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List of works by Jason A. Roberts

A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

scientific article published on 01 November 2017

A Multicenter Randomized Trial of Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis

scientific article published on 22 July 2015

A Population Pharmacokinetic Model-Guided Evaluation of Ceftolozane-Tazobactam Dosing in Critically Ill Patients Undergoing Continuous Venovenous Hemodiafiltration

scientific article published on 20 December 2019

A Protocol for the Pharmacokinetics of Enteric Coated Mycophenolate Sodium in Lupus Nephritis (POEMSLUN): an open-label, randomised controlled trial

scientific article published on 07 August 2013

A Simulation Study Reveals Lack of Pharmacokinetic/Pharmacodynamic Target Attainment in De-escalated Antibiotic Therapy in Critically Ill Patients

scientific article published on 26 May 2015

A Systematic Review of Studies Reporting Antibiotic Pharmacokinetic Data in the Cerebrospinal Fluid of Critically Ill Patients with Uninflamed Meninges

scientific article published on 19 October 2020

A Systematic Review of the Definitions, Determinants, and Clinical Outcomes of Antimicrobial De-escalation in the Intensive Care Unit

scientific article published on 23 December 2015

A UHPLC-MS/MS method for the simultaneous determination of piperacillin and tazobactam in plasma (total and unbound), urine and renal replacement therapy effluent

scientific article published on 25 October 2017

A comparison of estimates of glomerular filtration in critically ill patients with augmented renal clearance

scientific article published on 8 June 2011

A method for determining the free (unbound) concentration of ten beta-lactam antibiotics in human plasma using high performance liquid chromatography with ultraviolet detection

A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharmacokinetics

scientific article published on 13 March 2015

A national survey of renal replacement therapy prescribing practice for acute kidney injury in Malaysian intensive care units

scientific article published on 01 August 2014

A new regimen for continuous infusion of vancomycin during continuous renal replacement therapy

scientific article published on 25 June 2013

A novel way to investigate the effects of plasma exchange on antibiotic levels: use of microdialysis

scientific article published on 4 December 2007

A pharmacokinetic case study of intravenous posaconazole in a critically ill patient with hypoalbuminaemia receiving continuous venovenous haemodiafiltration

scientific article published on 19 July 2018

A simple LC–MS/MS method using HILIC chromatography for the determination of fosfomycin in plasma and urine: Application to a pilot pharmacokinetic study in humans

scientific article published on 30 November 2014

A systematic review on clinical benefits of continuous administration of beta-lactam antibiotics

scientific article published on June 2009

A validated UHPLC-MS/MS method for the measurement of riluzole in plasma and myocardial tissue samples

scientific article

A validated method for the quantification of fosfomycin on dried plasma spots by HPLC-MS/MS: application to a pilot pharmacokinetic study in humans

scientific article published on 19 July 2015

ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO.

scientific article

Adequacy of high-dose cefepime regimen in febrile neutropenic patients with hematological malignancies

scientific article

Advances in antibiotic therapy in the critically ill

scientific article

Albumin concentration significantly impacts on free teicoplanin plasma concentrations in non-critically ill patients with chronic bone sepsis

scientific article published on 6 March 2015

Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?

article

Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy

scientific article

Amikacin Initial Dose in Critically Ill Patients: a Nonparametric Approach To Optimize A Priori Pharmacokinetic/Pharmacodynamic Target Attainments in Individual Patients

scientific article published on 22 October 2019

Amikacin dosing in the ICU: we now know more, but still not enough…

scientific article published on 10 May 2014

Ampicillin/sulbactam: its potential use in treating infections in critically ill patients

scientific article

An LC–MS/MS method to determine vancomycin in plasma (total and unbound), urine and renal replacement therapy effluent

scientific article published on 15 June 2017

An UHPLC-MS/MS method for the simultaneous determination of ampicillin and sulbactam in human plasma and urine

scientific article

An international, multicentre survey of β-lactam antibiotic therapeutic drug monitoring practice in intensive care units

scientific article published on 16 January 2014

Analysis of 12 beta-lactam antibiotics in human plasma by HPLC with ultraviolet detection

scientific article published on 24 May 2010

Analysis of capillary microsamples obtained from a skin-prick to measure vancomycin concentrations as a valid alternative to conventional sampling: A bridging study

scientific article published on 09 March 2019

Antibacterial dosing in intensive care: pharmacokinetics, degree of disease and pharmacodynamics of sepsis

scientific article published on January 2006

Antibacterial therapeutic drug monitoring in cerebrospinal fluid: difficulty in achieving adequate drug concentrations

scientific article published on 2 November 2012

Antibiotic Distribution into Cerebrospinal Fluid: Can Dosing Safely Account for Drug and Disease Factors in the Treatment of Ventriculostomy-Associated Infections?

scientific article published on 13 September 2017

Antibiotic Dosing In Critically Ill Patients Receiving Renal Replacement Therapy

scientific article published on 29 January 2016

Antibiotic Therapy of Pneumonia in Critical Care

scholarly article by Jayesh Dhanani et al published 1 May 2012 in Current Respiratory Medicine Reviews

Antibiotic dose optimization in critically ill patients.

scientific article published on 23 September 2015

Antibiotic dosing for multidrug-resistant pathogen pneumonia

scientific article published on 24 December 2016

Antibiotic dosing in critically ill patients with septic shock and on continuous renal replacement therapy: can we resolve this problem with pharmacokinetic studies and dosing guidelines?

scientific article

Antibiotic dosing in multiple organ dysfunction syndrome

scientific article published on May 2011

Antibiotic dosing in obesity: a BIG challenge

scientific article published on 10 August 2016

Antibiotic dosing in the 'at risk' critically ill patient: Linking pathophysiology with pharmacokinetics/pharmacodynamics in sepsis and trauma patients

scientific article

Antibiotic exposure at the site of infection: principles and assessment of tissue penetration

scientific article published on 28 May 2019

Antibiotic resistance--what's dosing got to do with it?

scientific article published on August 2008

Antimicrobial Stewardship in Australian Hospitals and Other Settings

scientific article

Antimicrobial chemotherapy and lung microdialysis: a review.

scientific article published on 16 October 2010

Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study

scientific article published on 09 June 2020

Antimicrobial pharmacokinetic and pharmacodynamic issues in the critically ill with severe sepsis and septic shock

scientific article published on January 2011

Antimicrobial pharmacokinetics and preclinical in vitro models to support optimized treatment approaches for uncomplicated lower urinary tract infections

scientific article published on 21 August 2020

Antimicrobial stewardship activities: a survey of Queensland hospitals.

scientific article published on November 2014

Antimicrobial stewardship of β-lactams in intensive care units

scientific article published on 22 March 2014

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

scientific article

Applying pharmacokinetic/pharmacodynamic principles in critically ill patients: optimizing efficacy and reducing resistance development

scientific article published on 2 February 2015

Are interstitial fluid concentrations of meropenem equivalent to plasma concentrations in critically ill patients receiving continuous renal replacement therapy?

scientific article published on 21 October 2014

Are new gentamicin dosing guidelines suitable for achieving target concentrations in patients with sepsis and septic shock?

scientific article published on 01 October 2016

Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?

scientific article

Assays for therapeutic drug monitoring of β-lactam antibiotics: A structured review

scientific article published on 29 July 2015

Association between augmented renal clearance and clinical outcomes in patients receiving β-lactam antibiotic therapy by continuous or intermittent infusion: a nested cohort study of the BLING-II randomised, placebo-controlled, clinical trial

scientific article published on 9 March 2017

Augmented Renal Clearance in Traumatic Brain Injury: A Single-Center Observational Study of Atrial Natriuretic Peptide, Cardiac Output, and Creatinine Clearance

scientific article published on 14 June 2016

Augmented renal clearance in critically ill patients: etiology, definition and implications for beta-lactam dose optimization

scientific article published on 25 June 2015

Augmented renal clearance in septic and traumatized patients with normal plasma creatinine concentrations: identifying at-risk patients

scientific article

Augmented renal clearance in the Intensive Care Unit: an illustrative case series

scientific article published on 21 March 2010

Augmented renal clearance: implications for antibacterial dosing in the critically ill.

scientific article published on January 2010

Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis.

scientific article

Better outcomes through continuous infusion of time-dependent antibiotics to critically ill patients?

scientific article published on August 2008

Can optimal drug dosing during ECMO improve outcomes?

scientific article published on 14 September 2013

Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models

scientific article

Can population pharmacokinetic modelling guide vancomycin dosing during continuous renal replacement therapy in critically ill patients?

scientific article published on 06 March 2013

Can therapeutic drug monitoring optimize exposure to piperacillin in febrile neutropenic patients with haematological malignancies? A randomized controlled trial

scientific article published on 7 May 2015

Can we use an ex vivo continuous hemofiltration model to describe the adsorption and elimination of meropenem and piperacillin?

scientific article published on 4 August 2015

Caspofungin Population Pharmacokinetics in Critically Ill Patients Undergoing Continuous Veno-Venous Haemofiltration or Haemodiafiltration

scientific article published on 29 December 2016

Cefazolin plasma protein binding in different human populations: more than cefazolin-albumin interaction

scientific article

Cefepime versus ceftazidime: considerations for empirical use in critically ill patients

scientific article published on 8 December 2006

Cerebrospinal fluid penetration of ceftolozane/tazobactam in critically ill patients with an indwelling external ventricular drain

scientific article published on 19 October 2020

Characterisation of 40 mg/ml and 100 mg/ml tobramycin formulations for aerosol therapy with adult mechanical ventilation

scientific article published on 18 April 2018

Characteristics of bloodstream infections in burn patients: An 11-year retrospective study

scientific article published on 18 February 2012

Characterization of Effects of Renal Replacement Therapy Modalities and Settings on Pharmacokinetics of Meropenem and Vaborbactam

scientific article published on 24 September 2018

Characterization of Poliovirus Variants Selected for Resistance to the Antiviral Compound V-073 ⬇️

scientific article published on August 13, 2012

Clearance of intravenous 5-fluorocytosine during continuous venovenous haemodiafiltration in a patient with hepatosplenic candidiasis.

scientific article published on 18 June 2009

Clinical Pharmacokinetics and Pharmacodynamics of Oxazolidinones

scientific article

Clinical implications of antibiotic pharmacokinetic principles in the critically ill.

scientific article

Comparative Evaluation of the Predictive Performances of Three Different Structural Population Pharmacokinetic Models To Predict Future Voriconazole Concentrations

scientific article published on 6 September 2016

Comparative Population Plasma and Tissue Pharmacokinetics of Micafungin in Critically Ill Patients with Severe Burn Injuries and Patients with Complicated Intra-Abdominal Infection

scientific article published on 25 July 2016

Comparative total and unbound pharmacokinetics of cefazolin administered by bolus versus continuous infusion in patients undergoing major surgery: a randomized controlled trial

scientific article published on 15 May 2017

Comparison of equal doses of continuous venovenous haemofiltration and haemodiafiltration on ciprofloxacin population pharmacokinetics in critically ill patients

scientific article published on 7 March 2016

Comparison of the accuracy and precision of pharmacokinetic equations to predict free meropenem concentrations in critically ill patients

scientific article

Conclusions regarding the efficacy of treatments for neuroleptic malignant syndrome should be tempered given poor quality data, regardless of the analysis conducted

scientific article

Continuous beta-lactam infusion in critically ill patients: the clinical evidence

scientific article

Continuous infusion of beta-lactam antibiotics in severe infections: a review of its role

scientific article published on 17 April 2007

Continuous infusion of beta-lactam antibiotics in severe sepsis: a multicenter double-blind, randomized controlled trial

scientific article published on 16 October 2012

Continuous infusion of beta-lactams in the intensive care unit--best way to hit the target?

scientific article published in May 2008

Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials

scientific article

DALI: Defining Antibiotic Levels in Intensive care unit patients: a multi-centre point of prevalence study to determine whether contemporary antibiotic dosing for critically ill patients is therapeutic

scientific article

Decreasing the time to achieve therapeutic vancomycin concentrations in critically ill patients: developing and testing of a dosing nomogram

scientific article published on 5 December 2014

Defining optimal dosing of ciprofloxacin in patients with septic shock

scientific article published on 01 June 2019

Determinants of Urinary Output Response to IV Furosemide in Acute Kidney Injury: A Pharmacokinetic/Pharmacodynamic Study.

scientific article published on 13 May 2016

Determination of Cefalothin and Cefazolin in Human Plasma, Urine and Peritoneal Dialysate by UHPLC-MS/MS: application to a pilot pharmacokinetic study in humans

scientific article published on 23 September 2015

Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds

scientific article

Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime

scientific article published on 05 March 2020

Development of multiplex PCRs for detection of common viral pathogens and agents of congenital infections.

scientific article

Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy

scientific article

Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli.

scientific article published on 3 January 2018

Does Appropriate Antibiotic Therapy Mean Only Adequate Spectrum and Timing?

scientific article

Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review

scientific article

Does Critical Illness Change Levofloxacin Pharmacokinetics?

scientific article published on 14 December 2015

Does Furosemide Increase Oxidative Stress in Acute Kidney Injury?

scientific article published on 16 August 2016

Does contemporary vancomycin dosing achieve therapeutic targets in a heterogeneous clinical cohort of critically ill patients? Data from the multinational DALI study

scientific article

Doripenem population pharmacokinetics and dosing requirements for critically ill patients receiving continuous venovenous haemodiafiltration

scientific article published on 30 May 2014

Dose Adjustment and Pharmacodynamic Considerations for Antibiotics in Severe Sepsis and Septic Shock

Dosing antibiotic prophylaxis during cardiopulmonary bypass-a higher level of complexity? A structured review

scientific article

Early target attainment of continuous infusion piperacillin/tazobactam and meropenem in critically ill patients: A prospective observational study

scientific article published on 09 April 2019

Echovirus 19 associated with a case of acute flaccid paralysis

scientific article published on 18 December 2012

Editorial Commentary: Closing the Loop--A Colistin Clinical Study to Confirm Dosing Recommendations From PK/PD Modeling

scientific article published on 15 March 2012

Editorial [Hot Topic: Relevance of Pharmacokinetics to Antibiotic Dosing in Critically Ill Patients (Guest Editor: Jason A. Roberts)]

scientific article published on 01 December 2011

Effect of Obesity on the Population Pharmacokinetics of Fluconazole in Critically Ill Patients

scientific article published on 22 August 2016

Effect of Obesity on the Population Pharmacokinetics of Meropenem in Critically Ill Patients

scientific article published on 16 May 2016

Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling.

scientific article published on 26 May 2016

Effect of intravenous GLutamine supplementation IN Trauma patients receiving enteral nutrition study protocol (GLINT Study): a prospective, blinded, randomised, placebo-controlled clinical trial

scientific article

Effect of obesity on the pharmacokinetics of antimicrobials in critically ill patients: A structured review

scientific article published on 23 February 2016

Effect of time on recovery of plasma microsamples for the quantitative determination of vancomycin

scientific article published on 26 September 2016

Electron microscope detection of an endogenous infection of retrovirus-like particles in L20B cells

scientific article published on 16 January 2013

Enterovirus D68 disease and molecular epidemiology in Australia.

scientific article published on 17 June 2015

Erratum to: Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

scientific article published on 2 August 2017

Erratum to: Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients.

scientific article published in May 2015

Evaluation of Medication-Related Problems in Medication Reviews: A Comparative Perspective ⬇️

scientific article published on July 10, 2012

Evaluation of target attainment of oral posaconazole suspension in immunocompromised children

scientific article published on 01 March 2020

Even high-dose extended infusions may not yield desired concentrations of β-lactams: the value of therapeutic drug monitoring.

scientific article published on 10 March 2015

Evidence of clinical response and stability of Ceftolozane/Tazobactam used to treat a carbapenem-resistant Pseudomonas Aeruginosa lung abscess on an outpatient antimicrobial program

scientific article

Evolutionary changes in the capsid P2 region of Australian strains of the norovirus GII.Pe_GII.4.

scientific article

Executive Summary: Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society

scientific article published on September 2016

First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis

scientific article published on 16 December 2009

Flucloxacillin dosing in critically ill patients with hypoalbuminaemia: special emphasis on unbound pharmacokinetics

scientific article published on 8 June 2010

Fundamentals of aerosol therapy in critical care

scientific article

Ganciclovir pharmacokinetics and suggested dosing in continuous venovenous haemodiafiltration

scientific article published on 13 November 2010

Global survey on nebulization of antimicrobial agents in mechanically ventilated patients: a call for international guidelines

scientific article

How can we ensure effective antibiotic dosing in critically ill patients receiving different types of renal replacement therapy?

scientific article published on 2 February 2015

How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients?

scientific article

How severe is antibiotic pharmacokinetic variability in critically ill patients and what can be done about it?

scientific article published on 30 April 2014

How should we dose antibiotics for pneumonia in the ICU?

scientific article published on April 2013

How to optimise antimicrobial prescriptions in the Intensive Care Unit: principles of individualised dosing using pharmacokinetics and pharmacodynamics

scientific article published on 09 January 2012

Impact of 30 mg/kg amikacin and 8 mg/kg gentamicin on serum concentrations in critically ill patients with severe sepsis.

scientific article

Impact of renal replacement modalities on the clearance of piperacillin-tazobactam administered via continuous infusion in critically ill patients

scientific article published on 06 July 2017

Impact of the MIC of piperacillin/tazobactam on the outcome for patients with bacteraemia due to Enterobacteriaceae: the Bacteraemia-MIC project.

scientific article published on 3 November 2015

Impact of β-lactam antibiotic therapeutic drug monitoring on dose adjustments in critically ill patients undergoing continuous renal replacement therapy

scientific article published on 21 March 2017

Implications of augmented renal clearance in critically ill patients

scientific article published on 19 July 2011

Imported case of poliomyelitis, Melbourne, Australia, 2007.

scientific article published on January 2009

Improving antibiotic dosing in special situations in the ICU: burns, renal replacement therapy and extracorporeal membrane oxygenation

scientific article published on October 2012

Improving vancomycin prescription in critical illness through a drug use evaluation process: a weight-based dosing intervention study.

scientific article

In Vivo Microdialysis To Determine Subcutaneous Interstitial Fluid Penetration and Pharmacokinetics of Fluconazole in Intensive Care Unit Patients with Sepsis

scientific article published on 23 November 2015

In-vitro adsorption and sieving coefficient of ticarcillin-clavulanate during continuous haemofiltration

scientific article published on 21 March 2019

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions

scientific article

Individualization of piperacillin dosing for critically ill patients: dosing software to optimize antimicrobial therapy ⬇️

scientific article

Influence of Renal Replacement Modalities on Amikacin Population Pharmacokinetics in Critically Ill Patients on Continuous Renal Replacement Therapy

scientific article published on 06 June 2016

Influence of sustained low-efficiency diafiltration (SLED-f) on interstitial fluid concentrations of fluconazole in a critically ill patient: Use of microdialysis

scientific article published on 28 March 2015

Infusional β-lactam antibiotics in febrile neutropenia: has the time come?

scientific article published on December 2012

Integrated pharmacokinetic-pharmacodynamic modelling to evaluate antimicrobial prophylaxis in abdominal surgery

scientific article published on 7 July 2016

Interethnic differences in pharmacokinetics of antibacterials

scientific article

Intrapulmonary pharmacokinetics of antibiotics used to treat nosocomial pneumonia caused by Gram-negative bacilli: A systematic review

scientific article published on 23 November 2018

Intratracheal Administration of Antimicrobial Agents in Mechanically Ventilated Adults: An International Survey on Delivery Practices and Safety.

scientific article

Intravenous fosfomycin for the treatment of multidrug-resistant pathogens: what is the evidence on dosing regimens?

scientific article published on 04 February 2019

Investigation of a predicted N-terminal amphipathic α-helix using atomistic molecular dynamics simulation of a complete prototype poliovirus virion

article

Is inhaled prophylactic heparin useful for prevention and Management of Pneumonia in ventilated ICU patients?: The IPHIVAP investigators of the Australian and New Zealand Intensive Care Society Clinical Trials Group

scientific article

Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patien

scientific article

Is there a role for microsampling in antibiotic pharmacokinetic studies?

scientific article published on 18 April 2016

Isolation and Characterization of Poliovirus in Cell Culture Systems

scientific article published on January 2016

Key considerations on nebulization of antimicrobial agents to mechanically ventilated patients.

scientific article published on 24 March 2017

Kidney transplant recipient's perceptions of blood testing through microsampling and venepuncture

scientific article published on 06 July 2020

Linguistic and cultural adaptation to the Portuguese language of antimicrobial dose adjustment software

scientific article published on 27 January 2020

Low flucloxacillin concentrations in a patient with central nervous system infection: the need for plasma and cerebrospinal fluid drug monitoring in the ICU.

scientific article published on 20 June 2014

Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software

scientific article published in 2022

Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society

scientific article

Meeting the challenges of advanced drug delivery in critical illness

scientific article published on 08 November 2014

Meropenem and piperacillin/tazobactam prescribing in critically ill patients: does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used?

scientific article

Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution.

scientific article published on 27 April 2009

Meropenem dosing in critically ill patients with sepsis receiving high-volume continuous venovenous hemofiltration

scientific article

Meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections due to ceftriaxone non-susceptible Escherichia coli and Klebsiella spp (the MERINO trial): study protocol for a randomised controlled trial.

scientific article published on 27 January 2015

Meropenem-Tobramycin Combination Regimens Combat Carbapenem-Resistant Pseudomonas aeruginosa in the Hollow-Fiber Infection Model Simulating Augmented Renal Clearance in Critically Ill Patients

scientific article published on 20 December 2019

Micafungin pharmacokinetic/pharmacodynamic adequacy for the treatment of invasive candidiasis in critically ill patients on continuous venovenous haemofiltration

scientific article published on 05 February 2014

Microbiologic clearance following transition from standard infusion piperacillin-tazobactam to extended-infusion for persistent Gram-negative bacteremia and possible endocarditis: A case report and review of the literature

scientific article published on 09 June 2015

Monte Carlo simulations: maximizing antibiotic pharmacokinetic data to optimize clinical practice for critically ill patients.

scientific article

Multidrug-resistant Acinetobacter baumannii infections: Current evidence on treatment options and the role of pharmacokinetics/pharmacodynamics in dose optimisation

article

Nebulization of Antiinfective Agents in Invasively Mechanically Ventilated Adults: A Systematic Review and Meta-analysis

scientific article

New Regimen for Continuous Infusion of Vancomycin in Critically Ill Patients

scientific article published on 23 May 2016

New paradigm for rapid achievement of appropriate therapy in special populations: coupling antibiotic dose optimization rapid microbiological methods

scientific article published on 14 June 2018

Optimal doripenem dosing simulations in critically ill nosocomial pneumonia patients with obesity, augmented renal clearance, and decreased bacterial susceptibility

scientific article

Optimising intraperitoneal gentamicin dosing in peritoneal dialysis patients with peritonitis (GIPD) study

scientific article

Optimising meropenem dosing in critically ill Australian Indigenous patients with severe sepsis

scientific article

Optimization of Ganciclovir use in allogeneic hematopoietic cell transplant recipients - the role of therapeutic drug monitoring

scientific article published on 17 November 2020

Optimization of flucloxacillin dosing regimens in critically ill patients using population pharmacokinetic modelling of total and unbound concentrations

scientific article published on 22 May 2020

Optimizing dosing of antibiotics in critically ill patients

scientific article published on 18 September 2015

Optimizing use of beta-lactam antibiotics in the critically ill.

scientific article published on December 2007

Oral Fosfomycin Efficacy with Variable Urinary Exposures following Single and Multiple Doses against Enterobacterales: the Importance of Heteroresistance for Growth Outcome

scientific article published on 21 February 2020

Oral Fosfomycin Treatment for Enterococcal Urinary Tract Infections in a Dynamic In Vitro Model

scientific article published on 06 April 2020

Oral ciprofloxacin activity against ceftriaxone-resistant <i>Escherichia coli</i> in an <i>in vitro</i> bladder infection model

scientific article published in 2022

Oral poliovirus vaccine type 3 from a patient with transverse myelitis is neurovirulent in a transgenic mouse model

scientific article published on 9 March 2009

Overcoming barriers to optimal drug dosing during ECMO in critically ill adult patients

scientific article published on 03 January 2019

Personalized antibiotic dosing for the critically ill

scientific article published on 14 January 2019

Pharmacodynamic Target Attainment for Cefepime, Meropenem, and Piperacillin-Tazobactam Using a Pharmacokinetic/Pharmacodynamic-Based Dosing Calculator in Critically Ill Patients

scientific article published on 27 August 2018

Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against <i>Escherichia coli</i> clinical isolates

scientific article published in 2022

Pharmacodynamic evaluation of piperacillin/tazobactam against extended-spectrum β-lactamase (ESBL)-producing versus non-ESBL-producing Escherichia coli in a hollow-fibre infection model

scientific article published in 2022

Pharmacodynamic evaluation of piperacillin/tazobactam versus meropenem against extended-spectrum β-lactamase-producing and non-producing <i>Escherichia coli</i> clinical isolates in a hollow-fibre infection model

scientific article published in 2022

Pharmacodynamic profiling of intravenous antibiotics against prevalent Gram-negative organisms across the globe: the PASSPORT Program-Asia-Pacific Region

scientific article

Pharmacodynamics of Aerosolized Fosfomycin and Amikacin against Resistant Clinical Isolates of Pseudomonas aeruginosa and Klebsiella pneumoniae in a Hollow-Fiber Infection Model: Experimental Basis for Combination Therapy

scientific article published on 24 October 2016

Pharmacodynamics of Piperacillin-Tazobactam/Amikacin Combination versus Meropenem against Extended-Spectrum β-Lactamase-Producing Escherichia coli in a Hollow Fiber Infection Model

scientific article published in 2022

Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation

scientific article published on 18 April 2012

Pharmacokinetic evaluation of fluconazole in critically ill patients

scientific article published on 02 September 2011

Pharmacokinetic evaluation of piperacillin-tazobactam

scientific article published on August 2010

Pharmacokinetic issues for antibiotics in the critically ill patient

scientific article published on March 2009

Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients: Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study

scientific article

Pharmacokinetic/Pharmacodynamics-Optimized Antimicrobial Therapy in Patients with Hospital-Acquired Pneumonia/Ventilator-Associated Pneumonia.

scientific article published on 4 June 2017

Pharmacokinetic/pharmacodynamic considerations for the optimization of antimicrobial delivery in the critically ill.

scientific article published on October 2015

Pharmacokinetics and pharmacodynamics in critically ill patients

scientific article published on August 2010

Pharmacokinetics and preliminary safety of high dose linezolid for the treatment of Gram-positive bacterial infections

scientific article published on 19 June 2015

Pharmacokinetics of Intraperitoneal Cefalothin and Cefazolin in Patients Being Treated for Peritoneal Dialysis-Associated Peritonitis

scientific article published on 13 January 2016

Pharmacokinetics of Intravenous Posaconazole in Critically Ill Patients.

scientific article published on 25 May 2018

Pharmacokinetics of Piperacillin in Critically Ill Australian Indigenous Patients with Severe Sepsis

scientific article published on 10 October 2016

Pharmacokinetics of a novel dosing regimen of oral melatonin in critically ill patients

scientific article published on September 2015

Pharmacokinetics of beta-lactam antibiotics in patients with intra-abdominal disease: a structured review

scientific article published on 08 February 2012

Pharmacokinetics of flucloxacillin during prolonged intermittent renal replacement therapy in a 76-year-old man

scientific article published on 25 October 2019

Pharmacokinetics of intraperitoneal gentamicin in peritoneal dialysis patients with peritonitis (GIPD study).

scientific article

Pharmacokinetics of meropenem and piperacillin in critically ill patients with indwelling surgical drains

scientific article published on 13 April 2013

Pharmacokinetics of meropenem in critically ill patients receiving continuous venovenous haemofiltration: a randomised controlled trial of continuous infusion versus intermittent bolus administration

scientific article published on 18 October 2014

Pharmacokinetics of piperacillin and tazobactam in plasma and subcutaneous interstitial fluid in critically ill patients receiving continuous venovenous haemodiafiltration

scientific article published on 10 February 2014

Pharmacokinetics of piperacillin in critically ill patients receiving continuous venovenous haemofiltration: A randomised controlled trial of continuous infusion versus intermittent bolus administration

scientific article published on 28 March 2015

Piperacillin penetration into tissue of critically ill patients with sepsis--bolus versus continuous administration?

scientific article published in March 2009

Pitfalls of using estimations of glomerular filtration rate in an intensive care population

scientific article published on 01 July 2011

Plasma and cerebrospinal fluid concentrations of linezolid in neurosurgical critically ill patients with proven or suspected central nervous system infections.

scientific article published on 20 August 2014

Plasma and peritoneal fluid population pharmacokinetics of micafungin in post-surgical patients with severe peritonitis

scientific article published on 14 July 2015

Plasma and target-site subcutaneous tissue population pharmacokinetics and dosing simulations of cefazolin in post-trauma critically ill patients

scientific article published on 20 January 2015

Plasma and tissue pharmacokinetics of cefazolin in patients undergoing elective and semielective abdominal aortic aneurysm open repair surgery

scientific article

Polyene Antifungals

Population Pharmacokinetics of Doripenem in Critically Ill Patients with Sepsis in a Malaysian Intensive Care Unit.

scientific article

Population Pharmacokinetics of Fosfomycin in Critically Ill Patients.

scientific article

Population Pharmacokinetics of Piperacillin in Nonobese, Obese, and Morbidly Obese Critically Ill Patients

scientific article published on 4 January 2017

Population Pharmacokinetics of Tigecycline in Critically Ill Patients with Severe Infections

scientific article published on 12 June 2017

Population Pharmacokinetics of Unbound Ceftolozane and Tazobactam in Critically Ill Patients without Renal Dysfunction

scientific article published on 23 September 2019

Population pharmacokinetics and dose simulation of vancomycin in critically ill patients during high-volume haemofiltration

scientific article published on 28 April 2014

Population pharmacokinetics and dosing simulations of amoxicillin/clavulanic acid in critically ill patients

scientific article published on 25 June 2013

Population pharmacokinetics and dosing simulations of cefepime in septic shock patients receiving continuous renal replacement therapy

scientific article published on 6 July 2015

Population pharmacokinetics and dosing simulations of ceftazidime in critically ill patients receiving sustained low-efficiency dialysis

scientific article published on 8 February 2017

Population pharmacokinetics and dosing simulations of cefuroxime in critically ill patients: non-standard dosing approaches are required to achieve therapeutic exposures

scientific article published on 10 June 2014

Population pharmacokinetics and evaluation of the predictive performance of pharmacokinetic models in critically ill patients receiving continuous infusion meropenem: a comparison of eight pharmacokinetic models

scientific article published in 2018

Population pharmacokinetics of fluconazole in critically ill patients receiving continuous venovenous hemodiafiltration: using Monte Carlo simulations to predict doses for specified pharmacodynamic targets

scientific article published on 19 September 2011

Population pharmacokinetics of linezolid in critically ill patients on renal replacement therapy: comparison of equal doses in continuous venovenous haemofiltration and continuous venovenous haemodiafiltration

scientific article published on 3 November 2015

Population pharmacokinetics of teicoplanin and attainment of pharmacokinetic/pharmacodynamic targets in adult patients with haematological malignancy.

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Population pharmacokinetics of ticarcillin in critically ill patients receiving extended daily diafiltration

scientific article published on 04 July 2019

Predictive performance of a gentamicin population pharmacokinetic model in two western populations of critically ill patients

scientific article published on 26 April 2018

Prolonged administration of β-lactam antibiotics - a comprehensive review and critical appraisal

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Protein binding of β-lactam antibiotics in critically ill patients: can we successfully predict unbound concentrations?

scientific article published on 30 September 2013

Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study

scientific article published on 14 April 2015

Public health response to imported case of poliomyelitis, Australia, 2007.

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Quantification of seven β-lactam antibiotics and two β-lactamase inhibitors in human plasma using a validated UPLC-MS/MS method

scientific article published on 10 August 2012

Quantitative bioanalytical validation of fosfomycin in human whole blood with volumetric absorptive microsampling

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Reply to Rhodes et al.

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Reply to Soman et al.

scientific article published in April 2013

Reporting Guidelines for Clinical Pharmacokinetic Studies: The ClinPK Statement

scientific article published on 01 July 2015

Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection

scientific article published on 11 January 2022

Right Dose, Right Now: Customized Drug Dosing in the Critically Ill.

scientific article published on February 2017

Risk Factors in Hospitalized Patients With Burn Injuries for Developing Heterotopic Ossification--A Retrospective Analysis

scientific article published on July 2015

Risk factors for multidrug-resistant Gram-negative infection in burn patients

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Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients

scientific article published on 23 July 2014

SaMpling Antibiotics in Renal Replacement Therapy (SMARRT): an observational pharmacokinetic study in critically ill patients

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Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation

scientific article published on 15 October 2012

Should β-lactam antibiotics be administered by continuous infusion in critically ill patients? A survey of Australia and New Zealand intensive care unit doctors and pharmacists

scientific article published on 25 April 2016

Software for dose adjustment of antimicrobials. Implications for plasma concentrations and pratical limitations

scientific article published on 23 October 2020

Solid nanoparticles for oral antimicrobial drug delivery: a review

scientific article published on 14 January 2019

Stability of Antibiotics for Intraperitoneal Administration in Extraneal 7.5% Icodextrin Peritoneal Dialysis Bags (STAB Study).

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Standard dosing of amikacin and gentamicin in critically ill patients results in variable and subtherapeutic concentrations

scientific article published on 19 March 2015

Streamlined research funding using short proposals and accelerated peer review: an observational study

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Substantial Impact of Altered Pharmacokinetics in Critically Ill Patients on the Antibacterial Effects of Meropenem Evaluated via the Dynamic Hollow-Fiber Infection Model

scientific article published on 6 March 2017

Subtherapeutic Initial β-Lactam Concentrations in Select Critically Ill Patients

scientific article published on 01 July 2012

Subtleties in practical application of prolonged infusion of β-lactam antibiotics

scientific article published on 16 February 2015

Sustained low efficiency dialysis allows rational renal replacement therapy, but does it allow rational drug dosing?*

scientific article published on 01 March 2011

The ADMIN-ICU survey: a survey on antimicrobial dosing and monitoring in ICUs

scientific article published on 13 July 2015

The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation

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The Effect of Paracetamol on Core Body Temperature in Acute Traumatic Brain Injury: A Randomised, Controlled Clinical Trial

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The Global Alliance for Infections in Surgery: defining a model for antimicrobial stewardship-results from an international cross-sectional survey.

scientific article published on August 2017

The Impact of Variation in Renal Replacement Therapy Settings on Piperacillin, Meropenem, and Vancomycin Drug Clearance in the Critically Ill

scientific article published on 01 July 2014

The Use of Bloodstream Infection Mortality to Measure the Impact of Antimicrobial Stewardship Interventions: Assessing the Evidence

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The authors reply

The clinical relevance of plasma protein binding changes

scientific article published in January 2013

The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study

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The effect of pharmacists on ward rounds measured by the STOPP/START tool in a specialized geriatric unit

scientific article published on 16 December 2016

The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients

scientific article published on February 2011

The effects of major burn related pathophysiological changes on the pharmacokinetics and pharmacodynamics of drug use: An appraisal utilizing antibiotics

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The efficacy and safety of adrenergic blockade after burn injury: A systematic review and meta-analysis

scientific article published on 29 October 2015

The influence of acute kidney injury on antimicrobial dosing in critically ill patients: are dose reductions always necessary?

scientific article published on 24 January 2014

The need for cost-effectiveness analyses of antimicrobial stewardship programmes: A structured review.

scientific article published on 28 May 2015

The pharmacokinetics of cefazolin in patients undergoing elective & semi-elective abdominal aortic aneurysm open repair surgery

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The risks of medical complacency towards poliomyelitis

scientific article published on 29 June 2020

The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections

scientific article published on 13 April 2017

The use and risks of antibiotics in critically ill patients

scientific article published on 9 March 2016

Therapeutic Drug Monitoring of Beta-Lactam Antibiotics in Burns Patients—A One-Year Prospective Study

scientific article published on 01 April 2012

Therapeutic drug monitoring of anti-infective agents in critically ill patients

scientific article published on 28 March 2016

Therapeutic drug monitoring of antibiotics – Author's reply

scientific article published on 17 November 2014

Therapeutic drug monitoring of antimicrobials

scientific article published on January 2012

Therapeutic drug monitoring of beta-lactams for critically ill patients: unwarranted or essential?

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Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept

scientific article published on 3 August 2010

Therapeutic drug monitoring of the β-lactam antibiotics: what is the evidence and which patients should we be using it for?

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Therapeutic drug monitoring of β-lactam antibiotics in the critically ill: direct measurement of unbound drug concentrations to achieve appropriate drug exposures

scientific article published on 01 November 2018

Tigecycline use in the outpatient parenteral antibiotic therapy setting.

scientific article published on 20 June 2016

Total and unbound ceftriaxone pharmacokinetics in critically ill Australian Indigenous patients with severe sepsis.

scientific article published on 4 November 2016

Uncertainty in Antibiotic Dosing in Critically Ill Neonate and Pediatric Patients: Can Microsampling Provide the Answers?

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Understanding PK/PD

scientific article published on 03 September 2015

Use of nebulized antimicrobials for the treatment of respiratory infections in invasively mechanically ventilated adults: a position paper from the European Society of Clinical Microbiology and Infectious Diseases.

scientific article published on 13 April 2017

Using PK/PD to Optimize Antibiotic Dosing for Critically Ill Patients ⬇️

scientific article published on December 1, 2011

Using Population Pharmacokinetic Modeling and Monte Carlo Simulations To Determine whether Standard Doses of Piperacillin in Piperacillin-Tazobactam Regimens Are Adequate for the Management of Febrile Neutropenia

scientific article published on 14 August 2017

Using pharmacokinetics and pharmacodynamics to optimise dosing of antifungal agents in critically ill patients: a systematic review

scientific article published on 16 September 2011

Using population pharmacokinetics to determine gentamicin dosing during extended daily diafiltration in critically ill patients with acute kidney injury

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Vancomycin dosing in critically ill patients: robust methods for improved continuous-infusion regimens

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Vancomycin population pharmacokinetics during extracorporeal membrane oxygenation therapy: a matched cohort study

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Vancomycin-associated nephrotoxicity in the critically ill: a retrospective multivariate regression analysis*.

scientific article published in December 2014

Vancomycin-associated nephrotoxicity: A meta-analysis of administration by continuous versus intermittent infusion

scientific article published on 07 June 2015

Variability in Trough Total and Unbound Teicoplanin Concentrations and Achievement of Therapeutic Drug Monitoring Targets in Adult Patients with Hematological Malignancy.

scientific article published on 20 March 2017

Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study

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Variable ganciclovir concentrations in a critically ill patient receiving continuous renal replacement therapy and plasma exchange?

scientific article published on 04 April 2014

We need to optimize piperacillin-tazobactam dosing in critically ill patients-but how?

scientific article published on 06 June 2016

What Antibiotic Exposures Are Required to Suppress the Emergence of Resistance for Gram-Negative Bacteria? A Systematic Review

scientific article published on 01 November 2019

What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?

scientific article published on 24 December 2015

What is the relevance of fosfomycin pharmacokinetics in the treatment of serious infections in critically ill patients? A systematic review

scientific article published on 20 July 2013

What's behind the failure of emerging antibiotics in the critically ill? Understanding the impact of altered pharmacokinetics and augmented renal clearance

scientific article published on 06 April 2012

What's new in pharmacokinetics of antimicrobials in AKI and RRT?

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β-Lactam Dosage Regimens in Septic Patients with Augmented Renal Clearance

scholarly article by Alexandra Jacobs et al published September 2018 in Antimicrobial Agents and Chemotherapy

β-Lactam pharmacodynamics in Gram-negative bloodstream infections in the critically ill

scientific article published on 01 February 2020

β-Lactam pharmacokinetics during extracorporeal membrane oxygenation therapy: A case-control study

scientific article published on 8 December 2014

β-Lactam therapeutic drug monitoring in the critically ill: optimising drug exposure in patients with fluctuating renal function and hypoalbuminaemia

scientific article published on 13 November 2012

β-lactam pharmacokinetics and pharmacodynamics in critically ill patients and strategies for dose optimization: a structured review

scientific article published on June 2012

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