List of works - Tom N Grossmann

A protein tertiary structure mimetic modulator of the Hippo signalling pathway

scientific article published on 27 October 2020

Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis

scientific article published on 26 March 2020

Achieving turnover in DNA-templated reactions

scientific article published on September 2008

Adapting free energy perturbation simulations for large macrocyclic ligands: how to dissect contributions from direct binding and free ligand flexibility

scientific article published on 22 January 2020

Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions

scientific article published on 10 July 2017

Chemical biology 2012: from drug targets to biological systems and back

scientific article published on 26 November 2012

Chemical control of biomolecular interaction modules

Coiled-coil Peptide Beacon: A Tuneable Conformational Switch for Protein Detection

scientific article published on 28 November 2018

Constrained Peptides with Fine-Tuned Flexibility Inhibit NF-Y Transcription Factor Assembly

scientific article published on 17 October 2019

Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction

scientific article

Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis

scientific article

DNA-Catalyzed Transfer of a Reporter Group

scientific article published on 01 December 2006

DNA-Triggered Synthesis and Bioactivity of Proapoptotic Peptides

scientific article published on 21 February 2011

DNA-instructed acyl transfer reactions for the synthesis of bioactive peptides

scientific article

Direct Modulation of Small GTPase Activity and Function

scientific article published on 16 October 2015

Direct targeting of Rab-GTPase-effector interactions

scientific article published on 31 January 2014

Direct targeting of β-catenin: Inhibition of protein-protein interactions for the inactivation of Wnt signaling

scientific article published on 22 March 2013

Hydrocarbon stapled peptides as modulators of biological function

scientific article published on 31 March 2015

In Situ Cyclization of Proteins (INCYPRO): Cross-Link Derivatization Modulates Protein Stability

scientific article published on 16 December 2019

Increased Conformational Flexibility of a Macrocycle-Receptor Complex Contributes to Reduced Dissociation Rates.

scientific article published on 4 August 2017

Inducing the replacement of PNA in DNA·PNA duplexes by DNA

scientific article published on 06 May 2007

Inhibition of oncogenic Wnt signaling through direct targeting of -catenin

scientific article

In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme

scientific article published on 21 June 2018

Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners

scientific article published on 22 August 2018

Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119

scientific article published on 19 November 2019

Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments

scientific article published on 02 March 2020

Modulators of protein-protein interactions

scientific article published on 15 April 2014

New Modalities for Challenging Targets in Drug Discovery

scientific article

New aspects in fragmentation of peptide nucleic acids: comparison of positive and negative ions by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry

scientific article published in April 2009

Nucleic acid templated reactions: consequences of probe reactivity and readout strategy for amplified signaling and sequence selectivity.

scientific article

Oligonucleotides with Cationic Backbone and Their Hybridization with DNA: Interplay of Base Pairing and Electrostatic Attraction

scientific article published on 19 October 2017

Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

scientific article

Photo-thermal haptotropism in cyclopentadienylcobalt complexes of linear phenylenes: intercyclobutadiene metal migration.

scientific article published in January 2009

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

scientific article

Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase

scientific article published on 23 June 2016

Protein Macrocyclization for Tertiary Structure Stabilization

scientific article

Protein-RNA interactions: structural characteristics and hotspot amino acids

scientific article published on 09 August 2018

Protein-templated peptide ligation

scientific article published on 18 March 2014

Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns

scientific article published on 06 February 2020

Recognizing and controlling biomolecules with "Smart" hybridization-based switches

scientific article published on 01 January 2008

Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes.

scientific article published on 29 September 2015

Reversible covalent inhibition of a protein target.

scientific article

Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization

scientific article published on 28 June 2016

Small-molecule modulation of Ras signaling

scientific article

Structural Analysis of the Interaction between the Bacterial Cell Division Proteins FtsQ and FtsB

article published in 2018

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.

scientific article published on 26 June 2015

Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions

scientific article published on 13 October 2017

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

scientific article published on 12 May 2011

Target-catalyzed transfer reactions for the amplified detection of RNA.

scientific article

Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage

scientific article published on 17 March 2018

The Therapeutic Potential of PTEN Modulation: Targeting Strategies from Gene to Protein

scientific article published on 13 November 2017

Translocation of an Intracellular Protein via Peptide-Directed Ligation.

scientific article published on 21 December 2016

Triplex molecular beacons as modular probes for DNA detection

scientific article published in January 2007

List of works by Tom N Grossmann

A protein tertiary structure mimetic modulator of the Hippo signalling pathway

Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis

Achieving turnover in DNA-templated reactions

Adapting free energy perturbation simulations for large macrocyclic ligands: how to dissect contributions from direct binding and free ligand flexibility

Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions

Chemical biology 2012: from drug targets to biological systems and back

Chemical control of biomolecular interaction modules

Coiled-coil Peptide Beacon: A Tuneable Conformational Switch for Protein Detection

Constrained Peptides with Fine-Tuned Flexibility Inhibit NF-Y Transcription Factor Assembly

Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction

Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis

DNA-Catalyzed Transfer of a Reporter Group

DNA-Triggered Synthesis and Bioactivity of Proapoptotic Peptides

DNA-instructed acyl transfer reactions for the synthesis of bioactive peptides

Direct Modulation of Small GTPase Activity and Function

Direct targeting of Rab-GTPase-effector interactions

Direct targeting of β-catenin: Inhibition of protein-protein interactions for the inactivation of Wnt signaling

Hydrocarbon stapled peptides as modulators of biological function

In Situ Cyclization of Proteins (INCYPRO): Cross-Link Derivatization Modulates Protein Stability

Increased Conformational Flexibility of a Macrocycle-Receptor Complex Contributes to Reduced Dissociation Rates.

Inducing the replacement of PNA in DNA·PNA duplexes by DNA

Inhibition of oncogenic Wnt signaling through direct targeting of -catenin

In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme

Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners

Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119

Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments

Modulators of protein-protein interactions

New Modalities for Challenging Targets in Drug Discovery

New aspects in fragmentation of peptide nucleic acids: comparison of positive and negative ions by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry

Nucleic acid templated reactions: consequences of probe reactivity and readout strategy for amplified signaling and sequence selectivity.

Oligonucleotides with Cationic Backbone and Their Hybridization with DNA: Interplay of Base Pairing and Electrostatic Attraction

Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

Photo-thermal haptotropism in cyclopentadienylcobalt complexes of linear phenylenes: intercyclobutadiene metal migration.

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase

Protein Macrocyclization for Tertiary Structure Stabilization

Protein-RNA interactions: structural characteristics and hotspot amino acids

Protein-templated peptide ligation

Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns

Recognizing and controlling biomolecules with "Smart" hybridization-based switches

Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes.

Reversible covalent inhibition of a protein target.

Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization

Small-molecule modulation of Ras signaling

Structural Analysis of the Interaction between the Bacterial Cell Division Proteins FtsQ and FtsB

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.

Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

Target-catalyzed transfer reactions for the amplified detection of RNA.

Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage

The Therapeutic Potential of PTEN Modulation: Targeting Strategies from Gene to Protein

Translocation of an Intracellular Protein via Peptide-Directed Ligation.

Triplex molecular beacons as modular probes for DNA detection