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List of works by Andrew L. Kung

18F-FDG-PET/CT imaging of drug-induced metabolic changes in genetically engineered mouse lung cancer models.

scientific article

A Class of Human Proteins that Deliver Functional Proteins into Mammalian Cells In Vitro and In Vivo ⬇️

scientific article published on July 29, 2011

A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma.

scientific article published on 31 October 2016

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

scientific article

A novel noninvasive model of endometriosis for monitoring the efficacy of antiangiogenic therapy

scientific article

A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo

scientific article

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.

scientific article published on 31 October 2003

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.

scientific article

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

scientific article published on November 2010

AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/β-catenin signaling pathway

scientific article published on 03 May 2013

Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice.

scientific article published on 23 July 2015

Acute gastrointestinal graft-vs-host disease is associated with increased enteric bacterial bloodstream infection density in pediatric allogeneic hematopoietic cell transplant recipients

scientific article published on 5 May 2015

Adipocytes sensitize melanoma cells to environmental TGF-β cues by repressing the expression of miR-211

scientific article published on 23 July 2019

Allogeneic Hematopoietic Cell Transplantation for Children with Sickle Cell Disease Is Beneficial and Cost-Effective: A Single-Center Analysis

scientific article published on 20 January 2015

An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells

scientific article

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

scientific article

An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma

scientific article

Anti-apoptosis mechanisms in malignant gliomas.

scientific article published on January 2008

Anti-inflammatory properties of histone deacetylase inhibitors: a mechanistic study

scientific article published on February 2012

Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cells

scientific article published on 26 September 2008

Antimyeloma activity of heat shock protein-90 inhibition.

scientific article published on 18 October 2005

Antiproliferative effects of CDK4/6 inhibition in CDK4-amplified human liposarcoma in vitro and in vivo

scientific article

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

scientific article (publication date: 16 September 2011)

BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia

scientific article

Bacterial bloodstream infections in pediatric allogeneic hematopoietic stem cell recipients before and after implementation of a central line-associated bloodstream infection protocol: A single-center experience

scientific article published on July 2016

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

scientific article

Beneficial effects of combining a type II ATP competitive inhibitor with an allosteric competitive inhibitor of BCR-ABL for the treatment of imatinib-sensitive and imatinib-resistant CML.

scientific article published on 27 May 2010

CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications.

scientific article published on 16 April 2013

CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas

scientific article published in November 2006

CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.

scientific article

Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

scientific article

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.

scientific article published on February 2005

Characterization of a novel fusion gene EML4-NTRK3 in a case of recurrent congenital fibrosarcoma.

scientific article published on October 2015

Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency ⬇️

scientific article published on April 17, 2012

Clinical Implementation of Genomic Sequencing in Pediatric Oncology: Identification and Valuation of Resources and Costs Associated with Next-Generation Sequencing

scientific article published on 26 October 2014

Co-clinical trials demonstrate superiority of crizotinib to chemotherapy in ALK-rearranged non-small cell lung cancer and predict strategies to overcome resistance

scientific article published on 10 December 2013

Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer

scientific article published on 21 February 2013

Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case

scientific article published on October 2015

Computational repositioning and preclinical validation of pentamidine for renal cell cancer.

scientific article

Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities

scientific article

Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.

scientific article

Cyclin B1 expression in HeLa S3 cells studied by flow cytometry.

scientific article published in April 1994

Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism

scientific article

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

scientific article published on March 2014

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

scientific journal article

Differential disruption of EWS-FLI1 binding by DNA-binding agents

scientific article

Differentiation of NUT midline carcinoma by epigenomic reprogramming

scientific article

Direct inhibition of the NOTCH transcription factor complex

scientific article

Discovery and characterization of novel mutant FLT3 kinase inhibitors

scientific article published on 31 August 2010

Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.

scientific article

Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFR , Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants

scientific article

Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity

scientific article published on 20 September 2006

Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer

scientific article published on 17 September 2013

Efficacy of tacrolimus/mycophenolate mofetil as acute graft-versus-host disease prophylaxis and the impact of subtherapeutic tacrolimus levels in children after matched sibling donor allogeneic hematopoietic cell transplantation

scientific article published on 20 December 2014

Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells

scientific article

Examining the utility of patient-derived xenograft mouse models

scientific article published in May 2015

Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.

scientific article published in March 2018

Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation

scientific article

Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer

scientific article

Favorable outcome of allogeneic hematopoietic stem cell transplantation for relapsed or refractory acute promyelocytic leukemia in childhood

scientific article published on 01 November 2004

Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers

scientific article published on 18 May 2022

Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition ⬇️

scientific article published on January 23, 2012

Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo

scientific article published on January 2009

Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C/vascular endothelial growth factor receptor 2 expression and signaling in experimental endometriosis in vivo.

scientific article

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

scientific article published on November 2008

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling

scientific article

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

scientific article

High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma

scientific article published on 27 March 2013

Human herpesvirus-6 viremia is not associated with poor clinical outcomes in children following allogeneic hematopoietic cell transplantation

scientific article published on 29 August 2015

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features ⬇️

scientific article published on March 6, 2012

Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF.

scientific article

Identification of AML1-ETO modulators by chemical genomics

scientific article

Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach

scientific article published on April 2015

Impact of palifermin on incidence of oral mucositis and healthcare utilization in children undergoing autologous hematopoietic stem cell transplantation for malignant diseases

scientific article

Implementation of next generation sequencing into pediatric hematology-oncology practice: moving beyond actionable alterations

scientific article published on 23 December 2016

In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging

scientific article published in September 2005

In vivo imaging method to distinguish acute and chronic inflammation

scientific article published on 16 August 2013

In vivo imaging of endogenous enzyme activities using luminescent 1,2-dioxetane compounds

scientific article published on 24 June 2015

In vivo imaging of inflammatory phagocytes

scientific article published in September 2012

Inactivation of a single copy of Crebbp selectively alters pre-mRNA processing in mouse hematopoietic stem cells

scientific article

Incongruity of imaging using fluorescent 2-DG conjugates compared to 18F-FDG in preclinical cancer models

scientific article published on 01 October 2012

Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene

scientific article

Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib

scientific article

Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification

scientific article published in February 2003

Inhibition of inflammatory arthritis using fullerene nanomaterials

scientific article

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

scientific article published in March 2004

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

scholarly article

Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma.

scientific article published on September 2012

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

scientific article published on 04 February 2013

Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas

scientific article published on 19 January 2011

MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment.

scientific article

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

scientific article published in July 2011

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

scientific article

Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer

scientific article published on 28 May 2013

Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia

scientific article

Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm

scientific article

Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation

scientific article

Molecular and cellular effects of NEDD8-activating enzyme inhibition in myeloma.

scientific article published on 12 January 2012

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma

scientific article published on September 2014

Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation

scientific article

Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination

scientific article

Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

scientific article

NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis

scientific article published on 25 September 2014

New cast for a new era: preclinical cancer drug development revisited.

scientific article published on 03 September 2013

Noninvasive bioluminescence imaging of luciferase expressing intracranial U87 xenografts: correlation with magnetic resonance imaging determined tumor volume and longitudinal use in assessing tumor growth and antiangiogenic treatment effect

scientific article published on February 2006

Noninvasive imaging of tumor burden and molecular pathways in mouse models of cancer.

scientific article

Novel anti-B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma.

scientific article

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF ⬇️

scientific article published on March 7, 2013

Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.

scientific article

Optical techniques for tracking multiple myeloma engraftment, growth, and response to therapy ⬇️

scientific article published on January 1, 2011

Overcoming challenges to meaningful informed consent for whole genome sequencing in pediatric cancer research.

scientific article published on April 2015

P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment ⬇️

scientific article published on November 16, 2011

Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage

scientific article published on 27 June 2008

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

scientific article

Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells

scientific article

Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells

scientific article published on 9 January 2008

Practices and pitfalls of mouse cancer models in drug discovery.

scientific article published on January 2007

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

scientific article published on 19 January 2012

Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma

scientific article

Preclinical magnetic resonance imaging in mouse cancer models

scientific article published on 5 January 2015

Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis

scientific article published on 25 April 2006

Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line.

scientific article published on 22 November 2004

Proteomic and genetic approaches identify Syk as an AML target

scientific article

Quantitative bioluminescence imaging of mouse tumor models

scientific article published on 05 January 2015

Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins

scientific article

Risk Factors and Utility of a Risk-Based Algorithm for Monitoring Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections in Pediatric Recipients after Allogeneic Hematopoietic Cell Transplantation.

scientific article published on 29 May 2016

Risk Factors for Subtherapeutic Tacrolimus Levels after Conversion from Continuous Intravenous Infusion to Oral in Children after Allogeneic Hematopoietic Cell Transplantation.

scientific article

Role of T-bet in commitment of TH1 cells before IL-12-dependent selection

scientific article published in June 2001

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

scientific article

SYK is a critical regulator of FLT3 in acute myeloid leukemia

scientific article

Selective HDAC1/HDAC2 Inhibitors Induce Neuroblastoma Differentiation ⬇️

scientific article published on May 23, 2013

Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALL.

scientific article

Selective inhibition of BET bromodomains

scientific article

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

scientific article

Shikonin, a natural product from the root of Lithospermum erythrorhizon, is a cytotoxic DNA-binding agent

scientific article published on 17 February 2013

Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma

scientific article

Smac mimetics: implications for enhancement of targeted therapies in leukemia

scientific article

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

scientific article

Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells

scientific article

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

scientific article

Summary of COVID-19 clinical practice adjustments across select institutions

scientific article published on 19 July 2020

Suppression of tumor growth through disruption of hypoxia-inducible transcription

scientific article published in December 2000

Survival Impact of Early Post-Transplant Toxicities in Pediatric and Adolescent Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Malignant and Nonmalignant Diseases: Recognizing Risks and Optimizing Outcomes

scientific article

Systematic in vivo structure-function analysis of p300 in hematopoiesis

scientific article published on 12 October 2009

Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling

scientific article

Targeted imaging of Ewing sarcoma in preclinical models using a 64Cu-labeled anti-CD99 antibody

scientific article

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

scientific article published on 21 February 2013

Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia

scientific article

Targeting the AIB1 oncogene through mammalian target of rapamycin inhibition in the mammary gland

scientific article published in December 2006

The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth.

scientific article published on 04 March 2016

The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity

scientific article

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

scientific article published on April 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

scientific article published on 11 July 2016

The Requirement for Cyclin D Function in Tumor Maintenance ⬇️

scientific article published on October 16, 2012

The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations

scientific article

The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia ⬇️

scientific article published on February 13, 2012

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors

scientific article

Therapeutic targeting of apoptosis pathways in cancer.

scientific article published on January 2008

Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity.

scientific article published on 14 March 2010

Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors.

scientific article

Using glow stick chemistry for biological imaging

scientific article published on August 2014

Vascular endothelial growth factor C is increased in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis

scientific article published on 19 January 2013

Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies

scientific article published in December 2005

p53 targets simian virus 40 large T antigen for acetylation by CBP

scientific article

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