Search filters

List of works by Diarmaid Hughes

A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

scientific article published on 7 September 2015

A new mutation in 16S rRNA of Escherichia coli conferring spectinomycin resistance.

scientific article

Acetate availability and utilization supports the growth of mutant sub-populations on aging bacterial colonies

scientific article

Antibiotic resistance and its cost: is it possible to reverse resistance?

scientific article published on 08 March 2010

Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene

scientific article published on 28 January 2020

Assays of sensitivity of antibiotic-resistant bacteria to hydrogen peroxide and measurement of catalase activity

scientific article published in January 2010

Autoregulation of the tufB operon in Salmonella.

scientific article

Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus

scientific article published in April 2001

Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections.

scientific article

Biological roles of translesion synthesis DNA polymerases in eubacteria.

scientific article published on 28 June 2010

Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

scientific article published on 30 August 2018

Both genes for EF-Tu in Salmonella typhimurium are individually dispensable for growth

scientific article

Can phylogenetic type predict resistance development?

scientific article

Cell-wall-inhibiting antibiotic combinations with activity against multidrug-resistant Klebsiella pneumoniae and Escherichia coli.

scientific article published on 2 October 2013

Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects.

scientific article published on 12 September 2016

Co-evolution of the tuf genes links gene conversion with the generation of chromosomal inversions.

scientific article

Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella

article

Comparison of the complete sequence of the str operon in Salmonella typhimurium and Escherichia coli

scientific article published on October 12, 1992

Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis

scientific article published on 31 October 2014

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB).

scientific article

Discovery and preclinical development of new antibiotics.

scientific article published on 19 March 2014

Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.

scientific article published on 28 July 2016

Dose-related selection of fluoroquinolone-resistant Escherichia coli.

scientific article published on 16 July 2007

Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli

scientific article published on 01 December 2018

Effect of translesion DNA polymerases, endonucleases and RpoS on mutation rates in Salmonella typhimurium

scientific article published on 26 April 2010

Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance

scientific article published in February 2000

Error-prone EF-Tu reduces in vivo enzyme activity and cellular growth rate ⬇️

scientific article published on March 1, 1991

Establishment of a superficial skin infection model in mice by using Staphylococcus aureus and Streptococcus pyogenes

scientific article

Evidence against reciprocal recombination as the basis for tuf gene conversion in Salmonella enterica serovar Typhimurium

scientific article

Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain

scientific article published on 3 November 2015

Evolution of antibiotic resistance at non-lethal drug concentrations ⬇️

scientific article published on April 18, 2012

Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms

scientific article published on 07 July 2015

Exploiting genomics, genetics and chemistry to combat antibiotic resistance.

scientific article

Fitness cost: a bacteriological explanation for the demise of the first international methicillin-resistant Staphylococcus aureus epidemic

scientific article published on 29 February 2012

Fitness-compensatory mutations in rifampicin-resistant RNA polymerase

scientific article published on 31 May 2012

Fusidic acid-resistant mutants define three regions in elongation factor G of Salmonella typhimurium

scientific article published in May 1994

Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS induction.

scientific article

Fusidic acid-resistant mutants of Salmonella enterica serovar typhimurium have low levels of heme and a reduced rate of respiration and are sensitive to oxidative stress

scientific article published on October 2004

Gene amplification and adaptive evolution in bacteria.

scientific article published on January 2009

Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus

scientific article published on 8 October 2007

Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates.

scientific article published on 11 June 2013

Genetic complexity of fusidic acid-resistant small colony variants (SCV) in Staphylococcus aureus

scientific article

Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus

scientific article published on 16 March 2009

Genetics: Location affects sporulation

scientific article

Genome-wide detection of spontaneous chromosomal rearrangements in bacteria

scientific article

Growth and translation elongation rate are sensitive to the concentration of EF-Tu

scientific article published in May 1993

Homologous recombination between the tuf genes of Salmonella typhimurium.

scientific article published in July 1996

Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics.

scientific article

Identification of the genetic basis for clinical menadione-auxotrophic small-colony variant isolates of Staphylococcus aureus

scientific article published on 08 September 2008

Interplay in the selection of fluoroquinolone resistance and bacterial fitness

scientific article

Intra- and extracellular activities of dicloxacillin and linezolid against a clinical Staphylococcus aureus strain with a small-colony-variant phenotype in an in vitro model of THP-1 macrophages and an in vivo mouse peritonitis model

scientific article

Measurements of heme levels and respiration rate in Salmonella enterica serovar typhimurium

scientific article published in January 2010

Mechanisms and consequences of bacterial resistance to antimicrobial peptides

scientific article

Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB

scientific article published in Scientific Reports

Microbiological effects of sublethal levels of antibiotics.

scientific article published on 27 May 2014

Missense substitutions lethal to essential functions of EF-Tu

scientific article published in December 1991

Mutant forms of tufA and tufB independently suppress nonsense mutations

scientific article published in October 1987

Mutant prevention concentrations of ciprofloxacin for urinary tract infection isolates of Escherichia coli

scientific article published on 28 April 2005

Mutant prevention concentrations of pradofloxacin for susceptible and mutant strains of Escherichia coli with reduced fluoroquinolone susceptibility

scientific article published on 25 July 2014

Mutants of EF-Tu defective in binding aminoacyl-tRNA.

scientific article published in March 1996

Mutants of the RNA-processing enzyme RNase E reverse the extreme slow-growth phenotype caused by a mutant translation factor EF-Tu

scientific article published in December 2008

Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coli

scientific article published on 12 January 2017

Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.

scientific article

Mutations to kirromycin resistance occur in the interface of domains I and III of EF-Tu.GTP.

scientific article published in September 1994

Novel Mutants of EF-Tu

Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium

scientific article published in January 1999

Persistence of antibiotic resistance in bacterial populations.

scientific article

Population bottlenecks strongly influence the evolutionary trajectory to fluoroquinolone resistance in Escherichia coli

scientific article published on 07 February 2020

Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria

scientific article published in 2022

Reducing ppGpp level rescues an extreme growth defect caused by mutant EF-Tu

scientific article

Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution

scientific article published on 03 April 2013

Selection and evolution of resistance to antimicrobial drugs

scientific article

Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration.

scientific article

Selection of resistance at lethal and non-lethal antibiotic concentrations.

scientific article published on 08 August 2012

Selection of resistant bacteria at very low antibiotic concentrations

scientific article

Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site

scientific article

Suppression of rpsL phenotypes by tuf mutations reveals a unique relationship between translation elongation and growth rate

scientific article published on 01 January 1993

Temperature-sensitive mutants of RNase E in Salmonella enterica

scientific article published on 23 September 2011

Ternary complex-ribosome interaction: its influence on protein synthesis and on growth rate

scientific article

The Origin of Mutants under Selection: Interactions of Mutation, Growth, and Selection

scientific article published on 01 December 2011

The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation

scientific article published on 04 March 2020

The Selective Advantage of Synonymous Codon Usage Bias in Salmonella

scientific article

The dynamic structure of EF-G studied by fusidic acid resistance and internal revertants

scientific article published in May 1996

The isolation and mapping of EF-Tu mutations in Salmonella typhimurium

scientific article published in January 1986

The nucleotide sequence of rpsL and its flanking regions in Salmonella typhimurium

scientific article

The processive kinetics of gene conversion in bacteria.

scientific article

The role of EF-Tu and other translation components in determining translocation step size

scientific article published in August 1990

The role of EF-Tu and other translation components in determining translocation step size (BBAEXP 92116)

Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in

article

Turnover of mRNAs is one of the essential functions of RNase E.

scientific article published on 19 June 2015

Using the power of genetic suppressors to probe the essential functions of RNase E.

scientific article published on August 2015

Virulence of antibiotic-resistant Salmonella typhimurium ⬇️

scientific article published on March 31, 1998

Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli

scientific article

Paulina is supported by:

About Paulina

Help