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List of works by Marival Bermejo

"Development of Fixed Dose Combination Products" Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy

scientific article published on 06 June 2019

A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

scientific article published on 17 January 2020

A new mathematical approach for the estimation of the AUC and its variability under different experimental designs in preclinical studies.

scientific article published on 25 January 2011

A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability.

scientific article

A provisional biopharmaceutical classification of the top 200 oral drug products in the United States, Great Britain, Spain, and Japan

scientific article published on 01 November 2006

An exploratory study of two Caco-2 cell models for oral absorption: a report on their within-laboratory and between-laboratory variability, and their predictive capacity.

scientific article published on October 2010

Assessment of the Regulatory Methods for the Comparison of Highly Variable Dissolution Profiles.

scientific article published on 29 August 2016

Availability of Authorizations from EMA and FDA for Age-Appropriate Medicines Contained in the WHO Essential Medicines List for Children 2019

scientific article published on 01 April 2020

Bias in estimation of transporter kinetic parameters from overexpression systems: Interplay of transporter expression level and substrate affinity.

scientific article published on 12 October 2006

Biomimetic Artificial Membrane Permeability Assay over Franz Cell Apparatus Using BCS Model Drugs

scientific article published on 19 October 2020

Biopharmaceutical optimization in neglected diseases for paediatric patients by applying the provisional paediatric biopharmaceutical classification system

scientific article published on 17 July 2018

Candesartan Cilexetil In Vitro-In Vivo Correlation: Predictive Dissolution as a Development Tool

scientific article published on 06 July 2020

Classification of WHO Essential Oral Medicines for Children Applying a Provisional Pediatric Biopharmaceutics Classification System

scientific article published on 31 October 2019

Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2.

scientific article published on 29 December 2017

Comparison of segmental-dependent permeability in human and in situ perfusion model in rat.

scientific article

Computer simulations for bioequivalence trials: Selection of analyte in BCS class II and IV drugs with first-pass metabolism, two metabolic pathways and intestinal efflux transporter

scientific article published on 13 February 2018

Computer simulations for bioequivalence trials: selection of analyte in BCS drugs with first-pass metabolism and two metabolic pathways

scientific article published on 13 October 2010

Computer simulations of bioequivalence trials: selection of design and analyte in BCS drugs with first-pass hepatic metabolism: Part II. Non-linear kinetics.

scientific article

Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin

scientific article published on 14 January 2019

Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation.

scientific article published on 19 April 2018

Determination of intestinal permeability using in situ perfusion model in rats: Challenges and advantages to BCS classification applied to digoxin

scientific article published on 13 September 2018

Development of an ion-pair to improve the colon permeability of a low permeability drug: Atenolol

scientific article published on 20 August 2016

Drug gastrointestinal absorption in rat: Strain and gender differences

scientific article published on 27 July 2015

Effect of antiinflammatory agents on the accumulation of ofloxacin in human polymorphonuclear leukocytes

scientific article published in June 1999

Effects of ethanol on intestinal absorption of drugs: in situ studies with ciprofloxacin analogs in acute and chronic alcohol-fed rats

scientific article published on 01 August 1999

Enhancing Oral Absorption of β-Lapachone: Progress Till Date.

scientific article

Erratum: Hens, B.; et al. Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola<sup>®</sup> on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b). <i>Pharmaceutics</i>, 202

scientific article published on 25 November 2020

Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach.

scientific article published on 25 January 2018

Evaluation of the intestinal permeability of rosemary (Rosmarinus officinalis L.) extract polyphenols and terpenoids in Caco-2 cell monolayers.

scientific article

Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

scientific article published on 15 March 2019

Exploring different strategies for imbalanced ADME data problem: case study on Caco-2 permeability modeling.

scientific article

Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project

scientific article published on 23 June 2018

Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach

scientific article published on 29 May 2018

Gated Mesoporous Silica Nanocarriers for a "Two-Step" Targeted System to Colonic Tissue

scientific article published on 24 October 2017

Giardiasis: characteristics, pathogenesis and new insights about treatment

scientific article published on 01 January 2018

Hydrogels: an interesting strategy for smart drug delivery.

scientific article published in February 2013

IVIVC approach based on carbamazepine bioequivalence studies combination

scientific article published in August 2017

Impact on intestinal permeability of pediatric hyperosmolar formulations after dilution: Studies with rat perfusion method

scientific article published on 27 December 2018

In Silico Prediction of Caco-2 Cell Permeability by a Classification QSAR Approach

scientific article

In Situ Perfusion Model in Rat Colon for Drug Absorption Studies: Comparison with Small Intestine and Caco-2 Cell Model.

scientific article

In Vitro Dissolution as a Tool for Formulation Selection: Telmisartan Two-Step IVIVC

scientific article published on 17 May 2018

In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance

scientific article published on 06 September 2018

In vitro-in situ permeability and dissolution of fexofenadine with kinetic modeling in the presence of sodium dodecyl sulfate

scientific article published on 11 August 2011

In vitro-in vivo correlations: general concepts, methodologies and regulatory applications

scientific article published on 02 July 2015

In-situ intestinal rat perfusions for human Fabs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches

scientific article published on 13 January 2015

Influence of polyunsaturated fatty acids on Cortisol transport through MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model.

scientific article published on 21 December 2010

Innovative in vitro method to predict rate and extent of drug delivery to the brain across the blood-brain barrier

scientific article published on 9 September 2013

Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers ⬇️

scientific article published on 31 March 2019

Intestinal Permeability of β-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures.

scientific article published on 24 November 2015

Intrinsic absolute bioavailability prediction in rats based on in situ absorption rate constants and/or in vitro partition coefficients: 6-fluoroquinolones.

scientific article published in November 2000

Investigating drug absorption from the colon: Single-pass vs. Doluisio approaches to in-situ rat large-intestinal perfusion.

scientific article published on 10 May 2017

Investigating the Discriminatory Power of BCS-Biowaiver in Vitro Methodology to Detect Bioavailability Differences between Immediate Release Products Containing a Class I Drug.

scientific article published on 19 August 2015

Investigation to Explain Bioequivalence Failure in Pravastatin Immediate-Release Products

scientific article published on 09 December 2019

Ion-pair approach coupled with nanoparticle formation to increase bioavailability of a low permeability charged drug

scientific article published on 20 December 2018

Ion-pair strategy for enabling amifostine oral absorption: rat in situ and in vivo experiments.

scientific article published on 2 May 2013

Ionic Hydrogel Based on Chitosan Cross-Linked with 6-Phosphogluconic Trisodium Salt as a Drug Delivery System.

scientific article published on 14 March 2018

Kinetic Modeling of Triamterene Intestinal Absorption and its Inhibition by Folic Acid and Methotrexate

scientific article published on May 1, 2003

Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells.

scientific article published on April 2005

Linking the Gastrointestinal Behavior of Ibuprofen with The Systemic Exposure Between and Within Humans - Part 1: Fasted State

scientific article published on 12 November 2018

Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State

scientific article published on 12 November 2018

Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs

scientific article published on 3 November 2018

Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs

scientific article published on 24 July 2017

Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate-CO Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical Significance

scientific article published on 26 October 2018

Mathematical modeling of oral absorption and bioavailability of a fluoroquinolone after its precipitation in the gastrointestinal tract

scientific article published on 8 January 2013

Mathematical modelling of in situ and in vitro efflux of ciprofloxacin and grepafloxacin.

scientific article published on 27 October 2005

Measuring the Impact of Gastrointestinal Variables on the Systemic Outcome of Two Suspensions of Posaconazole by a PBPK Model

scientific article published on 29 March 2018

Mechanistic analysis and experimental verification of bicarbonate-controlled enteric coat dissolution: Potential in vivo implications

scientific article published on 11 March 2019

Modified nonsink equation for permeability estimation in cell monolayers: comparison with standard methods.

scientific article published on 7 April 2014

PAMPA--a drug absorption in vitro model 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones.

scientific article published in March 2004

PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen

scientific article published on 14 December 2017

Permeability Study of Polyphenols Derived from a Phenolic-Enriched Hibiscus sabdariffa Extract by UHPLC-ESI-UHR-Qq-TOF-MS.

scientific article published on 7 August 2015

Population pharmacokinetic model of lithium and drug compliance assessment

scientific article published on 16 November 2016

Preclinical models for colonic absorption, application to controlled release formulation development

scientific article published on 06 July 2018

Progress in the development of early diagnosis and a drug with unique pharmacology to improve cancer therapy

scientific article published on October 2008

Provisional Classification and in Silico Study of Biopharmaceutical System Based on Caco-2 Cell Permeability and Dose Number

scientific article published on 15 May 2013

Purely in silico BCS classification: science based quality standards for the world's drugs

scientific article published on 23 October 2013

Segmental-dependent permeability throughout the small intestine following oral drug administration: Single-pass vs. Doluisio approach to in-situ rat perfusion

scientific article published on 22 September 2016

Semi-mechanistic Pharmacokinetic/Pharmacodynamic model of three pegylated rHuEPO and ior®EPOCIM in New Zealand rabbits.

scientific article published on 2 May 2018

Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid.

scientific article

Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives.

scientific article

TOPS-MODE approach for the prediction of blood-brain barrier permeation

scientific article published on 01 July 2004

The Use of Rule-Based and QSPR Approaches in ADME Profiling: A Case Study on Caco-2 Permeability.

scientific article published on 15 May 2013

Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors.

scientific article

Unique pharmacology of KAR-2, a potential anti-cancer agent: absorption modelling and selective mitotic spindle targeting.

scientific article

Usefulness of Caco-2/HT29-MTX and Caco-2/HT29-MTX/Raji B Coculture Models To Predict Intestinal and Colonic Permeability Compared to Caco-2 Monoculture

scientific article

Validation of a biophysical drug absorption model by the PATQSAR system.

scientific article published in April 1999

Validation of a semi-physiological model for caffeine in healthy subjects and cirrhotic patients.

scientific article published on 2 April 2015

Validation of phenol red versus gravimetric method for water reabsorption correction and study of gender differences in Doluisio's absorption technique

scientific article published on 2 June 2014

Variability of permeability estimation from different protocols of subculture and transport experiments in cell monolayers.

scientific article published on 26 November 2014

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