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List of works by Olivia M. Merkel

A Method for Targeted Nonviral siRNA Delivery in Cancer and Inflammatory Diseases

scientific article published on 01 January 2020

A smart approach to enable preclinical studies in pharmaceutical industry: PLGA-based extended release formulation platform for subcutaneous applications

scientific article published on 20 March 2020

Amphiphilic and biodegradable hy-PEI-g-PCL-b-PEG copolymers efficiently mediate transgene expression depending on their graft density

scientific article published on 12 May 2011

Amphiphilic biodegradable PEG-PCL-PEI triblock copolymers for FRET-capable in vitro and in vivo delivery of siRNA and quantum dots.

scientific article

Applications of polymer micelles for imaging and drug delivery

scientific article

Biodegradable Three-Layered Micelles and Injectable Hydrogels

scientific article published on January 2016

Biodegradable poly(ethylene carbonate) nanoparticles as a promising drug delivery system with "stealth" potential

scientific article published on 5 April 2011

Biodistribution of the GATA-3-specific DNAzyme hgd40 after inhalative exposure in mice, rats and dogs

scientific article published on 29 June 2013

Biophysical characterization of hyper-branched polyethylenimine-graft- polycaprolactone-block-mono-methoxyl-poly(ethylene glycol) copolymers (hy-PEI-PCL-mPEG) for siRNA delivery ⬇️

scientific article published on April 23, 2011

CRISPR-cas gene-editing as plausible treatment of neuromuscular and nucleotide-repeat-expansion diseases: A systematic review

article

Characterization of Dopaminergic System in the Striatum of Young Adult Park2-/- Knockout Rats.

scientific article

Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles

scientific article published on 21 August 2019

Coming in and Finding Out: Blending Receptor-Targeted Delivery and Efficient Endosomal Escape in a Novel Bio-Responsive siRNA Delivery System for Gene Knockdown in Pulmonary T Cells

scientific article published on 26 April 2019

Comparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in mice

scientific article published on 9 January 2011

Controlled pulmonary drug and gene delivery using polymeric nano-carriers ⬇️

scientific article published on December 13, 2011

Correlating quantitative tumor accumulation and gene knockdown using SPECT/CT and bioluminescence imaging within an orthotopic ovarian cancer model

scientific article published in September 2018

Dry powder inhalation of siRNA

scientific article published on 16 May 2019

Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution

scientific article

Effects of Surface Charge, PEGylation and Functionalization with Dipalmitoylphosphatidyldiglycerol on Liposome-Cell Interactions and Local Drug Delivery to Solid Tumors via Thermosensitive Liposomes

scientific article published on 14 June 2021

Efficient and Tumor Targeted siRNA Delivery by Polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol)-folate (PEI-PCL-PEG-Fol).

scientific article published on 7 December 2015

Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers ⬇️

scientific article published on June 16, 2012

Evaluating the Regulation of Cytokine Levels After siRNA Treatment in Antigen-Specific Target Cell Populations via Intracellular Staining

scientific article published on 01 January 2019

Evaluation of β-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity

scientific article published on 15 November 2018

Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy

scientific article

Flow Cytometry-Based Cell Type-Specific Assessment of Target Regulation by Pulmonary siRNA Delivery

scientific article published on 01 January 2019

Flow cytometry-based cell type-specific assessment of target regulation by pulmonary siRNA delivery.

scientific article published on January 2013

Folate Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance.

scientific article

Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages

scientific article published on 24 August 2016

Immunogenicity of Cas9 Protein

scientific article published on 04 October 2019

In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly(ethylene glycol) block copolymers

scientific article published in July 2011

In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells

scientific article published on 20 February 2018

In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure

scientific article

In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes

scientific article

Indium-Labeling of siRNA for Small Animal SPECT Imaging

scientific article published on January 2016

Influence of oligospermines architecture on their suitability for siRNA delivery

scientific article

Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes

scientific article published on September 2006

Integrin alphaVbeta3 targeted gene delivery using RGD peptidomimetic conjugates with copolymers of PEGylated poly(ethylene imine).

scientific article

Lipids and polymers in pharmaceutical technology: Lifelong companions

scientific article published on 09 January 2019

Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy

scientific article published in July 2018

Microfluidic Assembly of siRNA-Loaded Micelleplexes for Tumor Targeting in an Orthotopic Model of Ovarian Cancer

scientific article published on 01 January 2019

Nanoimprinting of topographical and 3D cell culture scaffolds.

scientific article published on February 2014

Nanoparticle-Mediated Gene Silencing for Sensitization of Lung Cancer to Cisplatin Therapy

scientific article published on 24 April 2020

Nonviral pulmonary delivery of siRNA.

scientific article

Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance

scientific article published in July 2009

Nose-to-brain delivery of biologics

scientific article published on 01 April 2019

PEGylated poly(ethylene imine) copolymer-delivered siRNA inhibits HIV replication in vitro

scientific article published on 10 September 2011

PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application: structure-function relationships

scientific article published on 12 October 2009

Perfectly shaped siRNA delivery

scientific article published on December 2010

Physicochemical and In Vitro Evaluation of Drug Delivery of an Antibacterial Synthetic Benzophenone in Biodegradable PLGA Nanoparticles

scientific article published on 25 September 2018

Poly(ethylene carbonate) Nanoparticles as Carrier System for Chemotherapy Showing Prolonged in vivo Circulation and Anti-Tumor Efficacy

scientific article published on 30 May 2012

Polycationic triazine-based dendrimers: effect of peripheral groups on transfection efficiency

scientific article published on January 2009

Polymer-related off-target effects in non-viral siRNA delivery

scientific article published on 22 December 2010

Post-Transcriptional Regulation of the GASC1 Oncogene with Active Tumor-Targeted siRNA-Nanoparticles

scientific article

Pulmonary Delivery of siRNA via Polymeric Vectors as Therapies of Asthma

scientific article published on 07 July 2015

Pulmonary delivery of siRNA as a novel treatment for lung diseases

scientific article published on 01 April 2019

Recent Progress of Polymeric Nanogels for Gene Delivery

scientific article published on 16 January 2019

Revisiting the value of competition assays in folate receptor-mediated drug delivery

scientific article published in September 2017

Screening nylon-3 polymers, a new class of cationic amphiphiles, for siRNA delivery.

scientific article

Semifluorinated alkanes as a liquid drug carrier system for topical ocular drug delivery

scientific article published in September 2014

Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emissi

scientific article

T-cell targeted pulmonary siRNA delivery for the treatment of asthma

scientific article published on 08 April 2020

Tackling breast cancer chemoresistance with nano-formulated siRNA.

scientific article published on 20 September 2016

Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine.

scientific article published on 10 October 2016

Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma.

scientific article published on 18 March 2016

Targeting KRAS Mutant Lung Cancer Cells with siRNA-Loaded Bovine Serum Albumin Nanoparticles

scientific article published on 09 July 2019

Targeting the blind spot of polycationic nanocarrier-based siRNA delivery

scientific article published on 9 October 2012

The Impact of Nylon-3 Copolymer Composition on the Efficiency of siRNA Delivery to Glioblastoma Cells

scientific article published on 08 July 2019

The advantages of pulmonary delivery of therapeutic siRNA.

scientific article published in April 2015

The impact of microfluidic mixing of triblock micelleplexes on in vitro / in vivo gene silencing and intracellular trafficking

scientific article

Therapeutic delivery of RNA effectors: diseases affecting the respiratory system

scientific article published in January 2016

Three-Layered Biodegradable Micelles Prepared by Two-Step Self-Assembly of PLA-PEI-PLA and PLA-PEG-PLA Triblock Copolymers as Efficient Gene Delivery System

scientific article published on 2 February 2015

Tracking and treating activated T cells.

scientific article published on January 2013

Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins

scientific article published in 2022

Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity

scientific article

Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: the effects of peripheral groups and core structure on biological activity

scientific article published on August 2010

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