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List of works by José C Fernández-Checa

A simple technique to determine glutathione (GSH) levels and synthesis in ocular tissues as GSH-bimane adduct: application to normal and galactosemic guinea-pigs.

scientific article published in January 1993

APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease.

scientific article published on 06 May 2013

ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading.

scientific article published on 23 May 2013

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis

scientific article published on 16 June 2014

Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress

scientific article

Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways

scientific article published on 02 October 2014

Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis

scientific article

Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis

scientific article published on March 2004

Alcohol, signaling, and ECM turnover.

scientific article published on 23 October 2009

Alcohol-induced liver disease: from molecular damage to treatment.

scientific article

Alcohol-induced liver disease: when fat and oxidative stress meet.

scientific article published on April 2003

Alcoholic liver disease

scientific article published on 01 January 1996

Alcoholic liver injury and apoptosis--synopsis of the symposium held at ESBRA 2001: 8th Congress of the European Society for Biomedical Research on Alcoholism, Paris, September 16, 2001.

scientific article published in October 2002

Angiogenin secretion from hepatoma cells activates hepatic stellate cells to amplify a self-sustained cycle promoting liver cancer

scientific article

Augmenter of liver regeneration links mitochondrial function to steatohepatitis and hepatocellular carcinoma

scientific article

Bidirectional mechanism of plasma membrane transport of reduced glutathione in intact rat hepatocytes and membrane vesicles

scientific article

Brain mitochondrial alterations after chronic alcohol consumption.

scientific article published in September 2009

Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats ⬇️

scientific article published in Journal of Biological Chemistry

Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease

scientific article published on 18 November 2011

Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential

scientific article published on April 2009

Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility.

scientific article published on 14 April 2011

Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-α-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation

scientific article published on 01 August 2002

Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells. ⬇️

scientific article published on 8 June 2015

Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death

scientific article

Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity

scientific journal article

Chronic Ethanol Feeding Induces Cellular Antioxidants Decrease and Oxidative Stress in Rat Peripheral Nerves. Effect of S-Adenosyl-l-Methionine and N-Acetyl-l-Cysteine

scientific article published on 01 August 1998

Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury.

scientific article

Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia

scientific article

Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis

scientific article published on July 2011

Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation.

scientific article

Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice

scientific article

Defective TNF-α–mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice

Differential modulation of interleukin 8 by interleukin 4 and interleukin 10 in HepG2 cells treated with acetaldehyde.

scientific article published on February 2005

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

scientific article published in Journal of Biological Chemistry

Divergent role of ceramide generated by exogenous sphingomyelinases on NF-kappa B activation and apoptosis in human colon HT-29 cells.

scientific article published in August 2002

Dual Role of Mitochondrial Reactive Oxygen Species in Hypoxia Signaling: Activation of Nuclear Factor- B via c-SRC and Oxidant-Dependent Cell Death

article

Editorial [Hot Topic: Lipids in Cancer Cell Biology and Therapy Guest Editor: Jose C. Fernandez-Checa)]

scientific article published on 01 May 2012

Effect of indomethacin on the uptake, metabolism and excretion of 3-oxocholic acid: studies in isolated hepatocytes and perfused rat liver

scientific article published in July 1991

Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes

scientific article

Effects of steroid treatment on activation of nuclear factor kappaB in patients with inflammatory bowel disease

scientific article published on June 1998

Endoplasmic reticulum stress mediates amyloid β neurotoxicity via mitochondrial cholesterol trafficking

scientific article

Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.

scientific article

Evidence that interference with binding to hepatic cytosol binders can inhibit bile acid excretion in rats

article

Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione. Expression studies in Xenopus laevis oocytes

scientific article published in July 1995

Expression cloning of the cDNA for a polypeptide associated with rat hepatic sinusoidal reduced glutathione transport: characteristics and comparison with the canalicular transporter.

scientific article

Expression of rat liver reduced glutathione transport in Xenopus laevis oocytes

scientific article

Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes

scientific article published on January 1995

Functional properties of isolated hepatocytes from ethanol-treated rat liver

scientific article

GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect.

scientific article published on July 1997

GSH transporters: molecular characterization and role in GSH homeostasis

scientific article published on May 1996

Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy

scientific article published on 25 September 2002

Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation

scientific article

Gastric mucosal damage in experimental diabetes in rats: Role of endogenous glutathione

scientific article published on 01 March 1997

Glutathione and mitochondria

scientific article

Glutathione depletion impairs myogenic differentiation of murine skeletal muscle C2C12 cells through sustained NF-kappaB activation

scientific article

Glycosphingolipids and cell death: one aim, many ways

scientific article

Glycosphingolipids and mitochondria: role in apoptosis and disease.

scientific article published in January 2004

Growth arrest-specific protein 6 is hepatoprotective against murine ischemia/reperfusion injury.

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats

scientific article published in December 1992

Hepatic mitochondrial glutathione: transport and role in disease and toxicity.

scientific article

Hepatocellular oxidative stress and initial graft injury in human liver transplantation

scientific article published on 01 November 1999

How is the liver primed or sensitized for alcoholic liver disease?

scientific article published in May 2001

Identification and functional analysis of mutations in FAD-binding domain of mitochondrial glycerophosphate dehydrogenase in caucasian patients with type 2 diabetes mellitus.

scientific article

Increased tumour necrosis factor‐α plasma levels during moderate-intensity exercise in COPD patients

scientific article published on 01 May 2003

Inhibition of glutathione efflux in the perfused rat liver and isolated hepatocytes by organic anions and bilirubin. Kinetics, sidedness, and molecular forms

scientific article

Inhibition of rat sinusoidal GSH transporter by thioethers: specificity, sidedness, and kinetics

scientific article

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death

scientific article published on 9 January 2014

Liver Cholesterol Overload Aggravates Obstructive Cholestasis by Inducing Oxidative Stress and Premature Death in Mice

scientific article published on 21 August 2016

Liver and lens glutathione and cysteine regulation in galactose-fed guinea pigs

scientific article

Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy

scientific article

MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content

scientific article published on 2 March 2017

Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation.

scientific article

Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy

scientific article published on 2 August 2016

Metabolic therapy: lessons from liver diseases.

scientific article published on December 2011

Mitochondria, cholesterol and amyloid beta peptide: a dangerous trio in Alzheimer disease.

scientific article published on October 2009

Mitochondria, cholesterol and cancer cell metabolism

scientific article

Mitochondrial Cholesterol and the Paradox in Cell Death

scientific article

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis.

scientific article

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease.

scientific article

Mitochondrial Glutathione: Importance and Transport

article

Mitochondrial S-adenosyl-L-methionine transport is insensitive to alcohol-mediated changes in membrane dynamics.

scientific article published on 9 April 2009

Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress.

scientific article

Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.

scientific article

Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity

scientific article published on May 2009

Mitochondrial cholesterol: a connection between caveolin, metabolism, and disease

scientific article published on 25 August 2011

Mitochondrial dysfunction in COPD patients with low body mass index

scientific article published on 20 December 2006

Mitochondrial glutathione depletion in alcoholic liver disease

scientific article published on November 1993

Mitochondrial glutathione, a key survival antioxidant

scientific article

Mitochondrial glutathione: features, regulation and role in disease

scientific article

Mitochondrial permeability transition induced by reactive oxygen species is independent of cholesterol-regulated membrane fluidity

scientific article published in February 2004

Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis

scientific article published on 2 November 2015

Neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes

scientific article

Oxidative damage of mitochondrial and nuclear DNA induced by ionizing radiation in human hepatoblastoma cells

scientific article published on 01 August 1998

Oxidative stress and alcoholic liver disease.

scientific article

Oxidative stress: role of mitochondria and protection by glutathione

scientific article published in January 1998

PGE1 protection against apoptosis induced by D-galactosamine is not related to the modulation of intracellular free radical production in primary culture of rat hepatocytes

scientific article published in March 2002

Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo

article

Pharmacological modulation of sphingolipids and role in disease and cancer cell biology.

scientific article published on April 2007

Plasma membrane and mitochondrial transport of hepatic reduced glutathione

scientific article published on May 1996

Probiotic sonicates selectively induce mucosal immune cells apoptosis through ceramide generation via neutral sphingomyelinase

scientific article

Protective role of endogenous plasmalogens against hepatic steatosis and steatohepatitis in mice

scientific article

Qualitative and quantitative changes in skeletal muscle mtDNA and expression of mitochondrial-encoded genes in the human aging process

scientific article published in December 1997

Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion

scientific article published on 06 April 2009

Redox control of liver function in health and disease

scientific article

Redox regulation and signaling lipids in mitochondrial apoptosis ⬇️

scientific article published on May 9, 2003

Redox regulation of hepatocyte apoptosis

scientific article published on June 2007

Reduced muscle redox capacity after endurance training in patients with chronic obstructive pulmonary disease

scientific article published in October 2001

Reply

Role of Mitochondria in Alcoholic Liver Disease

scientific article

Role of apoptosis in alcoholic liver injury

scientific article published in July 2003

Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondri

scientific article published on 01 November 1995

S-Adenosyl-L-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease

scientific article

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity

scientific article

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

scientific article published on 01 December 1998

Selective induction by phenobarbital of the electrogenic transport of glutathione and organic anions in rat liver canalicular membrane vesicles.

scientific article published in May 1993

Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione.

scientific article

Sphingolipid signalling and liver diseases

scientific article published on May 2007

Sphingolipids and cell death.

scientific article published on May 2007

Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis

scientific article published on 18 November 2020

Statins and Protein Prenylation in Cancer Cell Biology and Therapy ⬇️

scientific article published on May 1, 2012

Systemic effects of cigarette smoke exposure in the guinea pig.

scientific article published on 5 December 2005

Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia–reperfusion injury

scientific article published on 29 October 2010

Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma

scientific article published on 22 January 2016

Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione.

scientific article published in November 2001

The fluidity of liver plasma membranes from patients with different types of liver injury

scientific article published in July 1986

The use of monochlorobimane to determine hepatic GSH levels and synthesis

scientific article published on 01 November 1990

To binge or not to binge: binge drinking disrupts glucose homeostasis by impairing hypothalamic but not liver insulin signaling

scientific article

Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha

scientific journal article

Transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase by ionizing radiation.

scientific article published in May 1998

Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: Effect of membrane physical properties andS-adenosyl-L-methionine

scientific article published on 01 September 1997

Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase.

scientific article published on November 1997

VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis

scientific article published on 01 April 1999

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