List of works by Jean-Sébastien Hulot

2013 ESC guidelines on the management of stable coronary artery disease

scientific article published on 30 August 2013

A PDGFRα-Mediated Switch toward CD9high Adipocyte Progenitors Controls Obesity-Induced Adipose Tissue Fibrosis.

scientific article published on 9 February 2017

Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium.

scientific article

An allele-specific PCR system for rapid detection and discrimination of the CYP2C19∗4A, ∗4B, and ∗17 alleles: implications for clopidogrel response testing.

scientific article published on 5 September 2013

Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes

scientific article published on 05 August 2019

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

scientific article published in 2022

Anti-integrin αv therapy improves cardiac fibrosis after myocardial infarction by blunting cardiac PW1+ stromal cells

scientific article published on 09 July 2020

Antilipemics and prevention of cerebrovascular accidents. Meta-analysis

scientific article

Antiplatelet Therapy and Coronary Artery Bypass Graft Surgery

scientific article published on 01 December 2010

Antiplatelet and anticoagulation therapy for acute coronary syndromes

scientific article

Antiplatelet drug interactions with proton pump inhibitors

scientific article

Antiplatelet therapy: Personalized medicine for clopidogrel resistance?

scientific article published in May 2009

Arrhythmogenic right ventricular dysplasia and sudden cardiac death

scientific article published in January 2005

Assessment of signal quality measured with a smart 12-lead ECG acquisition T-shirt

scientific article published on 24 July 2019

Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy.

scientific article published on 26 October 2006

Association of Oral Contraceptives With Drug-Induced QT Interval Prolongation in Healthy Nonmenopausal Women

scientific article published on 01 September 2018

Avancées récentes et perspectives dans le traitement des dyslipidémies athérogènes

scientific article published on 06 March 2007

Beta-blocker benefit according to severity of heart failure.

scientific article

Beta-blocker treatment in heart failure.

scientific article

Blockbuster interactions: are they bad for the patient?

scientific article published on 21 May 2012

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

scientific article

CRISPR/Cas9 gene-editing strategies in cardiovascular cells

scientific article published on 01 April 2020

CRISPRed Cardiomyocytes to Decrypt Variants of Uncertain Significance ∗

scientific article published on 01 July 2018

CYP2C19 But Not PON1 Genetic Variants Influence Clopidogrel Pharmacokinetics, Pharmacodynamics, and Clinical Efficacy in Post–Myocardial Infarction Patients

scientific article published on 04 October 2011

Can we override clopidogrel resistance?

scientific article published in June 2009

Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling

scientific article published on 2 March 2016

Cardiac inflammatory CD11b/c cells exert a protective role in hypertrophied cardiomyocyte by promoting TNFR- and Orai3- dependent signaling

scientific article published on 15 April 2019

Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.

scientific article

Cardiomyocyte-Specific STIM1 (Stromal Interaction Molecule 1) Depletion in the Adult Heart Promotes the Development of Arrhythmogenic Discordant Alternans

scientific article published on 15 November 2019

Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19*2 loss-of-function allele or proton pump inhibitor coadministration: a systematic meta-analysis

scientific article published on July 2010

Changes in enoxaparin pharmacokinetics during pregnancy and implications for antithrombotic therapeutic strategy

scientific article published on 23 April 2008

Clinical Pharmacogenetics Implementation Consortium guidelines for CYP2C19 genotype and clopidogrel therapy: 2013 update.

scientific article published on 22 May 2013

Clinical implications of neuropharmacogenetics.

scientific article published on 23 May 2015

Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis

scientific article published on October 2011

Clopidogrel and CYP2C19 Testing: Ready for Clinical Prime Time?

scientific article published on 22 September 2011

Clopidogrel and CYP2C19: pharmacogenetic testing ready for clinical prime time?

scientific article published on 13 August 2015

Clustering of acute and subacute stent thrombosis related to the introduction of generic clopidogrel

scientific article published on 22 November 2013

Combination of B-type natriuretic peptide and peak oxygen consumption improves risk stratification in outpatients with chronic heart failure

scientific article published in October 2003

Comparison of echocardiography and plasma B-type natriuretic peptide for monitoring the response to treatment in acute heart failure

scientific article published in October 2004

Complex Association of Sex Hormones on Left Ventricular Systolic Function: Insight into Sexual Dimorphism

scientific article published on 12 December 2017

Considerations for pre-clinical models and clinical trials of pluripotent stem cell-derived cardiomyocytes

scientific article

Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy

scientific article

Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters.

scientific article published on 16 October 2012

Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects

scientific article published on 13 June 2006

Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study

scientific article

Cytotoxic CD8<sup>+</sup> T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling

scientific article published on 05 March 2021

Design and Validation of an Automated Process for the Expansion of Peripheral Blood-Derived CD34+ Cells for Clinical Use After Myocardial Infarction

scientific article published on 29 April 2019

Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus

scientific article

Development and validation of a rapid and simple LC-MS/MS method for quantification of vemurafenib in human plasma: application to a human pharmacokinetic study.

scientific article

Differential Sarcomere and Electrophysiological Maturation of Human iPSC-Derived Cardiac Myocytes in Monolayer vs. Aggregation-Based Differentiation Protocols

scientific article published on June 2017

Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity

scientific article published on 26 May 2021

Dosing strategy in patients with renal failure receiving enoxaparin for the treatment of non-ST-segment elevation acute coronary syndrome

scientific article published in June 2005

Downregulation of the calcium current in human right atrial myocytes from patients in sinus rhythm but with a high risk of atrial fibrillation.

scientific article published on 7 April 2008

ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure

scientific article published on 01 March 2019

Effect of an increased clopidogrel maintenance dose or lansoprazole co-administration on the antiplatelet response to clopidogrel in CYP2C19-genotyped healthy subjects

scientific article published on 21 December 2009

Effect of intracoronary administration of AAV1/SERCA2a on ventricular remodelling in patients with advanced systolic heart failure: results from the AGENT-HF randomized phase 2 trial

scientific article published on 10 April 2017

Effect of renal function on the pharmacokinetics of enoxaparin and consequences on dose adjustment

scientific article

Effectiveness of gene delivery systems for pluripotent and differentiated cells.

scientific article published on 18 February 2015

Effectiveness of heart rate control on hemodynamics in critically ill patients with atrial tachyarrhythmias managed by amiodarone

scholarly article by Joe-Elie Salem et al published August 2017 in Pharmacological Research

Emergence of Orai3 activity during cardiac hypertrophy.

scientific article published on 11 September 2014

Emerging Drug Classes and Their Potential Use in Hypertension

scientific article published on 09 September 2019

Exome sequencing of extreme clopidogrel response phenotypes identifies B4GALT2 as a determinant of on-treatment platelet reactivity

scientific article published on 23 May 2016

Faut-il doser l'hydroxychloroquine chez les patients lupiques ?

scientific article published on 01 September 2006

Feasibility and safety of ultrasound-aided thoracentesis in mechanically ventilated patients

scientific article published on 01 September 1999

Fibrogenic Potential of PW1/Peg3 Expressing Cardiac Stem Cells

scientific article published in August 2017

Functional Human Beige Adipocytes From Induced Pluripotent Stem Cells.

scientific article

GENomE wide analysis of sotalol-induced IKr inhibition during ventricular REPOLarization, "GENEREPOL study": Lack of common variants with large effect sizes.

scientific article published on 11 August 2017

Gene therapy for the treatment of heart failure: promise postponed

scientific article published on 27 February 2016

Generating patient-specific induced pluripotent stem cells-derived cardiomyocytes for the treatment of cardiac diseases

scientific article published on 02 July 2015

Genetic and platelet function testing of antiplatelet therapy for percutaneous coronary intervention: the ARCTIC-GENE study

scientific article published on 13 August 2015

Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy

scientific article

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).

scientific article published on 17 December 2017

Genomic correction of familial cardiomyopathy in human engineered cardiac tissues.

scientific article published on 22 July 2016

Get Your Cell K.O. in the First Round

scientific article published on 01 May 2017

Heart conduction disorders related to antimalarials toxicity: an analysis of electrocardiograms in 85 patients treated with hydroxychloroquine for connective tissue diseases

scientific article published on 3 January 2007

Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology

scientific article published on 01 December 2018

High on-thienopyridine platelet reactivity in elderly coronary patients: the SENIOR-PLATELET study

scientific article published on 07 November 2011

Hydroxychloroquine in systemic lupus erythematosus

scientific article published in The Lancet

Hydroxychloroquine in systemic lupus erythematosus: results of a French multicentre controlled trial (PLUS Study).

scientific article published on 10 November 2012

Impact of ABCC2 polymorphisms on high-dose methotrexate pharmacokinetics in patients with lymphoid malignancy

scientific article published on 16 October 2012

Impact of Inodilator Drugs on Echocardiographic Assessments of Left Ventricular Filling Pressure in Patients With Decompensated End-Stage Heart Failure*

scientific article published on 01 December 2014

Impact of negative inotropic drugs on accuracy of diastolic stress echocardiography for evaluation of left ventricular filling pressure

scientific article published on 25 August 2017

Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice.

scientific article

In Vitro Adherence Defines Therapeutic Cardiac Mesenchymal Cell Subpopulation ∗

scientific article published on 01 April 2017

Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects

article

Influence of endogenous oestrogens on QT interval duration

scientific article published in September 2003

Influence of methotrexate exposure on outcome in patients treated with MBVP chemotherapy for primary central nervous system lymphoma

scientific article

Inhalable delivery of AAV-based MRP4/ABCC4 silencing RNA prevents monocrotaline-induced pulmonary hypertension

scientific article published on 4 February 2015

Intravenous Clopidogrel (MDCO-157) Compared with Oral Clopidogrel: The Randomized Cross-Over AMPHORE Study

scientific article published on 19 September 2015

Long-Term Evolution of Premature Coronary Artery Disease

scientific article published on 01 October 2019

Low blood concentration of hydroxychloroquine is a marker for and predictor of disease exacerbations in patients with systemic lupus erythematosus

scientific article published on October 2006

Lower vitamin D levels are associated with higher systemic lupus erythematosus activity, but not predictive of disease flare-up

scientific article

MRP4 (ABCC4) as a potential pharmacologic target for cardiovascular disease.

scientific article published on 5 April 2016

Modeling CVD in human pluripotent cells by genome editing

scientific article published on August 2014

Modeling Cardiac Arrhythmias With Organoids

scientific article published on 01 May 2019

Modeling of Amiodarone Effect on Heart Rate Control in Critically Ill Patients with Atrial Tachyarrhythmias

scientific article published on 5 March 2016

Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells

scientific article published on 30 January 2017

Multi-ethnic distribution of clinically relevant CYP2C genotypes and haplotypes.

scientific article

Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation

scientific article

Mycophenolic acid area under the curve correlates with disease activity in lupus patients treated with mycophenolate mofetil

scientific article published in July 2010

Myocardial delivery of stromal cell-derived factor 1 in patients with ischemic heart disease: safe and promising

scientific article published on 21 February 2013

Nelfinavir and felodipine: a cytochrome P450 3A4-mediated drug interaction

scientific article published in April 2004

Omeprazole, pantoprazole, and CYP2C19 effects on clopidogrel pharmacokinetic-pharmacodynamic relationships in stable coronary artery disease patients

scientific article published on 14 June 2015

Opioid-related genetic polymorphisms do not influence postoperative opioid requirement: A prospective observational study.

scientific article

Overexpression of Cyclic Adenosine Monophosphate Effluent Protein MRP4 Induces an Altered Response to β-Adrenergic Stimulation in the Senescent Rat Heart

scientific article published on 01 February 2015

PON1 Q192R genetic variant and response to clopidogrel and prasugrel: pharmacokinetics, pharmacodynamics, and a meta-analysis of clinical outcomes

article

Perivascular fibrosis and the microvasculature of the heart. Still hidden secrets of pathophysiology?

scientific article published on 27 April 2018

PharmGKB summary: very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 19.

scientific article

Pharmacokinetic and pharmacodynamic interactions between metoprolol and dronedarone in extensive and poor CYP2D6 metabolizers healthy subjects.

scientific article

Pharmacokinetic study of mycophenolate mofetil in patients with systemic lupus erythematosus and design of Bayesian estimator using limited sampling strategies

scientific article published in January 2008

Pharmacology and mechanisms of action of new oral anticoagulants.

scientific article published on 25 September 2014

Platelet reactivity in human immunodeficiency virus infected patients on dual antiplatelet therapy for an acute coronary syndrome: the EVERE2ST-HIV study

scientific article

Point-of-care genetic profiling and/or platelet function testing in acute coronary syndrome.

scientific article published in October 2015

Population pharmacokinetic study of methotrexate in patients with lymphoid malignancy

scientific article published on 10 March 2006

Population pharmacokinetics of tacrolimus in full liver transplant patients: modelling of the post-operative clearance.

scientific article published on July 2005

Potentialisation de la fluindione et de la warfarine par la dexaméthasone dans le myélome multiple et l'amylose AL

scientific article published in October 2007

Potentiation of fluindione or warfarin by dexamethasone in multiple myeloma and AL amyloidosis.

scientific article published on 6 July 2007

Prevention of atrial fibrillation onset by beta-blocker treatment in heart failure: a meta-analysis.

scientific article published on 8 February 2007

Quality of life in systemic lupus erythematosus: description in a cohort of French patients and association with blood hydroxychloroquine levels

scientific article

Quantification of coproporphyrin isomers I and III in urine by HPLC and determination of their ratio for investigations of multidrug resistance protein 2 (MRP2) function in humans

scientific article published on 8 October 2009

RNA interference targeting STIM1 suppresses vascular smooth muscle cell proliferation and neointima formation in the rat.

scientific article

Reduced risk of cancer among low-dose aspirin users: Data from French health care databases

scientific article published on 23 July 2019

Reg3β is associated with cardiac inflammation and provides prognostic information in patients with acute coronary syndrome.

scientific article published in May 2018

Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes

scientific article published on 16 November 2011

Relationship between blood hydroxychloroquine and desethylchloroquine concentrations and cigarette smoking in treated patients with connective tissue diseases

scientific article published on November 2007

Renal Tubular Drug Transporters

scientific article published on 22 March 2006

Renal safety of adefovir dipivoxil in patients with chronic hepatitis B: two double-blind, randomized, placebo-controlled studies

scientific article

Renal safety of tenofovir in HIV treatment-experienced patients.

scientific article published in April 2004

Resident PW1 + Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial Hypertension

article

Role of sarco/endoplasmic reticulum calcium content and calcium ATPase activity in the control of cell growth and proliferation

scientific article published on 11 January 2008

Simultaneous determination of rivaroxaban and dabigatran levels in human plasma by high-performance liquid chromatography–tandem mass spectrometry

scientific article published on 15 August 2014

Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes.

scientific article

Spontaneous renal CT-scan hyperdensity of an HIV-associated nephropathy.

scientific article

Stem cell factor gene transfer promotes cardiac repair after myocardial infarction via in situ recruitment and expansion of c-kit+ cells.

scientific article published on 29 August 2012

Stent thrombosis: who's guilty?

scientific article published on 23 October 2009

The CLIPMERGE PGx Program: clinical implementation of personalized medicine through electronic health records and genomics-pharmacogenomics

scientific article published on 03 April 2013

The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial

scientific article published in January 2011

The CYP2C19*17 allele is associated with better platelet response to clopidogrel in patients admitted for non-ST acute coronary syndrome.

scientific article published on 30 May 2009

The continuous heart failure spectrum: moving beyond an ejection fraction classification

scientific article published on 01 July 2019

The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks.

scientific article published on 9 February 2018

The pharmacogenetic control of antiplatelet response: candidate genes and CYP2C19

scientific article (publication date: 2015)

Therapeutic drug monitoring of clozapine in a hemodialysed smoking patient with schizophrenia

scientific article

Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension.

scientific article published on 26 June 2013

Towards Precision Medicine With Human iPSCs for Cardiac Channelopathies

scientific article published on 29 August 2019

Urinary coproporphyrin I/(I + III) ratio as a surrogate for MRP2 or other transporter activities involved in methotrexate clearance

scientific article

Use of an indirect effect model to describe the LDL cholesterol-lowering effect by statins in hypercholesterolaemic patients

scientific article published on 01 June 2006

Very low blood hydroxychloroquine concentration as an objective marker of poor adherence to treatment of systemic lupus erythematosus

scientific article

miR-322 regulates insulin signaling pathway and protects against metabolic syndrome-induced cardiac dysfunction in mice

scientific article

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