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List of works by Gregory L. Challis

2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining ⬇️

scholarly article

A Flavin-Dependent Decarboxylase-Dehydrogenase-Monooxygenase Assembles the Warhead of α,β-Epoxyketone Proteasome Inhibitors.

scientific article published on 25 March 2016

A Sweet Origin for the Key Congocidine Precursor 4-Acetamidopyrrole-2-carboxylate

scientific article published on 15 June 2012

A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically 13C-labelled glycerols

scientific article published in April 2010

A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics. ⬇️

scientific article

A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units

scientific article published on 21 December 2016

A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis

scientific article published on 23 September 2019

A new family of ATP-dependent oligomerization-macrocyclization biocatalysts

scientific article

A novel streptococcal integrative conjugative element involved in iron acquisition.

scientific article published on December 2008

A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases

scientific article

AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis

scientific article

An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles ‘fungal’ icosalide antibiotics

scientific article published on 25 April 2019

Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes ⬇️

scientific article published in August 2001

Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights.

scientific article published on 26 June 2017

Antimalarial activity of natural and synthetic prodiginines

scientific article published on 8 July 2011

Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC

scientific article published on 19 December 2018

Bisucaberin biosynthesis: an adenylating domain of the BibC multi-enzyme catalyzes cyclodimerization of N-hydroxy-N-succinylcadaverine

scientific article published on 22 September 2008

Chapter 17. Siderophore biosynthesis a substrate specificity assay for nonribosomal peptide synthetase-independent siderophore synthetases involving trapping of acyl-adenylate intermediates with hydroxylamine

scientific article published in January 2009

Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of Kinamycins ⬇️

scientific article published on 30 December 2010

Chemical Biotechnology: bioactive small molecules—targets and discovery technologies

Concise Synthesis of Key 3-Polyenoyl-5-methylenefuran-2,4-dione Putative Intermediates in Quartromicin Biosynthesis

Correction: Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from sp. FXJ1.264

Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis ⬇️

scientific article published on 13 November 2013

Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis

scientific article

Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC.

scientific article published in June 2018

Developmentally regulated volatiles geosmin and 2-methylisoborneol attract a soil arthropod to Streptomyces bacteria promoting spore dispersal

scientific article published on 06 April 2020

Discovery and Biosynthesis of Bolagladins: Unusual Lipodepsipeptides from Burkholderia gladioli Clinical Isolates** ⬇️

scientific article published on 12 August 2020

Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis ⬇️

scientific article published on 22 May 2017

Discovery and biosynthesis of bolagladins: unusual lipodepsipeptides from Burkholderia gladioli clinical isolates

scientific article published on 11 August 2020

Discovery of Unusual Biaryl Polyketides by Activation of a Silent Streptomyces venezuelae Biosynthetic Gene Cluster. ⬇️

scientific article published on 8 September 2016

Discovery of a new peptide natural product by Streptomyces coelicolor genome mining

scientific article published on 11 September 2005

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

scientific article published on 29 June 2015

Discovery of the Pseudomonas Polyyne Protegencin by a Phylogeny-Guided Study of Polyyne Biosynthetic Gene Cluster Diversity

scientific article published on 03 August 2021

Distinct extracytoplasmic siderophore binding proteins recognize ferrioxamines and ferricoelichelin in Streptomyces coelicolor A3(2).

scientific article published on September 2010

Editorial: Biosynthetic assembly lines themed issue

scientific article published in February 2016

Editorial: Fungal natural products themed issue

scientific article published on 01 October 2014

Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis

scientific article

Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis

scientific article published on 11 September 2006

Enacyloxins Are Products of an Unusual Hybrid Modular Polyketide Synthase Encoded by a Cryptic Burkholderia ambifaria Genomic Island

scientific article published on 01 May 2011

Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbA.

scientific article published on 16 February 2009

Engineering Escherichia coli to produce nonribosomal peptide antibiotics

scientific article published in August 2006

Engineering p-hydroxyphenylpyruvate dioxygenase to a p-hydroxymandelate synthase and evidence for the proposed benzene oxide intermediate in homogentisate formation

scientific article (publication date: 27 January 2004)

Enzymatic Logic of Anthrax Stealth Siderophore Biosynthesis: AsbA Catalyzes ATP-Dependent Condensation of Citric Acid and Spermidine

scientific article published on 19 June 2007

Erratum: A new family of ATP-dependent oligomerization-macrocyclization biocatalysts

scholarly article published in Nature Chemical Biology

Evidence for the Unusual Condensation of a Diketide with a Pentulose in the Methylenomycin Biosynthetic Pathway of Streptomyces coelicolor A3(2)

article

Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways ⬇️

scientific article published on 10 December 2013

Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.

scientific article

Functional and Structural Analysis of the Siderophore Synthetase AsbB through Reconstitution of the Petrobactin Biosynthetic Pathway from Bacillus anthracis

scientific article

Genome mining for novel natural product discovery

scientific article published on 05 April 2008

Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria

article

Genome mining of Streptomyces ambofaciens. ⬇️

scientific article

Genomic Assemblies of Members of and Related Genera as a Resource for Natural Product Discovery

scientific article published on 15 October 2020

Genomic Assemblies of Members of and Related Genera as a Resource for Natural Product Discovery

Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens

scientific article published on 11 May 2009

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei

scientific article

Genomics-driven discovery of a novel glutarimide antibiotic from Burkholderia gladioli reveals an unusual polyketide synthase chain release mechanism ⬇️

scientific article published on 12 September 2020

Heavy Tools for Genome Mining

scientific article published on 01 January 2007

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens ⬇️

scientific article

Identification of a cluster of genes that directs desferrioxamine biosynthesis in Streptomyces coelicolor M145.

scientific article published in December 2004

Identification of a gene cluster that directs putrebactin biosynthesis in Shewanella species: PubC catalyzes cyclodimerization of N-hydroxy-N-succinylputrescine

scientific article published on 17 July 2008

In Vitro Biosynthetic Studies of Bottromycin Expand the Enzymatic Capabilities of the YcaO Superfamily

scientific article published on 4 December 2017

Kill and cure: genomic phylogeny and bioactivity of bacteria capable of pathogenic and beneficial lifestyles

scientific article published in January 2021

LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18.

scientific article published on 18 December 2015

MbtH-like protein-mediated cross-talk between non-ribosomal peptide antibiotic and siderophore biosynthetic pathways in Streptomyces coelicolor M145

scientific article published on 01 May 2007

Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases

scientific article published on October 2013

Mechanism of intersubunit ketosynthase-dehydratase interaction in polyketide synthases

scientific article published on 8 January 2018

Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites

scientific article

Mechanistic insights into class B radical-S-adenosylmethionine methylases: ubiquitous tailoring enzymes in natural product biosynthesis

scientific article published on 12 September 2016

Microbiology: a talented genus.

scientific article published on 29 January 2014

Mining microbial genomes for new natural products and biosynthetic pathways

scientific article published on 01 June 2008

MmfL catalyses formation of a phosphorylated butenolide intermediate in methylenomycin furan biosynthesis

scientific article published on 04 November 2020

Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877

scientific article published on 01 November 2006

Natural product proteomining, a quantitative proteomics platform, allows rapid discovery of biosynthetic gene clusters for different classes of natural products

scientific article published on 8 May 2014

New natural product biosynthetic chemistry discovered by genome mining

scientific article published on 22 May 2009

Oxidative tailoring reactions catalyzed by nonheme iron-dependent enzymes: streptorubin B biosynthesis as an example

scientific article published on January 2012

PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin

scientific article

Pentamycin Biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-Catalyzed Installation of the C-14 Hydroxyl Group ⬇️

scientific article published on 31 May 2019

Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N8-citryl-spermidine and its N1-(3,4-dihydroxybenzoyl) derivative

scientific article published on 31 July 2008

Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains

article

Protein-protein interactions in trans-AT polyketide synthases

scientific article published on 01 October 2018

Purification, crystallization and data collection of Pectobacterium chrysanthemi AcsD, a type A siderophore synthetase

scientific article

Recent advances in siderophore biosynthesis

scientific article published on April 2009

Regio- and stereodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes

scientific article published on 17 April 2011

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

scientific article

Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis

scientific article published on 01 July 2018

Role and substrate specificity of the Streptomyces coelicolor RedH enzyme in undecylprodiginine biosynthesis

scientific article published on 14 March 2008

SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone.

scientific article published on 8 April 2015

Stereochemical elucidation of streptorubin B.

scientific article published on 17 December 2010

Stereochemistry and Mechanism of Undecylprodigiosin Oxidative Carbocyclization to Streptorubin B by the Rieske Oxygenase RedG

scientific article published on 12 June 2015

Strategies for the discovery of new natural products by genome mining

scientific article published on March 2009

Structural Basis for Acyl Acceptor Specificity in the Achromobactin Biosynthetic Enzyme AcsD

scientific article

Structural aspects of non-ribosomal peptide biosynthesis

scientific article

Structural basis for chain release from the enacyloxin polyketide synthase

scientific article published on 23 September 2019

Structural changes in freshwater fish and chironomids exposed to bacterial exotoxins

scientific article published on 28 February 2012

Structure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway in Streptomyces coelicolor

scientific article

Structure and biosynthesis of scabichelin, a novel tris-hydroxamate siderophore produced by the plant pathogen Streptomyces scabies 87.22. ⬇️

scientific article published on 11 June 2013

Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products

scientific article published on 17 June 2016

Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

scientific article published on 04 May 2021

Tailoring reactions catalyzed by heme-dependent enzymes: spectroscopic characterization of the L-tryptophan-nitrating cytochrome P450 TxtE.

scientific article published on January 2012

The Scottish Structural Proteomics Facility: targets, methods and outputs

scientific article

The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081.

scientific article

The dynamic architecture of the metabolic switch in Streptomyces coelicolor.

scientific article

The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin

scientific article

The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis

scientific article published on 14 September 2009

The plant pathogen Streptomyces scabies 87-22 has a functional pyochelin biosynthetic pathway that is regulated by TetR- and AfsR-family proteins

article

The role of glutathione S-transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus

scientific article published on April 2011

The vbs genes that direct synthesis of the siderophore vicibactin in Rhizobium leguminosarum: their expression in other genera requires ECF sigma factor RpoI.

scientific article published in June 2002

Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis

scientific article published on 22 August 2016

Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining ⬇️

scientific article published on November 2006

Understanding biosynthetic protein-protein interactions

scientific article published on 01 November 2018

Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264 ⬇️

scientific article

Unusual odd-electron fragments from even-electron protonated prodiginine precursors using positive-ion electrospray tandem mass spectrometry

scientific article published on 9 August 2008

Watasemycin biosynthesis in Streptomyces venezuelae: thiazoline C-methylation by a type B radical-SAM methylase homologue ⬇️

scientific article

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