type 2 diabetes (Zucker diabetic fatty rat).

scientific article published on 30 November 2011

Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases

scientific article published on 06 November 2019

Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy

scientific article published on 18 January 2020

Diet-induced rodent models of obesity-related metabolic disorders-A guide to a translational perspective

scientific article published on 20 July 2020

Differential effects of acute (extenuating) and chronic (training) exercise on inflammation and oxidative stress status in an animal model of type 2 diabetes mellitus

scientific article published on 15 November 2011

Dipeptidyl peptidase-IV inhibition prevents blood–retinal barrier breakdown, inflammation and neuronal cell death in the retina of type 1 diabetic rats

scientific article published in September 2014

Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy.

scientific article published on 18 January 2018

Dual effect of nitrate therapy for cyclosporine-induced hypertension on vascular and platelet morphofunctional markers; an animal model

scientific article published in October 2007

EXPERIMENTAL PATHOLOGY

scholarly article by H. Vethe et al published 1 May 2014 in Nephrology Dialysis Transplantation

Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide overexpression seems to be the best marker ⬇️

scientific article published on March 7, 2013

Editorial: Combating Redox Imbalance-Associated Complications With Natural Products

scientific article published in 2021

Effect of Recombinant Human Erythropoietin in a Rat Model of Moderate Chronic Renal Failure - Focus on Inflammation, Oxidative Stress and Function/Renoprotection

Effect of hemodialysis procedure in prohepcidin serum levels in regular hemodialysis patients

scientific article published in February 2009

Effect of preventive and regressive isosorbide 5-mononitrate treatment on catecholamine levels in plasma, platelets, adrenals, left ventricle and aorta in cyclosporin A-induced hypertensive rats.

scientific article published in September 2005

Effects of cyclosporine and sirolimus on insulin-stimulated glucose transport and glucose tolerance in a rat model.

scientific article published on April 2013

Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat)

scientific article

Elastase release during the hemodialysis procedure seems to induce changes in red blood cell membrane proteins

scientific article published on 31 May 2011

Emergent biomarkers of residual cardiovascular risk in patients with low HDL-c and/or high triglycerides and average LDL-c concentrations: focus on HDL subpopulations, Oxidized LDL, adiponectin, and uric acid.

scientific article published on 4 November 2013

Endocannabinoid system in cardiovascular disorders - new pharmacotherapeutic opportunities.

scientific article

Erythroid disturbances before and after treatment of Portuguese psoriasis vulgaris patients: a cross-sectional and longitudinal study

scientific article published in February 2012

Erythropoietin promotes deleterious cardiovascular effects and mortality risk in a rat model of chronic sports doping

scientific article published in December 2009

Exercise training decreases proinflammatory profile in Zucker diabetic (type 2) fatty rats

scientific article

Expression of genes encoding extracellular matrix macromolecules and metalloproteinases in avian tibial dyschondroplasia.

scientific article published on 9 February 2011

Extracellular Vesicles and MicroRNA: Putative Role in Diagnosis and Treatment of Diabetic Retinopathy

scientific article published on 04 August 2020

Functional and molecular characterization of cancer stem-like cells in bladder cancer: a potential signature for muscle-invasive tumors.

scientific article published on 5 October 2015

Gamma-hydroxybutyric acid endogenous production and post-mortem behaviour - the importance of different biological matrices, cut-off reference values, sample collection and storage conditions

scientific article published on August 2014

Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet.

scientific article

Gut Microbiota Dysbiosis-Immune Hyperresponse-Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches

scientific article published on 01 October 2020

HYPERTENSION

Haptoglobin 2–2 phenotype is associated with decreased serum iron levels in endstage renal disease patients resistant to rhEPO therapy

Health-related quality of life in Portuguese psoriatic patients: Relation with Psoriasis Area and Severity Index and different types of classical psoriatic treatment

article

Hepcidin Serum Levels and Resistance to Recombinant Human Erythropoietin Therapy in Haemodialysis Patients

scientific article published on 30 October 2009

Hepcidin in chronic kidney disease anemia

scientific article published on 06 February 2019

High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus.

scientific article

Hypertension induced by immunosuppressive drugs: a comparative analysis between sirolimus and cyclosporine

scientific article published in April 2009

Impaired renal endothelial nitric oxide synthase and reticulocyte production as modulators of hypertension induced by rHuEPO in the rat.

scientific article published on 25 February 2016

Impairment of vascular and platelet levels of nitric oxide and cyclic guanosine-3',5'-monophosphate in cyclosporin A-induced hypertensive rats

scientific article published in February 2003

Implication of low HDL-c levels in patients with average LDL-c levels: a focus on oxidized LDL, large HDL subpopulation, and adiponectin.

scientific article published on 24 October 2013

Influence of the 6-month physical activity programs on renal function in obese boys

scientific article published on 11 April 2018

Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model

scientific article

Inhibition of bladder tumour growth by sirolimus in an experimental carcinogenesis model

scientific article published in January 2011

Interleukin (IL)-22, IL-17, IL-23, IL-8, vascular endothelial growth factor and tumour necrosis factor-α levels in patients with psoriasis before, during and after psoralen-ultraviolet A and narrowband ultraviolet B therapy

scientific article published on 08 November 2010

Iron as the key modulator of hepcidin expression in erythroid antibody-mediated hypoplasia

scientific article published on 18 December 2014

Iron therapy in chronic kidney disease: Recent changes, benefits and risks

scientific article published on 18 August 2015

Iron-hepcidin dysmetabolism, anemia and renal hypoxia, inflammation and fibrosis in the remnant kidney rat model

scientific article

Is Gut Microbiota Dysbiosis a Predictor of Increased Susceptibility to Poor Outcome of COVID-19 Patients? An Update

scientific article published on 28 December 2020

Isosorbide-5-mononitrate treatment prevents cyclosporin A-induced platelet hyperactivation and the underlying nitric oxide-cyclic guanosine-3',5'-monophosphate disturbances

scientific article published in May 2003

Letter to the editor: A potential mechanism for the pathogenesis of psoriasis vulgaris

scientific article

Liver iron is a major regulator of hepcidin gene expression via BMP/SMAD pathway in a rat model of chronic renal failure under treatment with high rHuEPO doses

scientific article

Main Determinants of PON1 Activity in Hemodialysis Patients

scientific article published on 22 September 2012

Major Determinants of BMP-2 Serum Levels in Hemodialysis Patients

scientific article published on 27 September 2012

Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations.

scientific article published on 28 July 2013

Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model

scientific article published on 22 January 2014

Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells.

scientific article published on 21 October 2016

New Potential Biomarkers for Chronic Kidney Disease Management-A Review of the Literature

scientific article published on 22 December 2020

New markers of early cardiovascular risk in multiple sclerosis patients: oxidized-LDL correlates with clinical staging.

scientific article published on January 2013

Obesity and brain inflammation: a focus on multiple sclerosis.

scientific article

Omega-3 fatty acids inhibit tumor growth in a rat model of bladder cancer.

scientific article

Oxidative stress in cyclosporine-induced hypertension: evidence of beneficial effects or tolerance development with nitrate therapy.

scientific article published in October 2007

PO9-243 EXERCISE TRAINING AND THE INFLAMMATORY RESPONSE IN ZDF (TYPE 2) DIABETIC RATS

Pathological and molecular mechanisms underlying resistance to recombinant human erythropoietin therapy in the remnant kidney rat model of chronic kidney disease associated anemia

scientific article published on 30 March 2016

Platelet hyperactivation in maintained growth hormone-deficient childhood patients after therapy withdrawal as a putative earlier marker of increased cardiovascular risk

scientific article

Potential cardiovascular risk protection of bilirubin in end-stage renal disease patients under hemodialysis.

scientific article

Preventive but not curative efficacy of celecoxib on bladder carcinogenesis in a rat model

scientific article

Protective effects of the dipeptidyl peptidase IV inhibitor sitagliptin in the blood-retinal barrier in a type 2 diabetes animal model

scientific article published on 6 January 2012

Psoriasis therapy and cardiovascular risk factors: a 12-week follow-up study

scientific article published in December 2010

Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes

scientific article

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule

scientific article published on 28 December 2015

Recent Advances and Challenges of mTOR Inhibitors Use in the Treatment of Patients with Tuberous Sclerosis Complex

scientific article published on 12 March 2017

Recombinant human erythropoietin treatment protects the cardio-renal axis in a model of moderate chronic renal failure.

scientific article published in January 2010

Recombinant human erythropoietin-induced erythropoiesis regulates hepcidin expression over iron status in the rat.

scientific article

Regular physical exercise as a strategy to improve antioxidant and anti-inflammatory status: benefits in type 2 diabetes mellitus.

scientific article

Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties.

scientific article

Renal risk-benefit determinants of recombinant human erythropoietin therapy in the remnant kidney rat model - hypertension, anaemia, inflammation and drug dose

scientific article published in March 2016

Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes

scientific article published on 27 August 2017

Resistance to Recombinant Human Erythropoietin Therapy in a Rat Model of Chronic Kidney Disease Associated Anemia

scientific article published on 25 December 2015

Role of Prohepcidin, Inflammatory Markers and Iron Status in Resistance to rhEPO Therapy in Hemodialysis Patients

scientific article published on 20 March 2008

SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma

scientific article published on 10 August 2019

SP089IMPAIRED RENAL ENDOTHELIAL NITRIC OXIDE SYNTHASE AND RETICULOCYTE PRODUCTION AS MODULATORS OF HYPERTENSION INDUCED BY RECOMBINANT HUMAN ERYTHROPOIETIN IN THE RAT

SP313LIVER IRON IS A MAJOR REGULATOR OF HEPCIDIN GENE EXPRESSION VIA BMP/SMAD PATHWAY IN A RAT MODEL OF CHRONIC RENAL FAILURE UNDER TREATMENT WITH HIGH rHuEPO DOSES

article

Safety profile of solid lipid nanoparticles loaded with rosmarinic acid for oral use: in vitro and animal approaches

scientific article

Serum and renal tissue markers of nephropathy in rats under immunosuppressive therapy: cyclosporine versus sirolimus.

scientific article published on April 2013

Short and long term in vivo effects of Cyclosporine A and Sirolimus on genes and proteins involved in lipid metabolism in Wistar rats

scientific article published on 11 February 2014

Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective properties

scientific article published on 20 March 2014

Sitagliptin prevents inflammation and apoptotic cell death in the kidney of type 2 diabetic animals

scientific article published on 08 April 2014

Solid lipid nanoparticles as oral delivery systems of phenolic compounds: Overcoming pharmacokinetic limitations for nutraceutical applications.

scientific article published on 20 July 2015

Spatial memory impairments in a prediabetic rat model

scientific article

Subtle thinning of retinal layers without overt vascular and inflammatory alterations in a rat model of prediabetes.

scientific article

The HIF System Response to ESA Therapy in CKD‐Anemia

The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class?

scientific article published on 17 May 2015

The Protective Role of Adiponectin for Lipoproteins in End-Stage Renal Disease Patients: Relationship with Diabetes and Body Mass Index

scientific article published on 18 February 2019

The dipeptidyl peptidase 4 inhibitor sitagliptin improves oxidative stress and ameliorates glomerular lesions in a rat model of type 1 diabetes

scientific article published on 06 August 2019

The distribution of catecholamines between plasma and platelets in cyclosporin A-induced hypertensive rats

scientific article published on 01 February 2000

The incretin system ABCs in obesity and diabetes - novel therapeutic strategies for weight loss and beyond

scientific article published on 29 April 2016

The peripheral serotonergic system and platelet aggregation in cyclosporin A-induced hypertensive rats

scientific article published on 01 December 1999

The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders

scientific article published on 15 November 2019

Therapeutic Options Targeting Oxidative Stress, Mitochondrial Dysfunction and Inflammation to Hinder the Progression of Vascular Complications of Diabetes

scientific article published on 01 January 2018

Therapeutic Use of mTOR Inhibitors in Renal Diseases: Advances, Drawbacks, and Challenges

scientific article published on 29 October 2018

Therapeutic and nutraceutical potential of rosmarinic acid-Cytoprotective properties and pharmacokinetic profile.

scientific article published on 26 June 2015

Therapeutic strategies targeting oxidative stress to improve dyslipidemia and left ventricular hypertrophy

scientific article published on 18 August 2017

Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model

scientific article

Treadmill running and swimming imposes distinct cardiovascular physiological adaptations in the rat: focus on serotonergic and sympathetic nervous systems modulation

scientific article

Vascular access versus the effect of statins on inflammation and fibrinolysis in renal dialysis patients

scientific article published on 3 May 2013

Vitreous humour as a complementary sample to blood for the detection/confirmation of diazepam: ante-mortem and post-mortem studies in an animal model

scientific article published in December 2004

Weight loss achieved by bariatric surgery modifies high-density lipoprotein subfractions and low-density lipoprotein oxidation towards atheroprotection

scientific article published on 17 October 2018

mTOR Signaling in Cardiometabolic Disease, Cancer, and Aging

scientific article published on 10 July 2017

mTOR Signaling in Cardiometabolic Disease, Cancer, and Aging 2018

scientific article published on 04 February 2019

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