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List of works by Luigi Bubacco

1H NMR spectroscopy of the binuclear Cu(II) active site of Streptomyces antibioticus tyrosinase

scientific article published on 01 January 1999

2-Hydroxypyridine-N-oxide-Embedded Aurones as Potent Human Tyrosinase Inhibitors

scientific article published on 17 November 2016

A novel prion protein-tyrosine hydroxylase interaction

scientific article published on January 2014

A protein-based oxygen biosensor for high-throughput monitoring of cell growth and cell viability.

scientific article

A topological model of the interaction between alpha-synuclein and sodium dodecyl sulfate micelles.

scientific article

Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

scientific article published on 14 March 2017

Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells

scientific article

Alpha-synuclein pore forming activity upon membrane association

article by Laura Tosatto et al published November 2012 in BBA - Biomembranes

Analysis of the Catecholaminergic Phenotype in Human SH-SY5Y and BE(2)-M17 Neuroblastoma Cell Lines upon Differentiation

scientific article published on 28 August 2015

Anti-Oxidants in Parkinson's Disease Therapy: A Critical Point of View

scientific article

Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?

scientific article published on 16 February 2016

Are dopamine derivatives implicated in the pathogenesis of Parkinson's disease?

scientific article published on 03 January 2014

Binding Interactions of Agents That Alter α-Synuclein Aggregation

scientific article published in January 2015

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

scientific article

Biophysical groundwork as a hinge to unravel the biology of α-synuclein aggregation and toxicity

scientific article published on 21 January 2014

Broken helix in vesicle and micelle-bound alpha-synuclein: insights from site-directed spin labeling-EPR experiments and MD simulations.

scientific article published on 6 May 2008

COVID-19 and possible links with Parkinson's disease and parkinsonism: from bench to bedside

scientific article published on 20 August 2020

Ceftriaxone blocks the polymerization of α-synuclein and exerts neuroprotective effects in vitro

scientific article published on 24 October 2013

Ceramides in Parkinson's Disease: From Recent Evidence to New Hypotheses

article

Cloning, expression, purification, and spectroscopic analysis of the fragment 57-102 of human alpha-synuclein

scientific article published on 01 January 2005

Comparison of the X-ray absorption properties of the binuclear active site of molluscan and arthropodan hemocyanins.

scientific article published on 4 August 2001

Comprehensive Structural and Thermodynamic Analysis of Prefibrillar WT α-Synuclein and Its G51D, E46K, and A53T Mutants by a Combination of Small-Angle X-ray Scattering and Variational Bayesian Weighting

scientific article published on 17 September 2020

Conformational equilibria in monomeric alpha-synuclein at the single-molecule level

scientific article

Copper Ions and Parkinson's Disease: Why Is Homeostasis So Relevant?

scientific article published on 29 January 2020

Copper(I)-α-Synuclein Interaction: Structural Description of Two Independent and Competing Metal Binding Sites

scientific article published on 23 January 2013

Covalent α-synuclein dimers: chemico-physical and aggregation properties

scientific article

Cross-talk between LRRK2 and PKA: implication for Parkinson's disease?

scientific article published on February 2017

Cu(II) coordination in arthropod and mollusk green half-methemocyanins analyzed by electron spin-echo envelope modulation spectroscopy

scientific article published on 01 February 1995

DJ-1 is a copper chaperone acting on SOD1 activation

scientific article

DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function.

scientific article published on 13 January 2017

Designed hairpin peptides interfere with amyloidogenesis pathways: fibril formation and cytotoxicity inhibition, interception of the preamyloid state

scientific article published on 30 August 2011

Determination of ATP, ADP, and AMP Levels by Reversed-Phase High-Performance Liquid Chromatography in Cultured Cells

scientific article published on 01 January 2019

Diabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View

scientific article published on 28 March 2018

Differences in the binding of copper(I) to α- and β-synuclein

scientific journal article

Dopamine Oxidation Products as Mitochondrial Endotoxins, a Potential Molecular Mechanism for Preferential Neurodegeneration in Parkinson's Disease

scientific article published on 03 July 2018

Dopamine quinones interact with alpha-synuclein to form unstructured adducts.

scientific article published on 10 March 2010

Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53

scientific article

Dysfunction of dopamine homeostasis: clues in the hunt for novel Parkinson's disease therapies.

scientific article published on 05 March 2013

EPR study of the dinuclear active copper site of tyrosinase from Streptomyces antibioticus

scientific article published on 01 June 2000

Effects of Trehalose on Thermodynamic Properties of Alpha-synuclein Revealed through Synchrotron Radiation Circular Dichroism

scientific article published on 4 May 2015

Erratum to: Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells.

scientific article published on April 2016

Fibrils of α-Synuclein Abolish the Affinity of Cu2+-Binding Site to His50 and Induce Hopping of Cu2+ Ions in the Termini

scientific article published on 01 August 2019

GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.

scientific article published on 26 April 2017

GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

scientific article

High-Pressure-Driven Reversible Dissociation of α-Synuclein Fibrils Reveals Structural Hierarchy.

scientific article published in October 2017

Human SOD2 modification by dopamine quinones affects enzymatic activity by promoting its aggregation: possible implications for Parkinson's disease

scientific article

Human leucine-rich repeat kinase 1 and 2: intersecting or unrelated functions?

scientific article published on October 2012

Human tyrosinase produced in insect cells: a landmark for the screening of new drugs addressing its activity.

scientific article

Impacts of increased α-synuclein on clathrin-mediated endocytosis at synapses: implications for neurodegenerative diseases.

scientific article published in April 2018

Impaired dopamine metabolism in Parkinson's disease pathogenesis

scientific article published on 20 August 2019

Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction

scientific article published on 15 April 2019

Insights into the oligomerization process of the C-terminal domain of human plasma membrane Ca²+-ATPase.

scientific article

Insights on Channel-Like Activity of Membrane Bound Alpha-Synuclein

article by Laura Tosatto et al published January 2010 in Biophysical Journal

Interaction and coordination geometries for Ag(I) in the two metal sites of hemocyanin

scientific article published in March 2000

Interaction between alpha-synuclein and metal ions, still looking for a role in the pathogenesis of Parkinson's disease.

scientific article published on January 2009

Interaction between the type-3 copper protein tyrosinase and the substrate analogue p-nitrophenol studied by NMR.

scientific article published in January 2005

Investigation of Streptomyces antibioticus tyrosinase reactivity toward chlorophenols

scientific article published in 2011

Investigation of binding-site homology between mushroom and bacterial tyrosinases by using aurones as effectors

scientific article published on 21 May 2014

Kinetic and structural analysis of the early oxidation products of dopamine: analysis of the interactions with alpha-synuclein.

scientific article published on 29 March 2007

LRRK2 and neuroinflammation: partners in crime in Parkinson's disease?

scientific article published on 21 March 2014

LRRK2 deficiency impacts ceramide metabolism in brain.

scientific article published on 15 August 2016

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

scientific article

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate

scientific article published on 13 January 2016

Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4

scientific article published on 27 October 2018

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

scientific article

Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells

scientific article published on 9 December 2015

Lysines, Achilles' heel in alpha-synuclein conversion to a deadly neuronal endotoxin

scientific article published on 09 December 2015

MXAN analysis of the XANES energy region of a mononuclear copper complex: applications to bioinorganic systems

scientific article

Mechanistic insight into the activity of tyrosinase from variable-temperature studies in an aqueous/organic solvent

scientific article

Molecular Evolution and Phylogeny of Sipunculan Hemerythrins

scientific article published on 14 December 2005

Molecular Insights and Functional Implication of LRRK2 Dimerization

scientific article published in January 2017

Molecular basis of the Bohr effect in arthropod hemocyanin

scientific article published on 25 August 2008

Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: implications for mitochondrial dysfunction in Parkinson disease

scientific article published on 18 June 2010

Molecular heterogeneity of the hemocyanin isolated from the king crab Paralithodes camtschaticae

scientific article published on 01 December 2000

Molecular insights into the interaction between alpha-synuclein and docosahexaenoic acid

scientific article published on 8 September 2009

NADH fluorescence lifetime is an endogenous reporter of α-synuclein aggregation in live cells

scientific article published on 24 February 2015

Neuronal Proteins as Targets of 3-Hydroxykynurenine: Implications in Neurodegenerative Diseases

scientific article published on 26 July 2019

New aspects of the reactivity of tyrosinase

scientific article published in January 2004

Nitrite Reductase Activity of Deoxy Carcinus maenas Hemocyanin: Formation of the Half-Met Derivative

scientific article published on 01 February 1996

Number and Brightness analysis of alpha-synuclein oligomerization and the associated mitochondrial morphology alterations in live cells

scientific article published on 20 February 2014

Observing the osmophobic effect in action at the single molecule level

scientific article published on 09 May 2011

Oxidized derivatives of Octopus vulgaris and Carcinus aestuarii hemocyanins at pH 7.5 and related models by x-ray absorption spectroscopy.

scientific article published on June 2002

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.

scientific article published on 14 December 2017

Paramagnetic properties of the halide-bound derivatives of oxidised tyrosinase investigated by 1H NMR spectroscopy

scientific article published on 01 October 2006

Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

scientific article

Pathogenic mutations shift the equilibria of alpha-synuclein single molecules towards structured conformers

scientific article published in January 2009

Peptides as modulators of α-synuclein aggregation.

scientific article

Preparation and spectroscopic characterization of a coupled binuclear center in cobalt(II)-substituted hemocyanin

scientific article published on September 1992

Pressure effects on α-synuclein amyloid fibrils: An experimental investigation on their dissociation and reversible nature.

scientific article published on 14 June 2017

Probing kojic acid binding to tyrosinase enzyme: insights from a model complex and QM/MM calculations

scientific article published on 14 November 2013

Quaternary structure and functional properties of Penaeus monodon hemocyanin

scientific article published on 01 April 2005

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.

scientific article published on 18 August 2017

Role of the tertiary structure in the diphenol oxidase activity of Octopus vulgaris hemocyanin

scientific article published on 19 January 2008

SARS-CoV-2-Mimicking Pseudoviral Particles Accelerate α-Synuclein Aggregation In Vitro

scientific article published in 2023

Saccharose solid matrix embedded proteins: a new method for sample preparation for X-ray absorption spectroscopy

scientific article published on 01 January 2000

Seasonal variation of trehalose and glycerol concentrations in winter snow-active insects

scientific article published on November 2008

Semisynthetic Modification of Tau Protein with Di-Ubiquitin Chains for Aggregation Studies

scientific article published on 20 June 2020

Semisynthetic and Enzyme-Mediated Conjugate Preparations Illuminate the Ubiquitination-Dependent Aggregation of Tau Protein

scientific article published on 05 February 2020

Single-molecule force spectroscopy of chimeric polyprotein constructs containing intrinsically disordered domains.

scientific article published in January 2012

Single-molecule-level evidence for the osmophobic effect

article

Small molecules interacting with α-synuclein: antiaggregating and cytoprotective properties.

scientific article published on 5 May 2013

Spectroscopic characterization of the electronic changes in the active site of Streptomyces antibioticus tyrosinase upon binding of transition state analogue inhibitors.

scientific article published on 6 December 2002

Stopped-flow fluorescence studies of inhibitor binding to tyrosinase from Streptomyces antibioticus

scientific article

Structural and morphological characterization of aggregated species of α-synuclein induced by docosahexaenoic acid

scientific article published on 28 April 2011

Structural basis and mechanism of the inhibition of the type-3 copper protein tyrosinase from Streptomyces antibioticus by halide ions

scientific article published on 4 June 2002

Structural basis of the lactate-dependent allosteric regulation of oxygen binding in arthropod hemocyanin

scientific article published on 20 April 2010

Structural characterization of a high affinity mononuclear site in the copper(II)-α-synuclein complex

scientific article published on 8 December 2010

Structural characterization of mononuclear Cu(II) and its nitrite complex in the active site of Carcinus maenas hemocyanin

scientific article published on 01 February 1995

Structural insights on physiological functions and pathological effects of alpha-synuclein.

scientific article published on 23 October 2008

Structural properties, conformational stability and oxygen binding properties of Penaeus monodon hemocyanin

scientific article published in January 2004

Structural role of the copper ions in the dinuclear active site of Carcinus aestuarii hemocyanin

scientific article published in January 2004

Structure and topology of the non-amyloid-beta component fragment of human alpha-synuclein bound to micelles: implications for the aggregation process

scientific article published in June 2006

Superoxide Dismutase (SOD)-mimetic M40403 Is Protective in Cell and Fly Models of Paraquat Toxicity: IMPLICATIONS FOR PARKINSON DISEASE.

scientific article published on 07 March 2016

Superoxide Dismutases SOD1 and SOD2 Rescue the Toxic Effect of Dopamine-Derived Products in Human SH-SY5Y Neuroblastoma Cells

scientific article published on 21 June 2019

Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson's Disease

scientific article published on 01 August 2018

Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss.

scientific article published in May 2018

Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease

scientific article published on 25 July 2018

Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains

scientific article published on 13 January 2018

Synthesis and structural characterization of soluble neuromelanin analogs provides important clues to its biosynthesis ⬇️

scientific article published on October 31, 2012

Synthesis, Structure Characterization, and Evaluation in Microglia Cultures of Neuromelanin Analogues Suitable for Modeling Parkinson's Disease.

scientific article published on 28 November 2016

The aromatic circular dichroism spectrum as a probe for conformational changes in the active site environment of hemocyanins

scientific article published on 01 March 1992

The binding of Cd(II) to the hemocyanin of the Mediterranean crab Carcinus maenas

scientific article published on 01 April 1993

The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity

scientific article

The functional dissection of the plasma corona of SiO₂-NPs spots histidine rich glycoprotein as a major player able to hamper nanoparticle capture by macrophages

scientific article published on 01 November 2015

The oxidation of hemocyanin. Kinetics, reaction mechanism and characterization of met-hemocyanin product

scientific article published on August 1995

The reaction of alpha-synuclein with tyrosinase: possible implications for Parkinson disease.

scientific article

Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils

scientific article published on 15 May 2019

Trapping tyrosinase key active intermediate under turnover

scientific article published on 15 July 2009

Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies

scientific article

Tryptophan-to-dye fluorescence energy transfer applied to oxygen sensing by using type-3 copper proteins

scientific article published on 01 January 2007

Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease

scientific article

Tyrosinase-catalyzed oxidation of fluorophenols

scientific article published on 13 September 2002

USP14 inhibition corrects an model of impaired mitophagy

scientific article published on 01 November 2018

Understanding the electronic properties of the CuA site from the soluble domain of cytochrome c oxidase through paramagnetic 1H NMR

scientific article published on 01 May 1998

Unsaturated Fatty Acid-Induced Conformational Transitions and Aggregation of the Repeat Domain of Tau

scientific article published on 11 June 2020

Unsymmetrical binding modes of the HOPNO inhibitor of tyrosinase: from model complexes to the enzyme

scientific article published on 29 January 2013

Water‐Soluble Melanin–Protein–Fe/Cu Conjugates Derived from Norepinephrine as Reliable Models for Neuromelanin of Human Brain Locus Coeruleus

Water‐Soluble Melanin–Protein–Fe/Cu Conjugates Derived from Norepinephrine as Reliable Models for Neuromelanin of Human Brain Locus Coeruleus

What are the structural features of the active site that define binuclear copper proteins function?

scientific article published in January 2004

Worm-like Ising model for protein mechanical unfolding under the effect of osmolytes

scientific article

X-ray absorption analysis of the active site of Streptomyces antibioticus Tyrosinase upon binding of transition state analogue inhibitors

scientific article published on 17 July 2007

α-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling.

scientific article published on 11 December 2017

α-Synuclein is a Novel Microtubule Dynamase.

scientific article

α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity

scientific article

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