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List of works by Dietbert Neumann

2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes

scientific article

AICAR Protects against High Palmitate/High Insulin-Induced Intramyocellular Lipid Accumulation and Insulin Resistance in HL-1 Cardiac Cells by Inducing PPAR-Target Gene Expression

scientific article published on 16 November 2015

AMP-Activated Protein Kinase Signalling ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2019

AMP-activated Protein Kinase Up-regulates Mitogen-activated Protein (MAP) Kinase-interacting Serine/Threonine Kinase 1a-dependent Phosphorylation of Eukaryotic Translation Initiation Factor 4E.

scientific article published on 13 July 2016

AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2.

scientific article published on 14 July 2006

AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase

scientific article published on 21 April 2008

AMP-activated protein kinase undergoes nucleotide-dependent conformational changes

scientific article

AMP-activated protein kinase β-subunit requires internal motion for optimal carbohydrate binding

scientific article published on January 2012

AMPK activation by long chain fatty acyl analogs

scientific article published on 3 September 2008

AMPK beta subunits display isoform specific affinities for carbohydrates

scientific article

AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits

scientific article published on 01 July 2006

AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

scientific article published on 25 February 2020

Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.

scientific article published on 9 January 2006

Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species

scientific article

Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells

scientific article published on 17 August 2016

An automated home-built low-cost fermenter suitable for large-scale bacterial expression of proteins in Escherichia coli

scientific article published on 01 August 2008

Assessment of AMPK-Stimulated Cellular Long-Chain Fatty Acid and Glucose Uptake

scientific article published on 01 January 2018

Augmenting Vacuolar H+-ATPase Function Prevents Cardiomyocytes from Lipid-Overload Induced Dysfunction

scientific article published on 23 February 2020

Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process

scientific journal article

Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake.

scientific article published on 3 June 2014

Cardiac contraction-induced GLUT4 translocation requires dual signaling input

scientific article published on 29 June 2015

Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex.

scientific article published in July 2007

Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK)

scientific article

Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism

scientific article published on 16 April 2008

Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase

scientific article published on 30 August 2006

Dual mechanisms regulating AMPK kinase action in the ischemic heart.

scientific article published on 13 January 2005

Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells.

scientific article published on 7 March 2005

Fluorescent labelling of membrane fatty acid transporter CD36 (SR-B2) in the extracellular loop

scientific article published in PLoS ONE

GSK-3 Inhibitors: Anti-Diabetic Treatment Associated with Cardiac Risk? : Editorial to: "The Impact of Chronic Glycogen Synthase Kinase-3 Inhibition on Remodeling of Normal and Pre-Diabetic Rat Hearts." by Barbara Huisamen et al.

scientific article published on 16 June 2016

Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway

scientific article

Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix.

scientific article published on 03 August 2009

Human embryonic stem cell-derived cardiomyocytes as an in vitro model to study cardiac insulin resistance

scientific article

Hypoxia impairs adaptation of skeletal muscle protein turnover- and AMPK signaling during fasting-induced muscle atrophy

scientific article published in PLoS ONE

Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis

scientific article published on 21 May 2003

In Vitro Methods to Study AMPK.

scientific article published on January 2016

Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.

scientific article

Is TAK1 a Direct Upstream Kinase of AMPK?

scholarly article by Dietbert Neumann published in August 2018

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

scientific journal article

Letter by Neumann et al Regarding Article, “Myostatin Regulates Energy Homeostasis in the Heart and Prevents Heart Failure”

MK3 modulation affects BMI1-dependent and independent cell cycle check-points

scientific article published on 8 April 2015

MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis

scientific article published on 09 September 2016

MSP: an emerging player in metabolic syndrome

scientific article

Macrophage Stimulating Protein Enhances Hepatic Inflammation in a NASH Model

scientific article

Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli

scientific article published in August 2003

Molecular mechanism of lipid-induced cardiac insulin resistance and contractile dysfunction

scientific article

Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes

scientific article

New candidate targets of AMP-activated protein kinase in murine brain revealed by a novel multidimensional substrate-screen for protein kinases.

scientific article

Novel candidate substrates of AMP-activated protein kinase identified in red blood cell lysates.

scientific article published on 25 June 2010

PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis

scientific article

PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells

scientific article

Palmitate-Induced Vacuolar-Type H+-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction

scientific article published on 16 March 2017

Pharmacological Targeting of AMP-Activated Protein Kinase and Opportunities for Computer-Aided Drug Design

scientific article

Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effects

scientific article

Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.

scientific article

Post-translational modifications of CD36 (SR-B2): Implications for regulation of myocellular fatty acid uptake

scientific article published on 8 September 2016

Protein kinase-D1 overexpression prevents lipid-induced cardiac insulin resistance

scientific article

Putative Role of Protein Palmitoylation in Cardiac Lipid-Induced Insulin Resistance

scientific article published on 11 December 2020

Regulation of brain-type creatine kinase by AMP-activated protein kinase: interaction, phosphorylation and ER localization

scientific article published on 12 April 2014

Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells

scientific article

Small heterodimer partner (SHP) contributes to insulin resistance in cardiomyocytes.

scientific article

Structural Properties of AMP-activated Protein Kinase

scientific article published in Journal of Biological Chemistry

The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells

scientific article published on 19 August 2010

The Phosphocreatine Circuit: Molecular and Cellular Physiology of Creatine Kinases, Sensitivity to Free Radicals, and Enhancement by Creatine Supplementation

article

The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target

scientific article published on 29 November 2018

The interaction between AMPKβ2 and the PP1-targeting subunit R6 is dynamically regulated by intracellular glycogen content

scientific article published on February 2016

The recruitment of AMP-activated protein kinase to glycogen is regulated by autophosphorylation

scientific article published on 19 March 2015

Tracking and quantification of 32P-labeled phosphopeptides in liquid chromatography matrix-assisted laser desorption/ionization mass spectrometry

scientific article

Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase

scientific article

β1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells.

scientific article published in June 2018

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