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List of works by Ken I. Mills

A critical appraisal of tools available for monitoring epigenetic changes in clinical samples from patients with myeloid malignancies

scientific article

A sensitive method of screening for dominant T cell clones by amplification of T cell gamma gene rearrangements with the polymerase chain reaction

scientific article published on November 1990

A simple PCR/RFLP analysis can differentiate between Candida albicans, Aspergillus niger, and Aspergillus fumigatus

scientific article published in July 2003

Abnormalities of adherent layers grown from bone marrow of patients with myelodysplasia

scientific article published on 01 December 2000

Addiction to Runx1 is partially attenuated by loss of p53 in the Eµ-Myc lymphoma model

scientific article published on 2 April 2016

Altered methylation levels in elderly acute myeloid leukaemia patients compared to elderly well individuals

scientific article

Altered splicing and cytoplasmic levels of tRNA synthetases in SF3B1-mutant myelodysplastic syndromes as a therapeutic vulnerability

scientific article published on 25 February 2019

An integrated meta-analysis approach to identifying medications with potential to alter breast cancer risk through connectivity mapping.

scientific article published on 21 December 2017

An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in LEukemia study prephase.

scientific article published on September 2008

Application of the pMHC Array to Characterise Tumour Antigen Specific T Cell Populations in Leukaemia Patients at Disease Diagnosis.

scientific article published on 22 October 2015

Assessment of the cellular response to the induced expression of defensin sense and antisense cDNA in acute promyelocytic leukemia cell lines

scientific article published on May 2005

CD200 as a prognostic factor in acute myeloid leukaemia

scientific article published on 25 January 2007

Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors

scientific article published on 01 March 2022

Changing p53 mutations with the evolution of chronic myeloid leukaemia from the chronic phase to blast crisis.

scientific article

Characterisation of genome-wide PLZF/RARA target genes

scientific article

Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group

scientific article published on 20 April 2010

Comparison of the survival implications of tumour-associated versus cancer-testis antigen expression in acute myeloid leukaemia

scientific article published on 01 February 2007

Compositional analysis gives insight into leukaemia cell lines expression profiles compared to those within patient sub-groups

scientific article published on 27 June 2017

Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC

scientific article

Consensus guidelines for microarray gene expression analyses in leukemia from three European leukemia networks

scientific article published on 08 June 2006

Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes

scientific article published on 23 May 2016

Cytogenetic and molecular analysis of relapse following bone marrow transplantation

scientific article published on 01 August 1990

DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML).

scientific article published on 12 August 2014

DNA methylation: biology and significance

scientific article

Deregulation of genes related to iron and mitochondrial metabolism in refractory anemia with ring sideroblasts

scientific article published on 8 May 2015

Detecting DNA methylation using the methylated CpG island amplification and microarray technique

scientific article

Detection and analysis of DNA methylation by pyrosequencing

scientific article published in January 2012

Differential TERT promoter methylation and response to 5-aza-2'-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death.

scientific article

Differential display as an approach to study differentiation and differentiation therapy in AML.

scientific article

Differential expression of SHP-1 in chronic myeloid leukemia.

scientific article published on 30 October 2014

Distinct poor prognostic subgroups of acute myeloid leukaemia, FLT3-ITD and P-glycoprotein-positive, have contrasting levels of FOXO1.

scientific article published on 8 November 2013

Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts

scientific article published on 26 March 2008

Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL.

scientific article published on 6 July 2012

Elevated expression of the leukemia-associated antigen SSX2IP predicts survival in acute myeloid leukemia patients who lack detectable cytogenetic rearrangements

scientific article published on 01 January 2009

Entinostat prevents leukemia maintenance in a collaborating oncogene-dependent model of cytogenetically normal acute myeloid leukemia

scientific article published in July 2013

Epigenetic Gene Mutations Impact on Outcome in Acute Myeloid Leukaemia

scientific article

Erythropoietin drives breast cancer progression by activation of its receptor EPOR

scientific article

Ex vivo purging by adenoviral p53 gene therapy does not affect NOD-SCID repopulating activity of human CD34+ cells

scientific article

False-positive results with PCR to detect leukaemia-specific transcript.

scientific article published in April 1990

Focal xanthogranulomatous pyelonephritis presenting as a renal tumor with vena caval thrombus

scientific article published on 01 July 1998

GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways

scientific article published on 27 January 2016

Gene expression profiling for the diagnosis and prognosis of acute myeloid leukaemia.

scientific article published on May 2008

Gene expression profiling in MDS and AML: potential and future avenues.

scientific article published on 29 March 2011

Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes.

scientific article published on 31 August 2012

HOXA/PBX3 knockdown impairs growth and sensitizes cytogenetically normal acute myeloid leukemia cells to chemotherapy

scientific article published on 28 March 2013

Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling.

scientific article

High FUS/TLS expression in acute myeloid leukaemia samples

scientific article published on 01 February 2000

High and low, but not intermediate, PRAME expression levels are poor prognostic markers in myelodysplastic syndrome at disease presentation

scientific article published on 18 April 2013

Highly purified CD38+ and CD38- sub-clones derived from the same chronic lymphocytic leukemia patient have distinct gene expression signatures despite their monoclonal origin

scientific article published on 8 February 2007

Homozygous MHC genotypes and longevity

scientific article published on 01 September 1994

Hoxa6 potentiates short-term hemopoietic cell proliferation and extended self-renewal.

scientific article

Human major histocompatibility complex contains several leukemia susceptibility genes

scientific article published on January 1994

Identification and validation of the dopamine agonist bromocriptine as a novel therapy for high-risk myelodysplastic syndromes and secondary acute myeloid leukemia.

scientific article published on 28 December 2015

Identification of Gene Expression–Based Prognostic Markers in the Hematopoietic Stem Cells of Patients With Myelodysplastic Syndromes

article

Identification of a retinoic acid responsive aldoketoreductase expressed in HL60 leukaemic cells

scientific article

Identification of transcription factors expressed during ATRA-induced neutrophil differentiation of HL60 cells

scientific article published on October 1998

Immunotherapy of myeloid leukaemia.

scientific article published on 20 December 2006

Increased circulating normal and BCR-ABL+Ve progenitor numbers in Philadelphia chromosome-positive acute myeloid leukaemia

scientific article published in November 2002

Increased heterozygosity for MHC class II lineages in newborn males

scientific article published on 01 August 2002

Increasing methylation of the calcitonin gene during disease progression in sequential samples from CML patients

scientific article published on 01 September 1996

Influence of the major histocompatibility complex on age at onset of chronic lymphoid leukaemia

scientific article published in January 1996

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

scientific article published on 11 March 2012

Inter-Laboratory Evaluation of a Next-Generation Sequencing Panel for Acute Myeloid Leukemia

scientific article

Living long and ageing well: is epigenomics the missing link between nature and nurture?

scientific article published on 02 July 2015

Long term outcome in Lambert-Eaton myasthenic syndrome without lung cancer

scientific article

Low-dose salinomycin induces anti-leukemic responses in AML and MLL.

scientific article published on 06 September 2016

Methods for the molecular analysis of cancer. An overview.

scientific article

Microarray analysis of tumour antigen expression in presentation acute myeloid leukaemia

scientific article published on August 2005

Microarray for epigenetic changes: gene expression arrays.

scientific article

Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome

scientific article published on 14 May 2009

Molecular similarity between myelodysplastic form of chronic myelomonocytic leukemia and refractory anemia with ring sideroblasts

scientific article published on 12 October 2012

Mutational spectrum defines primary and secondary myelofibrosis

scientific article published on January 2014

New prognostic markers, determined using gene expression analyses, reveal two distinct subtypes of chronic myelomonocytic leukaemia patients

scientific article published on 6 March 2012

New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia

scientific article published on 22 January 2020

Novel observation of three FLT3 codons mutated in tandem in an elderly acute myeloid leukaemia patient

scientific article published on 01 January 2006

Nuclear factor-kappaB as a potential therapeutic target for the novel cytotoxic agent LC-1 in acute myeloid leukaemia

scientific article published on December 2008

Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia.

scientific article published on 08 August 2013

Patients with triple-negative, JAK2V617F- and CALR-mutated essential thrombocythemia share a unique gene expression signature

scientific article published on 01 February 2021

Persistence of DNMT3A does not influence clinical outcome in acute myeloid leukaemia

scientific article published on 08 September 2016

Phosphoramidates of 2'-beta-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism

scientific article published on March 2010

Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model

scientific article published on 9 March 2010

Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia

scientific article published on 20 November 2012

Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes

scientific article published on 10 April 2012

Protein migration from transplanted nuclei in Amoeba proteus. I. The relation to the cell cycle and RNA migration, as studied by autoradiography

scientific article published on 01 November 1982

Protein migration from transplanted nuclei in Amoeba proteus. II. An electrophoretic study

scientific article published on 01 December 1981

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

scientific article

Rapid and sensitive detection of internal tandem duplication and activating loop mutations of FLT3.

scientific article published in July 2005

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia

scientific article published on 16 August 2005

Relationship between genome and epigenome--challenges and requirements for future research

scientific article published on 18 June 2014

Relationship between the debrisoquine hydroxylase polymorphism and cancer susceptibility.

scientific article

Repurposing medicinal compounds for blood cancer treatment.

scientific article published on 7 June 2015

SSX2IP expression in acute myeloid leukaemia: an association with mitotic spindle failure in t(8;21), and cell cycle in t(15;17) patients.

scientific article published on 19 November 2007

Screening for miRNA expression changes using quantitative PCR (Q-PCR).

scientific article published in January 2012

Serum profiling identifies ibrutinib as a treatment option for young adults with B-cell acute lymphoblastic leukaemia

scientific article published on 16 February 2020

Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936.

scientific article published on 14 December 2006

The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases

scientific article published on 25 July 2006

The relationship between the location of the breakpoint within the M-bcr and clinical parameters

scientific article

The sensitivity of human cells expressing RUNX1-RUNX1T1 to chemotherapeutic agents

scientific article published on 17 August 2006

The tumour antigens RAGE-1 and MGEA6 are expressed more frequently in the less lineage restricted subgroups of presentation acute myeloid leukaemia

scientific article published on 01 July 2006

Third party mediated graft rejection despite irradiation of blood products

scientific article published on 01 February 1992

Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia

scientific article

Up-regulated MSI2 is associated with more aggressive chronic myeloid leukemia.

scientific article

Validation of next generation sequencing technologies in comparison to current diagnostic gold standards for BRAF, EGFR and KRAS mutational analysis

scientific article

WTX is rarely mutated in acute myeloid leukemia

scientific article published on 06 May 2008

c-myc locus amplification and the acquisition of trisomy 8 in the evolution of chronic myeloid leukaemia

scientific article published on 01 October 1998

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