List of works - Ricardo M Biondi

2-(3-Oxo-1,3-diphenylpropyl)malonic Acids as Potent Allosteric Ligands of the PIF Pocket of Phosphoinositide-Dependent Kinase-1: Development and Prodrug Concept

article

3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.

scientific article published in August 2009

4-benzimidazolyl-3-phenylbutanoic acids as novel PIF-pocket-targeting allosteric inhibitors of protein kinase PKCζ.

scientific article published on 14 September 2011

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

scientific article (publication date: 7 July 2000)

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

scientific article

AGC kinases, mechanisms of regulation and innovative drug development.

scientific article published on 4 June 2017

AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases.

scientific article published on 21 March 2013

Allosteric activation of the protein kinase PDK1 with low molecular weight compounds

scientific article

Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket

scientific article

An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms

scientific article published on 3 January 2017

Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase

scientific article

Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase

scientific article

Brain specific kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environment

scientific article published on 12 October 2011

Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE.

scientific article published on 12 October 2017

Candida albicans Tpk1p and Tpk2p isoforms differentially regulate pseudohyphal development, biofilm structure, cell aggregation and adhesins expression.

scientific article published on 12 January 2011

Candida albicansNucleoside-Diphosphate Kinase: Purification and Characterization

scientific article published on 01 October 1995

Catalytic isoforms Tpk1 and Tpk2 of Candida albicans PKA have non-redundant roles in stress response and glycogen storage.

scientific article published in May 2009

Cellular phosphorylation of anti-HIV nucleosides. Role of nucleoside diphosphate kinase

scientific article published on 01 April 1996

Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor

scientific article published on 07 February 2014

Cross regulation between Candida albicans catalytic and regulatory subunits of protein kinase A.

scientific article

DNA mismatch repair activity of MutLα is regulated by CK2-dependent phosphorylation of MLH1 (S477)

scientific article published on 05 September 2018

Depletion of yeast PDK1 orthologs triggers a stress-like transcriptional response

scientific article published on 21 September 2015

Differential stability of cell-free circulating microRNAs: implications for their utilization as biomarkers

scientific article

Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods ⬇️

scientific article published on 4 September 2015

Discrimination between acid and alkali-labile phosphorylated residues on Immobilon: phosphorylation studies of nucleoside diphosphate kinase.

scientific article

Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells

scientific article

Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors

scientific article published on 03 August 2020

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

scientific article

Identification of Key Phospholipids That Bind and Activate Atypical PKCs

scientific article published on 06 January 2021

Identification of a novel type of cGMP phosphodiesterase that is defective in the chemotactic stmF mutants.

scientific article published on November 2002

Inhibition of nucleoside diphosphate kinase activity by in vitro phosphorylation by protein kinase CK2 Differential phosphorylation of NDP kinases in HeLa cells in culture

article

InterAKTions with FKBPs--mutational and pharmacological exploration

scientific article

Lipid regulators of Pkh2 in Candida albicans, the protein kinase ortholog of mammalian PDK1.

scientific article published on 29 December 2015

Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation

scientific journal article

Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds

scientific article published on 28 June 2018

Molecular Basis of the Activity and the Regulation of the Eukaryotic-like S/T Protein Kinase PknG from Mycobacterium tuberculosis

scientific article

PIF-pocket as a target for C. albicans Pkh selective inhibitors

scientific article

Phosphoinositide-regulated kinases and phosphoinositide phosphatases.

scientific article

Phosphorylation-dependent signaling controls degradation of DNA mismatch repair protein PMS2.

scientific article published on 2 August 2017

Predicting protein targets for drug-like compounds using transcriptomics

scientific article published on 07 December 2018

Pyrazolo[1,5a]pyrimidines as a new class of FUSE binding protein 1 (FUBP1) inhibitors

scientific article published on 14 September 2016

Random insertion of GFP into the cAMP-dependent protein kinase regulatory subunit from Dictyostelium discoideum

scientific article

Random insertion of green fluorescent protein into the regulatory subunit of cyclic adenosine monophosphate-dependent protein kinase

scientific article published on 01 January 2002

Regulation of Protein Kinase C-related Protein Kinase 2 (PRK2) by an Intermolecular PRK2-PRK2 Interaction Mediated by Its N-terminal Domain ⬇️

scientific article published on April 16, 2012

Role of Mg2+in Nucleoside Diphosphate Kinase Autophosphorylation

scientific article published on 01 May 1998

Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions

scientific article

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1

scientific article

Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site

scientific article

The mechanism of phosphorylation of anti-HIV D4T by nucleoside diphosphate kinase

article

Use of a fluorescent ATP analog to probe the allosteric conformational change in the active site of the protein kinase PDK1.

scientific article

X-ray analysis of azido-thymidine diphosphate binding to nucleoside diphosphate kinase

scientific article

List of works by Ricardo M Biondi

2-(3-Oxo-1,3-diphenylpropyl)malonic Acids as Potent Allosteric Ligands of the PIF Pocket of Phosphoinositide-Dependent Kinase-1: Development and Prodrug Concept

3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.

4-benzimidazolyl-3-phenylbutanoic acids as novel PIF-pocket-targeting allosteric inhibitors of protein kinase PKCζ.

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

AGC kinases, mechanisms of regulation and innovative drug development.

AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases.

Allosteric activation of the protein kinase PDK1 with low molecular weight compounds

Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket

An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms

Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase

Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase

Brain specific kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environment

Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE.

Candida albicans Tpk1p and Tpk2p isoforms differentially regulate pseudohyphal development, biofilm structure, cell aggregation and adhesins expression.

Candida albicansNucleoside-Diphosphate Kinase: Purification and Characterization

Catalytic isoforms Tpk1 and Tpk2 of Candida albicans PKA have non-redundant roles in stress response and glycogen storage.

Cellular phosphorylation of anti-HIV nucleosides. Role of nucleoside diphosphate kinase

Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor

Cross regulation between Candida albicans catalytic and regulatory subunits of protein kinase A.

DNA mismatch repair activity of MutLα is regulated by CK2-dependent phosphorylation of MLH1 (S477)

Depletion of yeast PDK1 orthologs triggers a stress-like transcriptional response

Differential stability of cell-free circulating microRNAs: implications for their utilization as biomarkers

Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods ⬇️

Discrimination between acid and alkali-labile phosphorylated residues on Immobilon: phosphorylation studies of nucleoside diphosphate kinase.

Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells

Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

Identification of Key Phospholipids That Bind and Activate Atypical PKCs

Identification of a novel type of cGMP phosphodiesterase that is defective in the chemotactic stmF mutants.

Inhibition of nucleoside diphosphate kinase activity by in vitro phosphorylation by protein kinase CK2 Differential phosphorylation of NDP kinases in HeLa cells in culture

InterAKTions with FKBPs--mutational and pharmacological exploration

Lipid regulators of Pkh2 in Candida albicans, the protein kinase ortholog of mammalian PDK1.

Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation

Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds

Molecular Basis of the Activity and the Regulation of the Eukaryotic-like S/T Protein Kinase PknG from Mycobacterium tuberculosis

PIF-pocket as a target for C. albicans Pkh selective inhibitors

Phosphoinositide-regulated kinases and phosphoinositide phosphatases.

Phosphorylation-dependent signaling controls degradation of DNA mismatch repair protein PMS2.

Predicting protein targets for drug-like compounds using transcriptomics

Pyrazolo[1,5a]pyrimidines as a new class of FUSE binding protein 1 (FUBP1) inhibitors

Random insertion of GFP into the cAMP-dependent protein kinase regulatory subunit from Dictyostelium discoideum

Random insertion of green fluorescent protein into the regulatory subunit of cyclic adenosine monophosphate-dependent protein kinase

Regulation of Protein Kinase C-related Protein Kinase 2 (PRK2) by an Intermolecular PRK2-PRK2 Interaction Mediated by Its N-terminal Domain ⬇️

Role of Mg2+in Nucleoside Diphosphate Kinase Autophosphorylation

Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1

Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site

The mechanism of phosphorylation of anti-HIV D4T by nucleoside diphosphate kinase

Use of a fluorescent ATP analog to probe the allosteric conformational change in the active site of the protein kinase PDK1.

X-ray analysis of azido-thymidine diphosphate binding to nucleoside diphosphate kinase