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List of works by Matilde Merino-Sanjuán

A Bayesian method for predicting 5-fluorouracil pharmacokinetic parameters following short-term infusion in patients with colorectal cancer.

scientific article published in June 2003

A Pharmacokinetic Model for Evaluating the Impact of Hepatic and Intestinal First-Pass Loss of Saquinavir in the Rat

scientific article published on 26 October 2010

A Wide Linearity Range Method for the Determination of Lenalidomide in Plasma by High-Performance Liquid Chromatography: Application to Pharmacokinetic Studies

scientific article published on 08 March 2016

A model-based meta-analysis of sofosbuvir-based treatments in chronic hepatitis C patients

scientific article

A multilevel object-oriented modelling methodology for physiologically-based pharmacokinetics (PBPK): Evaluation with a semi-mechanistic pharmacokinetic model

scientific article published on 09 January 2020

A preclinical study to model taurine pharmokinetics in the undernourished rat.

scientific article published in April 2018

Adsorption of methotrexate and calcium leucovorin onto cholestyramine in vitro

scientific article

Animal model of undernutrition for the evaluation of drug pharmacokinetics.

scientific article published in November 2011

Antibiotic-loaded Bone Cement as Prophylaxis in Total Joint Replacement.

scientific article published in November 2017

Assessment of the Inter-Batch Variability of Microstructure Parameters in Topical Semisolids and Impact on the Demonstration of Equivalence

scientific article published on 01 October 2019

Bioactivity of Ceftazidime and Fluconazole Included in Polymethyl Methacrylate Bone Cement for Use in Arthroplasty.

scientific article published on 4 May 2017

Bioavailability and Pharmacokinetic Model for Ritonavir in the Rat

scientific article published on 01 March 2007

Cellular Uptake of Glucocerebrosidase in Gaucher Patients Receiving Enzyme Replacement Treatment.

scientific article

Chitosan–xanthan gum microparticle-based oral tablet for colon-targeted and sustained delivery of quercetin

scientific article published on 06 June 2014

Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2.

scientific article published on 29 December 2017

Comparison of segmental-dependent permeability in human and in situ perfusion model in rat.

scientific article

Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation

scientific article published on 19 April 2018

Design, characterization and in vitro evaluation of 5-aminosalicylic acid loaded N-succinyl-chitosan microparticles for colon specific delivery

scientific article published on 01 February 2012

Development of an ion-pair to improve the colon permeability of a low permeability drug: Atenolol

scientific article published on 20 August 2016

Development of antibiotic loaded biodegradable matrices to prevent superficial infections associated to total knee arthroplasty

scientific article published on 11 May 2019

Effect of age on systemic exposure and haematological toxicity of carboplatin in advanced non-small cell lung cancer patients

scientific article

Enhancement of nortriptyline penetration through human epidermis: influence of chemical enhancers and iontophoresis.

scientific article published in April 2008

Enzyme-responsive silica mesoporous supports capped with azopyridinium salts for controlled delivery applications

scientific article published on 7 December 2012

Hydroxypropylmethylcellulose films for the ophthalmic delivery of diclofenac sodium.

scientific article published on 13 September 2012

IVIVC approach based on carbamazepine bioequivalence studies combination

scientific article published in August 2017

Impact of Undernutrition on the Pharmacokinetics and Pharmacodynamics of Anticancer Drugs: A Literature Review

scientific article published on 29 March 2017

Impact of nutritional status on the oral bioavailability of leucine administered to rats as part of a standard enteral diet

scientific article published on 02 February 2011

Impact of nutritional status on the pharmacokinetics of erlotinib in rats.

scientific article published on 12 March 2015

Improving oral bioavailability and pharmacokinetics of liposomal metformin by glycerolphosphate-chitosan microcomplexation.

scientific article published on 8 March 2013

In Situ Perfusion Model in Rat Colon for Drug Absorption Studies: Comparison with Small Intestine and Caco-2 Cell Model.

scientific article

In Situ Study of the Effect of Naringin, Talinolol and Protein-Energy Undernutrition on Intestinal Absorption of Saquinavir in Rats

scientific article published on 26 May 2011

In vitro-in vivo correlations: general concepts, methodologies and regulatory applications

scientific article published on 02 July 2015

In-situ intestinal rat perfusions for human Fabs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches

scientific article published on 13 January 2015

Influence of Inter- and Intra-Batch Variability on the Sample Size Required for Demonstration of Equivalent Microstructure of Semisolid Dosage Forms

scientific article published on 28 November 2020

Intestinal transport of cefuroxime axetil in rats: absorption and hydrolysis processes

scientific article published in March 2002

Investigating drug absorption from the colon: Single-pass vs. Doluisio approaches to in-situ rat large-intestinal perfusion.

scientific article published on 10 May 2017

Investigation of Different Iontophoretic Currents Profiles for Short-Term Applications in Cosmetics

scientific article published on 07 December 2018

Ion-pair approach coupled with nanoparticle formation to increase bioavailability of a low permeability charged drug

scientific article published on 20 December 2018

Levofloxacin effect on erlotinib absorption. Evaluation of the interaction in undernutrition situations through population pharmacokinetic analysis in rats.

scientific article published on 18 January 2017

Monitoring the quality of the hospital pharmacoterapeutic process by sentinel patient program

scientific article published on 01 March 2018

Multi-output Model with Box-Jenkins Operators of Quadratic Indices for Prediction of Malaria and Cancer Inhibitors Targeting Ubiquitin- Proteasome Pathway (UPP) Proteins.

scientific article

Multi-output model with Box-Jenkins operators of linear indices to predict multi-target inhibitors of ubiquitin-proteasome pathway

scientific article published on 10 March 2015

N-Succinyl-chitosan systems for 5-aminosalicylic acid colon delivery: In vivo study with TNBS-induced colitis model in rats

scientific article published on 23 June 2011

PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen

scientific article published on 14 December 2017

Pharmacokinetic models for the saturable absorption of cefuroxime axetil and saturable elimination of cefuroxime.

scientific article published in February 2004

Pharmacokinetics and absolute bioavailability of oral cefuroxime axetil in the rat.

scientific article

Physiologically-Based Pharmacokinetic/Pharmacodynamic Model of MBQ-167 to Predict Tumor Growth Inhibition in Mice

scientific article published on 15 October 2020

Population modelling to describe pharmacokinetics of amiodarone in rats: Relevance of plasma protein and tissue depot binding

scientific article published on 17 November 2006

Population pharmacokinetics of lenalidomide in multiple myeloma patients.

scientific article published on 30 December 2016

Quality Improvement Project to Evaluate Discharge Prescriptions in Children With Cystic Fibrosis

scientific article published on 06 September 2019

Relationship between Glucocerebrosidase Activity and clinical response to Enzyme Replacement Therapy in patients with Gaucher Disease type I.

scientific article published on 8 February 2018

Relationship between rheological properties, in vitro release and in vivo equivalency of topical formulations of diclofenac

scientific article published on 09 November 2019

Segmental-dependent permeability throughout the small intestine following oral drug administration: Single-pass vs. Doluisio approach to in-situ rat perfusion

scientific article published on 22 September 2016

Transdermal nortriptyline hydrocloride patch formulated within a chitosan matrix intended to be used for smoking cessation

scientific article published on 09 February 2010

Use of nonlinear mixed effect modeling for the intestinal absorption data: application to ritonavir in the rat.

scientific article

Usefulness of Caco-2/HT29-MTX and Caco-2/HT29-MTX/Raji B Coculture Models To Predict Intestinal and Colonic Permeability Compared to Caco-2 Monoculture

scientific article

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