List of works by Mark J. Smyth

2018 Nobel Prize in physiology or medicine

A Network of PDZ-Containing Proteins Regulates T Cell Polarity and Morphology during Migration and Immunological Synapse Formation

scientific article published on 01 June 2005

A New Therapeutic Target for Leukemia Comes to the Surface

scientific article published on 01 July 2009

A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1.

scientific article published on 24 July 2015

A balance of interleukin-12 and -23 in cancer

scientific article published on 13 August 2013

A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas

scientific article

A fresh look at tumor immunosurveillance and immunotherapy.

scientific article

A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells

scientific article published on May 2004

A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage

scientific article

A nonclassical non-Valpha14Jalpha18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance

scientific article

A novel axis of innate immunity in cancer ⬇️

scientific article published on 01 November 2010

A novel substrate-binding pocket interaction restricts the specificity of the human NK cell-specific serine protease, Met-ase-1.

scientific article

A potential role for RAG-1 in NK cell development revealed by analysis of NK cells during ontogeny

article

A role for Blimp1 in the transcriptional network controlling natural killer cell maturation

scientific article published on 3 December 2010

A role for CCL2 in both tumor progression and immunosurveillance

scientific article published on July 2013

A role for IFN-gamma in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivo

scientific article

A role for P-glycoprotein in regulating cell death

scientific article

A role for granzyme M in TLR4-driven inflammation and endotoxicosis.

scientific article published on 28 June 2010

A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties

scientific article

A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.

scientific article

A2A blockade enhances anti-metastatic immune responses

scientific article published on 22 October 2013

A2AR adenosine signaling suppresses natural killer cell maturation in the tumor microenvironment.

scientific article published on 11 December 2017

ACCESSORY FUNCTION FOR NK1.1+ NATURAL KILLER CELLS PRODUCING INTERFERON-?? IN XENOSPECIFIC CYTOTOXIC T LYMPHOCYTE DIFFERENTIATION1

scientific article published on 01 September 1999

Aberrant erythropoiesis fuels tumor growth

Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice

scientific article published on 27 March 2008

Acquired resistance to anti-PD1 therapy: checkmate to checkpoint blockade?

scientific article

Acquired resistance to immunotherapy and future challenges

scientific article published in January 2016

Activating and inhibitory receptors of natural killer cells

scientific article published on 22 June 2010

Activation of NK cell cytotoxicity

scientific article

Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation ⬇️

scientific article published on November 1, 1992

Activation of invariant NKT cells exacerbates experimental visceral leishmaniasis

scientific article

Activation of natural killer (NK) T cells during murine cytomegalovirus infection enhances the antiviral response mediated by NK cells

scientific article

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors

scientific article (publication date: October 2009)

Adaptive immunity maintains occult cancer in an equilibrium state

scientific article published on 18 November 2007

Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis

scientific article published on 24 May 2016

Adoptive immunotherapy combined with intratumoral TLR agonist delivery eradicates established melanoma in mice

scientific article

Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice

scholarly article

Adoptive transfer of chimeric FcepsilonRI gene-modified human T cells for cancer immunotherapy

scientific article published on November 2006

Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection

scientific article published on 19 July 2005

Age-dependent, polyclonal hyperactivation of T cells is reduced in TNF-negative gld/gld mice.

scientific article published on 23 October 2008

Agonistic CD40 mAb-Driven IL12 Reverses Resistance to Anti-PD1 in a T-cell-Rich Tumor.

scientific article

Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation.

scientific article published on 28 April 2015

Alloreactive natural killer cells in hematopoietic stem cell transplantation

scientific article published on 16 August 2010

Alpha-galactosylceramide (KRN7000) suppression of chemical- and oncogene-dependent carcinogenesis

scientific article

Alpha-galactosylceramide: potential immunomodulatory activity and future application

scientific article published on January 2004

An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneum

scientific article

An immunosurveillance mechanism controls cancer cell ploidy

scientific article

An intact immune system is required for the anticancer activities of histone deacetylase inhibitors

scientific article published on 24 October 2013

Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

scholarly article

Anti-CD137 enhances anti-CD20 therapy of systemic B-cell lymphoma with altered immune homeostasis but negligible toxicity

scientific article published on 30 June 2016

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

scientific article

Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy

scientific article (publication date: 26 April 2011)

Anti-IL-23 monoclonal antibody synergizes in combination with targeted therapies or IL-2 to suppress tumor growth and metastases

scientific article published on 31 January 2011

Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells

scientific article published on 19 July 2013

Anti-T cell monoclonal antibodies for in vivo treatment of cardiac allograft rejection in mice

scientific article published on 01 February 1989

Anti-T cell-specific immunoconjugates in mice: in vivo effects

scientific article published on 01 October 1989

Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors

article

Anti-Tumor Activity of Genetically Redirected T Cells Against Orthotopic Kidney Cancer in Mice~!2010-01-06~!2010-03-24~!2010-05-13~!

Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response

scholarly article

Antibody responses to glycolipid-borne carbohydrates require CD4+ T cells but not CD1 or NKT cells

Antibody responses to glycolipid-borne carbohydrates require CD4+ T cells but not CD1 or NKT cells

scientific article published on 01 February 2011

Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells

scientific article published on 4 April 2013

Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.

scientific article

Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors

scientific article

Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor

scientific article

Antitumor activities and on-target toxicities mediated by a TRAIL receptor agonist following cotreatment with panobinostat

article

Antitumor activity of dual-specific T cells and influenza virus

scientific article published on 2 March 2007

Antitumor activity of idarubicin-monoclonal antibody conjugates in a disseminated thymic lymphoma model

scientific article published on 01 January 1991

Apoptosis induced by the lymphocyte effector molecule perforin

scientific article

Application of CD27 as a marker for distinguishing human NK cell subsets.

scientific article published on 7 March 2008

Are We Really on the Right TRAIL?

scientific article published on 01 January 2005

Assessing Immune-Related Adverse Events of Efficacious Combination Immunotherapies in Preclinical Models of Cancer.

scientific article published on 8 August 2016

Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms

scientific article published on 07 June 2010

Autophagy and proteasome interconnect to coordinate cross-presentation through MHC class I pathway in B cells

scientific article published on 14 June 2016

BAFF and MyD88 signals promote a lupuslike disease independent of T cells

scientific article

BRAF-targeted therapy and immune responses to melanoma

scientific article published on 9 May 2013

Balancing natural killer cell activation through paired receptors

scientific article

Bench to bedside: NK cells and control of metastasis.

scientific article published on 14 October 2015

Biology and clinical observations of regulatory T cells in cancer immunology

scientific article published on January 2011

Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo

scientific journal article

Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology.

scientific article published on 14 January 2016

Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors

scientific article published on 20 August 2013

Blockade of ErbB2 and PD-L1 using a bispecific antibody to improve targeted anti-ErbB2 therapy

scientific article published on 26 August 2019

Both IFN-γ and IL-17 are required for the development of severe autoimmune gastritis

scientific article published on 15 August 2012

CCL2/CCR2-dependent recruitment of functional antigen-presenting cells into tumors upon chemotherapy

scientific article published on 3 December 2013

CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells

scientific article

CD1-restricted T cells and tumor immunity

scientific article published on January 2007

CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors

scientific article

CD1d activation and blockade: a new antitumor strategy

scientific article

CD1d-based combination therapy eradicates established tumors in mice.

scientific article

CD3bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+ T cells

scientific article published on 11 November 2014

CD4+ natural killer T cells potently augment aortic root atherosclerosis by perforin- and granzyme B-dependent cytotoxicity

scientific article published on 14 November 2014

CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer

scientific article published on February 2006

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

scientific article published on 17 June 2013

CD73 promotes resistance to HER2/ErbB2 antibody therapy

scientific article published on 30 August 2017

CD73-deficient mice are resistant to carcinogenesis

scientific article

CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis

scientific article published on 3 February 2011

CD73: a potent suppressor of antitumor immune responses

scientific article published on 07 April 2012

CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity.

scientific article published in February 2018

CIS is a potent checkpoint in NK cell-mediated tumor immunity

scientific article

CTL granules: evolution of vesicles essential for combating virus infections

scientific article

Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

scientific article

Calreticulin exposure increases cancer immunogenicity.

scientific article published in February 2007

Can NK cells be a therapeutic target in human cancer?

scientific article

Cancer Immunoediting

Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

scientific article

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

scientific article published on 08 February 2012

Cancer immunoediting and resistance to T cell-based immunotherapy

scientific article published on 01 March 2019

Cancer immunoediting by the innate immune system in the absence of adaptive immunity.

scientific article

Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion

scientific article (publication date: 25 March 2011)

Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity

scientific article

Cancer vaccines for established cancer: how to make them better?

scientific article published on April 2008

Cancer-killing, decoy-resistant interleukin-18

scientific article published on 13 June 2020

Cancer. Can cancer trigger autoimmunity?

scientific article

Cancer: novel therapeutic strategies that exploit the TNF-related apoptosis-inducing ligand (TRAIL)/TRAIL receptor pathway

scientific article published on 7 October 2006

Characterizing the anti-tumor function of adoptively transferred NK cells in vivo

scientific article published on 8 April 2010

Checkpoint Immunotherapy: Picking a Winner.

scientific article published on August 2016

Chemoimmunoconjugates for the treatment of cancer

scientific article published on January 1994

Chemokine-chemokine receptors in cancer immunotherapy

scientific article published on January 2009

Chemotherapy and radiotherapy: cryptic anticancer vaccines

scientific article published on 18 April 2010

Clarification of data used in three studies on MCA-induction of sarcoma in mice

scientific article

Classification of current anticancer immunotherapies

scientific article

Classifying Cancers Based on T-cell Infiltration and PD-L1.

scientific article published on June 2015

Clinical relevance of host immunity in breast cancer: from TILs to the clinic

scientific article published on 15 December 2015

Cloning and characterization of a novel NK cell-specific serine protease gene and its functional 5'-flanking sequences

scientific article published on January 1995

Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3

scientific article

Cloning and expression of the recombinant mouse natural killer cell granzyme Met-ase-1.

scientific article published on January 1996

Close encounters of different kinds: dendritic cells and NK cells take centre stage

scientific article

Co-blockade of immune checkpoints and adenosine A2A receptor suppresses metastasis

scientific article

Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses

scientific article published on September 2016

Co-inhibition of colony stimulating factor-1 receptor and BRAF oncogene in mouse models of BRAFV600E melanoma

scientific article published on 10 December 2015

Coinfection with Human Cytomegalovirus Genetic Variants in Transplant Recipients and Its Impact on Antiviral T Cell Immune Reconstitution

scientific article published on 8 June 2016

Combination Anti-CTLA-4 and Anti-RANKL in Metastatic Melanoma

scientific article published on 13 October 2014

Combination antibody-based cancer immunotherapy

scientific article published on 8 June 2007

Combination cancer immunotherapies tailored to the tumour microenvironment

scientific article

Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist

scholarly article

Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules

Combined anti-CD40 and anti-IL-23 monoclonal antibody therapy effectively suppresses tumor growth and metastases

scientific article published on 20 February 2014

Combined natural killer T-cell based immunotherapy eradicates established tumors in mice

scientific article published on August 2007

Comparison of the effect of IL-2 and IL-6 on the lytic activity of purified human peripheral blood large granular lymphocytes.

scientific article

Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth

scientific article published on 5 October 2010

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

scientific article published on 01 March 2020

Consensus guidelines for the detection of immunogenic cell death

scientific article published on October 2014

Consensus nomenclature for CD8(+) T cell phenotypes in cancer

scientific article published on 25 February 2015

Constitutive expression of pore-forming protein in peripheral blood gamma/delta T cells: implication for their cytotoxic role in vivo

scientific article

Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy

scientific article

Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

Contribution of Thy1+ NK cells to protective IFN-γ production during Salmonella typhimurium infections

scientific article published on 23 January 2013

Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines

scientific article published on 07 June 2013

Control of Metastasis by NK Cells

scientific article published on August 2017

Correction: Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology

scientific article published on 12 February 2016

Correction: Figure 7

Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease

scientific article published on 14 October 2007

Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development

scientific article

Cross-talk between dendritic cells and natural killer cells in viral infection

scientific article

Cutting edge: DNAX accessory molecule 1-deficient CD8+ T cells display immunological synapse defects that impair antitumor immunity

scientific article published on 13 December 2013

Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection

scientific article published in July 2003

Cutting edge: novel priming of tumor-specific immunity by NKG2D-triggered NK cell-mediated tumor rejection and Th1-independent CD4+ T cell pathway

scientific article published on January 2004

Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin

scientific article published in November 2002

Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth

scientific article

Cytokine-driven role of Srebps in killer cell metabolism

scientific article

Cytokines in cancer immunity and immunotherapy

scientific article

Cytomegalovirus MHC class I homologues and natural killer cells: an overview

scientific article

Cytotoxic lymphocyte-mediated immunotherapy

scientific article published on December 1995

Cytotoxic lymphocytes: redirecting the cell-mediated immune response for the therapy of cancer

scientific article published on June 1995

DNAM-1 control of natural killer cells functions through nectin and nectin-like proteins

scientific article

DNAM-1 expression marks an alternative program of NK cell maturation.

scientific article published on 26 March 2015

DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors

scientific article

DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases

scientific article

DNAM-1: would the real natural killer cell please stand up!

scientific article published on October 2015

Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease

scholarly article

Death receptor-induced apoptosis signalling - essential guardian against autoimmune disease.

scientific article published on 9 February 2012

Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis

scholarly article by Heidi Harjunpää et al published 2018 in OncoImmunology

Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis

scholarly article

Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1

scientific article published on 01 October 2000

Differential Recognition of CD1d-α-Galactosyl Ceramide by the Vβ8.2 and Vβ7 Semi-invariant NKT T Cell Receptors

scientific article

Differential antitumor immunity mediated by NKT cell subsets in vivo

scientific article

Differential lymphotoxin-beta and interferon gamma signaling during mouse liver regeneration induced by chronic and acute injury.

scientific article published on February 2005

Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors

scientific article

Differential regulation of interleukin-1 gene expression in human CD3− large granular lymphocytes

article

Differential requirement for Nfil3 during NK cell development.

scientific article

Differential tumor surveillance by natural killer (NK) and NKT cells.

scientific article

Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin

scientific article

Discovery of an innate cancer resistance gene?

scientific article

Dissecting the apoptotic mechanisms of chemotherapeutic drugs and lymphocytes to design effective anticancer therapies

Distinct granzyme expression in human CD3- CD56+ large granular- and CD3- CD56+ small high density-lymphocytes displaying non-MHC-restricted cytolytic activity

scientific article published on 01 January 1995

Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression

scientific article published on 16 October 2007

Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population

scholarly article

Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease.

scientific article published on 13 July 2015

Dual mechanisms of lymphocyte-mediated cytotoxicity serve to control and deliver the immune response

scientific article published on October 1995

Dual targeting of RANKL and PD-1 with a bispecific antibody improves anti-tumor immunity

scientific article published on 27 September 2019

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting.

scientific article published on 13 December 2016

Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

scientific article published in Journal of Biological Chemistry

Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity.

scientific article published on 13 November 2009

Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies

scientific article published on December 2012

Equivalent Death of P-Glycoprotein Expressing and Nonexpressing Cells Induced by the Protein Kinase C Inhibitor Staurosporine

scientific article published on 01 September 2000

Eradication of established tumors in mice by a combination antibody-based therapy

scientific article published on 7 May 2006

Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodies

scientific article

Erratum: Interleukin 21: combination strategies for cancer therapy

scholarly article published in Nature Reviews Drug Discovery

Erratum: Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells

scholarly article by Daniel M Andrews et al published April 2013 in Nature Immunology

Erratum: anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.

scientific article published in March 2015

Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype.

scientific article published on 29 April 2010

Expression in cytotoxic T lymphocytes of a single-chain anti-carcinoembryonic antigen antibody. Redirected Fas ligand-mediated lysis of colon carcinoma

scientific article published on May 1998

Expression of human perforin in a mouse cytotoxic T lymphocyte cell line: evidence for perturbation of granule-mediated cytotoxicity.

scientific article published on December 1993

Expression of recombinant human Met-ase-1: a NK cell-specific granzyme.

scientific article published on December 1995

Expression of recombinant human granzyme B. A processing and activation role for dipeptidyl peptidase I.

scientific article

Extracellular adenosine triphosphate and adenosine in cancer.

scientific article published on 26 July 2010

Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas

scientific article published on 2 February 2014

Fas ligand-mediated lysis of self bystander targets by human papillomavirus-specific CD8+ cytotoxic T lymphocytes

scientific article

Fas-ligand-mediated lysis of erbB-2-expressing tumour cells by redirected cytotoxic T lymphocytes

scientific article published on January 1999

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

scientific article

Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth

scientific article

From cancer immunosurveillance to cancer immunotherapy

scientific article published on December 2007

From mice to humans: developments in cancer immunoediting

scientific article

Functional analysis of granzyme M and its role in immunity to infection

scientific article published in September 2005

Functional dissection of the granzyme family: cell death and inflammation.

scientific article published on May 2010

Functional interactions between dendritic cells and NK cells during viral infection

scientific article published on 23 December 2002

Functional significance of the perforin/granzyme cell death pathway

scientific article

Functional subsets of mouse natural killer cells

scientific article published on December 2006

G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis

scientific article published on 19 June 2017

Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer

scientific article

Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen.

scientific article published on 4 March 2010

Generation of lymphokine-activated killer activity in T cells. Possible regulatory circuits ⬇️

scientific article published on May 15, 1991

Granule serine proteases are normal nuclear constituents of natural killer cells

scientific article published on July 1994

Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity

scientific article

Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria

scientific article published on 27 April 2011

Granzyme M

Granzyme M mediates a novel form of perforin-dependent cell death

scientific article

Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies

scientific article

Granzymes: exogenous proteinases that induce target cell apoptosis.

scientific article published on April 1995

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2+ Tumors

scientific article

HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance

HYPOTHESIS: CYTOTOXIC LYMPHOCYTE GRANULE SERINE PROTEASES ACTIVATE TARGET CELL ENDONUCLEASES TO TRIGGER APOPTOSIS

scientific article published on 01 January 1994

Harnessing the immune system in acute myeloid leukaemia

scientific article published on 11 May 2016

Her 2 in 1.

scientific article

Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin

scientific article

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

scientific article published on February 2013

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

scientific article published on 23 November 2015

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.

scientific article published in July 2013

Host perforin reduces tumor number but does not increase survival in oncogene-driven mammary adenocarcinoma.

scientific article published in June 2007

Human peripheral blood DNAM-1neg NK cells are a terminally differentiated subset with limited effector functions

scientific article published on 01 June 2019

Hypoxia-driven immunosuppression contributes to the pre-metastatic niche

scientific article published in January 2013

IFN type III: in vivo NK cell response

scientific article published in August 2015

IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2.

scientific article published on 3 March 2005

IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting

scientific article published on 24 February 2017

IFN-γ production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice

scientific article published on 28 June 2011

IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.

scientific article published on 29 June 2015

IL-17A-Producing γδ T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver.

scientific article published on 4 November 2015

IL-2 and IL-6 synergize to augment the pore-forming protein gene expression and cytotoxic potential of human peripheral blood T cells

scientific article published on 01 August 1990

IL-21 Modulates Activation of NKT Cells in Patients with Stage IV Malignant Melanoma

scientific article published on 18 October 2013

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

scientific article

IL-21 enhances tumor rejection through a NKG2D-dependent mechanism

scientific article

IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy

scientific article published on May 2006

IL-21 induces the functional maturation of murine NK cells

scientific journal article

IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production

scientific article published in March 2007

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

scientific article

IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis

scientific article

IL-7 and the thymus dictate the NK cell 'labor market'

scientific article published on 01 November 2006

IL-7 regulation of cytotoxic lymphocytes: pore-forming protein gene expression, interferon-gamma production, and cytotoxicity of human peripheral blood lymphocytes subsets

scientific article published in December 1991

IL-8 gene expression and production in human peripheral blood lymphocyte subsets

scientific article published on June 1991

Imatinib Mesylate — Uncovering a Fast Track to Adaptive Immunity

scientific article published on 01 May 2006

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

scientific article

Immune responses in multiple myeloma: role of the natural immune surveillance and potential of immunotherapies

scientific article

Immune surveillance of tumors

scientific article

Immune-mediated dormancy: an equilibrium with cancer

scientific article published on 30 May 2008

Immunochemotherapy of a murine thymoma with the use of idarubicin monoclonal antibody conjugates

scientific article published on 01 February 1988

Immunogenic anti-cancer chemotherapy as an emerging concept

scientific article published on 23 June 2008

Immunology. Making macrophages eat cancer

scientific article published in July 2013

Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody

scientific article published on September 1993

Immunoregulation in cancer-bearing hosts. Down-regulation of gene expression and cytotoxic function in CD8+ T cells ⬇️

scientific article published on 01 August 1992

Immunosurveillance and therapy of multiple myeloma are CD226 dependent

scientific article published on 20 April 2015

Immunosurveillance and therapy of multiple myeloma are CD226 dependent

scientific article published on 15 June 2015

Immunotherapeutic strategies as adjuncts to local radiotherapy.

scientific article published in February 2012

Immunotherapy of cancer using systemically delivered gene-modified human T lymphocytes

scientific article published in July 2004

Improved Treatment of Breast Cancer with Anti-HER2 Therapy Requires Interleukin-21 Signaling in CD8+ T Cells

scientific article published on 7 January 2016

Improved mouse models to assess tumour immunity and irAEs after combination cancer immunotherapies

scientific article

Improving cancer immunotherapy by targeting tumor-induced immune suppression

scientific article published on March 2011

Increased antitumor effect of immunoconjugates and tumor necrosis factor in vivo

scientific article published on 01 July 1988

Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice

scientific article published in February 2002

Induction of natural killer T cell-dependent alloreactivity by administration of granulocyte colony-stimulating factor after bone marrow transplantation

scientific article published on 29 March 2009

Induction of potent NK cell-dependent anti-myeloma cytotoxic T cells in response to combined mapatumumab and bortezomib

scientific article

Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy

scientific article

Induction of tumor-specific T cell memory by NK cell–mediated tumor rejection

scientific article published on 17 December 2001

Inflammation and immune surveillance in cancer

scientific article published on 24 December 2011

Influenza A infection enhances cross-priming of CD8+ T cells to cell-associated antigens in a TLR7- and type I IFN-dependent fashion

scientific article published on 18 October 2010

Inhibition of early tumor growth requires J alpha 18-positive (natural killer T) cells.

scientific article

Innate immune recognition and suppression of tumors

scientific article

Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells

scientific article

Innate immunity defines the capacity of antiviral T cells to limit persistent infection

scientific article

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells.

scientific article published on 14 August 2014

Innate tumor immune surveillance

scientific article published on January 2007

Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer

scientific article published on 17 July 2017

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

scientific article

Interleukin 2 induction of pore-forming protein gene expression in human peripheral blood CD8+ T cells

scientific article

Interleukin 2 receptor signaling regulates the perforin gene through signal transducer and activator of transcription (Stat)5 activation of two enhancers

scientific article

Interleukin 21 enhances antibody-mediated tumor rejection

scientific article

Interleukin 21: a key player in lymphocyte maturation

scientific article

Interleukin 21: combination strategies for cancer therapy

scientific article published on March 2008

Interleukin-12 from CD103+ Batf3-Dependent Dendritic Cells Required for NK-Cell Suppression of Metastasis

scientific article published on 25 October 2017

Interleukin-21 and Cancer Therapy

Interleukin-21 signaling: functions in cancer and autoimmunity

scientific article published on December 2007

Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites

scientific article published on August 2015

Intrathymic NKT cell development is blocked by the presence of alpha-galactosylceramide

scientific article published on July 2003

Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration

scientific article published on 15 April 2009

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth

scientific article published on December 2001

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

scientific article published on 01 January 2001

KHYG-1, a model for the study of enhanced natural killer cell cytotoxicity

scientific article published on October 2005

Killing by cytotoxic T cells and natural killer cells: multiple granule serine proteases as initiators of DNA fragmentation

scientific article

Letter to the Editor

scientific article published on 01 January 2004

Liberating tumor immunity

article published in 2012

Limited correlation between human thymus and blood NKT?cell content revealed by an ontogeny study of paired tissue samples

scientific article published on 01 May 2005

Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis

scientific article published on February 1996

Locally administered TLR7 agonists drive systemic antitumor immune responses that are enhanced by anti-CD40 immunotherapy

scientific article

Long-term retention of mature NK1.1+ NKT cells in the thymus.

scientific article published in April 2006

Lymphocyte-mediated immunosurveillance of epithelial cancers?

scientific article published on 01 August 2001

Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance

scientific article published on July 2013

Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma

scientific article

Mechanisms of TIGIT-driven immune suppression in cancer

Mechanisms of cytotoxicity used by human peripheral blood CD4+ and CD8+ T cell subsets. The role of granule exocytosis

scientific article published on 01 July 1993

Mechanistic studies of transforming growth factor-beta inhibition of IL-2-dependent activation of CD3- large granular lymphocyte functions. Regulation of IL-2R beta (p75) signal transduction ⬇️

scientific article published on June 1, 1991

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

scientific article published on October 2009

Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells

scientific article (publication date: December 1993)

Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation

scientific article published on 14 February 2014

Modulation of antitumour immune responses by intratumoural Stat1 expression

scientific article published on 20 August 2013

Molecular Pathways: Targeting CD96 and TIGIT for Cancer Immunotherapy

scientific article published on 12 September 2016

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

scientific article

Monoclonal antibody-drug/toxin immunoconjugates in transplantation

scientific article

Monoclonal antibody-mediated targeting of alkylating agents for the treatment of cancer

scientific article

Mouse Models of Tumor Immunotherapy

scientific article published on 19 January 2016

Mouse models in oncoimmunology

scientific article

Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion

scientific article published on 23 March 2010

Multiple cytolytic mechanisms displayed by activated human peripheral blood T cell subsets.

scientific article

Multiple functions of CXCL12 in a syngeneic model of breast cancer

scientific article

Multiple physiological functions for multidrug transporter P-glycoprotein?

scientific article

Multiple roles of perforin in hampering ERBB-2 (Her-2/neu) carcinogenesis in transgenic male mice.

scientific article published on 30 April 2014

Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux.

scientific article published on September 2004

Myeloid TGF-β responsiveness promotes metastases

scientific article published in August 2013

Myeloid immunosuppression and immune checkpoints in the tumor microenvironment

scientific article published on 14 October 2019

NK Cells and Cancer Immunoediting

scientific article published on 30 May 2015

NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy

scientific article

NK cell intrinsic regulation of MIP-1α by granzyme M

scientific article published on 13 March 2014

NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation

scientific article

NK cell-based cancer immunotherapy

scientific article published on April 2007

NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma

scientific article published on 11 March 2008

NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma.

scientific article published in April 2001

NK cells and apoptosis.

scientific article

NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection

scientific article published in April 2006

NK cells require IL-28R for optimal in vivo activity

scientific article published on 21 April 2015

NK cells use NKG2D to recognize a mouse renal cancer (Renca), yet require intercellular adhesion molecule-1 expression on the tumor cells for optimal perforin-dependent effector function

scientific article published on August 2006

NKG2A inhibits invariant NKT cell activation in hepatic injury

scientific article

NKG2D and cytotoxic effector function in tumor immune surveillance

scientific article

NKG2D function protects the host from tumor initiation

scientific article

NKG2D recognition and perforin effector function mediate effective cytokine immunotherapy of cancer

scientific article

NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma

scientific article published on 28 August 2012

NKT cell adjuvants in therapeutic vaccines against hematological cancers

scientific article published on January 2013

NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge

scientific article published in September 2005

NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs.

scientific article

NKT cells - conductors of tumor immunity?

scientific article

NKT cells and tumor immunity—a double-edged sword

scientific article published in December 2000

NKT cells are not critical for HSV-1 disease resolution

scientific article published on 07 November 2005

NKT cells are phenotypically and functionally diverse

scientific article published in November 1999

NKT cells: facts, functions and fallacies.

scientific article

NKT cells: what's in a name?

scientific article published in March 2004

NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma

scientific article published on 25 September 2012

NLRP3 suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases

scientific article

Natural Killer cell control of BRAF(V600E) mutant melanoma during targeted therapy

scientific article published on April 2015

Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E-mutant metastatic melanoma

scientific article

Nature's TRAIL--on a path to cancer immunotherapy

scientific article

New aspects of natural-killer-cell surveillance and therapy of cancer

scientific article

New insights into cancer immunoediting and its three component phases--elimination, equilibrium and escape

scientific article

No requirement for TRAIL in intrathymic negative selection

scientific article published on 11 January 2008

Non-classical MHC Class I molecules regulating natural killer cell function.

scientific article published on March 2013

Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas

scientific article

Normal thymocyte negative selection in TRAIL-deficient mice

scientific article

Oncolytic virus and anti-4-1BB combination therapy elicits strong antitumor immunity against established cancer

scientific article published on 7 February 2012

Opposing roles for IL-23 and IL-12 in maintaining occult cancer in an equilibrium state

scientific article

Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo

scientific article published on 08 September 2008

P-4 and RNKP-7, new granzyme-like serine proteases expressed in activated rat lymphocytes

scientific article published on 01 May 1997

P-glycoprotein Does Not Protect Cells against Cytolysis Induced by Pore-forming Proteins

scientific article published in Journal of Biological Chemistry

P-glycoprotein as a General Antiapoptotic Protein

P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation.

scientific article published in November 2002

PD1 functions by inhibiting CD28-mediated co-stimulation

scientific article published on 5 May 2017

Parallels and distinctions between T and NKT cell development in the thymus.

scientific article published on June 2004

Patients with multiple myeloma treated with thalidomide: evaluation of clinical parameters, cytokines,angiogenic markers, mast cells and marrow CD57+ cytotoxic T cells as predictors of outcome.

scientific article

Perforin and Granzymes Have Distinct Roles in Defensive Immunity and Immunopathology

scientific article published on 01 November 2006

Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis.

scientific article

Perforin-Dependent Cytolytic Responses in β2-Microglobulin-Deficient Mice

article

Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction

scientific article

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

scientific article

Perforin-mediated suppression of B-cell lymphoma

scholarly article

Perforin-mediated target-cell death and immune homeostasis

scientific article

Perioperative, Spatiotemporally Coordinated Activation of T and NK Cells Prevents Recurrence of Pancreatic Cancer

scientific article published on 27 November 2017

Peripheral natural killer cell maturation depends on the transcription factor Aiolos

scientific article

Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia

scientific article published on 08 July 2013

Phase I clinical trial of drug-monoclonal antibody conjugates in patients with advanced colorectal carcinoma: a preliminary report

scientific article published on 01 September 1989

Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors

scientific article published on 6 June 2011

Plasmodium strain determines dendritic cell function essential for survival from malaria

scientific article

Potentiation of the in vitro cytotoxicity of chlorambucil by monoclonal antibodies

scientific article published on 01 November 1986

Preclinical studies with immunoconjugates

scientific article published on January 1989

Predictors of responses to immune checkpoint blockade in advanced melanoma

scientific article published on 19 September 2017

Presumed guilty: natural killer T cell defects and human disease

scientific article

Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche.

scientific article

Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo.

scientific article

Prognostically relevant natural killer cell-mediated immunoediting in acute myeloid leukemia

scientific article published on 7 November 2013

Promoting regulation via the inhibition of DNAM-1 after transplantation

scientific article published on 21 February 2013

Prospects for TIM3-Targeted Antitumor Immunotherapy

scientific article published on 18 October 2011

Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia

scientific journal article

Purification of a factor from the granules of a rat natural killer cell line (RNK) that reduces tumor cell growth and changes tumor morphology. Molecular identity with a granule serine protease (RNKP-1) ⬇️

scientific article published on January 1, 1992

Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells

scientific article

RANKL blockade improves efficacy of PD1-PD-L1 blockade or dual PD1-PD-L1 and CTLA4 blockade in mouse models of cancer

article

Radiotherapy complements immune checkpoint blockade

scientific article

Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies

scientific article published on 8 May 2012

Receptors that interact with nectin and nectin-like proteins in the immunosurveillance and immunotherapy of cancer.

scientific article published on 28 January 2012

Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells.

scientific article published on 11 November 2012

Redirected Perforin-Dependent Lysis of Colon Carcinoma by Ex Vivo Genetically Engineered CTL

scientific article published on 01 April 2000

Redirected cytotoxic effector function. Requirements for expression of chimeric single chain high affinity immunoglobulin e receptors.

scientific article

Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma

scientific article published on January 2001

Redundancy in the immune system restricts the spread of HSV-1 in the central nervous system (CNS) of C57BL/6 mice

scientific article published on 2 March 2010

Regulation of antitumour immunity by CD1d-restricted NKT cells

scientific article published on June 2004

Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance.

scientific article published in April 2007

Regulation of lymphokine-activated killer activity and pore-forming protein gene expression in human peripheral blood CD8+ T lymphocytes. Inhibition by transforming growth factor-beta ⬇️

scientific article published on May 15, 1991

Report on apoptosis and immunity, 31 May-3 June 2005, Palm Cove, Queensland, Australia.

scientific article

Response to 'A cancer immunosurveillance controversy'

scholarly article by Robert D Schreiber et al published January 2004 in Nature Immunology

Response: dexamethasone dose alters expression of NK activating receptors in vivo

Retraction Note to: Retraction: Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors

scientific article published on 01 August 2006

Reversal in the immunodominance hierarchy in secondary CD8+ T cell responses to influenza A virus: roles for cross-presentation and lysis-independent immunodomination

scientific article

Role of T Cells in -Galactosylceramide-Mediated Immunity

scientific article published on 12 March 2012

Role of TNF in lymphocyte-mediated cytotoxicity

scientific article

Role of monoclonal antibodies in the therapy of solid tumours

scientific article published on November 1988

Roles of the RANKL–RANK axis in antitumour immunity — implications for therapy

article

SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo

scientific article published on 4 September 2009

Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases

scientific article

Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma

scientific article

Selective enhancement of antitumor activity of N-acetyl melphalan upon conjugation to monoclonal antibodies

scientific article published on 01 January 1987

Sensitivity of a novel model of mammary cancer stem cell-like cells to TNF-related death pathways

scientific article published on 24 January 2012

Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer

scientific article

Sequential production of interferon-gamma by NK1.1+ T cells and natural killer cells is essential for the antimetastatic effect of alpha -galactosylceramide

scientific article published on 01 February 2002

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

scientific article published on 22 July 2012

Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

scientific article published on November 2002

SnapShot: Extrinsic Apoptosis Pathways

Specific targeting of chlorambucil to tumors with the use of monoclonal antibodies

scientific article published on 01 March 1986

Stable IL-10: A New Therapeutic that Promotes Tumor Immunity

scientific article published on 01 December 2011

Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma

scientific article published on 30 April 2010

Stress gets under your skin

scientific article published on 01 February 2008

Studying the role of the immune system on the antitumor activity of a Hedgehog inhibitor against murine osteosarcoma

scientific article

Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-glycoprotein-expressing cells

scientific article

Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates

scientific article published on February 2004

Supernatural T cells: genetic modification of T cells for cancer therapy

scientific article

Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy

scientific article published on 19 January 2016

Suppression of lymphoma and epithelial malignancies effected by interferon gamma

scientific article published in July 2002

Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade

scientific article published on 03 September 2019

Sustained antigen-specific antitumor recall response mediated by gene-modified CD4+ T helper-1 and CD8+ T cells

scientific article published in December 2007

Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies

scientific article published on 01 June 2004

Systemic administration of IL-33 induces a population of circulating KLRG1hi type 2 innate lymphoid cells and inhibits type 1 innate immunity against multiple myeloma

scientific article published on 04 August 2020

T cells gene-engineered with DAP12 mediate effector function in an NKG2D-dependent and major histocompatibility complex-independent manner

scientific article published on 16 September 2005

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

scientific article

TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy

scientific article

TIGIT immune checkpoint blockade restores CD8+ T-cell immunity against multiple myeloma

scientific article published on 09 July 2018

TIGIT predominantly regulates the immune response via regulatory T cells.

scientific article

TIM3(+)FOXP3(+) regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer

scientific article published on April 2013

TNF contributes to the immunopathology of perforin/Fas ligand double deficiency

scientific article published on 01 October 2002

TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice

scientific article published on 01 October 2005

TNF-related apoptosis-inducing ligand as a therapeutic agent in autoimmunity and cancer

scientific article

TNFR2/BIRC3-TRAF1 signaling pathway as a novel NK cell immune checkpoint in cancer

scientific article published on 11 October 2017

TRAIL and its receptors as targets for cancer therapy

scientific article published in October 2004

TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver

scientific article published on 09 November 2004

TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity.

scientific article published on October 2014

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

scientific article

Targeting CD39 in cancer

scientific article published on 29 July 2020

Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs

scientific article

Targeting cancer-derived adenosine: new therapeutic approaches

scientific article published on 17 July 2014

Targeting cancer-related inflammation in the era of immunotherapy

scientific article published on 21 December 2016

Targeting death-inducing receptors in cancer therapy

scientific article published on May 2007

Targeting immune checkpoints in hematological malignancies

scientific article published on 12 August 2020

Targeting immunosuppressive adenosine in cancer

scientific article published on 23 October 2017

Targeting immunosuppressive adenosine in cancer

scientific article published in November 2017

Targeting natural killer cells in cancer immunotherapy

scientific article published on August 2016

Targeting regulatory T cells in tumor immunotherapy

scientific article published on 29 April 2014

Targeting the IL-12/IL-23 axis: An alternative approach to removing tumor induced immune suppression

scientific article published on 23 May 2014

Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects.

scientific article published on 23 July 2015

The Adjuvant Effects of Antibodies

scientific article

The Elusive NKT Cell Antigen--Is the Search Over?

scientific article

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

scientific article published on 9 January 2016

The Interactions of Multiple Cytokines Control NK Cell Maturation

scientific article published on 25 October 2010

The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum

scientific article

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

scientific article published on 24 August 2020

The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies

scientific article published on 20 July 2020

The TRAIL apoptotic pathway in cancer onset, progression and therapy

scientific article published on October 2008

The anticancer effects of HDAC inhibitors require the immune system

scientific article published on January 2014

The atypical chemokine receptor CCX-CKR regulates metastasis of mammary carcinoma via an effect on EMT.

scientific article published on 15 July 2014

The cellular uptake and cytotoxicity of chlorambucil-monoclonal antibody conjugates

scientific article published on August 1987

The combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects

scientific article published on May 2012

The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis

scientific article published on June 1998

The early kinetics of cytomegalovirus-specific CD8+ T-cell responses are not affected by antigen load or the absence of perforin or gamma interferon

scientific article published on 12 March 2008

The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene

scientific article

The gene encoding a human natural killer cell granule serine protease, Met-ase 1, maps to chromosome 19p13.3

scientific article

The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte granule tryptases.

scientific article

The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress.

scientific article

The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

scientific article

The immune checkpoint CD96 defines a distinct lymphocyte phenotype and is highly expressed on tumor-infiltrating T cells

scientific article published on 17 October 2018

The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy

scientific article published on 26 October 2010

The in vitro and in vivo anti-tumour activity of N-AcMEL-(Fab')2 conjugates

scientific article published on January 1987

The influence of CD1d in postselection NKT cell maturation and homeostasis

scientific article published on September 2005

The interaction between murine melanoma and the immune system reveals that prolonged responses predispose for autoimmunity

scientific article published on February 2013

The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence

scientific article published on 14 December 2012

The mode of action of methotrexate-monoclonal antibody conjugates

scientific article published on April 1987

The natural killer cell serine protease gene Lmet1 maps to mouse chromosome 10

article

The peptide loop consisting of amino acids 139–157 of human granzyme B (fragmentin 2) contains an immunodominant epitope recognized by the mouse

scientific article published on 01 August 1995

The pre-metastatic niche: finding common ground

scientific article

The question begs — what is the role of P-glycoprotein in normal physiology?

scientific article published on 01 January 1998

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

scientific journal article

The relative role of lymphocyte granule exocytosis versus death receptor-mediated cytotoxicity in viral pathophysiology

scientific article

The role of NK cells and CD39 in the immunological control of tumor metastases

scientific article published on 02 April 2019

The role of NK cells in autoimmune disease

scientific article

The role of natural killer cells in tumor control--effectors and regulators of adaptive immunity

scientific article

The roles of interferon-γ and perforin in antiviral immunity in mice that differ in genetically determined NK-cell-mediated antiviral activity

scientific article published on 30 June 2009

The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity

scientific article (publication date: May 2003)

The use of anthracycline-antibody complexes for specific antitumor activity

scientific article

The use of chimeric human Fc(epsilon) receptor I to redirect cytotoxic T lymphocytes to tumors

scientific article

The use of monoclonal antibody conjugates for the diagnosis and treatment of cancer

scientific article published on April 1987

Three agonist antibodies in combination with high-dose IL-2 eradicate orthotopic kidney cancer in mice

scientific article

Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy

scientific article published on 19 September 2013

Toll-Like Receptor Triggering and T-Cell Costimulation Induce Potent Antitumor Immunity in Mice.

scientific article published in December 2009

Toll-like receptor 3 regulates NK cell responses to cytokines and controls experimental metastasis

scientific article

Transforming growth factor-β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells.

scientific article published on 3 May 2016

Transient Foxp3(+) regulatory T-cell depletion enhances therapeutic anticancer vaccination targeting the immune-stimulatory properties of NKT cells

scientific article

Translational biology of osteosarcoma

scientific article

Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody

scientific article published on 29 April 2008

Tumor ablation by gene-modified T cells in the absence of autoimmunity.

scientific article published on 23 November 2010

Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity

scientific article published on 19 January 2010

Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.

scientific article

Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial

scientific article

Tumor necrosis factor is dispensable for the success of immunogenic anticancer chemotherapy

scientific article published on 30 April 2013

Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype

scientific article

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis

scientific article

Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer

scientific article published on January 2003

Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin

scientific article published on April 2002

Tumour immunology

scholarly article by Mark J. Smyth published April 2007 in Current Opinion in Immunology

Type I NKT-cell-mediated TNF-α is a positive regulator of NLRP3 inflammasome priming.

scientific article

Type I interferon and cancer immunoediting

scientific article published on 01 July 2005

Type I interferons in anticancer immunity

scientific article published on June 2015

Type I natural killer T cells suppress tumors caused by p53 loss in mice

scientific article published on 20 February 2009

Unexpectedly, induction of cytotoxic T lymphocytes enhances the humoral response after DNA immunization

scientific article

Unlocking the secrets of cytotoxic granule proteins

scientific article

Use of the 5'-flanking region of the mouse perforin gene to express human Fc gamma receptor I in cytotoxic T lymphocytes

scientific article published on April 1994

Use of vasoactive agents to increase tumor perfusion and the antitumor efficacy of drug-monoclonal antibody conjugates

scientific article published on 01 December 1987

Working with NKT cells — pitfalls and practicalities [Curr. Opin. Immunol. 17 (2005) 448]

Working with NKT cells--pitfalls and practicalities

scientific article

XENOSPECIFIC CD8+ CYTOTOXIC T LYMPHOCYTE GENERATION

scientific article published on 01 May 1998

XENOSPECIFIC CYTOTOXIC T LYMPHOCYTES

scientific article published on 01 April 1997

Xenospecific cytotoxic T lymphocytes use perforin- and Fas-mediated lytic pathways

scientific article published on November 1996

cDNA cloning of granzyme J.

scientific article published in January 1997

m144, a murine cytomegalovirus (MCMV)-encoded major histocompatibility complex class I homologue, confers tumor resistance to natural killer cell-mediated rejection

scientific article

Paulina is supported by:

About Paulina

Help