List of works by Gail Petuna Risbridger

17beta-estradiol induces apoptosis in the developing rodent prostate independently of ERalpha or ERbeta

scientific article

6 The physiology of testicular inhibin and related proteins ⬇️

scientific article published on April 1, 1992

A bioengineered microenvironment to quantitatively measure the tumorigenic properties of cancer-associated fibroblasts in human prostate cancer.

scientific article published on 2 April 2013

A comparative assessment of α-lipoic acid N-phenylamides as non-steroidal androgen receptor antagonists both on and off gold nanoparticles

scientific article

A critical role for estrogen signaling in penis development

scientific article published on 21 June 2019

A loss of estrogen signaling in the aromatase deficient mouse penis results in mild hypospadias

scientific article published on 06 September 2019

A preclinical xenograft model identifies castration-tolerant cancer-repopulating cells in localized prostate tumors.

scientific article published in May 2013

A preclinical xenograft model of prostate cancer using human tumors

scientific article published on 4 April 2013

A pro-tumourigenic loop at the human prostate tumour interface orchestrated by oestrogen, CXCL12 and mast cell recruitment

scientific article

A single nucleotide polymorphism genotyping platform for the authentication of patient derived xenografts

scientific article published on 09 August 2016

A versatile monoclonal antibody specific to human SERPINB5

scientific article

Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo

scientific article published on 18 December 2008

Activin-β(c) reduces reproductive tumour progression and abolishes cancer-associated cachexia in inhibin-deficient mice

scientific article published on 25 January 2013

Activin-βC modulates cachexia by repressing the ubiquitin-proteasome and autophagic degradation pathways.

scientific article

Activin-βC modulates gonadal, but not adrenal tumorigenesis in the inhibin deficient mice.

scientific article

Activins as regulators of branching morphogenesis.

scientific article

Adult rat Leydig cell cultures: Minimum requirements for maintenance of luteinizing hormone responsiveness and testosterone production

article

Age Related Differences in Responsiveness to Sildenafil and Tamsulosin are due to Myogenic Smooth Muscle Tone in the Human Prostate

scientific article published on 31 August 2017

An in vivo model of prostate carcinoma growth and invasion in bone

scientific article published on 14 February 2002

Analysis of the effect of estrogen/androgen perturbation on penile development in transgenic and diethylstilbestrol-treated mice

scientific article published on 08 May 2013

Anti-androgenic action by red clover-derived dietary isoflavones reduces non-malignant prostate enlargement in aromatase knockout (ArKo) mice.

scientific article published in June 2003

Are we disrupted?

scientific article published on 19 March 2014

Aromatase and regulating the estrogen:androgen ratio in the prostate gland.

scientific article

Aromatase transgenic upregulation modulates basal cardiac performance and the response to ischemic stress in male mice

scientific article

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

scientific article published on 11 June 2018

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

scholarly article published in Nature Genetics

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

scholarly article published in Nature Genetics

Breaking through a roadblock in prostate cancer research: an update on human model systems.

scientific article published on 08 February 2012

Breast and prostate cancer: more similar than different.

scientific article published on 11 February 2010

Brief report: a bioassay to identify primary human prostate cancer repopulating cells.

scientific article published in August 2011

Cancer progression: is inhibin alpha from Venus or Mars?

scientific article published in October 2004

Castrate-tolerant cells: what are the implications for the treatment of localized prostate cancer?

scientific article published on 22 July 2013

Cell-specific expression of betaC-activin in the rat reproductive tract, adrenal and liver

scientific article published in July 2004

Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis ⬇️

scientific article published on March 28, 2003

Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target

scientific article published on 20 March 2019

Comparative biomarker expression and RNA integrity in biospecimens derived from radical retropubic and robot-assisted laparoscopic prostatectomies

scientific article published on July 2010

Computer-based detection of neonatal changes to branching morphogenesis reveals different mechanisms of and predicts prostate enlargement in mice haplo-insufficient for bone morphogenetic protein 4

scientific journal article

Contemporary approaches to prostate cancer research.

scientific article published in May 2011

Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance.

scientific article published on 26 June 2015

Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling.

scientific article published on 07 October 2016

Cross-species stromal signaling programs human embryonic stem cell differentiation

scientific article published on January 2014

Current understanding of hypospadias: relevance of animal models.

scientific article published on 07 April 2015

DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation.

scientific article published on 24 January 2014

Development of the external genitalia: perspectives from the spotted hyena (Crocuta crocuta)

scientific article (publication date: 2014)

Developmental response by Leydig cells to acidic and basic fibroblast growth factor.

scientific article published on February 1997

Differential Localization of Fibroblast Growth Factor Receptor-i, -2, -3, and -4 in Fetal, Immature, and Adult Rat Testes1

scientific article published on 01 May 1998

Differential localization of inhibin subunit proteins in the ovine testis during fetal gonadal development

scientific article published on 01 February 1999

Direct response of the murine prostate gland and seminal vesicles to estradiol.

scientific article published on December 2002

Discrete stimulatory effects of platelet-derived growth factor (PDGF-BB) on Leydig cell steroidogenesis

scientific article published on 01 November 1993

Early prostate development and its association with late-life prostate disease.

scientific article

Editorial: The Future of Our Basic Science and Scientists

scientific article published on December 2015

Effect of ethane dimethane sulphonate on proopiomelanocortin (POMC) mRNA and POMC-derived peptides in the rat testis

scientific article published on August 1989

Effect of serum and serum lipoproteins on testosterone production by adult rat Leydig cells in vitro

scientific article published in November 1992

Effects of steroids on fibroblasts: Identification of glucocorticoid-regulated proteins by two-dimensional gel electrophoresis

scientific article published on 01 June 1983

Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland

scientific journal article

Elevated expression of inhibin alpha in prostate cancer.

scientific article published on January 2004

Elevated seminal plasma estradiol and epigenetic inactivation of ESR1 and ESR2 is associated with CP/CPPS.

scientific article

Enduring epigenetic landmarks define the cancer microenvironment.

scientific article published on 12 April 2018

Enhancing active surveillance of prostate cancer: the potential of exercise medicine

scientific article published on 8 March 2016

Epigenetic regulation of inhibin alpha-subunit gene in prostate cancer cell lines

scientific article published in February 2004

Erratum: Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome

scientific article published on November 2015

Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia.

scientific article published on 26 October 2006

Establishing a cryopreservation protocol for patient-derived xenografts of prostate cancer

scientific article published on 18 June 2019

Establishment of primary patient-derived xenografts of palliative TURP specimens to study castrate-resistant prostate cancer.

scientific article published on 14 July 2015

Estrogen action on the prostate gland: a critical mix of endocrine and paracrine signaling.

scientific article published on September 2007

Estrogen receptor subtypes dictate the proliferative nature of the mammary gland

scientific article published on 10 April 2018

Estrogen-regulated development and differentiation of the prostate.

scientific article published on 28 June 2008

Evidence for efficacy of new Hsp90 inhibitors revealed by ex vivo culture of human prostate tumors.

scientific article

Evidence that epithelial and mesenchymal estrogen receptor-alpha mediates effects of estrogen on prostatic epithelium.

scientific article

Evidence that estrogens directly alter androgen-regulated prostate development

scientific article published on 01 September 2000

Evidence that heparin binding autocrine factors modulate testosterone production by the adult rat Leydig cell

article

Expression of estrogen receptor alpha and beta is decreased in hypospadias.

scientific article

Expression of fibroblast growth factor-8 in adult rat tissues and human prostate carcinoma cells

scientific article published on February 1996

Fibroblast growth factor receptors and their ligands in the adult rat kidney

scientific article published on 01 July 2001

Fibroblast studies on clinical androgen insensitivity.

scientific article

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

scientific article published on 11 June 2018

Follitropin (FSH) stimulation of inhibin biological and immunological activities by seminiferous tubules and Sertoli cell cultures from immature rats

article

Formation of human prostate tissue from embryonic stem cells

scientific article published on March 2006

Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories.

scientific article published on 09 January 2017

Global levels of specific histone modifications and an epigenetic gene signature predict prostate cancer progression and development

scientific article

Growth inhibitory response to activin A and B by human prostate tumour cell lines, LNCaP and DU145

scientific article published on 01 September 1997

Hedgehog signaling is active in human prostate cancer stroma and regulates proliferation and differentiation of adjacent epithelium

scientific article published on 16 September 2013

Human cell lines as tools of our trade: "laying it on the (cell) line".

scientific article published on January 2015

Human epithelial basal cells are cells of origin of prostate cancer, independent of CD133 status.

scientific article

Humanization of the Prostate Microenvironment Reduces Homing of PC3 Prostate Cancer Cells to Human Tissue-Engineered Bone

scientific article published on 13 November 2018

Hypermethylation of the Inhibin -Subunit Gene in Prostate Carcinoma

article

Identification of receptor tyrosine kinases in the rat testis

scientific article published on 01 December 1993

Immuno- and bioactive inhibin and inhibin alpha-subunit expression in rat Leydig cell cultures

scientific article published in September 1989

In vitro modeling of the prostate cancer microenvironment.

scientific article published on 09 May 2014

In vitro synthesis and release of inhibin in response to FSH stimulation by isolated segments of seminiferous tubules from normal adult male rats

scientific article

Increased endogenous estrogen synthesis leads to the sequential induction of prostatic inflammation (prostatitis) and prostatic pre-malignancy.

scientific article published on 21 August 2009

Informing men about prostate cancer screening: a randomized controlled trial of patient education materials

scientific article published on April 2008

Inhibin and activin regulate [3H]thymidine uptake by rat thymocytes and 3T3 cells in vitro

scientific article published on January 1989

Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia.

scientific article published in January 1998

Inhibition of compensatory renal growth by the N-terminus of a sheep-derived peptide

scientific article published on 08 November 2008

Intraductal carcinoma of the prostate can evade androgen deprivation, with emergence of castrate-tolerant cells

scientific article published on 4 October 2017

Intragonadal control mechanisms

scientific article published on February 1987

Kallikrein-related peptidase 4 induces cancer-associated fibroblast features in prostate-derived stromal cells

scientific article

Knowing what's growing: Why ductal and intraductal prostate cancer matter

scientific article published on 01 March 2020

Lineage enforcement by inductive mesenchyme on adult epithelial stem cells across developmental germ layers

scientific article

Local regulation of leydig cell function by inhibitors of steroidogenic activity ⬇️

scientific article published on May 1, 1992

Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit.

scientific article

Mammary stem cells and parity-induced breast cancer protection- new insights.

scientific article

Minireview: regulation of prostatic stem cells by stromal niche in health and disease.

scientific article published on 05 June 2008

Molecular profiling of bladder cancer: involvement of the TGF-beta pathway in bladder cancer progression.

scientific article

Morphology of the external genitalia of the adult male and female mice as an endpoint of sex differentiation

scientific article

Mouse hypospadias: A critical examination and definition

scientific article

Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient-derived xenograft (PDX) models

scientific article published on 02 August 2018

Multiple factors with steroidogenesis-regulating activity in testicular interbular fluid from normal and experimentally cryptorchid adult rats

scientific article published on 01 December 1994

Mysterious inhibitory cell regulator investigated and found likely to be secretogranin II related

scientific article published on 13 October 2017

New insights on the morphology of adult mouse penis

scientific article published on 14 September 2011

New perspectives on growth factor-sex steroid interaction in the prostate.

scientific article

Novel imaging of the prostate reveals spontaneous gland contraction and excretory duct quiescence together with different drug effects

scientific article published on 31 October 2017

Obesity does not promote tumorigenesis of localized patient-derived prostate cancer xenografts.

scientific article published on 23 June 2016

Oestrogens and prostate cancer.

scientific article

Over-Expression of Activin-βC Is Associated with Murine and Human Prostate Disease.

scientific article published on 23 January 2017

PDX: Moving Beyond Drug Screening to Versatile Models for Research Discovery

scientific article published on 12 September 2020

Patient-Derived Prostate Cancer: from Basic Science to the Clinic

scientific article published on 13 May 2016

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy

scientific article published on 23 July 2018

Patient-derived xenografts reveal that intraductal carcinoma of the prostate is a prominent pathology in BRCA2 mutation carriers with prostate cancer and correlates with poor prognosis.

scientific article published on 22 August 2014

Peripubertal aromatase inhibition in male rats has adverse long-term effects on bone strength and growth and induces prostatic hyperplasia

scientific article published on 30 July 2010

Platelet-derived growth factor ligand and receptor subunit mRNA in the Sertoli and Leydig cells of the rat testis

scientific article published on 01 February 1995

Preclinical Models of Prostate Cancer: Patient-Derived Xenografts, Organoids, and Other Explant Models

scientific article published on 8 January 2018

Preliminary investigations into triazole derived androgen receptor antagonists.

scientific article published on April 2014

Primary culture and propagation of human prostate epithelial cells.

scientific article

Prostate cancer: Novel xenografts in mice--a new wave of preclinical models

scientific article published on 18 August 2015

Prostate-regenerating capacity of cultured human adult prostate epithelial cells

scientific article published on 18 September 2009

Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha signaling.

scientific article published on 30 November 2007

Prostatic tumor stroma: a key player in cancer progression.

scientific article published on September 2008

Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment

scientific article published on 06 May 2019

Re-evaluating the role of activin-βC in cancer biology.

scientific article published on 28 May 2015

Re-evaluation of inhibin α subunit as a tumour suppressor in prostate cancer

scientific article published on 01 October 2004

Regional localization of activin-βA, activin-βC, follistatin, proliferation, and apoptosis in adult and developing mouse prostate ducts.

scientific article published on 28 March 2017

Regulation of prostate branching morphogenesis by activin A and follistatin

scientific article published in September 2001

Regulation of the transcriptional coactivator FHL2 licenses activation of the androgen receptor in castrate-resistant prostate cancer

scientific article

Reproduction, development, and the early origins of adult disease

article

Requirement for heparan sulphate proteoglycans to mediate basic fibroblast growth factor (FGF-2)-induced stimulation of Leydig cell steroidogenesis.

scientific article published on September 1995

Role of activin C in normal ovaries and granulosa cell tumours of mice and humans.

scientific article published on 6 December 2017

Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.

scientific article published on 13 November 2015

Searching the Internet for information on prostate cancer screening: an assessment of quality

scientific article published in July 2004

Sex specific retinoic acid signaling is required for the initiation of urogenital sinus bud development.

scientific article

Specific morphogenetic events in mouse external genitalia sex differentiation are responsive/dependent upon androgens and/or estrogens.

scientific article published on 25 August 2012

Stem cells in prostate cancer: treating the root of the problem.

scientific article published on 23 September 2010

Stimulation of interstitial cell growth after selective destruction of foetal Leydig cells in the testis of postnatal rats

scientific article published in April 1988

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

scientific article published on 01 February 2019

Synthesis and preliminary investigations into novel 1,2,3-triazole-derived androgen receptor antagonists inspired by bicalutamide

scientific article published on 19 September 2014

Systematic Review Links the Prevalence of Intraductal Carcinoma of the Prostate to Prostate Cancer Risk Categories

scientific article published on 22 March 2017

The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer

scientific article published on 2 August 2016

The Evolving Narrative of DNA Repair Gene Defects: Distinguishing Indolent from Lethal Prostate Cancer.

scientific article published on 25 January 2017

The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology

scientific article published on 19 August 2021

The complexities of identifying a cell of origin for human prostate cancer

scientific article published on 18 October 2010

The dual, opposing roles of estrogen in the prostate.

scientific article published on February 2009

The effect of insulin on inhibin production in isolated seminiferous tubule segments from adult rats cultured in vitro

scientific article

The effect of testicular macrophages and interleukin-1 on testosterone production by purified adult rat Leydig cells cultured under in vitro maintenance conditions

scientific article

The in vivo effect of red clover diet on ventral prostate growth in adult male mice

scientific article published in January 2001

The influence of BRCA2 mutation on localized prostate cancer

scientific article published on 01 May 2019

The inhibin/activin signalling pathway in human gonadal and adrenal cancers.

scientific article published on September 2014

The metaplastic effects of estrogen on mouse prostate epithelium: proliferation of cells with basal cell phenotype

scientific article

The path toward identifying prostatic stem cells.

scientific article published on July 2008

The power and perils of animal models with urogenital anomalies: handle with care.

scientific article published on 12 April 2014

The prognostic value of stromal FK506-binding protein 1 and androgen receptor in prostate cancer outcome.

scientific article published on 08 October 2016

The role of calcium in luteinizing hormone/human chorionic gonadotrophin stimulation of Leydig cell immunoactive inhibin secretion in vitro

scientific article published on January 1991

The role of inhibins and activins in prostate cancer pathogenesis.

scientific article

The therapeutic potential of blocking the activin signalling pathway.

scientific article published on 18 June 2013

Treating prostate cancer: a rationale for targeting local oestrogens

scientific article published on 05 July 2007

betaA- and betaC-activin, follistatin, activin receptor mRNA and betaC-activin peptide expression during rat liver regeneration.

scientific article published in April 2005

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