List of works - Laura Belvisi

A 3D QSAR CoMFA study of non-peptide angiotensin II receptor antagonists

scientific article published on 01 December 1996

A 3D QSAR approach to the search for geometrical similarity in a series of nonpeptide angiotensin II receptor antagonists

scientific article published on 01 April 1994

A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein.

scientific article

A critical assessment of force field accuracy against NMR data for cyclic peptides containing β-amino acids

scientific article published on 01 June 2018

A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts.

scientific article

A potent integrin antagonist from a small library of cyclic RGD pentapeptide mimics including benzyl-substituted azabicycloalkane amino acids

scientific article

Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics

scientific article

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

scientific article published on 27 November 2013

Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist

scientific article

Bromine-Promoted Glycosidation of Conformationally Superarmed Thioglycosides

scientific article published on 20 August 2019

Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

scientific article published on March 2015

Crystal Structure of Human E-Cadherin-EC1EC2 in Complex with a Peptidomimetic Competitive Inhibitor of Cadherin Homophilic Interaction

scientific article

Cyclic RGD Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin Ligands

Cyclic RGD and isoDGR Integrin Ligands Containing cis-2-amino-1-cyclopentanecarboxylic (cis-β-ACPC) Scaffolds

scientific article published on 16 December 2020

Cyclic RGD-containing functionalized azabicycloalkane peptides as potent integrin antagonists for tumor targeting.

scientific article published in April 2009

Cyclic RGD-peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands.

scientific article published in November 2009

Cyclic isoDGR and RGD peptidomimetics containing bifunctional diketopiperazine scaffolds are integrin antagonists.

scientific article

Cyclic isoDGR peptidomimetics as low-nanomolar αvβ3 integrin ligands.

scientific article published on 19 February 2013

Design and synthesis of nonpeptide angiotensin II receptor antagonists featuring acyclic imidazole-mimicking structural units

scientific article published on 01 November 1998

Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.

scientific article

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

scientific article

Determination of the binding epitope of RGD-peptidomimetics to αvβ3 and α(IIb)β3 integrin-rich intact cells by NMR and computational studies.

scientific article published on June 2013

Development of isoxazoline-containing peptidomimetics as dual αvβ3 and α5β1 integrin ligands

scientific article published on 26 September 2011

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

scientific article

Fast Cyclization of a Proline-Derived Self-Immolative Spacer Improves the Efficacy of Carbamate Prodrugs

scientific article published on 22 January 2020

First round of a focused library of cholera toxin inhibitors

scientific article published on 9 June 2007

Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition.

scientific article published in May 2005

Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders.

scientific article

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

scientific article published in 2012

Innovative Linker Strategies for Tumor-Targeted Drug Conjugates

scientific article published on 20 September 2019

Insights into the Binding of Cyclic RGD Peptidomimetics to α5β1 Integrin by using Live-Cell NMR And Computational Studies

scientific article

Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ₆ Integrin by Biochemical and Molecular Docking Studies

scientific article published on 21 September 2017

Metadynamics Simulations Rationalise the Conformational Effects Induced by N-Methylation of RGD Cyclic Hexapeptides

scientific article published on 6 August 2015

Modulation of αvβ₃- and α₅β₁-integrin-mediated adhesion by dehydro-β-amino acids containing peptidomimetics.

scientific article published on 12 June 2013

Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin αV β3.

scientific article published on 17 August 2017

N-3-Substituted Pyrimidinones as Potent, Orally Active, AT1 Selective Angiotensin II Receptor Antagonists

scientific article published on 01 November 1995

Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin-Targeted Conjugate

scientific article published on 27 December 2018

New Insights into the Molecular Mechanism of E-Cadherin-Mediated Cell Adhesion by Free Energy Calculations

scientific article published on 01 April 2015

New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics

scientific article published on 26 February 2016

New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins

scientific article

Nonpeptide Angiotensin II Receptor Antagonists. Synthesis, in vitro Activity, and Molecular Modeling Studies of N-[(Heterobiaryl)methyl]imidazoles

scientific article published on 01 November 1994

Potent integrin antagonists from a small library of RGD-including cyclic pseudopeptides.

scientific article

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

scientific article

STD and trNOESY NMR study of receptor-ligand interactions in living cancer cells.

scientific article published on 3 February 2011

Second generation of fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin

scientific article published on 07 July 2011

Simulation of carbohydrate-protein interactions: computer-aided design of a second generation GM1 mimic.

scientific article published on February 2001

Stem-Like Cancer Cells in a Dynamic 3D Culture System: A Model to Study Metastatic Cell Adhesion and Anti-Cancer Drugs

scientific article published on 13 November 2019

Structural investigations of isomeric oxidised forms of hyperforin by HPLC-NMR and HPLC-MSn

scientific article published in September 2003

Structure-activity relationship of Ca2+ channel blockers: A study using conformational analysis and chemometric methods

scientific article published on 01 December 1991

Synthesis and Biological Evaluation of RGD and isoDGR-Monomethyl Auristatin Conjugates Targeting Integrin αV β3

scientific article published on 22 March 2019

Synthesis and biological evaluation of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers

scientific article

Synthesis and conformational analysis of an α-d-mannopyranosyl-(1→2)-α-d-mannopyranosyl-(1→6)-α-d-mannopyranose mimic

scientific article published on 24 March 2007

Synthesis and conformational studies of peptidomimetics containing a new bifunctional diketopiperazine scaffold acting as a beta-hairpin inducer.

scientific article published on 13 December 2007

Synthesis of Gd and (68)Ga complexes in conjugation with a conformationally optimized RGD sequence as potential MRI and PET tumor-imaging probes.

scientific article

Synthesis, Characterization, and Biological Evaluation of a Dual-Action Ligand Targeting αvβ3 Integrin and VEGF Receptors

scientific article

Targeting integrins: insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids

scientific article

Thermodynamically-Weighted Conformational Ensemble of Cyclic RGD Peptidomimetics from NOE Data.

scientific article

Transferred-NOE NMR experiments on intact human platelets: receptor-bound conformation of RGD-peptide mimics.

scientific article published on 29 November 2007

Tumor Targeting with an isoDGR-Drug Conjugate

scientific article published on 27 April 2017

αvβ3 Integrin-Targeted Peptide/Peptidomimetic-Drug Conjugates: In-Depth Analysis of the Linker Technology

scientific article published on July 2015

List of works by Laura Belvisi

A 3D QSAR CoMFA study of non-peptide angiotensin II receptor antagonists

A 3D QSAR approach to the search for geometrical similarity in a series of nonpeptide angiotensin II receptor antagonists

A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein.

A critical assessment of force field accuracy against NMR data for cyclic peptides containing β-amino acids

A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts.

A potent integrin antagonist from a small library of cyclic RGD pentapeptide mimics including benzyl-substituted azabicycloalkane amino acids

Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist

Bromine-Promoted Glycosidation of Conformationally Superarmed Thioglycosides

Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

Crystal Structure of Human E-Cadherin-EC1EC2 in Complex with a Peptidomimetic Competitive Inhibitor of Cadherin Homophilic Interaction

Cyclic RGD Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin Ligands

Cyclic RGD and <i>iso</i>DGR Integrin Ligands Containing <i>cis</i>-2-amino-1-cyclopentanecarboxylic (<i>cis</i>-β-ACPC) Scaffolds

Cyclic RGD-containing functionalized azabicycloalkane peptides as potent integrin antagonists for tumor targeting.

Cyclic RGD-peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands.

Cyclic isoDGR and RGD peptidomimetics containing bifunctional diketopiperazine scaffolds are integrin antagonists.

Cyclic isoDGR peptidomimetics as low-nanomolar αvβ3 integrin ligands.

Design and synthesis of nonpeptide angiotensin II receptor antagonists featuring acyclic imidazole-mimicking structural units

Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

Determination of the binding epitope of RGD-peptidomimetics to αvβ3 and α(IIb)β3 integrin-rich intact cells by NMR and computational studies.

Development of isoxazoline-containing peptidomimetics as dual αvβ3 and α5β1 integrin ligands

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

Fast Cyclization of a Proline-Derived Self-Immolative Spacer Improves the Efficacy of Carbamate Prodrugs

First round of a focused library of cholera toxin inhibitors

Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition.

Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders.

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

Innovative Linker Strategies for Tumor-Targeted Drug Conjugates

Insights into the Binding of Cyclic RGD Peptidomimetics to α5β1 Integrin by using Live-Cell NMR And Computational Studies

Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ₆ Integrin by Biochemical and Molecular Docking Studies

Metadynamics Simulations Rationalise the Conformational Effects Induced by N-Methylation of RGD Cyclic Hexapeptides

Modulation of αvβ₃- and α₅β₁-integrin-mediated adhesion by dehydro-β-amino acids containing peptidomimetics.

Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin αV β3.

N-3-Substituted Pyrimidinones as Potent, Orally Active, AT1 Selective Angiotensin II Receptor Antagonists

Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin-Targeted Conjugate

New Insights into the Molecular Mechanism of E-Cadherin-Mediated Cell Adhesion by Free Energy Calculations

New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics

New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins

Nonpeptide Angiotensin II Receptor Antagonists. Synthesis, in vitro Activity, and Molecular Modeling Studies of N-[(Heterobiaryl)methyl]imidazoles

Potent integrin antagonists from a small library of RGD-including cyclic pseudopeptides.

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

STD and trNOESY NMR study of receptor-ligand interactions in living cancer cells.

Second generation of fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin

Simulation of carbohydrate-protein interactions: computer-aided design of a second generation GM1 mimic.

Stem-Like Cancer Cells in a Dynamic 3D Culture System: A Model to Study Metastatic Cell Adhesion and Anti-Cancer Drugs

Structural investigations of isomeric oxidised forms of hyperforin by HPLC-NMR and HPLC-MSn

Structure-activity relationship of Ca2+ channel blockers: A study using conformational analysis and chemometric methods

Synthesis and Biological Evaluation of RGD and isoDGR-Monomethyl Auristatin Conjugates Targeting Integrin αV β3

Synthesis and biological evaluation of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers

Synthesis and conformational analysis of an α-d-mannopyranosyl-(1→2)-α-d-mannopyranosyl-(1→6)-α-d-mannopyranose mimic

Synthesis and conformational studies of peptidomimetics containing a new bifunctional diketopiperazine scaffold acting as a beta-hairpin inducer.

Synthesis of Gd and (68)Ga complexes in conjugation with a conformationally optimized RGD sequence as potential MRI and PET tumor-imaging probes.

Synthesis, Characterization, and Biological Evaluation of a Dual-Action Ligand Targeting αvβ3 Integrin and VEGF Receptors

Targeting integrins: insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids

Thermodynamically-Weighted Conformational Ensemble of Cyclic RGD Peptidomimetics from NOE Data.

Transferred-NOE NMR experiments on intact human platelets: receptor-bound conformation of RGD-peptide mimics.

Tumor Targeting with an isoDGR-Drug Conjugate

αvβ3 Integrin-Targeted Peptide/Peptidomimetic-Drug Conjugates: In-Depth Analysis of the Linker Technology