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List of works by Giampaolo Tortora

2-weekly docetaxel: issues for clinical practice.

scientific article published on January 2015

2015 and human cancer: back to overall survival.

scientific article

8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation.

scientific article published in January 1990

8-Chloro-cyclic AMP inhibits autocrine and angiogenic growth factor production in human colorectal and breast cancer

article

8-chloro-cAMP enhances the growth inhibitory effect of cytotoxic drugs in human colon cancer cells

scientific article

8-chloro-cAMP inhibits smooth muscle cell proliferation in vitro and neointima formation induced by balloon injury in vivo

scientific article published on July 2000

A Novel Toll-Like Receptor 9 Agonist Cooperates with Trastuzumab in Trastuzumab-Resistant Breast Tumors through Multiple Mechanisms of Action

scientific article published on 10 November 2009

A chemically modified tetracycline (CMT-3) is a new antifungal agent

scientific article

A circulating TH2 cytokines profile predicts survival in patients with resectable pancreatic adenocarcinoma.

scientific article

A clinical-biological risk stratification model for resected gastric cancer: prognostic impact of Her2, Fhit, and APC expression status.

scientific article published on 6 November 2012

A meta-analysis on the interaction between HER-2 expression and response to endocrine treatment in advanced breast cancer

scientific article published in July 2005

A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer.

scientific article

A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor.

scientific article

A propensity score analysis exploring the impact of adjuvant chemotherapy (aCT) in a multi-center series of resected early stage pure invasive lobular breast carcinoma (ILC)

ALK gene copy number in lung cancer: Unspecific polyploidy versus specific amplification visible as double minutes.

scientific article published on 16 December 2016

ALK/EML4 fusion gene may be found in pure squamous carcinoma of the lung.

scientific article

AR-V7 and prostate cancer: The watershed for treatment selection?

scientific article published on 18 December 2015

Acquired hemophagocytic syndrome in a patient with synovial sarcoma: a case report.

scientific article published on November 2015

Acquired hemophagocytic syndrome: comment to the case report.

scientific article published on November 2015

Addition of erlotinib to fluoropyrimidine-oxaliplatin-based chemotherapy with or without bevacizumab: Two sequential phase I trials

scientific article

Addressing the best treatment for non-clear cell renal cell carcinoma: A meta-analysis of randomised clinical trials comparing VEGFR-TKis versus mTORi-targeted therapies

scientific article

Addressing the expected survival benefit for clinical trial design in metastatic castration-resistant prostate cancer: Sensitivity analysis of randomized trials

scientific article published on 17 November 2015

Adenocarcinoma of the paraurethral glands: a case report

scientific article published on 07 March 2014

Adjuvant chemotherapy for resected non-small-cell lung cancer: future perspectives for clinical research

scientific article published on 29 December 2011

Adjuvant treatment for resected renal cell carcinoma: are all strategies equally negative? Potential implications for trial design with targeted agents.

scientific article published on 28 June 2013

Advances towards the design and development of personalized non-small-cell lung cancer drug therapy.

scientific article published on 03 October 2013

Ampulla of Vater Carcinoma: Sequencing Analysis Identifies TP53 Status as a Novel Independent Prognostic Factor and Potentially Actionable ERBB, PI3K, and WNT Pathways Gene Mutations.

scientific article published on 8 September 2016

An FGFR3 Autocrine Loop Sustains Acquired Resistance to Trastuzumab in Gastric Cancer Patients.

scientific article published on 7 June 2016

An Italian cost-effectiveness analysis of paclitaxel albumin (nab-paclitaxel) + gemcitabine vs gemcitabine alone for metastatic pancreatic cancer patients: the APICE study.

scientific article

An angiopoietin-like protein 2 autocrine signaling promotes EMT during pancreatic ductal carcinogenesis.

scientific article

An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects

scientific article

An antisense oligodeoxynucleotide that depletes RI alpha subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells

scientific article published on 01 February 1993

An improved method for coronary sinus blood flow monitoring by intravascular Doppler technique

scientific article published on 01 December 1998

An innovative adaptive control strategy for sensorized left ventricular assist devices

scientific article published on 11 September 2014

An overview of angiogenesis inhibitors in Phase II studies for non-small-cell lung cancer

scientific article published on 12 June 2015

Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer.

scientific article published in February 2018

Anti-angiogenic drugs and biomarkers in non-small-cell lung cancer: a 'hard days night'.

scientific article published on January 2014

Anti-tumor activity of the combination of cetuximab, an anti-EGFR blocking monoclonal antibody and ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinases

scientific article published on August 2006

Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis, and cooperate with cytotoxic drugs in human cancer cell lines.

scientific article published in July 2001

Antisense strategies targeting protein kinase C: preclinical and clinical development.

scientific article

Antisense targeting protein kinase A type I as a drug for integrated strategies of cancer therapy.

scientific article published on December 2003

Antitumor Activity of Combined Blockade of Epidermal Growth Factor Receptor and Protein Kinase A

scientific article published on 01 December 1996

Antitumor activity of ZD6126, a novel vascular-targeting agent, is enhanced when combined with ZD1839, an epidermal growth factor receptor tyrosine kinase inhibitor, and potentiates the effects of radiation in a human non-small cell lung cancer xeno

scientific article published on August 2004

Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy.

scientific article published on January 2004

Antitumor activity of ZD6474, a vascular endothelial growth factor-2 and epidermal growth factor receptor small molecule tyrosine kinase inhibitor, in combination with SC-236, a cyclooxygenase-2 inhibitor.

scientific article published on February 2005

Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide

scientific article published on 01 November 2000

Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225.

scientific article published on April 1999

Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor

scientific article published on 01 May 2000

Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase.

scientific article published on April 2003

Assessment of Ramucirumab plus paclitaxel as switch maintenance versus continuation of first-line chemotherapy in patients with advanced HER-2 negative gastric or gastroesophageal junction cancers: the ARMANI phase III trial

scientific article published on 29 March 2019

AtezoTRIBE: a randomised phase II study of FOLFOXIRI plus bevacizumab alone or in combination with atezolizumab as initial therapy for patients with unresectable metastatic colorectal cancer

scientific article published on 22 July 2020

Avoiding chemotherapy for advanced nononcogene addicted NSCLC overexpressing PD-L1: Rule or option?

scientific article published on 01 June 2018

BRCA somatic and germline mutation detection in paraffin embedded ovarian cancers by next-generation sequencing

scientific article published on 7 January 2016

Balancing activity and tolerability of neoadjuvant paclitaxel- and docetaxel-based chemotherapy for HER2-positive early stage breast cancer: sensitivity analysis of randomized trials

scientific article

Beyond Primary Tumor Location and RAS/BRAF Mutational Status as Prognostic Factor in Stage III Colon Cancer

scientific article published on 01 September 2018

Biological and clinical relevance of proliferative activity in inflammatory breast-cancer

scientific article published on 01 March 1995

Biomarkers of response to advanced prostate cancer therapy

scientific article published on 27 January 2020

Bladder cancer: molecular determinants of personalized therapy.

scientific article published on January 2015

Blood serum amyloid A as potential biomarker of pembrolizumab efficacy for patients affected by advanced non-small cell lung cancer overexpressing PD-L1: results of the exploratory "FoRECATT" study

scientific article published on 24 November 2020

CXC and CC chemokines as angiogenic modulators in nonhaematological tumors.

scientific article published on 29 May 2014

Cabozantinib After a Previous Immune Checkpoint Inhibitor in Metastatic Renal Cell Carcinoma: A Retrospective Multi-Institutional Analysis

scientific article published on 15 July 2020

Cabozantinib in Advanced Renal Cell Carcinoma: Is it a METEOR?

scientific article

Cabozantinib-related cardiotoxicity: a prospective analysis in a real-world cohort of metastatic renal cell carcinoma patients

scientific article published on 31 March 2019

Cabozantinib-related pneumothorax in rapidly responding patients with renal cell carcinoma

scientific article published on 01 February 2019

Can histogram analysis of MR images predict aggressiveness in pancreatic neuroendocrine tumors?

scientific article published on 19 January 2018

Capecitabine plus weekly oxaliplatin in gastrointestinal tumors: a phase I study.

scientific article published in February 2006

Carcinoembryonic antigen regulation in human colorectal tumor cells by a site-selective cyclic AMP analogue: a comparison with interferon-gamma

scientific article published on May 1991

Cardiovascular monitoring of drug-resistant lymphoma patients treated with epoch chemotherapy plus high-dose verapamil in continuous-infusion

scientific article published on 01 March 1994

Castration resistant prostate cancer (CRPC): state of the art, perspectives and new challenges

scientific article published on July 2013

Cathepsin K expression in castration-resistant prostate carcinoma: a therapeutical target for patients at risk for bone metastases.

scientific article published on 12 January 2017

Chemotherapy in metastatic renal cell carcinoma today? A systematic review

scientific article

Circulating Tumor Cells: A Reliable Biomarker for Prostate Cancer Treatment Assessment?

scientific article published on 18 May 2017

Clinical impact of anti-epidermal growth factor receptor monoclonal antibodies in first-line treatment of metastatic colorectal cancer

scientific article published on 25 August 2011

Clinical implication of changes in body composition and weight in patients with early-stage and metastatic breast cancer

article

Clinical meta-analyses of targeted therapies in adenocarcinoma

scientific article published on 25 January 2013

Clinical outcome of patients who reduced sunitinib or pazopanib during first-line treatment for advanced kidney cancer.

scientific article published on 29 May 2017

Clinical results of randomized trials and 'real-world' data exploring the impact of Bevacizumab for breast cancer: opportunities for clinical practice and perspectives for research.

scientific article

Clinical studies in patients with solid tumors using a second-generation antisense oligonucleotide (GEM 231) targeted against protein kinase A type I.

scientific article published in December 2003

Clinico-pathological nomogram for predicting BRAF mutational status of metastatic colorectal cancer.

scientific article published on 17 November 2015

Combination of a selective cyclooxygenase-2 inhibitor with epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 and protein kinase A antisense causes cooperative antitumor and antiangiogenic effect.

scientific article published on April 2003

Combination of biological therapies in non-small cell lung cancer.

scientific article

Combined blockade of protein kinase A and bcl-2 by antisense strategy induces apoptosis and inhibits tumor growth and angiogenesis

scientific article published on 01 August 2001

Combined inhibition of IL1, CXCR1/2, and TGFβ signaling pathways modulates in-vivo resistance to anti-VEGF treatment

scientific article published on 15 October 2015

Combined targeted inhibition of bcl-2, bcl-XL, epidermal growth factor receptor, and protein kinase A type I causes potent antitumor, apoptotic, and antiangiogenic activity.

scientific article

Combined targeting of endothelin A receptor and epidermal growth factor receptor in ovarian cancer shows enhanced antitumor activity

scientific article

Combined targeting of epidermal growth factor receptor and MDM2 by gefitinib and antisense MDM2 cooperatively inhibit hormone-independent prostate cancer

scientific article published on July 2004

Comparison Between Prognostic Classifications in De Novo Metastatic Hormone Sensitive Prostate Cancer

scientific article published on 01 October 2018

Complete remission with sunitinib in a poor-risk patient with metastatic renal cell carcinoma: the fine balance between toxicity and efficacy.

scientific article

Conjunctival Melanoma: Genetic and Epigenetic Insights of a Distinct Type of Melanoma ⬇️

scientific article published on 31 October 2019

Cooperative Antitumor Effect of Mixed Backbone Oligonucleotides Targeting Protein Kinase A in Combination with Cytotoxic Drugs or Biologic Agents

scientific article published on 01 April 1998

Cooperative antitumor effect of multitargeted kinase inhibitor ZD6474 and ionizing radiation in glioblastoma

scientific article

Cooperative effect of 8-Cl-cAMP and rhGM-CSF on the differentiation of HL-60 human leukemia cells

scientific article published on June 1991

Cooperative inhibition of renal cancer growth by anti-epidermal growth factor receptor antibody and protein kinase A antisense oligonucleotide

scientific article published in July 1998

Cooperative inhibitory effect of novel mixed backbone oligonucleotide targeting protein kinase A in combination with docetaxel and anti-epidermal growth factor-receptor antibody on human breast cancer cell growth

scientific article published on 01 April 1999

Correction to: Cabozantinib After a Previous Immune Checkpoint Inhibitor in Metastatic Renal Cell Carcinoma: A Retrospective Multi-Institutional Analysis

scientific article published on 28 August 2020

Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours

scientific article published on 27 September 2017

Could a biomarkers-based patients' selection help to plan a clinical trial with targeted agents (TA) for metastatic renal cell carcinoma (mRCC)? Interaction and power analysis of randomized trials (RCTs)

scientific article published on 20 February 2013

Current Strategies to Overcome Resistance to ALK-Inhibitor Agents

scientific article published on 12 August 2015

Cut-off analysis and prognostic relevance of Ki67 for resected early stage pure invasive lobular breast carcinoma (ILC)

Cyclic AMP-dependent protein kinase type I is involved in hypersensitivity of human breast cells to topoisomerase II inhibitors

scientific article published on 01 January 1995

Dabrafenib and Trametinib in BRAF Mutant Metastatic Conjunctival Melanoma

De Novo, Progressed, and Neglected Metastatic Castration-Sensitive Prostate Cancer: Is One Therapy Fit for All?

scientific article published on 20 July 2018

De novo metastatic castration sensitive prostate cancer: State of art and future perspectives

scientific article published on 11 August 2018

Development of novel cancer chemopreventive agents in Europe – Neglected Cinderella or rising phoenix?

article

Diagnosis and Treatment of Bone Metastases in Breast Cancer: Radiotherapy, Local Approach and Systemic Therapy in a Guide for Clinicians

scientific article published on 24 August 2020

Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers

scientific article

Differential effects of protein kinase a sub-units on chinese-hamster-ovary cell cycle and proliferation

article

Differential growth sensitivity to 4-cis-hydroxy-L-proline of transformed rodent cell lines

scientific article published on May 1988

Differential sensitivity to non-major histocompatibility complex-restricted recombinant interleukin 2-activated lymphocyte killing of human mammary epithelial MCF-10A cells overexpressing oncogenes or protein kinase A subunits

scientific article published on 01 January 1996

Digital Subtraction of Magnetic Resonance Images Improves Detection and Characterization of Pancreatic Neuroendocrine Neoplasms

scientific article

Do immune checkpoint inhibitors need new studies methodology?

scientific article

Docetaxel, Vinorelbine, and Zoledronic Acid as First-Line Treatment in Patients with Hormone Refractory Prostate Cancer: A Phase II Study

article

Down-regulation of RI alpha subunit of cAMP-dependent protein kinase induces growth inhibition of human mammary epithelial cells transformed by c-Ha-ras and c-erbB-2 proto-oncogenes

scientific article published on February 1993

Down-regulation of type I protein kinase A by transfection of human breast cancer cells with an epidermal growth factor receptor antisense expression vector

scientific article published on 01 January 1998

EGFR antagonists in cancer treatment

scientific article (publication date: 13 March 2008)

Effect of thymic extract 'thymostimulin' on the incidence of infections and myelotoxicity during adjuvant chemotherapy for breast cancer.

scientific article

Effects of 8-chloroadenosine 3',5'-monophosphate and N6-benzyl-cyclic adenosine 5'-monophosphate on cell cycle kinetics of HL-60 leukemia cells

scientific article published on December 1991

Effects of Antiangiogenetic Drugs on Microcirculation and Macrocirculation in Patients with Advanced-Stage Renal Cancer

scientific article published on 28 December 2018

Effects of mutant p53 genes on transformation of human mammary epithelial-cells

scientific article published on May 1994

Effects of nutritional interventions on nutritional status in patients with gastric cancer: A systematic review and meta-analysis of randomized controlled trials

scientific article published on 16 June 2020

Effects of thyroid hormones on cardiac structure: a tissue characterization study in patients with thyroid disorders before and after treatment

scientific article published in July 2001

Efficacy of VEGFR-TKI plus immune checkpoint inhibitor (ICI) in metastatic renal cell carcinoma (mRCC) patients with favorable IMDC prognosis.

scientific article published on 02 March 2021

Efficacy of immune checkpoint inhibitors in different types of melanoma

scientific article published on 14 July 2020

Emerging Immunotargets in Bladder Cancer.

scientific article

Emerging concepts on drug resistance in bladder cancer: Implications for future strategies.

scientific article published on 15 May 2015

Emerging pathways and future targets for the molecular therapy of pancreatic cancer

scientific article published on 07 August 2011

Emerging role of tumor-associated macrophages as therapeutic targets in patients with metastatic renal cell carcinoma.

scientific article published on 17 October 2013

Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa).

scientific article published in October 2002

Enzastaurin inhibits tumours sensitive and resistant to anti-EGFR drugs

scientific article

Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs.

scientific article

Epidermal growth factor receptor tyrosine kinase inhibitors in late stage clinical trials.

scientific article published on November 2003

Evaluation of Second-line Anti-VEGF after First-line Anti-EGFR Based Therapy in RAS Wild-Type Metastatic Colorectal Cancer: The Multicenter "SLAVE" Study

scientific article published on 16 May 2020

Evaluation of cell-free DNA as a biomarker for pancreatic malignancies

scientific article published on 24 February 2015

Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival.

scientific article published in January 1998

Evaluation of nutritional status in non-small-cell lung cancer: screening, assessment and correlation with treatment outcome

scientific article published on 01 May 2020

Exceptional Response to Cabozantinib of Rapidly Evolving Brain Metastases of Renal Cell Carcinoma: A Case Report and Review of the Literature

scientific article published on 21 June 2018

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

scientific article

Exploiting MET dysregulation in EGFR-addicted non-small-cell lung carcinoma: a further step toward personalized medicine

scientific article published on 01 December 2018

Exploring the molecular and biological background of lung neuroendocrine tumours

scientific article published on 01 May 2019

Expression of Wnt5a is downregulated by extracellular matrix and mutated c-Ha-ras in the human mammary epithelial cell line MCF-10A.

scientific article

Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer

scientific article published on 01 November 2002

Expression of the Focal Adhesion Protein Paxillin in Normal and Breast Cancer Tissues

scientific article published on 01 September 2003

FGFR-1 amplification in metastatic lymph-nodal and haematogenous lobular breast carcinoma.

scientific article published on 27 December 2012

Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma

scientific article published on 28 August 2020

First Prospective Multicenter Italian Study on the Impact of the 21-Gene Recurrence Score in Adjuvant Clinical Decisions for Patients with ER Positive/HER2 Negative Breast Cancer

scientific article

First-line erlotinib followed by second-line cisplatin-gemcitabine chemotherapy in advanced non-small-cell lung cancer: the TORCH randomized trial

scientific article

Flow-cytometric detection of the RI alpha subunit of type I cAMP-dependent protein kinase in human cells

scientific article published on January 1994

Found in translation: Annals of Oncology and translational research

scientific article published on 01 August 2011

Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type 3.

scientific article

Gene Expression Profiling of Lung Atypical Carcinoids and Large Cell Neuroendocrine Carcinomas Identifies Three Transcriptomic Subtypes with Specific Genomic Alterations

scientific article published on 11 May 2019

Genetic alterations analysis in prognostic stratified groups identified TP53 and ARID1A as poor clinical performance markers in intrahepatic cholangiocarcinoma.

scientific article published on 8 May 2018

Genomic analyses identify molecular subtypes of pancreatic cancer

scientific article published on 24 February 2016

Going towards a precise definition of the therapeutic management of de-novo metastatic castration sensitive prostate cancer patients: How prognostic classification impact treatment decisions

scientific article published on 11 May 2019

Growth inhibition of human colon carcinoma cells by combinations of anti-epidermal growth factor-related growth factor antisense oligonucleotides.

scientific article

Gut microbiome, big data and machine learning to promote precision medicine for cancer

scientific article published on 09 July 2020

HER2/neu gene determination in women screened for breast carcinoma: how screening programs reduce the skyrocketing cost of targeted therapy

article

Has crizotinib significantly impacted non-small-cell lung cancer therapy?

scientific article published on 27 July 2020

Helicobacter pylori VacA toxin up-regulates vascular endothelial growth factor expression in MKN 28 gastric cells through an epidermal growth factor receptor-, cyclooxygenase-2-dependent mechanism.

scientific article

Heterogeneous drug target expression as possible basis for different clinical and radiological response to the treatment of primary and metastatic renal cell carcinoma: suggestions from bench to bedside

scientific article published on March 2014

High mobility group A1 protein expression reduces the sensitivity of colon and thyroid cancer cells to antineoplastic drugs

scientific article

High-dose recombinant interleukin-2/verapamil combination in advanced cancer

scientific article published on 01 July 1996

High-throughput mutation profiling identifies novel molecular dysregulation in high-grade intraepithelial neoplasia and early gastric cancers.

scientific article

Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients.

scientific article published on 15 March 2017

Human epidermal growth factor receptor 2-positive breast cancer: heat shock protein 90 overexpression, Ki67 proliferative index, and topoisomerase II-α co-amplification as predictors of pathologic complete response to neoadjuvant chemotherapy with t

scientific article

Hypermutation In Pancreatic Cancer

scientific article

Hyperprogressive Disease in Patients With Advanced Non-Small Cell Lung Cancer Treated With PD-1/PD-L1 Inhibitors or With Single-Agent Chemotherapy

scientific article published on 01 November 2018

Immune Checkpoint Inhibitors and Prostate Cancer: A New Frontier?

scientific article

Immune checkpoint inhibitors for non-small-cell lung cancer: does that represent a 'new frontier'?

scientific article

Immunoevolution of mouse pancreatic organoid isografts from preinvasive to metastatic disease

scientific article published on 22 August 2019

Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy?

scientific article published on 26 July 2019

Immunotherapy Bridge 2016 and Melanoma Bridge 2016: meeting abstracts.

scientific article

Immunotherapy versus standard of care in metastatic renal cell carcinoma. A systematic review and meta-analysis

scientific article published on 20 August 2018

Impact of neoadjuvant single or dual HER2 inhibition and chemotherapy backbone upon pathological complete response in operable and locally advanced breast cancer: Sensitivity analysis of randomized trials.

scientific article

In vitro expansion of human breast cancer epithelial and mesenchymal stromal cells: optimization of a coculture model for personalized therapy approaches.

scientific article published on December 2007

Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody.

scientific article

Infection with a transforming growth factor alpha anti-sense retroviral expression vector reduces the in vitro growth and transformation of a human colon cancer cell line

scientific article published on July 1993

Inhibition of CRIPTO expression and tumorigenicity in human colon cancer cells by antisense RNA and oligodeoxynucleotides.

scientific article

Inhibition of bcl-2 as cancer therapy

scientific article published on 01 April 2002

Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site-selective 8-Cl-cyclic adenosine monophosphate

article

Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor.

scientific article

Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukemia patients by site-selective 8-chloroadenosine 3',5'-cyclic monophosphate ⬇️

scientific article published on October 1, 1992

Inside the 2015 ASCO Genitourinary Cancers Symposium.

scientific article published in July 2015

Inside the 2016 American Society of Clinical Oncology Genitourinary Cancers Symposium: part 1 - kidney cancer

scientific article published on 17 June 2016

Inside the 2016 American Society of Clinical Oncology Genitourinary Cancers Symposium: part 2 - prostate and bladder cancer.

scientific article

Integrating the molecular background of targeted therapy and immunotherapy in lung cancer: a way to explore the impact of mutational landscape on tumor immunogenicity

scientific article

Interactions between the epidermal growth factor receptor and type I protein kinase A: biological significance and therapeutic implications

scientific article published on April 1998

Intraductal Pancreatic Mucinous Neoplasms: A Tumor-Biology Based Approach for Risk Stratification

scientific article published on 02 September 2020

Intrinsic and acquired resistance to EGFR inhibitors in human cancer therapy.

scientific article

Investigating BRCA Mutations: A Breakthrough in Precision Medicine of Castration-Resistant Prostate Cancer

scientific article

Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer

scientific article

Is It Possible to Improve Prognostic Classification in Patients Affected by Metastatic Renal Cell Carcinoma With an Intermediate or Poor Prognosis?

scientific article published on 07 May 2018

Juvenile and adult immature and in vitro matured ovine oocytes evaluated in relation to membrane electrical properties, calcium stores, IP3 sensitivity and apoptosis occurrence in cumulus cells.

scientific article published in December 2008

Key cancer cell signal transduction pathways as therapeutic targets.

scientific article

Kidney cancer and 2014: is innovation really over?

scientific article published on January 2015

LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

scientific article

Lung adenocarcinoma patient refractory to gefitinib and responsive to crizotinib, with concurrent rare mutation of the epidermal growth factor receptor (L861Q) and increased ALK/MET/ROS1 gene copy number.

scientific article published in December 2013

Lung and Gut Microbiota as Potential Hidden Driver of Immunotherapy Efficacy in Lung Cancer

scientific article published on 11 November 2019

Lung neuroendocrine tumours: deep sequencing of the four World Health Organization histotypes reveals chromatin-remodelling genes as major players and a prognostic role for TERT, RB1, MEN1 and KMT2D.

scientific article published on 22 November 2016

MEKK3 Sustains EMT and Stemness in Pancreatic Cancer by Regulating YAP and TAZ Transcriptional Activity

scientific article published in April 2018

MET exon 14 juxtamembrane splicing mutations: clinical and therapeutical perspectives for cancer therapy

scientific article published on January 2017

Magnitude of PD-1, PD-L1 and T Lymphocyte Expression on Tissue from Castration-Resistant Prostate Adenocarcinoma: An Exploratory Analysis.

scientific article

Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer

scientific article published on 02 June 2019

Maintenance therapy in epithelial ovarian cancer: from chemotherapy to targeted agents

scientific article

Maintenance with lanreotide in small-cell lung cancer expressing somatostatine receptors: A multicenter, randomized, phase 3 trial

scientific article published on 11 June 2019

Management of poor-risk metastatic renal cell carcinoma: current approaches, the role of temsirolimus and future directions

scientific article

Maximising the duration of disease control in metastatic renal cell carcinoma with targeted agents: an expert agreement

scientific article published on 07 July 2011

Measurement of neovascularization is an independent prognosticator of survival in node-negative breast cancer patients with long-term follow-up

scientific article published on 01 October 1999

Mechanisms of Resistance to HER2 Target Therapy

scientific article published on 01 January 2011

Mechanisms of resistance to chemotherapeutic and anti-angiogenic drugs as novel targets for pancreatic cancer therapy.

scientific article published on 30 April 2013

Metabolic Alterations in Renal and Prostate Cancer.

scientific article published on 15 October 2015

Metabolic alterations in renal cell carcinoma

scientific article published on 09 July 2015

Metabolic phenotype of bladder cancer

scientific article published on 08 March 2016

Metastatic castration-resistant prostate cancer: targeting the mechanisms of resistance to abiraterone acetate and enzalutamide.

scientific article published on July 2015

Metastatic pancreatic cancer: Is there a light at the end of the tunnel?

scientific article

Methods to identify molecular expression of mTOR pathway: a rationale approach to stratify patients affected by clear cell renal cell carcinoma for more likely response to mTOR inhibitors

scientific article

Mitoxantrone, Etoposide and bleomycin (meb) chemotherapy in non-hodgkins-lymphoma patients non-elegible for standard cyclophosphamide, Doxorubicin, vincristine and prednisone (chop) combination

scientific article published on 01 May 1995

Modulation of anthracycline activity in canine mammary tumour cells in vitro by medroxyprogesterone acetate.

scientific article

Molecular Pathology of Pancreatic Cancer: From Bench-to-Bedside Translation ⬇️

scientific article published on June 1, 2012

Molecular alterations in basal cell carcinoma subtypes

scientific article published on 24 June 2021

Molecular analysis of a male breast cancer patient with prolonged stable disease under mTOR/PI3K inhibitors BEZ235/everolimus.

scientific article published on March 2016

Molecular heterogeneity assessment by next-generation sequencing and response to gefitinib of EGFR mutant advanced lung adenocarcinoma.

scientific article published in May 2015

Molecular targets on the horizon for kidney and urothelial cancer

scientific article published on 27 August 2013

Molecular typing of lung adenocarcinoma on cytological samples using a multigene next generation sequencing panel

scientific article

Monosomy of chromosome 17 in breast cancer during interpretation of HER2 gene amplification

scientific article published on 15 June 2015

Moving towards a customized approach for drug development: lessons from clinical trials with immune checkpoint inhibitors in lung cancer

scientific article

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups

scientific article

Muscle derangement and alteration of the nutritional machinery in NSCLC

scientific article published on 15 June 2019

Muscle mass, assessed at diagnosis by L3-CT scan as a prognostic marker of clinical outcomes in patients with gastric cancer: A systematic review and meta-analysis

scientific article published on 01 November 2019

Necitumumab in the treatment of non-small-cell lung cancer: clinical controversies

scientific article published on 09 August 2018

Neoadjuvant strategies for triple negative breast cancer: 'state-of-the-art' and future perspectives.

scientific article

Neoadjuvant therapy for triple-negative breast cancer: potential predictive biomarkers of activity and efficacy of platinum chemotherapy, PARP- and immune-checkpoint-inhibitors

scientific article published on 13 February 2020

New molecular targets in non clear renal cell carcinoma: An overview of ongoing clinical trials.

scientific article published on 15 May 2015

Next-generation repeat-free FISH probes for DNA amplification in glioblastoma in vivo: Improving patient selection to MDM2-targeted inhibitors

scientific article published in December 2016

Non-motor effects of deep brain stimulation of the subthalamic nucleus in Parkinson's disease: preliminary physiological results

scientific article published on 01 February 2001

Novel toll-like receptor 9 agonist induces epidermal growth factor receptor (EGFR) inhibition and synergistic antitumor activity with EGFR inhibitors.

scientific article published in January 2006

Nutritional Support in Lung Cancer Patients: The State of the Art

scientific article published on 21 October 2020

Oncogene-Addicted Non-Small-Cell Lung Cancer: Treatment Opportunities and Future Perspectives

scientific article published on 08 May 2020

Oral administration of a novel taxane, an antisense oligonucleotide targeting protein kinase A, and the epidermal growth factor receptor inhibitor Iressa causes cooperative antitumor and antiangiogenic activity.

scientific article published in December 2001

Oral anticancer therapy project: Clinical utility of a specific home care nursing programme on behalf of Italian Association of Medical Oncology (AIOM)

scientific article published on 21 October 2019

Oral antisense that targets protein kinase A cooperates with taxol and inhibits tumor growth, angiogenesis, and growth factor production

article

Organoid-Transplant Model Systems to Study the Effects of Obesity on the Pancreatic Carcinogenesis in vivo

scientific article published on 28 April 2020

Overexpression of the RI alpha subunit of protein kinase A confers hypersensitivity to topoisomerase II inhibitors and 8-chloro-cyclic adenosine 3'5'-monophosphate in Chinese hamster ovary cells

scientific article published on August 1994

Overexpression of wild-type p53 overrides the mitogenic effect of ri-alpha subunit of protein-kinase-a in human breast cells.

scientific article

PD-1 blockade therapy in renal cell carcinoma: current studies and future promises.

scientific article

PD-L1 Expression in De Novo Metastatic Castration-sensitive Prostate Cancer

scientific article published on 01 September 2019

PD-L1 for selecting non-small-cell lung cancer patients for first-line immuno-chemotherapy combination: a systematic review and meta-analysis

scientific article published on 03 June 2019

PROFILing non-small-cell lung cancer patients for treatment with crizotinib according to anaplastic lymphoma kinase abnormalities: translating science into medicine.

scientific article published on 09 March 2013

PTEN in Colorectal Cancer: Shedding Light on Its Role as Predictor and Target

scientific article published on 09 November 2019

PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around

scientific article published on 09 August 2019

Palbociclib Plus Fulvestrant or Everolimus Plus Exemestane for Pretreated Advanced Breast Cancer with Lobular Histotype in ER+/HER2- Patients: A Propensity Score-Matched Analysis of a Multicenter Retrospective Patient Series

scientific article published on 18 December 2020

Pancreatic Cancer and Obesity: Molecular Mechanisms of Cell Transformation and Chemoresistance

scientific article published on 25 October 2018

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

scientific article

Pancreatic cancer: systemic combination therapies for a heterogeneous disease.

scientific article

Pancreatic neuroendocrine neoplasms: Magnetic resonance imaging features according to grade and stage.

scientific article published on January 2017

Panitumumab: the evidence of its therapeutic potential in metastatic colorectal cancer care.

scientific article

Paraneoplastic sensitive neuropathy associated with anti-hu antibodies in a neuroendocrine tumor of duodenum: a case report

scientific article published on 01 October 2010

Patients with sarcomatoid renal cell carcinoma - re-defining the first-line of treatment: A meta-analysis of randomised clinical trials with immune checkpoint inhibitors

scientific article published on 23 July 2020

Pembrolizumab as first-line treatment for metastatic uveal melanoma

scientific article published on 07 June 2019

Perfusion CT Changes in Liver Metastases from Pancreatic Neuroendocrine Tumors During Everolimus Treatment.

scientific article published in March 2017

Perspectives in immunotherapy: meeting report from the "Immunotherapy Bridge 2018" (28-29 November, 2018, Naples, Italy)

scientific article published on 29 November 2019

Phase I clinical study with 8-chloro-cAMP and evaluation of immunological effects in cancer patients

scientific article published on 01 April 1995

Phase II study of gefitinib in combination with docetaxel as first-line therapy in metastatic breast cancer

scientific article published on June 2006

Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer

scientific article published in November 2007

Platelet-derived growth factor receptor inhibitors for non-small cell lung cancer: is the odyssey over?

scientific article published on 25 April 2016

Pneumonitis from immune checkpoint inhibitors and COVID-19: current concern in cancer treatment

scientific article published on 01 July 2020

Poor efficacy of palbociclib in second-line treatment of metastatic lobular breast cancer in a case series: Use before or never more?

scientific article published on 31 December 2019

Potato dextrose agar antifungal susceptibility testing for yeasts and molds: evaluation of phosphate effect on antifungal activity of CMT-3

scientific article

Preclinical and phase I study of oxaliplatin and topotecan in combination in human cancer.

scientific article

Predictive and Prognostic Role of Tumor-Infiltrating Lymphocytes for Early Breast Cancer According to Disease Subtypes: Sensitivity Analysis of Randomized Trials in Adjuvant and Neoadjuvant Setting

scientific article published on 10 February 2016

Predictive biomarkers for the treatment of resectable esophageal and esophago-gastric junction adenocarcinoma: from hypothesis generation to clinical validation

scientific article published on 16 March 2018

Predictive role of changes in the tumor burden and International Metastatic Renal Cell Carcinoma Database Consortium class during active surveillance for metastatic renal cell carcinoma

scientific article published on 06 October 2018

Predictive role of erythrocyte macrocytosis during treatment with pemetrexed in advanced non-small cell lung cancer patients

scientific article

Predictors of outcome for patients with lung adenocarcinoma carrying the epidermal growth factor receptor mutation receiving 1st-line tyrosine kinase inhibitors: Sensitivity and meta-regression analysis of randomized trials.

scientific article published on December 2013

Present and future of personalized medicine in adult genitourinary tumors

scientific article published on January 2015

Profiling mTOR pathway in neuroendocrine tumors.

scientific article published on 14 August 2012

Prognostic Model for Resected Squamous-Cell Lung Cancer: External Multicenter Validation and Propensity Score Analysis exploring the Impact of Adjuvant and Neoadjuvant Treatment.

scientific article published on 18 December 2017

Prognostic Value of Beta-Tubulin-3 and c-Myc in Muscle Invasive Urothelial Carcinoma of the Bladder.

scientific article published on 5 June 2015

Prognostic and predictive factors in patients treated with chemotherapy for advanced urothelial cancer: where do we stand?

scientific article published on January 2015

Prognostic factors in human colorectal cancer

scientific article published on January 1997

Prognostic impact of alternative splicing-derived hMENA isoforms in resected, node-negative, non-small-cell lung cancer.

scientific article

Prognostic impact of early nutritional support in patients affected by locally advanced and metastatic pancreatic ductal adenocarcinoma undergoing chemotherapy.

scientific article published on 26 March 2018

Prognostic impact of proliferation for resected early stage 'pure' invasive lobular breast cancer: Cut-off analysis of Ki67 according to histology and clinical validation

scientific article published on 16 June 2017

Prognostic model for advanced breast carcinoma with luminal subtype and impact of hormonal maintenance: Implications for post-progression and conditional survival

scientific article published on 7 July 2016

Prognostication and response assessment in liver and pancreatic tumors: The new imaging

scientific article

Progression-free survival as primary endpoint in randomized clinical trials of targeted agents for advanced renal cell carcinoma. Correlation with overall survival, benchmarking and power analysis.

scientific article

Propensity score analysis investigating the role of hormonal maintenance (HM) for advanced breast carcinoma with luminal subtype (ABC-Lum): Implication for prognostic modeling, post-progression and conditional survival (PPS/CS)

scientific article published on 20 May 2016

Prostate cancer heterogeneity: Discovering novel molecular targets for therapy

scientific article published on 11 February 2017

Protein kinase A as target for novel integrated strategies of cancer therapy.

scientific article

Putative predictors of efficacy for immune checkpoint inhibitors in non-small-cell lung cancer: facing the complexity of the immune system

scientific article published on 14 October 2017

Quantitative score modulation of HSP90 and HSP27 in clear cell renal cell carcinoma

scientific article published on 01 October 2014

Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial

scientific article

Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): overall survival and updated results of a randomised, double-blind, phase 3 trial

scientific article published on 18 November 2019

Rational bases for the development of EGFR inhibitors for cancer treatment.

scientific article published on 21 May 2007

Rationale and clinical use of multitargeting anticancer agents

scientific article published on 13 July 2013

Re: Ian D. Davis, Wanling Xie, Carmel Pezaro, et al. Efficacy of Second-line Targeted Therapy for Renal Cell Carcinoma According to Change from Baseline in International Metastatic Renal Cell Carcinoma Database Consortium Prognostic Category. Eur Ur

scientific article published on 30 December 2016

Real-world efficacy and safety of nivolumab in previously-treated metastatic renal cell carcinoma, and association between immune-related adverse events and survival: the Italian expanded access program

article

Reduction of RI alpha subunit of cAMP-dependent protein kinase expression induces growth inhibition of human mammary epithelial cells transformed by TGF-alpha, c-Ha-ras, and c-erbB-2 genes

scientific article published on November 1993

Renal cell carcinoma in one year: Going inside the news of 2017 - A report of the main advances in RCC cancer research

Reporting tumor molecular heterogeneity in histopathological diagnosis

scientific article

Reprofiling Metastatic Samples for Chromosome 9p and 14q Aberrations as a Strategy to Overcome Tumor Heterogeneity in Clear-cell Renal Cell Carcinoma

scientific article published on 27 October 2015

Resistance to taxanes is induced by c-erbB-2 overexpression in human MCF-10A mammary epithelial cells and is blocked by combined treatment with an antisense oligonucleotide targeting type I protein kinase A.

scientific article

Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts.

scientific article published on July 1994

Revising PTEN in the Era of Immunotherapy: New Perspectives for an Old Story

scientific article published on 10 October 2019

Risk Stratification Model for Resected Squamous-Cell Lung Cancer Patients According to Clinical and Pathological Factors

scientific article published on 20 July 2015

Role of Combined 68Ga-DOTATOC and 18F-FDG Positron Emission Tomography/Computed Tomography in the Diagnostic Workup of Pancreas Neuroendocrine Tumors: Implications for Managing Surgical Decisions.

scientific article published in December 2016

Role of STAT3 pathway in genitourinary tumors.

scientific article published on November 2015

Role of site-selective cAMP analogs in the control and reversal of malignancy ⬇️

scientific article published on January 1, 1991

Safety and Efficacy of Cabozantinib in Metastatic Renal-Cell Carcinoma: Real-World Data From an Italian Managed Access Program

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Second-line therapy for metastatic urothelial carcinoma: Defining the best treatment option among immunotherapy, chemotherapy, and antiangiogenic targeted therapies. A systematic review and meta-analysis

scientific article published on 14 January 2019

Selected news from the 2014 Genitourinary Cancers Symposium: translating novel strategies into clinical practice.

scientific article published in November 2014

Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death

scientific article

Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth

scientific article

Sequence-dependent antiproliferative effects of cytotoxic drugs and epidermal growth factor receptor inhibitors.

scientific article

Sequencing new agents after docetaxel in patients with metastatic castration-resistant prostate cancer

scientific article published on August 2015

Sequential therapy in metastatic clear cell renal carcinoma: TKI-TKI vs TKI-mTOR.

scientific article published on December 2012

Serial 18F-choline-PET imaging in patients receiving enzalutamide for metastatic castration-resistant prostate cancer: response assessment and imaging biomarkers.

scientific article

Sex determining of cat embryo and some feline species.

scientific article

Site-selective 8-Cl-cAMP which causes growth inhibition and differentiation increases DNA (CRE)-binding activity in cancer cells

scientific article published in August 1989

Site-selective cyclic AMP analogs provide a new approach in the control of cancer cell growth

scientific article published on 01 October 1987

Skeletal Muscle Loss during Multikinase Inhibitors Therapy: Molecular Pathways, Clinical Implications, and Nutritional Challenges

scientific article published on 12 October 2020

Skin cancer triage and management during COVID-19 pandemic

scientific article published on 25 April 2020

Smoking habit and hospitalization for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related pneumonia: The unsolved paradox behind the evidence

scientific article published on 23 April 2020

Sorafenib for lung cancer: is the "Battle" still open?

scientific article published on 16 July 2012

Sorafenib in combination with erlotinib or with gemcitabine in elderly patients with advanced non-small-cell lung cancer: a randomized phase II study.

scientific article published on 6 January 2011

Subpopulation Treatment Effect Pattern Plot (STEPP) analysis of Ki67 assay according to histology: prognostic relevance for resected early stage 'pure' and 'mixed' lobular breast cancer

scientific article published on 22 March 2016

Suppression of mTOR pathway in solid tumors: lessons learned from clinical experience in renal cell carcinoma and neuroendocrine tumors and new perspectives.

scientific article published on January 2015

Suppression of malignancy targeting the intracellular signal transducing proteins of cAMP: The use of site-selective cAMP analogs, antisense strategy, and gene transfer ⬇️

scientific article published on January 1, 1991

Synergistic anti-proliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells

scientific article

Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer.

scientific article published on December 2006

Synergistic growth inhibition and induction of apoptosis by a novel mixed backbone antisense oligonucleotide targeting CRIPTO in combination with C225 anti-EGFR monoclonal antibody and 8-Cl-cAMP in human GEO colon cancer cells

scientific article published on 01 September 1999

Synergistic inhibition of growth and induction of apoptosis by 8-chloro-cAMP and paclitaxel or cisplatin in human cancer cells ⬇️

article by G Tortora et al published 15 November 1997 in Cancer Research

Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues

scientific article published in March 1988

Synergistic inhibition of human cancer cell growth by cytotoxic drugs and mixed backbone antisense oligonucleotide targeting protein kinase A.

scientific article published on November 1997

TAK1-regulated expression of BIRC3 predicts resistance to preoperative chemoradiotherapy in oesophageal adenocarcinoma patients

scientific article

TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts

scholarly article

Targeted next-generation sequencing identifies genomic abnormalities potentially driving the prognosis of early-stage invasive lobular breast carcinoma patients stratified according to a validated clinico-pathological model

scientific article published on 27 January 2020

Targeting Met and VEGFR Axis in Metastatic Castration-Resistant Prostate Cancer: 'Game Over'?

scientific article published on 5 February 2016

Targeting the epidermal growth factor receptor in solid tumors: focus on safety.

scientific article published on April 2014

The Anticancer Efficacy of Immune Checkpoint Inhibitors According to Patients' Age: A Systematic Review and Meta-Analysis

scientific article published on 01 April 2020

The Cardiovascular Toxicity of Abiraterone and Enzalutamide in Prostate Cancer.

scientific article published on 27 December 2017

The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer

scientific article published on 24 January 2019

The RI alpha subunit of protein kinase A controls serum dependency and entry into cell cycle of human mammary epithelial cells.

scientific article published on November 1994

The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor

scientific article

The Tumor Entity Denominated "clear cell-papillary renal cell carcinoma" According to the WHO 2016 new Classification, have the Clinical Characters of a Renal Cell Adenoma as does Harbor a Benign Outcome

scientific article

The coming of ramucirumab in the landscape of anti-angiogenic drugs: potential clinical and translational perspectives.

scientific article published on 20 July 2015

The development of PARP as a successful target for cancer therapy

scientific article published on 20 December 2017

The effect of a treatment delay on outcome in metastatic renal cell carcinoma

scientific article published on 29 March 2019

The identification of a small but significant subset of patients still targetable with anti-HER2 inhibitors when affected by triple negative breast carcinoma

scientific article published on 28 July 2013

The incidence and relative risk of pulmonary toxicity in patients treated with anti-PD1/PD-L1 therapy for solid tumors: a meta-analysis of current studies

scientific article published in June 2017

The obesity paradox in cancer: clinical insights and perspectives

scientific article published on 28 February 2018

The outcome to axitinib or everolimus after sunitinib in metastatic renal cell carcinoma

scientific article published on 01 August 2018

The prognostic value of pain in castration-sensitive prostate cancer

scientific article published on 10 July 2020

The prospect of precision therapy for renal cell carcinoma

scientific article

The rationale for the combination of selective EGFR inhibitors with cytotoxic drugs and radiotherapy.

scientific article published on January 2007

The route to personalized medicine in bladder cancer: where do we stand?

scientific article

The safety and efficacy of enzalutamide in the treatment of advanced prostate cancer

scientific article published on 21 May 2016

The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells.

scientific article published on 30 November 2010

The use of xenograft models for the selection of cancer treatments with the EGFR as an example.

scientific article published on March 2008

Therapeutic integration of signal transduction targeting agents and conventional anti-cancer treatments.

scientific article published on March 2004

Thyroid-stimulating hormone-regulated growth and cell cycle distribution of thyroid cells involve type I isozyme of cyclic AMP-dependent protein kinase

scientific article published on 01 May 1993

Toll-Like Receptor 9 Agonists for Cancer Therapy

scientific article published on 4 August 2014

Toll-like receptor 9 agonist IMO cooperates with cetuximab in K-ras mutant colorectal and pancreatic cancers

scientific article

Toll-like receptor 9 agonist IMO cooperates with everolimus in renal cell carcinoma by interfering with tumour growth and angiogenesis.

scientific article published on 9 April 2013

Tp53 and its potential therapeutic role as a target in bladder cancer

scientific article published on March 2017

Transfection with a CRIPTO anti-sense plasmid suppresses endogenous CRIPTO expression and inhibits transformation in a human embryonal carcinoma cell line

scientific article published on May 1996

Treatment of Locally Advanced Gastric Cancer (LAGC): Back to Lauren's Classification in Pan-Cancer Analysis Era?

scientific article published on 01 July 2020

Treatment-related fatigue with sorafenib, sunitinib and pazopanib in patients with advanced solid tumors: an up-to-date review and meta-analysis of clinical trials.

scientific article published on 07 February 2014

True 3q chromosomal amplification in squamous cell lung carcinoma by FISH and aCGH molecular analysis: impact on targeted drugs

scientific article

Tumor thrombosis: a peculiar finding associated with pancreatic neuroendocrine neoplasms. A pictorial essay.

scientific article

Type II regulatory subunit of protein kinase restores cAMP-dependent transcription in a cAMP-unresponsive cell line

scientific article published on October 1990

Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cells ⬇️

scientific article published on May 1, 1992

Unmasking the impact of Rictor in cancer: novel insights of mTORC2 complex

scientific article published on 01 July 2018

Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells.

scientific article

Weekly docetaxel and vinorelbine (VIN-DOX) as first line treatment in patients with hormone refractory prostate cancer

scientific article published in December 2004

Whole genomes redefine the mutational landscape of pancreatic cancer

scientific article published in February 2015

Whole-genome landscape of pancreatic neuroendocrine tumours.

scientific article published on 15 February 2017

Wide spetcrum mutational analysis of metastatic renal cell cancer: a retrospective next generation sequencing approach

scientific article published on 10 October 2016

ZD1839 (IRESSA), an EGFR-selective tyrosine kinase inhibitor, enhances taxane activity in bcl-2 overexpressing, multidrug-resistant MCF-7 ADR human breast cancer cells

scientific article published in March 2002

ZD1839 (Iressa): preclinical studies and pharmacology

scientific article

ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases.

scientific article

Zoledronic acid cooperates with a cyclooxygenase-2 inhibitor and gefitinib in inhibiting breast and prostate cancer.

scientific article published on December 2005

[New frontiers in cancer treatment]

scientific article published on 01 December 2006

[Rationales for the integration of molecular and conventional therapies]

scientific article published on 01 November 2002

c-MYC Expression Is a Possible Keystone in the Colorectal Cancer Resistance to EGFR Inhibitors

scientific article published on 10 March 2020

nab-Paclitaxel plus gemcitabine for metastatic pancreatic cancer: long-term survival from a phase III trial.

scientific article published on 31 January 2015

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