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List of works by Karen Chapman

'Liver-type' 11 beta-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS-7 cells.

scientific article published on October 1994

11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations

scientific article published in November 1995

11 beta-hydroxysteroid dehydrogenase type 1 expression in 2S FAZA hepatoma cells is hormonally regulated: a model system for the study of hepatic glucocorticoid metabolism

scientific article published on July 1996

11Beta-hydroxysteroid dehydrogenase 1 in adipocytes: expression is differentiation-dependent and hormonally regulated

scientific article published on March 1998

11Beta-hydroxysteroid dehydrogenase type 1--a role in inflammation?

scientific article

11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice.

scientific article published on 4 May 2016

11β-Hydroxysteroid Dehydrogenases: Intracellular Gate-Keepers of Tissue Glucocorticoid Action ⬇️

scientific article published on July 1, 2013

11β-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice

scientific article published on 8 November 2011

11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis

scientific article published on 9 January 2013

11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice

scientific article

3.3 kb of 5' flanking DNA from the rat preprotachykinin gene directs high level expression of a reporter gene in microinjected dorsal root ganglion neurons but not in transgenic mice

scientific article published in July 1993

5'-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events.

scientific article published in April 2000

5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor.

scientific article

7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type.

scientific article

A Novel Coculture Model for Benign Prostatic Hyperplasia Expressing Both Isoforms of 5α-Reductase1

scientific article published in January 1998

A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome

scientific article published on 27 May 2011

A high molecular mass steroid response element binding protein forms a 213 kDa complex with an oestrogen response element

scientific article published in August 1990

A novel promoter for the 11beta-hydroxysteroid dehydrogenase type 1 gene is active in lung and is C/EBPalpha independent

scientific article published on 16 March 2006

A novel role for the mineralocorticoid receptor in glucocorticoid driven vascular calcification

scientific article

Adrenal hormones mediate disease tolerance in malaria

scientific article published in Nature Communications

Antenatal endogenous and exogenous glucocorticoids and their impact on immune ontogeny and long-term immunity.

scientific article

C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways

scientific article

CCAAT/enhancer binding protein positively regulates the rat 11β-hydroxysteroid dehydrogenase type 1 promoter in liver cells

scientific article published in May 1997

Cardiac GR and MR: From Development to Pathology

scientific article

Cardiomyocyte and Vascular Smooth Muscle-Independent 11β-Hydroxysteroid Dehydrogenase 1 Amplifies Infarct Expansion, Hypertrophy, and the Development of Heart Failure After Myocardial Infarction in Male Mice

scientific article

Changing glucocorticoid action: 11β-hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation.

scientific article published on 19 February 2013

Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2

scientific article

Cloning, sequencing and tissue-distribution of mouse 11β-hydroxysteroid dehydrogenase-1 cDNA

scientific article published in February 1995

Complete nucleotide sequence of the Escherichia coli recB gene

scientific article

Corticosteroid receptor balance regulates life and death in cardiomyocytes

scientific article published on 16 April 2019

Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques.

scientific article published on 6 February 2007

Decreased Npas4 and Arc mRNA Levels in the Hippocampus of Aged Memory-Impaired Wild-Type But Not Memory Preserved 11β-HSD1 Deficient Mice

scientific article published on 13 November 2015

Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11β-hydroxysteroid dehydrogenase type 1 ⬇️

scientific article published on March 15, 2011

Differential regulation of 11β-hydroxysteroid dehydrogenase-1 by dexamethasone in glucocorticoid-sensitive and -resistant childhood lymphoblastic leukemia

scientific article published in December 2009

Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture

scientific article published in January 2003

Differential regulation of variant glucocorticoid receptor mRNAs in the rat hippocampus by the antidepressant fluoxetine

scientific article published in October 2004

Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites ⬇️

scientific article published on December 20, 2001

Effects of maternal high-fat diet on serum lipid concentration and expression of peroxisomal proliferator-activated receptors in the early life of rat offspring.

scientific article published on 13 August 2010

Expression of 11beta-hydroxysteroid dehydrogenase 2 contributes to glucocorticoid resistance in lymphoblastic leukemia cells

scientific article published on 26 July 2011

Functional effects of polymorphisms in the human gene encoding 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1): a sequence variant at the translation start of 11 beta-HSD1 alters enzyme levels.

scientific article

Getting to the heart of intracellular glucocorticoid regeneration: 11β-HSD1 in the myocardium

scientific article

Glucocorticoid receptor is required for foetal heart maturation

scientific article published on 16 April 2013

Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.

scientific article published on 6 April 2015

Glucocorticoid regulation of the promoter of 11beta-hydroxysteroid dehydrogenase type 1 is indirect and requires CCAAT/enhancer-binding protein-beta

scientific article

Glucocorticoids and fetal programming.

scientific article

Glucocorticoids and foetal heart maturation; implications for prematurity and foetal programming

scientific article

Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α.

scientific article

Growth hormone inhibits the 11 beta-Hydroxysteroid dehydrogenase type 1 gene promoter activity via insulin-like growth factor I in HepG2 cells

scientific article published in April 2008

Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.

scientific article published in June 2005

High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrPSc in vivo.

scientific article

Human placental 11 beta-hydroxysteroid dehydrogenase: evidence for and partial purification of a distinct NAD-dependent isoform

scientific article published in June 1993

Identification and cDNA sequence of delta-preprotachykinin, a fourth splicing variant of the rat substance P precursor

scientific article

Identification of a high molecular weight steroid response element binding protein.

scientific article

Identification of nerve growth factor-responsive sequences within the 5' region of the bovine preprotachykinin gene

scientific article

Increased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageing.

scientific article

Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia

scientific article published on 3 April 2014

It takes two to tango: dimerisation of glucocorticoid receptor and its anti-inflammatory functions.

scientific article

LLC-PK1 cells model 11 beta-hydroxysteroid dehydrogenase type 2 regulation of glucocorticoid access to renal mineralocorticoid receptors.

scientific article published in December 1995

Late-onset apparent mineralocorticoid excess caused by novel compound heterozygous mutations in the HSD11B2 gene

scientific article

Local Amplification of Glucocorticoids by 11 -Hydroxysteroid Dehydrogenase Type 1 Promotes Macrophage Phagocytosis of Apoptotic Leukocytes

scientific article published on 2 June 2006

Local amplification of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 and its role in the inflammatory response.

scientific article published on November 2006

Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate

scientific article

Mast cells express 11β-hydroxysteroid dehydrogenase type 1: a role in restraining mast cell degranulation

scientific article

Medical and physiological aspects of the 11beta-hydroxysteroid dehydrogenase system

scientific article published on October 1997

Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour

scientific article published on 11 September 2012

Modulation of 11β-hydroxysteroid dehydrogenase as a strategy to reduce vascular inflammation

scientific article

Mutations that alter the ability of the Escherichia coli cyclic AMP receptor protein to activate transcription.

scientific article published on December 1990

Novel fat depot-specific mechanisms underlie resistance to visceral obesity and inflammation in 11 β-hydroxysteroid dehydrogenase type 1-deficient mice ⬇️

scientific article published on 24 February 2011

Oestrogen and benign prostatic hyperplasia: effects on stromal cell proliferation and local formation from androgen.

scientific article

Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity

scientific article

Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity.

scientific article published on 15 July 2009

Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum

scientific article

Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone

scientific article

Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1) and lifetime cognitive change

scientific article published on 17 October 2005

Pravastatin ameliorates placental vascular defects, fetal growth, and cardiac function in a model of glucocorticoid excess

scientific article published on 16 May 2016

Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo

scientific article published on 3 January 2008

Prenatal programming of hepatocyte nuclear factor 4alpha in the rat: A key mechanism in the 'foetal origins of hyperglycaemia'?

scientific journal article

Prevention of 5-hydroxytryptamine2C receptor RNA editing and alternate splicing in C57BL/6 mice activates the hypothalamic-pituitary-adrenal axis and alters mood

scientific article

Pro-inflammatory cytokine induction of 11β-hydroxysteroid dehydrogenase type 1 in A549 cells requires phosphorylation of C/EBPβ at Thr235

scientific article

Proinflammatory cytokine induction of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in human adipocytes is mediated by MEK, C/EBPβ, and NF-κB/RelA.

scientific article published on 20 December 2013

Purification of 11 beta-hydroxysteroid dehydrogenase type 2 from human placenta utilizing a novel affinity labelling technique

scientific article

Reciprocal Regulation of 11β-HSDs May Predict Steroid Sensitivity in Childhood Nephrotic Syndrome

scientific article published on 9 August 2016

Regulation of 11 beta-hydroxysteroid dehydrogenase by sex steroids in vivo: further evidence for the existence of a second dehydrogenase in rat kidney.

scientific article published on October 1993

Regulation of adipocyte 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) by CCAAT/enhancer-binding protein (C/EBP) β isoforms, LIP and LAP.

scientific article

Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization

scientific article

Selective Interactions between Prostate Fibroblast and Epithelial Cells in Co-Culture Maintain the BPH Phenotype

scientific article published in 1998

Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression.

scientific article

Sexual dimorphism of hepatic 11β-hydroxysteroid dehydrogenase in the rat: the role of growth hormone patterns

scientific article published in December 1994

Stable conditional expression and effect of C/ebpβ-LIP in adipocytes using the pSLIK system

scientific article

Steroids: Modulators of inflammation and immunity

scientific article published in May 2010

The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights

scientific article published on 14 April 2010

The sequence of 5' flanking DNA from the mouse 11 beta-hydroxysteroid dehydrogenase type 1 gene and analysis of putative transcription factor binding sites

scientific article published in November 1996

The sequence of 5' flanking DNA from the rat preprotachykinin gene; analysis of putative transcription factor binding sites

scientific article published in March 1993

Tissue- and temporal-specific regulation of 11beta-hydroxysteroid dehydrogenase type 1 by glucocorticoids in vivo

scientific article

Tissue-specific differences in rat glucocorticoid receptor gene transcriptional regulation.

scientific article published in August 1998

Tissue-specific modulation of glucocorticoid action by the 11 beta-hydroxysteroid dehydrogenases

scientific article published on May 1997

cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A

scientific journal article

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