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List of works by Caitriona M O'Driscoll

7-formyl-10-methylisoellipticine, a novel ellipticine derivative, induces mitochondrial reactive oxygen species (ROS) and shows anti-leukaemic activity in mice

scientific article published on 12 November 2015

A click chemistry route to 2-functionalised PEGylated and cationic β-cyclodextrins: co-formulation opportunities for siRNA delivery

scientific article published on 21 May 2012

A comparison of intestinal lymphatic transport and systemic bioavailability of saquinavir from three lipid-based formulations in the anaesthetised rat model

scientific article published in July 2006

A comparison of the permeation enhancement potential of simple bile salt and mixed bile salt:fatty acid micellar systems using the CaCo-2 cell culture model

scientific article published in October 2000

A novel lipid-based solid dispersion for enhancing oral bioavailability of Lycopene--in vivo evaluation using a pig model.

scientific article published on 21 June 2013

A novel, anisamide-targeted cyclodextrin nanoformulation for siRNA delivery to prostate cancer cells expressing the sigma-1 receptor.

scientific article published on 22 December 2015

Amphiphilic polyallylamine based polymeric micelles for siRNA delivery to the gastrointestinal tract: in vitro investigations

scientific article published in March 2013

An examination of the effect of intestinal first pass extraction on intestinal lymphatic transport of saquinavir in the rat.

scientific article published on 2 November 2007

Anisamide-targeted cyclodextrin nanoparticles for siRNA delivery to prostate tumours in mice

scientific article

Antibody-Targeted Cyclodextrin-Based Nanoparticles for siRNA Delivery in the Treatment of Acute Myeloid Leukemia: Physicochemical Characteristics, in Vitro Mechanistic Studies, and ex Vivo Patient Derived Therapeutic Efficacy

scientific article published on February 2017

Bioavailability of lycopene in the rat: the role of intestinal lymphatic transport

scientific article published on 01 March 2010

Bioconjugated gold nanoparticles enhance cellular uptake: A proof of concept study for siRNA delivery in prostate cancer cells.

scientific article published on 14 May 2016

Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia

scientific article published on 16 September 2014

Biopharmaceutical challenges associated with drugs with low aqueous solubility--the potential impact of lipid-based formulations.

scientific article published on 6 November 2007

Biophysical and structural characterisation of nucleic acid complexes with modified cyclodextrins using circular dichroism

scientific article published on 6 March 2014

Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics? ⬇️

scientific article published on March 22, 2011

Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery

scientific article

Cell transfection with polycationic cyclodextrin vectors

scientific article published on April 2004

Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: effect of reversing primary and secondary face modifications

scientific article

Click-modified cyclodextrins as nonviral vectors for neuronal siRNA delivery

scientific article published on 3 August 2012

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.

scientific article

Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: case studies with fenofibrate.

scientific article

Cyclodextrin mediated delivery of NF-κB and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro

scientific article published on 25 May 2015

Delivering RNAi therapeutics with non-viral technology: a promising strategy for prostate cancer?

scientific article published on 14 March 2013

Delivering a disease-modifying treatment for Huntington's disease.

scientific article published on 26 September 2014

Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system.

scientific article published on 16 October 2013

Early-stage development of novel cyclodextrin-siRNA nanocomplexes allows for successful postnebulization transfection of bronchial epithelial cells.

scientific article published on December 2014

Estimation of absorption parameters from the non-steady-state phase in the rat gut perfusion model

scientific article

Evaluation of cellular uptake and gene transfer efficiency of pegylated poly-L-lysine compacted DNA: implications for cancer gene therapy

scientific article published on November 2006

Evaluation of the physicochemical properties and the biocompatibility of polyethylene glycol-conjugated gold nanoparticles: A formulation strategy for siRNA delivery.

scientific article published on 24 August 2015

Exploring the Impact of Drug Properties on the Extent of Intestinal Lymphatic Transport - In Vitro and In Vivo Studies

scientific article published on 27 November 2014

Folate-targeted amphiphilic cyclodextrin nanoparticles incorporating a fusogenic peptide deliver therapeutic siRNA and inhibit the invasive capacity of 3D prostate cancer tumours

scientific article

Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo

scientific article published on 4 July 2016

Formulation and Evaluation of Anisamide-Targeted Amphiphilic Cyclodextrin Nanoparticles To Promote Therapeutic Gene Silencing in a 3D Prostate Cancer Bone Metastases Model

scientific article published on 23 November 2016

Gastrointestinal gene delivery by cyclodextrins--in vitro quantification of extracellular barriers

scientific article published on 7 September 2013

Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system.

scientific article published on 14 March 2013

Gold nanoparticles enlighten the future of cancer theranostics.

scientific article published on 22 August 2017

In vitro investigations of the efficacy of cyclodextrin-siRNA complexes modified with lipid-PEG-Octaarginine: towards a formulation strategy for non-viral neuronal siRNA delivery

scientific article published on 29 November 2012

Life in 3D is never flat: 3D models to optimise drug delivery

scientific article published on 25 July 2015

Lipid-based formulations for intestinal lymphatic delivery

scientific article

Lipid-based nanocarriers for oral peptide delivery.

scientific article published on 11 April 2016

Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments.

scientific article

Mechanistic studies on nonviral gene delivery to the intestine using in vitro differentiated cell culture models and an in vivo rat intestinal loop

scientific article published on April 1, 2003

Mechanistic studies on the uptake and intracellular trafficking of novel cyclodextrin transfection complexes by intestinal epithelial cells

scientific article published on 16 April 2011

Mesoporous silica-based dosage forms improve bioavailability of poorly soluble drugs in pigs: case example fenofibrate

scientific article published on 20 June 2017

Mucus as a barrier to the permeability of hydrophilic and lipophilic compounds in the absence and presence of sodium taurocholate micellar systems using cell culture models

article

Nanoparticle-mediated siRNA delivery assessed in a 3D co-culture model simulating prostate cancer bone metastasis

scientific article

Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance

scientific article

Nanostructures of Cationic Amphiphilic Cyclodextrin Complexes with DNA

scientific article published on 27 February 2013

Non-viral nanosystems for gene and small interfering RNA delivery to the central nervous system: formulating the solution.

scientific article published on 26 July 2013

Oligonucleotide conjugates - Candidates for gene silencing therapeutics

scientific article published on 10 August 2016

Opportunities and Challenges for Oral Delivery of Hydrophobic Versus Hydrophilic Peptide and protein-like Drugs Using lipid-based Technologies ⬇️

scientific article published on December 1, 2011

PEGylated cyclodextrins as novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability.

scientific article published on 30 June 2014

Pattern recognition receptors--molecular orchestrators of inflammation in inflammatory bowel disease

scientific article published on 25 October 2012

Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs.

scientific article published on 16 June 2016

Physicochemical, pharmacokinetic and pharmacodynamic analyses of amphiphilic cyclodextrin-based nanoparticles designed to enhance intestinal delivery of insulin

scientific article published on 31 July 2018

Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model

scientific article

RNA interference for multiple myeloma therapy: targeting signal transduction pathways

scientific article published on 20 July 2015

RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies

scientific article published on 02 July 2015

Scaffold-Based Delivery of Nucleic Acid Therapeutics for Enhanced Bone and Cartilage Repair

scientific article published on 23 May 2019

Self-assembling modified β-cyclodextrin nanoparticles as neuronal siRNA delivery vectors: focus on Huntington's disease

scientific article published on 9 January 2013

Stimulation of Triglyceride-Rich Lipoprotein Secretion by Polysorbate 80: In Vitro and in Vivo Correlation Using Caco-2 Cells and a Cannulated Rat Intestinal Lymphatic Model

scientific article published on 01 December 2004

Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: in vitro analysis

scientific article

Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-L-lysine nanocarrier to suppress prostate cancer growth in mice.

scientific article

Targeted Drug Delivery via Folate Receptors for the Treatment of Brain Cancer: Can the Promise Deliver?

scientific article

Targeted gene delivery to hepatocytes with galactosylated amphiphilic cyclodextrins

article

The effects of casein on diclofenac release from hydroxypropylmethylcellulose (HPMC) compacts

scientific article

The effects of pluronics block copolymers and Cremophor EL on intestinal lipoprotein processing and the potential link with P-glycoprotein in Caco-2 cells

scientific article published in July 2003

The potential for clinical translation of antibody-targeted nanoparticles in the treatment of acute myeloid leukaemia

scientific article published on 29 July 2018

The relationship between rat intestinal permeability and hydrophilic probe size

scientific article published in October 1996

The role of transcription factors in prostate cancer and potential for future RNA interference therapy

scientific article published on 24 March 2014

The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease

scientific article published on 15 August 2016

The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics

scientific article published on 14 July 2015

Therapeutic targeting in the silent era: advances in non-viral siRNA delivery

scientific article published on 29 April 2010

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