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List of works by Lasse K. Bak

Activity of the lactate-alanine shuttle is independent of glutamate-glutamine cycle activity in cerebellar neuronal-astrocytic cultures.

scientific article published in January 2005

Among the branched-chain amino acids, only valine metabolism is up-regulated in astrocytes during glutamate exposure.

scientific article

Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation

scientific article published on 27 April 2012

Aspects of astrocytic cAMP signaling with an emphasis on the putative power of compartmentalized signals in health and disease

scientific article published on 29 April 2019

Aspects of cAMP Signaling in Epileptogenesis and Seizures and Its Potential as Drug Target

scientific article published on 14 August 2019

Astrocyte glycogenolysis is triggered by store-operated calcium entry and provides metabolic energy for cellular calcium homeostasis

scientific article published on 24 January 2014

Astrocytes take the stage in a tale of signaling-metabolism coupling

scientific article published on June 2017

Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA ⬇️

scientific article published on August 15, 2013

Astrocytic glycogen metabolism in the healthy and diseased brain.

scientific article

Brain Alanine Formation as an Ammonia-Scavenging Pathway during Hyperammonemia: Effects of Glutamine Synthetase Inhibition in Rats and Astrocyte—Neuron Co-Cultures ⬇️

scientific article published on May 15, 2013

Brain glycogen-new perspectives on its metabolic function and regulation at the subcellular level

scientific article published on 2 March 2012

Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects

scientific article published on 02 June 2011

Characterization of depolarization-coupled release of glutamate from cultured mouse cerebellar granule cells using dl-threo-β-benzyloxyaspartate (DL-TBOA) to distinguish between the vesicular and cytoplasmic pools ⬇️

scientific article published on September 1, 2003

Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons.

scientific article

Complex actions of ionomycin in cultured cerebellar astrocytes affecting both calcium-induced calcium release and store-operated calcium entry.

scientific article published on 22 March 2013

Complex glutamate labeling from [U-13C]glucose or [U-13C]lactate in co-cultures of cerebellar neurons and astrocytes

scientific article published on 5 October 2006

CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain

scientific article published on 2 January 2018

Demonstration of extensive GABA synthesis in the small population of GAD positive neurons in cerebellar cultures by the use of pharmacological tools

scientific article published on 3 March 2006

Demonstration of neuron-glia transfer of precursors for GABA biosynthesis in a co-culture system of dissociated mouse cerebral cortex

scientific article published on 16 August 2008

Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine

scientific article published on 18 May 2010

Dynamic Changes in Cytosolic ATP Levels in Cultured Glutamatergic Neurons During NMDA-Induced Synaptic Activity Supported by Glucose or Lactate

scientific article published on 17 July 2015

Effect of glutamine synthetase inhibition on brain and interorgan ammonia metabolism in bile duct ligated rats

scientific article published on 18 December 2013

Effects of adrenergic agents on intracellular Ca2+ homeostasis and metabolism of glucose in astrocytes with an emphasis on pyruvate carboxylation, oxidative decarboxylation and recycling: implications for glutamate neurotransmission and excitotoxici

scientific article published on 23 December 2011

Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro.

scientific article published on March 2014

Energy substrates to support glutamatergic and GABAergic synaptic function: role of glycogen, glucose and lactate

scientific article published on December 2007

Expression of the human isoform of glutamate dehydrogenase, hGDH2, augments TCA cycle capacity and oxidative metabolism of glutamate during glucose deprivation in astrocytes

scientific article

Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex

scientific article published on 25 June 2020

Fluctuations in Cytosolic Calcium Regulate the Neuronal Malate-Aspartate NADH Shuttle: Implications for Neuronal Energy Metabolism.

scientific article published on 03 July 2015

Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient.

scientific article published on 20 March 2010

Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons

scientific article published in February 2006

Glucose, Lactate and Glutamine but not Glutamate Support Depolarization-Induced Increased Respiration in Isolated Nerve Terminals

scientific article

Glutamate dehydrogenase isoforms with N-terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization.

scientific article published on 26 April 2013

Glutamate metabolism in the brain focusing on astrocytes.

scientific article published in January 2014

Glycogen Shunt Activity and Glycolytic Supercompensation in Astrocytes May Be Distinctly Mediated via the Muscle Form of Glycogen Phosphorylase

scientific article published on 11 May 2017

Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake.

scientific article

Impairment of the organization of locomotor and exploratory behaviors in bile duct-ligated rats

scientific article

Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons

scientific article published on 21 March 2011

Interorgan metabolism of ornithine phenylacetate (OP)--a novel strategy for treatment of hyperammonemia

scientific article published on 24 October 2012

Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes

scientific article published on 18 August 2014

Low cerebral energy metabolism in hepatic encephalopathy reflects low neuronal energy demand. Role of ammonia-induced increased GABAergic tone

scientific article published in 2022

Low cerebral oxygen consumption and blood flow in patients with cirrhosis and an acute episode of hepatic encephalopathy

scientific article

Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia.

scientific article

Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix

scientific article published on 01 September 2007

Misconceptions regarding basic thermodynamics and enzyme kinetics have led to erroneous conclusions regarding the metabolic importance of lactate dehydrogenase isoenzyme expression

scientific article published on 2 February 2017

Neuronal Cell Death Induced by Mechanical Percussion Trauma in Cultured Neurons is not Preceded by Alterations in Glucose, Lactate and Glutamine Metabolism.

scientific article published on 4 January 2016

Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels.

scientific article published in May 2009

Novel model of neuronal bioenergetics: postsynaptic utilization of glucose but not lactate correlates positively with Ca2+ signalling in cultured mouse glutamatergic neurons.

scientific article published on 5 April 2012

Oxidative metabolism of astrocytes is not reduced in hepatic encephalopathy: a PET study with [(11)C]acetate in humans

scientific article

PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

scientific article published on 05 July 2019

Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B

scientific article published on 06 February 2017

Potential role of adenylyl cyclase 8 signaling complexes in regulating insulin secretion from pancreatic beta cells

scientific article published on 10 April 2020

Primary cultures of astrocytes: their value in understanding astrocytes in health and disease.

scientific article published on 28 August 2012

Rebuttal from Lasse K. Bak and Anne B. Walls

scientific article published on 2 January 2018

Reply: To PMID 22886493.

scientific article published on 24 June 2013

Role of astrocytes in depolarization-coupled release of glutamate in cerebellar cultures

scientific article published in January 2004

Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission.

scientific article published on September 2004

Role of branched chain amino acids in cerebral ammonia homeostasis related to hepatic encephalopathy.

scientific article published on 31 January 2013

Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function

scientific article published on 06 June 2019

State-Dependent Changes in Brain Glycogen Metabolism

scientific article published on 01 January 2019

Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

scientific article published on 07 April 2011

The anticonvulsant action of the galanin receptor agonist NAX-5055 involves modulation of both excitatory- and inhibitory neurotransmission.

scientific article

The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.

scientific article

The glutamine-glutamate/GABA cycle: function, regional differences in glutamate and GABA production and effects of interference with GABA metabolism.

scientific article

The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms

scientific article published on 22 June 2018

The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes

scientific article published on 06 February 2007

The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2)

scientific article

Transcriptome analysis in patients with temporal lobe epilepsy

scientific article published on 01 October 2019

Valine but not leucine or isoleucine supports neurotransmitter glutamate synthesis during synaptic activity in cultured cerebellar neurons.

scientific article

Yield and Integrity of RNA from Brain Samples are Largely Unaffected by Pre-analytical Procedures

scientific article published on 29 November 2020

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