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List of works by David J. Brayden

A comparison of three Peyer's patch "M-like" cell culture models: particle uptake, bacterial interaction, and epithelial histology

scientific article published on 25 July 2017

A head-to-head multi-parametric high content analysis of a series of medium chain fatty acid intestinal permeation enhancers in Caco-2 cells

scientific article published on 01 November 2014

A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation.

scientific article published on 15 June 2017

A novel in vitro electrophysiological bioassay for transport of loperamide across intestinal epithelia

scientific article published on 01 July 1997

A novel method for culturing sweat gland epithelia: comparison of normal and cystic fibrosis tissues

scientific article published in February 1990

A tertiary amino-containing polymethacrylate polymer protects mucus-covered intestinal epithelial monolayers against pathogenic challenge.

scientific article published on 29 November 2007

Advances in PEGylation of important biotech molecules: delivery aspects

scientific article

Altered sensitivity to amiloride in cystic fibrosis. Observations using cultured sweat glands

scientific article published on February 1990

Amphiphilic star polypept(o)ides as nanomeric vectors in mucosal drug delivery

scientific article published on 28 April 2020

An Assessment of the Permeation Enhancer, 1-phenyl-piperazine (PPZ), on Paracellular Flux Across Rat Intestinal Mucosae in Ussing Chambers

scientific article

An Enteric-Coated Polyelectrolyte Nanocomplex Delivers Insulin in Rat Intestinal Instillations when Combined with a Permeation Enhancer

scientific article published on 12 March 2020

An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis

scientific article published on 4 February 2013

Antibacterial effects of poly(2-(dimethylamino ethyl)methacrylate) against selected gram-positive and gram-negative bacteria

scientific article published in February 2010

Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update

scientific article published on 19 January 2019

Avermectin transepithelial transport in MDR1- and MRP-transfected canine kidney monolayers

scientific article

Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia.

scientific article published on April 1998

Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles

scientific article published on 08 August 2017

Catching target receptors for drug and vaccine delivery using TOGA gene expression profiling.

scientific article published on November 2002

Cell culture modeling of specialized tissue: identification of genes expressed specifically by follicle-associated epithelium of Peyer's patch by expression profiling of Caco-2/Raji co-cultures.

scientific article published on January 2004

Chloride-led disruption of the intestinal mucous layer impedes Salmonella invasion: evidence for an 'enteric tear' mechanism

scientific article

Coated minispheres of salmon calcitonin target rat intestinal regions to achieve systemic bioavailability: Comparison between intestinal instillation and oral gavage

scientific article published on 29 July 2016

Colonic absorption of salmon calcitonin using tetradecyl maltoside (TDM) as a permeation enhancer

scientific article published on 23 January 2013

Comparison of methodologies for evaluating regional intestinal permeability

scientific article published on 01 January 1997

Conjugation of salmon calcitonin to a combed-shaped end functionalized poly(poly(ethylene glycol) methyl ether methacrylate) yields a bioactive stable conjugate

scientific article published on 8 January 2009

Controlled release drug delivery in farmed animals: commercial challenges and academic opportunities.

scientific article published on August 2009

Controlled release technologies for drug delivery

scientific article

CriticalSorb™ promotes permeation of flux markers across isolated rat intestinal mucosae and Caco-2 monolayers

scientific article published on 26 May 2012

Cultured human sweat gland epithelia: isolation of glands using neutral red

scientific article published on 01 January 1995

Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials.

scientific article published on 24 February 2016

Cystic Fibrosis, the CFTR, and Rectifying Cl- Channels ⬇️

scientific article published on January 1, 1991

Development of a Non-Aqueous Dispersion to Improve Intestinal Epithelial Flux of Poorly Permeable Macromolecules

scientific article published on 13 October 2016

Development of nanotoxicology: implications for drug delivery and medical devices

scientific article published on 26 June 2015

Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers.

scientific article published on 6 December 2008

Direct peptide bioconjugation/PEGylation at tyrosine with linear and branched polymeric diazonium salts

scientific article

Drug delivery systems in domestic animal species.

scientific article published on January 2010

Editorial overview: New technologies: drug delivery and medical devices combinations, more than the sum of the parts

scientific article published in October 2017

Effects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel disease

scientific article published on 20 December 2007

Effects of surfactant-based permeation enhancers on mannitol permeability, histology, and electrogenic ion transport responses in excised rat colonic mucosae

scientific article published on 13 January 2018

Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative

scientific article published on 25 June 2014

Encapsulation in biodegradable microparticles enhances serum antibody response to parenterally-delivered beta-amyloid in mice

scientific article published on 01 July 2001

Evaluation of PepT1 transport of food-derived antihypertensive peptides, Ile-Pro-Pro and Leu-Lys-Pro using in vitro, ex vivo and in vivo transport models.

scientific article

Evaluation of Sucrose Laurate as an Intestinal Permeation Enhancer for Macromolecules: Ex Vivo and In Vivo Studies

scientific article published on 31 October 2019

Evaluation of alkylmaltosides as intestinal permeation enhancers: comparison between rat intestinal mucosal sheets and Caco-2 monolayers

scientific article published on 23 August 2012

Evaluation of intestinal absorption and mucosal toxicity using two promoters. II. Rat instillation and perfusion studies

scientific article published on 5 August 2009

Evaluation of intestinal absorption enhancement and local mucosal toxicity of two promoters. I. Studies in isolated rat and human colonic mucosae

scientific article published on 6 September 2009

Evolving peptides for oral intake

scientific article published on 11 May 2020

Expression of specific markers and particle transport in a new human intestinal M-cell model

scientific article published on 01 December 2000

First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models

scientific article published on 30 September 2014

Formulation strategies to improve oral peptide delivery

scientific article published on May 2014

Growth and characterisation of a cell culture model of the feline blood-brain barrier

scientific article published on 22 September 2005

Heparin absorption across the intestine: effects of sodium N-[8-(2-hydroxybenzoyl)amino]caprylate in rat in situ intestinal instillations and in Caco-2 monolayers

scientific article published on 01 December 1997

Hepatic gateways.

scientific article

High content analysis of cytotoxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures

scientific article

High content analysis to determine cytotoxicity of the antimicrobial peptide, melittin and selected structural analogs

scientific article

High-content analysis for drug delivery and nanoparticle applications

scientific article published on 20 April 2015

Human eccrine sweat gland epithelial cultures express ductal characteristics

scientific article

Impact of amino acid replacements on in vitro permeation enhancement and cytotoxicity of the intestinal absorption promoter, melittin

scientific article published on 16 December 2009

In vitro and in vivo characterisation of a novel peptide delivery system: amphiphilic polyelectrolyte-salmon calcitonin nanocomplexes

scientific article published on 10 August 2010

In vitro and in vivo preclinical evaluation of a minisphere emulsion-based formulation (SmPill®) of salmon calcitonin

scientific article published on 5 September 2015

In vitro interactions between the oral absorption promoter, sodium caprate (C(10)) and S. typhimurium in rat intestinal ileal mucosae

scientific article published on 2 June 2007

Increased intestinal permeability in rats subjected to traumatic frontal lobe percussion brain injury

scientific article

Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C)

scientific article published on 13 February 2019

Intestinal permeation enhancers for oral peptide delivery

scientific article published on 16 June 2016

Intra-articular delivery of a nanocomplex comprising salmon calcitonin, hyaluronic acid, and chitosan using an equine model of joint inflammation

scientific article published on 01 October 2018

Introduction for the special issue on recent advances in drug delivery across tissue barriers

scientific article published on April 2016

Investigation of coco-glucoside as a novel intestinal permeation enhancer in rat models

scientific article

Investigations of Piperazine Derivatives as Intestinal Permeation Enhancers in Isolated Rat Intestinal Tissue Mucosae

scientific article published on 27 January 2020

Ion transport in cultured epithelia from human sweat glands: comparison of normal and cystic fibrosis tissues

scientific article published on January 1991

Iontophoresis-enhanced absorptive flux of polar molecules across intestinal tissue in vitro

scientific article published on 01 April 2000

Keynote review: intestinal Peyer's patch M cells and oral vaccine targeting.

scientific article

Labrasol® and salts of medium chain fatty acids can be combined in low concentrations to increase the permeability of a macromolecule marker across isolated rat intestinal mucosae.

scientific article published on 17 February 2018

Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies

scientific article published on 08 August 2019

Lymphocyte migration through the blood-brain barrier (BBB) in feline immunodeficiency virus infection is significantly influenced by the pre-existence of virus and tumour necrosis factor (TNF)-alpha within the central nervous system (CNS): studies u

scientific article published on 26 May 2009

Mechanisms of action of zinc on rat intestinal epithelial electrogenic ion secretion: insights into its antidiarrhoeal actions

article

Melittin as a permeability enhancer II: in vitro investigations in human mucus secreting intestinal monolayers and rat colonic mucosae.

scientific article published on 23 March 2007

Melittin as an epithelial permeability enhancer I: investigation of its mechanism of action in Caco-2 monolayers

scientific article published on 21 March 2007

Microparticle vaccine approaches to stimulate mucosal immunisation.

scientific article

Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro.

scientific article published in June 2008

Nanoparticle passage through porcine jejunal mucus: Microfluidics and rheology

scientific article published on 10 December 2016

Opportunities for drug-delivery Research in Nutraceuticals and Functional foods? ⬇️

scientific article published on March 1, 2013

Oral Delivery of Macromolecules: Rationale Underpinning Gastrointestinal Permeation Enhancement Technology (GIPET ® ) ⬇️

scientific article published on December 1, 2011

Oral absorption enhancement: taking the next steps in therapeutic delivery

scientific article published on 01 July 2010

Oral delivery of peptides: opportunities and issues for translation.

scientific article

Oral peptide delivery: prioritizing the leading technologies

scientific article published on 01 December 2011

PK/PD modelling of comb-shaped PEGylated salmon calcitonin conjugates of differing molecular weights

scientific article published on 11 October 2010

Peptidoglycan recognition protein expression in mouse Peyer's Patch follicle associated epithelium suggests functional specialization

scientific article published on July 2003

Per Artursson's major contributions to the Caco-2 cell literature in Pharmaceutical Sciences

scientific article published on 26 August 2020

Pharmacology applied: delivering the goods

scientific article published on 17 August 2006

Phosphine-mediated one-pot thiol-ene "click" approach to polymer-protein conjugates

scientific article published on 21 July 2009

Physicochemical, pharmacokinetic and pharmacodynamic analyses of amphiphilic cyclodextrin-based nanoparticles designed to enhance intestinal delivery of insulin

scientific article published on 31 July 2018

Poly(Ethylene glycol)-based backbones with high peptide loading capacities.

scientific article published on 30 October 2014

Progress in the delivery of nanoparticle constructs: towards clinical translation.

scientific article

Progress in the formulation and delivery of somatostatin analogs for acromegaly

scientific article published in October 2017

Protection against Bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: effect of formulation and route of immunization on induction of Th1 and Th2 cells

scientific article published on 01 February 2001

Rat, ovine and bovine Peyer's patches mounted in horizontal diffusion chambers display sampling function

scientific article published on 27 June 2006

Redox-mediated angiogenesis in the hypoxic joint of inflammatory arthritis

scientific article

Resistance of Staphylococcus aureus to the cationic antimicrobial agent poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) is influenced by cell-surface charge and hydrophobicity

scientific article published on 10 March 2011

Restoration of rat colonic epithelium after in situ intestinal instillation of the absorption promoter, sodium caprate.

scientific article

Safety concerns over the use of intestinal permeation enhancers: A mini-review

scientific article published on 12 April 2016

Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein.

scientific article published in June 2005

Silica-Coated Nanoparticles with a Core of Zinc, l-Arginine, and a Peptide Designed for Oral Delivery

scientific article published on 18 December 2019

Sodium caprate enables the blood pressure-lowering effect of Ile-Pro-Pro and Leu-Lys-Pro in spontaneously hypertensive rats by indirectly overcoming PepT1 inhibition

scientific article published on 20 April 2018

Sodium caprate-induced increases in intestinal permeability and epithelial damage are prevented by misoprostol.

scientific article

Stability, toxicity and intestinal permeation enhancement of two food-derived antihypertensive tripeptides, Ile-Pro-Pro and Leu-Lys-Pro

scientific article published on 3 June 2015

Stilbenes stimulate T84 Cl- secretion by elevating Ca2+.

scientific article published on February 1993

Stomaching Drug Delivery

scientific article published on 01 April 2019

Synchronous transporting activity in epithelial cells in relation to intracellular calcium concentration

scientific article published on 01 July 1991

TNFα-dependent anhedonia and upregulation of hippocampal serotonin transporter activity in a mouse model of collagen-induced arthritis

scientific article published on 01 May 2018

Targeting antigens to murine and human M-cells with Aleuria aurantia lectin-functionalized microparticles.

scientific article published in September 2005

Targeting polymerised liposome vaccine carriers to intestinal M cells

scientific article published in October 2001

Thapsigargin, a new calcium-dependent epithelial anion secretagogue

scientific article

The 2nd Annual Irish Drug Delivery Network Conference with UK and Ireland Controlled Release Society: advancing drug delivery

scientific article published in October 2010

The challenges and future of oral drug delivery: An interview with David Brayden

scientific article published on 8 November 2016

The effect of plant sterol-enriched turkey meat on cholesterol bio-accessibility during in vitro digestion and Caco-2 cell uptake.

scientific article

The mycotoxin patulin increases colonic epithelial permeability in vitro

scientific article published on 8 August 2012

The role of citric acid in oral peptide and protein formulations: relationship between calcium chelation and proteolysis inhibition

scientific article published on 31 December 2013

Track analysis of the passage of rhodamine-labeled liposomes across porcine jejunal mucus in a microchannel device.

scientific article published in May 2018

Transepithelial transport of PAMAM dendrimers across isolated rat jejunal mucosae in ussing chambers.

scientific article

Translocation of Vibrio parahaemolyticus across an in vitro M cell model.

scientific article

Zinc sulphate attenuates chloride secretion in human colonic mucosae in vitro

scientific article published on 26 September 2012

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